Endowed Professor: Kumar

Edgar L. and Patricia M. Makowski Endowment

The goals are to promote education, research and training in women’s health.

9U54AG062319-06 PI: Kohrt, CO-I: Kumar

04/22/2019-03/31/2020        NIH-NIA

Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function

To study the effects of FSH receptor mediated signaling in mouse and human adipocyte lineage.

P01AG029531-08 PI: Kumar

08/15/2018-05/31/2020        NIH-NIA (AWARDEE: WICHITA STATE UNIVERSITY)

Project 3 - Functional Analysis of Age-Specific FSH Analogs Using Genetically Altered Mice

The goals of this project are to determine the biological roles of FSH glycoforms using novel mouse models.

R01HD097202-01A1 PI: Stocco, CO-I: Kumar

09/06/2019-05/31/2020        NIH (AWARDEE: UNIVERSITY OF ILLINOIS)

Salt-Inducible Kinase Regulation of Ovarian Granulosa Cells

This project is relevant to public health because a full understanding of the mechanisms involved in the for- mation of preovulatory follicles will provide the foundation for perfecting the diagnosis and treatment of ovulatory defects and for improving IVF outcomes. This project will generate knowledge that will help reduce the burden of infertility treatments.

1R56AG056046-01A1_NCE  PI: Kumar

09/30/2017-08/31/2020        NIH-NIA

Gonadal and Extra-Gonadal Actions of FSH Glycoforms in Aging

To develop novel genetic tools to regulate FSH action in gonadal and non-gonadal tissues.

R01HD081162  PI: Polotsky, CO-I: Kumar

08/28/2015-05/31/2021        NIH-NICHD

Dysregulation of FSH in Obesity: Functional and Statistical Analysis

The objective is to determine the causes for dysregulation of FSH and its feedback in obesity.

1. ​Kumar TR, Schuff KG, Nusser KD and Low MJ (2006). Gonadotroph-specific expression of the human follicle-stimulating hormone beta gene in transgenic mice. Molecular and Cellular Endocrinology 247:103
2. Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papchristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, et al., (2006). FSH directly regulates bone mass: implications for understanding the pathogenesis of the osteoporosis due to hypogonadism. Cell, 125: 247-260
3. Kumar TR (2007). Mouse models for gonadotropin ligands: A 15-year saga. Molecular and Cellular Endocrinology 260-22:249-254
4. Oury F, Mathieu F, Lin, X, Prashanth S, Wang H, Cyrille C, Julie C, Francesca L, Ali G, Herve L, Kumar TR, Ingid P, Karsenty G (2012). Evidence for a pancreas-bone-testis axis in the mouse and for the conservation of osteocalcin function in humans. Journal of Clinical Investigation 123: 2421-2433
5. Wang H, Larson M, Shariff AJ, Pearl C, Miller WL, Conn PM, Boime I and Kumar TR (2014). Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function. Proceedings of The National Academy of Sciences (USA), 111: 5735-5740
6. Wang H, Graham I, Hastings R, Gunewardena S, Brinkmeier ML, Conn PM, Camper SA, Kumar TR (2015). Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects. Journal of Biological Chemistry, 290: 2699-2714
7. Wang, Hastings R, Miller WL, and Kumar TR (2016). Fshb-iCre mice are efficient and specific Cre delters for the gonadotrope lineage. Molecular and Cellular Endocrinology, 419: 124-138
8. Wang H, Butnev V, Bousfield GR and Kumar TR (2016). A human FSHB transgene encoding the double N-glycosylation mutant (Asn7Δ Asn24Δ) FSH beta subunit fails to rescue Fshb null mice. Molecular and Cellular Endocrinology, (In press)