Moore-Lorca Lab
Understanding the maternal physiologic responses contributing to fetal growth restriction.
Moore-Lorca Lab
Understanding the maternal physiologic responses contributing to fetal growth restriction.
Moore-Lorca Lab
Understanding the maternal physiologic responses contributing to fetal growth restriction.
About Us
Maternal vascular adaptation during pregnancy is a key process for properly delivering nutrients and oxygen to the developing fetus and impaired uteroplacental perfusion is common in pregnancy complications such as intrauterine growth restriction (IUGR) or preeclampsia. Our labs use the natural laboratory of high-altitude residence (>2500 m or 8250 ft) to understand the role of AMP-activated protein kinase (AMPK) and K+ channels in the regulation of uteroplacental vascular function with an emphasis on the interaction between molecular factors and physiological function in maternal and fetal circulations. In addition, with the help of innovative mouse models using optogenetics as well as the genetic adaptation that has occurred in long-resident high-altitude populations, we aim to understand the relationship between reduced uteroplacental blood flow and the development of fetal growth restriction.
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