Moore-Lorca Lab

Understanding the maternal physiologic responses contributing to fetal growth restriction.

Moore-Lorca Lab

Understanding the maternal physiologic responses contributing to fetal growth restriction.

High altitude (>2500 m or 8000 ft) exerts one of the most powerful effects on fetal growth, making it a natural laboratory for understanding maternal physiologic responses contributing to fetal growth restriction. Our past work showed that multigenerational populations (Andeans, Tibetans) are relatively protected from hypoxia-associated fetal growth restriction compared with shorter–term groups (Europeans, Han “Chinese”) due primarily to genetic factors enabling a normal pregnancy rise in uterine artery blood flow. Current studies are aimed at determining the physiological pathways involved and, in particular, the roles of AMPKα activation and epigenetic changes due to DNA methylation.

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Contact Info

Olivia Castillo
Division Administrator
12700 East 19th Avenue
Room 3000D, MS 8613
Aurora, CO 80045

Phone: (303) 724-4144