Endowed Professor: Kumar

Edgar L. and Patricia M. Makowski Endowment

The goals are to promote education, research and training in women’s health.

2K12HD001271-21 PI: Nanette Santoro

08/2020-06/2025        NIH/NICHD

Colorado Women’s Reproductive Health Research Career Development Center

This is a research training program for OB/GYN junior faculty

R01HD103384 PI: Rajendra Kumar

04/2021-03/2026        NIH

FSH Glycoforms and Ovarian Signaling Pathways

Our studies using novel genetic models expressing different age-specific FSH glycoforms will not only provide mechanistic insights but unequivocally test the role of FSH-mediated signaling pathways in vivo in the ovary which produces estrogen and eggs.

P01AG029531 PI: Rajendra Kumar

06/2023-05/2028        NIH-NIA (AWARDEE: WICHITA STATE UNIVERSITY)

Project 3 - Functional Analysis of Age-Specific FSH Analogs Using Genetically Altered Mice

The goals of this project are to determine the biological roles of FSH glycoforms using novel mouse models.

PI: Rajendra Kumar

2020-2024        Gates Center for Regenerative Medicine at the University of Colorado Anschutz Medical Campus

Gates Grubstake Award from the Gates Center for Regenerative Medicine at the University of Colorado Anschutz Medical Campus

1. ​Matzuk MM, Kumar TR and Bradley, A. (1995)Different phenotypes for mice deficient in either activins or activin receptor type II.. Nature 374: 356-360
2. Kumar TR, Lu H, Wang Y, and Matzuk MM. (1997). Follicle Stimulating hormone is required for ovarian follicle maturation but not male fertility.. Nature Genetics 15: 201-204
3. Wang H, Larson M, Shariff AJ, Pearl C, Miller WL, Conn PM, Boime I and Kumar TR (2014). Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function.. Proceedings of The National Academy of Sciences (USA), 111: 5735 - 5740
4. Wang H, Graham I, Hastings R, Gunewardena S, Brinkmeier ML, Conn PM, Camper SA, Kumar TR (2015). Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects.. Journal of Biological Chemistry, 290:2699-2714
5. Wang, Hastings R, Miller WL, and Kumar TR (2016). Fshb-iCre mice are efficient and specific Cre delters for the gonadotrope lineage. Molecular and Cellular Endocrinology, 419: 124-138
6. Wang H, Butnev V, Bousfield GR and Kumar TR (2016). A human FSHB transgene encoding the double N-glycosylation mutant (Asn7Δ Asn24Δ) FSH beta subunit fails to rescue Fshb null mice. Molecular and Cellular Endocrinology, (In press)
7. Wang H, May J, Butnev V, Shuai B, May JV, Bousfield GR and Kumar TR (2016). Evaluation of in vivo bioactivities of recombinant hypo- (FSH21/18) and fully (FSH24)- glycosylated human FSH glycoforms in Fshb null mice.. Molecular and Cellular Endocrinology, 437: 224-236.
8. Panneerdoss S, Suryavathi V, Timilsina S, Abdelfattah N, Onyeagucha BC, Mohammad TA, Chen Y, Drake M, Vuori K, Kumar TR and Rao MK (2017). Androgen regulates phagocytosis of apoptotic germ cells via miR471-5p-Doc1-Rac1 GTPase signaling pathway and autophagy component proteins.. Nature Communications, 8, Article number: 598, 1-14.
9. Luu TH, Kuhn K, Bradford, AP, Wempe M, Wittenburg, Johnson R, Carlson N, Kumar TR and Polotsky AJ (2023). Effects of pulsatile intravenous follicle-stimulating hormone treatment of ovarian function in women with obesity.. Fertility and Sterility, 120: 890-898.
10. Converse A, Liu Z, Patel J, Bousfield GR, Babu C, Kumar, TR* and Duncan FE* (2023). Hypoglycosylated FSH enhances oocyte quality via increased cell-to-cell interaction during mouse follicle development.. Development 150, dev202170. Doi:10.1242/dev.202170, * Co-Corresponding Authors.