Translational Clinical Research in the Department of Neurosurgery

Trial TypeTitlePrincipal InvestigatorEligibility & Information 
 Advanced Parkinson's Disease with Motor Fluctuations (Interventional)RESTORESteven Ojemann, MDPamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu
Arteriovenous MalformationsApollo TM Onyx Delivery Micro Catheter Post Market Safety StudyJoshua Seinfeld, MDJen Maitlen, RN
303-724-1995
https://clinicaltrials.gov/ct2/show/NCT02378883?term=apollo+onyx&rank=1
Brain Injury Device (interventional)Physiological Effects of Intrathoracic Pressure Regulation in Patients With Decreased Cerebral Perfusion Due to Brain Injury or Intracranial PathologyRobert Neumann, MDJen Maitlen, RN 303-724-1995
Brain Surgery BioBankingCentral Nervous System Biorepository ProtocolKevin O. Lillehei, MDJen Maitlen, RN 303-724-1995
Brain TumorA Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects with Advanced Solid Tumors, Including Glioma, with an IDH1 MutationLia Gore, MDMonica Robischon, RN
720-848-0663
https://clinicaltrials.gov/ct2/show/NCT02073994?term=A+Phase+1%2C+Multicenter%2C+Open-Label%2C+Dose-Escalation%2C+Safety%2C+Pharmacokinetic%2C+Pharmacodynamic%2C+and+Clinical+Activity+Study+of+Orally+Administered+AG-120+in+Subjects+with+Advanced+Solid+Tum
Brain TumorAn Expanded Access Protocol for the Treatement of Glioblastoma Multiforme in Patiens with Already Manufactured DCVax®-L, Autologous Dendritic Cells Pulsed with Tumor Lysate Antigen Who Have Screen-Failed Protocol 020221Kevin O. Lillehei, MDMonica Robischon, RN
720-848-0661
https://clinicaltrials.gov/ct2/show/NCT02146066?term=DCvax&rank=4
Brain Tumor Drug vs Radiation with Drug (interventional)Phase III Intergroup Study of Temozolomide Alone Versus Radiotherapy with Concomitant and Adjuvant Temozolomide Versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic GliomaBrian Kavanagh 
Brain Tumor Drug, Radiation (interventional)Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation versus Bevacizumab Alone as Treatment for Recurrent GlioblastomaLaurie Gaspar, MDMonica Robischon, RN 720-848-0661
Brain Tumor ObservationalFrailty as a Predictor of Neurosurgical Outcomes in Brain Tumor PatientsD. Ryan Ormond, MDJen Maitlen, RN 303-724-1995
Cerebral HemorrhageMinimally invasive Subcortical Parafascicular Access for   Clot Evacuation (MiSPACE) RegistrySamy Youssef, MDJen Maitlen, RN
303-724-1995
https://clinicaltrials.gov/ct2/show/NCT02331719?term=NCT02331719&rank=1
Electrophysiology during Deep Brain Stimulation Surgery (Research)Using Parkinson’s disease to study the role of Substantia nigra pars reticulata in movement initiation and perception Aviva Abosch, MD, PhDPamela David Gerecht, PhD 303-724-4134
Electrophysiology during Deep Brain Stimulation Surgery (Research)Local Field Potentials Recorded from Deep Brain Stimulating Electrodes Implanted for the Treatment of Parkinson’s Disease, Essential Tremor or DystoniaAviva Abosch, MD, PhDPamela David Gerecht, PhD 303-724-4134
Electrophysiology during Deep Brain Stimulation Surgery (Research)Sensory Gating Measured with Microelectrode Recording During Deep Brain Stimulation SurgeryAviva Abosch, MD, PhDPamela David Gerecht, PhD 303-724-4134
More Info
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Epilespy (interventional)Stereotactic Laser Ablation for Temporal Lobe EpilepsySteven Ojemann, MDPamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu
Neuropsychology ObservationalUniversity of Colorado School of Medicine Neuropsychology DatabaseBrian Hoyt, PhDJen Maitlen, RN 303-724-1995

 

Clinical Trials

TitleTrial TypePrincipal InvestigatorEligibility & Information
RESTOREAdvanced Parkinson's Disease with Motor Fluctuations (Interventional)Steven Ojemann, MDPamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu
Physiological Effects of Intrathoracic Pressure Regulation in Patients With Decreased Cerebral Perfusion Due to Brain Injury or Intracranial PathologyBrain Injury Device (interventional)Robert Neumann, MDJen Maitlen, RN 303-724-1995
Phase III Intergroup Study of Temozolomide Alone Versus Radiotherapy with Concomitant and Adjuvant Temozolomide Versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic GliomaBrain Tumor Drug vs Radiation with Drug (interventional)Brian Kavanagh 
Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation versus Bevacizumab Alone as Treatment for Recurrent GlioblastomaBrain Tumor Drug, Radiation (interventional)Laurie Gaspar, MDMonica Robischon, RN 720-848-0661
Stereotactic Laser Ablation for Temporal Lobe EpilepsyEpilespy (interventional)Steven Ojemann, MDPamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu

Clinical Research

TitleTrial Type Principal InvestigatorEligibility & Information 
Frailty as a Predictor of Neurosurgical Outcomes in Brain Tumor PatientsBrain Tumor ObservationalD. Ryan Ormond, MDJen Maitlen, RN 303-724-1995
Central Nervous System Biorepository ProtocolBrain Surgery BioBankingKevin O. Lillehei, MDJen Maitlen, RN 303-724-1995
University of Colorado School of Medicine Neuropsychology DatabaseNeuropsychology ObservationalBrian Hoyt, PhDJen Maitlen, RN 303-724-1995
Using Parkinson’s disease to study the role of Substantia nigra pars reticulata in movement initiation and perception Electrophysiology during Deep Brain Stimulation Surgery (Research)Aviva Abosch, MD, PhDPamela David Gerecht, PhD 303-724-4134
Local Field Potentials Recorded from Deep Brain Stimulating Electrodes Implanted for the Treatment of Parkinson’s Disease, Essential Tremor or DystoniaElectrophysiology during Deep Brain Stimulation Surgery (Research)Aviva Abosch, MD, PhDPamela David Gerecht, PhD 303-724-4134
Sensory Gating Measured with Microelectrode Recording During Deep Brain Stimulation SurgeryElectrophysiology during Deep Brain Stimulation Surgery (Research)Aviva Abosch, MD, PhDPamela David Gerecht, PhD 303-724-4134
More Info
email

 

Meet the Vice Chair, Research

Dr. Welle
Cristin Welle, PhD, Associate Professor
BIOElectrics Lab
Cristin.Welle@CUAnschutz.edu
303-724-9116

Meet the Research Administrator

Sophie Eggert, MPH
Sophie.Eggert@CUAnschutz.edu
303-724-4305