Dr. Tobias Eckle Program

eckleTobias Eckle, MD, PhD

Primary Appointment: Professor, Anesthesiology

Secondary Appointment: Professor, Cardiology

Dr. Eckle's Colorado Profiles page.


MD, Eberhard-Karls University, Tübingen, Germany

PhD, Eberhard-Karls University, Tübingen, Germany

Internship, Department of Anesthesiology and Intensive Care Medicine, Clinic of Internal Medicine, Department of Abdominal Surgery, Department of Cardiac Surgery, University Hospital of Tübingen, Germany

Residency in Anesthesia, Department of Anesthesiology and Critical Care Medicine, University Hospital of Tübingen, Germany

Contact Information

Mailstop B112
12700 E 19th Avenue, room 7121
Aurora, CO 80045
Telephone: (303) 724-2932
Email: tobias.eckle@CUAnschutz.edu

Training Programs

Cell Biology, Stem Cells and Development

Research Interests

The role of the circadian and light elicited protein Period 2 (PER2) in anesthesia and critical care relevant comorbidities.

Research Description


Our research has been directed towards identifying cellular adaptive mechanisms during hypoxic conditions such as myocardial ischemia - one of the leading causes of morbidity and mortality worldwide. Adenosine signaling has been implicated in cardiac adaptation to limited oxygen availability. In a wide search for adenosine receptor elicited cardio-adaptive responses, we identified the circadian rhythm protein period 2 (PER2) as an adenosine signaling target. Here we found that Per2-/-mice had larger infarct sizes and a limited ability to use carbohydrates for oxygen-efficient glycolysis compared to wild-type mice. This impairment was caused by a failure to stabilize the oxygen sensor hypoxia-inducible factor-1 alpha (HIF1A). Moreover, stabilization of PER2 in the heart by exposing mice to intense light resulted in the transcriptional induction of HIF1A regulated glycolytic enzymes and PER2-dependent cardio-protection from ischemia. Ongoing studies are directed towards elucidating the role of the light regulated circadian rhythm protein PER2 as oxygen and metabolic sensor during conditions of limited oxygen availability. The long-term goal of our studies is to introduce circadian (PER2) enhancer strategies into the hospital to prevent or treat hypoxic conditions such as myocardial ischemia in patients (https://clinicaltrials.gov; NCT02490397).

Our research is funded by NIH-NHBLI and AHA research grants.


Click here for Dr. Tobias Eckle's publications on NCBI

Anesthesiology (SOM)

CU Anschutz

Leprino Building

12401 East 17th Avenue

7th Floor

Aurora, CO 80045

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