Lorna Grindlay Moore, PhD


​​​​​Professor
Division of Reproductive Sciences
Department of Obstetrics and Gynecology

 

Education
BA, Anthropology (1968), Smith College
PhD Biomedical Anthropology (1973), University Michigan (Ann Arbor).

Contact
Research Complex 2
12700 East 19th Avenue
Room 3004, MS 8613
Aurora, CO 80045

Phone: (303) 724-7474
Fax: (303) 724-3512

Research Interests
My research centers on the physiological mechanisms underlying the normal maternal physiological responses to pregnancy and the pregnancy complications of fetal growth restriction and preeclampsia. I use the chronic hypoxia of residence at high altitude (>2500m or 8000 ft) as a natural laboratory for studying these mechanisms since high altitude exerts one of the strongest influences on fetal growth (being second in magnitude only to gestational age) and triples the frequency of preeclampsia.

Full List of Publications

Recent Publications

  1. Bailey B, Euser AG, Bol KA, Julian CG, Moore LG. High-altitude residence alters blood-pressure course and increases hypertensive disorders of pregnancy. J Matern Fetal Neonatal Med. 2020 Mar 30; 1-8. PMID: 32228111.
  2. Lane SL, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction†. Biol Reprod. 2020 Mar 13; 102(3):660-670. PMID: 31711123.
  3. Määttä J, Sissala N, Dimova EY, Serpi R, Moore LG, Koivunen P. Author Correction: Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism. Sci Rep. 2020 Mar 03; 10(1):4260. PMID: 32123262.
  4. Lamale-Smith LM, Gumina DL, Kramer AW, Browne VA, Toledo-Jaldin L, Julian CG, Winn VD, Moore LG. Uteroplacental Ischemia Is Associated with Increased PAPP-A2. Reprod Sci. 2020 Feb; 27(2):529-536. PMID: 31994005.
  5. Lane SL, Doyle AS, Bales ES, Houck JA, Lorca RA, Moore LG, Julian CG. Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy. FASEB J. 2020 Mar; 34(3):4283-4292. PMID: 31970838.
  6. Vaughan OR, Thompson F, Lorca RA, Julian CG, Powell TL, Moore LG, Jansson T. Effect of high altitude on human placental amino acid transport. J Appl Physiol (1985). 2020 Jan 01; 128(1):127-133. PMID: 31804891.
  7. Bailey BA, Donnelly M, Bol K, Moore LG, Julian CG. High Altitude Continues to Reduce Birth Weights in Colorado. Matern Child Health J. 2019 Nov; 23(11):1573-1580. PMID: 31243627.
  8. Lorca RA, Lane SL, Bales ES, Nsier H, Yi H, Donnelly MA, Euser AG, Julian CG, Moore LG. High Altitude Reduces NO-Dependent Myometrial Artery Vasodilator Response During Pregnancy. Hypertension. 2019 06; 73(6):1319-1326. PMID: 31006328.
  9. Lane SL, Dodson RB, Doyle AS, Park H, Rathi H, Matarrazo CJ, Moore LG, Lorca RA, Wolfson GH, Julian CG. Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction. FASEB J. 2019 Aug; 33(8):8999-9007. PMID: 31039323.
  10. Toledo-Jaldin L, Bull S, Contag S, Escudero C, Gutierrez P, Heath A, Roberts JM, Scandlyn J, Julian CG, Moore LG. Critical barriers for preeclampsia diagnosis and treatment in low-resource settings: An example from Bolivia. Pregnancy Hypertens. 2019 Apr; 16:139-144. PMID: 31056149.