Research Articles - Fecci Lab

• Hoyt-Miggelbrink A, Waibl Polania J, Wachsmuth LP, … Wilkinson DS, … Ayasoufi K*, Fecci PE.* Upregulation of TNFR2 precedes TOX expression by exhausted T cells and restricts antitumor and antiviral immunity. Clin Cancer Res. Online ahead of print. Nov 2025
  
  
•  Singh K, Foster MW, … Fecci PE*, Khasraw M*. A surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC I expression and CD8+ infiltration in glioma. Sci Rep. 15(1):37112. Oct 2025
  
  
• Singh K, Hotchkiss KM, Cook SL, Noldner P, … Fecci PE. IL-7-mediated expansion of autologous lymphocytes increases CD8+ T Cell VLA-4 expression and accumulation within glioblastoma. J Clin Invest. 135(12):e181471. Apr 2025.
  
  
• Waibl-Polania J, Hoyt-Miggelbrink A, Tomaszewski WH, Wachsmuth LP, Lorrey SJ, Wilkinson DS, … Fecci PE. Antigen presentation by tumor-associated macrophages mediates progenitor to terminal exhaustion transition in GBM and other solid tumors. Immunity. 58(1):232-46. Jan 2025. 
  
  
• Lerner EC, Woroniecka K, D’Anniballe VM, Wilkinson D, … Fecci PE. CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis. Nat Cancer. 4(9):1258-72. Sept 2023.
  
  
• Srinivasan ES, Liu Y, Odion RA, Chongsathidkiet P, … Fecci PE. Gold nanostars obviate limitations to laser interstitial thermal therapy for the treatment of intracranial tumors. Clin Cancer Res. 29(16):3214-24. Aug 2023.
  
  
• Woroniecka K, … Wilkinson D, Waibl-Polania J, Sanchez-Perez L, Fecci PE. 4-1BB agonism averts TIL exhaustion and licenses PD-1 blockade in glioblastoma and other intracranial cancers. Clin Cancer Res. 26(6):1349-58. Mar 2020.
  
  
• Kemeny HR, Elsamadicy AA, … Codd PJ, Dunn IF, Fecci PE. Targeting PD-L1 instigates effective anti-tumor immunity in a murine model of Cushing’s Disease. Clin Cancer Res. 26(5):1141-51. Mar 2020.
  
  
• Chongsathidkiet P*, Chen C*, Koyama S*, Loebel F, … Fecci PE. Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Nat Medicine. 24(9): 1459-68. Sep 2018.
  
  
• Woroniecka KI, Chongsathidkiet P, Rhodin KE, Kemeny HR, … Fecci PE. T Cell Exhaustion Signatures Vary with Tumor Type and are Severe in Gliobastoma. Clin Cancer Res. 24(17):4175-86. Sep 2018.

Review Articles and Commentaries

• Williams MM, Haskell-Mendoza AP, Massat EA, … Fecci PE. Contemporary management of radiation necrosis: Insights and avenues. Clinical Cancer Res. Online ahead of print. Feb 2026
  
  
• Mariani C, Wachsmuth L, Bramall A, … Fecci PE. Adapting laser interstitial thermal therapy (LITT) for the treatment of intracranial tumors in dogs. Clin Cancer Res. 31(20):4372-82. Oct 2025
  
  
• Puviindran BJ, Wallace S, Ayasoufi K, Lerner E, Fecci PE. Within and beyond the tumor: Mechanisms of glioblastoma-induced immunosuppression. Neurooncol Adv. 7(Supp 4): iv4-18. Sept 2025.
  
  
• Wachsmuth LP, Srinivasan ES, Puviindran BJ, Haskell-Mendoza AP, DeSpenza T, Fecci PE. Autonomic modulation of the immune response and implications for CNS malignancies. NPJ Precis Oncol  9(1):168. June 2025.
  
  
• Lorrey SJ, Waibl Polania J, Wachsmuth LP, Hoyt-Miggelbrink A, … Fecci PE*, Ayasoufi K*. Systemic immune derangements are shared across various CNS pathologies and reflect novel mechanisms of immune privilege. Neurooncol Adv. 5(1):vdad035. April 2023.
  
  
• Miggelbrink A, Jackson JD, Waibl-Polania J, Lorrey SJ, Srinivasan ES, Wilkinson DS, Fecci PE. CD4 T cell exhaustion: Does it exist and what are its roles in cancer and other pathologies? Clin Cancer Res. 27(21):5742-52. Nov 2021.
  
  
• Grabowski MM, Sankey EW, Ryan KJ, Chongsathidkiet P, Lorrey SJ, Wilkinson DS, Fecci PE. Immune suppression in gliomas. J Neurooncol. 151(1):3-12. Jan 2021.
  
  
• Sampson JH, Gunn MD, Fecci PE, Ashley DA. Brain immunology and immunotherapy in brain tumours. Nat Rev Cancer. 20(1):12-25. Jan 2020.
  
  
• Fecci PE, Champion CD, Hoj J, McKernan C, … Sampson JH. The evolving modern management of brain metastasis. Clin Cancer Res. 25(22):6570-80. Nov 2019.
  
  
• Lorrey SJ, Sanchez-Perez L, Fecci PE. Rescuing imperfect antigens for immune-oncology. Nat Biotech. 37(9): 1002-1003. Sept 2019.
  
  
• Fecci PE, Sampson JH. The current state of immunotherapy for gliomas: An eye towards the future. J Neurosurg. 131(3):657-666. Sept 2019.
  
  
• Woroniecka K, Rhodin K, Chongsathidkiet P, Keith K, Fecci PE. T cell dysfunction in glioblastoma: Applying a new framework. Clin Cancer Res. 24(16):3792-3802. Aug 2018.