Defining essential characteristics of FSH-ovarian interactions using a multidisciplinary approach.
In the United States, nearly one in three women of childbearing age is obese. As maternal obesity impacts the health of offspring, better understanding of the mechanisms is needed. It remains unclear whether the underlying pathophysiology is related to abnormal hypothalamic-pituitary dynamics, abnormal ovarian environment, or both. Obesity is associated with decreased pituitary output of luteinizing hormone (LH) and FSH, inadequate folliculogenesis and reduced ovarian steroid and protein production. Our overriding objective is to define essential characteristics of FSH-ovarian interactions using a multidisciplinary approach. We build upon existing statistical approaches to modeling pulsatile hormones, and transgenic FSH mouse models showing that pulsatile FSH secretion dramatically enhances ovarian function.
Chair for Nutrition Special Interest Group for the American Society of Reproductive Medicine (2015)