iC42 Research and Development
iC42 is advancing individualized medicine by examining the unique biology of an individual. iC42 prioritizes its work based on strong scientific understanding of the disease.
Our major foci are:
- to promote and enhance research in transplantation through the Colorado Center for Transplantation Care, Research and Education
- the evaluation of pediatric pharmacokinetics
- the development of clinical management tools for pediatric patients
- the provision of integrated solutions to systems biology
- drug metabolism
Pediatric Research
At iC42, we think big but we also think small. Surprisingly little research has been carried out examining pediatric pharmacology. The primary reason for this is a lack of sensitive drug assays that require very low sample volumes.
Currently, iC42’s most exciting pediatric pharmacokinetics project is the development of small volume sampling techniques that measure accurate drug levels from a single drop of blood. These novel and highly sensitive assays detect the drug, their metabolites and also the biomarkers. This current research has the potential to revolutionize pediatric drug studies and patient monitoring by enabling us to extract reliable data from miniscule samples obtained from our smallest subjects.
Reflecting our commitment to pediatric research, iC42’s co-director Dr. Jeffrey Galinkin from The Children’s Hospital in Aurora/ Denver, is designing and conducting pediatric pharmacokinetics/ pharmacodynamics studies to advance pediatric pharmacology using iC42’s novel and cutting-edge bioanalytical and translational technologies.
Colorado Center for Transplantation Care, Research
and Education (CCTCARE)
Colorado Center for Transplantation Care, Research and Education (CCTCARE) has been designed as a unique, comprehensive transplantation center that not only closely integrates basic, translational and clinical research, clinical services, educational and training programs, and community and outreach programs but also collaborates with other institutions and serves as a national and international resource for transplant research. It is CCTCARE’s vision to improve transplant patient care by advancing transplantation and its associated fields through its own highly integrated and innovative research, drug and diagnostics development programs.
We envision CCTCARE serving as the core of a global transplant research network, the International Centers for the Advancement of Transplantation (ICAT).
iC42 promotes and enhances research through the Colorado Center for Transplantation Care, Research and Education. For more information regarding CCTCARE please visit:
CCTCARE Welcome link
Individualized Medicine & Systems Biology
iC42 is committed to advancing individualized medicine by examining the unique biology of an individual to assess truly personalized treatments. Our state of the art facility provides integrated solutions to systems biology and is located at Colorado’s Fitzsimons Bioscience Park (http://www.fitzscience.com/).
Our services include:
- Highly sensitive HPLC, LC-MS/MS, and GC-MS-based bioanalytics
- Complex assay development & validation
- Sample analysis of pre-clinical and clinical studies in a GLP compliant, CAP accredited, CLIA certified environment
- Quantification and pharmacokinetics of drugs & metabolites
- Pediatric pharmacology
- Generation & isolation of drug metabolites, structural identification & enzyme kinetics
- Clinical Therapeutic Drug Monitoring
- Complete PK/PD package managed under one roof
- Molecular marker discovery and development including validation, verification, and qualification
- Consulting & strategic research partnerships
Publications
Presentations
Contact
Dr. Uwe Christians
[email protected]
Direct: +1 303-724-5665
Main: +1 303-724-5670
University of Colorado AMC
Bioscience II Building
12705 E Montview Blvd, Suite 200
Aurora, Colorado 80045-7503