Translational Clinical Research in the Department of Neurosurgery

Treatment AreaTitlePrincipal InvestigatorEligibility and Information
BiobankingNervous System Biorepository ProtocolKevin Lillehei, MDANTHONY.FRINGUELLO@CUANSCHUTZ.EDU;
303-724-4136
Brain InjuryUniversity of Colorado Department of Neurosurgery Exosomes in Traumatic Brain Injury (TBI) Protocol Kevin Lillehei, MD

TERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970

Brain Injury, StrokeImpact of Fever Prevention in Brain Injured Patients (INTREPID)Luis Cava, MDTERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970
Brain TumorVigilant ObservatIon of GlIadeL WAfer ImplaNT (VIGILANT) Registry: A Multicenter, Observational Registry to
Collect Information on the Safety and Effectiveness of Gliadel® Wafer (Carmustine Implant) Used in Usual
Medical Practice
Kevin Lillehei, MDTERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970
Chiari/SyringomyeliaPark Reeves Syringomyelia Research SymposiumBrent O’Neill, MD

KIM.POPPLETON@childrenscolorado.org;
720-777-5281

CraniopharyngiomaaDvancing Treatment for Pediatric Craniopharyngioma (ATPC): Prospective Pilot Study Idnetifying Clinically Relevant Biological Targets for Medical Therapy Tod Hankinson, MD

SUSAN.STAULCUP@CUANSCHUTZ.EDU;
303-724-5935

EpilepsyPediatric Brain Lesions Associated with Intractable Epilepsy: Molecular Biology in Comparison to Aggressive Brain TumorsAllyson Alexander, MDKIM.POPPLETON@childrenscolorado.org;
720-777-5281
EpilepsyUsing chronic epilepsy monitoring to study the role of parietal and occipital cortex in movement initiation and perceptionJohn Thompson, PhD

PAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134

EpilepsySLATE- Stereotactic Laser Ablation for Medial Temporal Lobe EpilepsySteven Ojemann, MDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
EpilepsyIdentifying relevant seizure biomarkers from RNS® System recorded electrocorticography for the development of optimized seizure detection algorithms.John Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
EpilepsyAssociation of depth recordings from the temporal cortex with sleep pattern detection and characterization of sleep dysfunction in patients with refractory epilepsy John Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
EpilepsyImpact of Surgical intervention treatment on sleep dysfunction in patients with refractory epilepsy.John Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
EpilepsyBarriers to Epilepsy Surgery- SurveySteven Ojemann, MDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU; 303-724-4134
Epilepsy Neurophysiological investigation of epistemic veracity in the context of ambiguous videographic evidenceJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
MeningiomaCorrelation of pre-operative MRI for olfactory tract imaging with intraoperative findings and olfaction outcome Samy Youssef, MD
Movement DisordersSensory Gating Measured with Microelectrode Recording during Deep Brain Stimulation SurgeryJudith Gault, PhDJUDITH.GAULT@CUANSCHUTZ.EDU;
303-724-4132
Movement DisordersAutomatic measurement of hand movements toward development of an objective assessment of primary motor symptoms in Parkinson’s disease and Essential TremorJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
NeurospychologyUniversity of Colorado School of Medicine Neuropsychology Database Brian Hoyt, PhD

JENNIFER.MAITLEN@CUANSCHUTZ.EDU;
303-724-1995

Parkinson’s disease and schizophreniaLeveraging ethical dissection among capacity, beneficence, and justice in clinical trials of neurotherapeutics in the severely disabledJudith Gault, PhD

JUDITH.GAULT@CUANSCHUTZ.EDU;
303-724-4132

Parkinsons DiseaseSubthalamic nucleus deep brain stimulation effect on olfactory dysfunction in Parkinson’s diseaseJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinsons DiseaseUnderstanding the role of subcortical oscillations in human sleep dysregulationJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinsons DiseaseSubthalamic nucleus activity during habitual versus controlled movementJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinsons DiseaseRESTORE-1: A Randomized, Placebo Surgery Controlled, Double-blinded, Multi-center, Phase 2 Clinical Trial, Evaluating the Efficacy and Safety of VY-AADC02 in Advanced Parkinson’s Disease with Motor FluctuationsSteven Ojemann, MDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinsons DiseaseA Post-Market Study Evaluating the Safety of Infinity DBS System with MR Conditional LabelingSteven Ojemann, MDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Skull Lesions (Calvarial Langerhans Cell Histiocytosis)Non-Operative Management of Suspected Calvarial Langerhans Cell HistiocytosisMichael Handler, MD

KIM.POPPLETON@childrenscolorado.org;
720-777-5281

Spine A Double Blinded Randomized control trial in Outcomes for Lumbar Decompressions with use of Liposomal BupivicainePeter Witt, MDTERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970