Translational Clinical Research in the Department of Neurosurgery

Treatment AreaTitlePrincipal InvestigatorEligibility and Information
BiobankingNervous System Biorepository ProtocolKevin Lillehei, MDARIN.GRANER@CUANSCHUTZ.EDU
303-724-4136
Brain InjuryUniversity of Colorado Department of Neurosurgery Exosomes in Traumatic Brain Injury (TBI) Protocol Kevin Lillehei, MD

TERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970

Brain and Nervous System CancerAdditional cancer clinical trials for patients with brain and nervous system cancer
Multiplehttps://researchstudies.cuanschutz.edu/
Brain TumorVigilant ObservatIon of GlIadeL WAfer ImplaNT (VIGILANT) Registry: A Multicenter, Observational Registry to
Collect Information on the Safety and Effectiveness of Gliadel® Wafer (Carmustine Implant) Used in Usual
Medical Practice
Kevin Lillehei, MDTERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970
Chiari/SyringomyeliaPark Reeves Syringomyelia Research SymposiumBrent O’Neill, MD

SUSAN.STAULCUP@CUANSCHUTZ.EDU; 
720-777-5281

ComaUniversity of Colorado Neuro-ICU Coma StudyRobert G. Kowalski, MD, MSROBERT.2.KOWALSKI@CUANSCHUUTZ.EDU
303-724-4136
443-651-4506
CraniopharyngiomaAdvancing Treatment for Pediatric Craniopharyngioma (ATPC): Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical TherapyTodd Hankinson, MD

SUSAN.STAULCUP@CUANSCHUTZ.EDU; 
720-777-4377

Epilepsy

Pediatric Brain Lesions Associated with Intractable Epilepsy: Molecular Biology in Comparison to Aggressive Brain Tumors

Additional Information

Allyson Alexander, MDSUSAN.STAULCUP@CUANSCHUTZ.EDU; 
720-777-5281
EpilepsyUsing chronic epilepsy monitoring to study the role of parietal and occipital cortex in movement initiation and perceptionJohn Thompson, PhD

PAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134

EpilepsySLATE- Stereotactic Laser Ablation for Medial Temporal Lobe EpilepsySteven Ojemann, MDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
EpilepsyIdentifying relevant seizure biomarkers from RNS® System recorded electrocorticography for the development of optimized seizure detection algorithms.John Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
EpilepsyAssociation of depth recordings from the temporal cortex with sleep pattern detection and characterization of sleep dysfunction in patients with refractory epilepsy John Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
EpilepsyImpact of Surgical intervention treatment on sleep dysfunction in patients with refractory epilepsy.John Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Epilepsy

Barriers to Epilepsy Surgery- Survey

Additional Information

Steven Ojemann, MDQR code for Barriers to Epilepsy Surgery trial
Epilepsy Neurophysiological investigation of epistemic veracity in the context of ambiguous videographic evidenceJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Hydrocephalus
Endoscopic versus Shunt Treatment of Hydrocephalus in Infants (ESTHI) 

Todd Hankinson, MD SUSAN.STAULCUP@CUANSCHUTZ.EDU
720-777-4377
HydrocephalusHCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)  

Todd Hankinson, MD 
SUSAN.STAULCUP@CUANSCHUTZ.EDU; 
720-777-4377
MeningiomaCorrelation of pre-operative MRI for olfactory tract imaging with intraoperative findings and olfaction outcome Samy Youssef, MD
Movement DisordersSensory Gating Measured with Microelectrode Recording during Deep Brain Stimulation SurgeryJudith Gault, PhDJUDITH.GAULT@CUANSCHUTZ.EDU;
303-724-4132
Movement DisordersAutomatic measurement of hand movements toward development of an objective assessment of primary motor symptoms in Parkinson’s disease and Essential TremorJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Neuro-Intensive Care         A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning from Mechanical Ventilation in ICU Patients (RESCUE 3)Robert T. Neumann, MD, PhDTERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970
  
NeurospychologyUniversity of Colorado School of Medicine Neuropsychology Database Brian Hoyt, PhD

JENNIFER.MAITLEN@CUANSCHUTZ.EDU;
303-724-1995

Parkinson’s disease and schizophreniaLeveraging ethical dissection among capacity, beneficence, and justice in clinical trials of neurotherapeutics in the severely disabledJudith Gault, PhD

JUDITH.GAULT@CUANSCHUTZ.EDU;
303-724-4132

Parkinson's DiseaseSubthalamic nucleus deep brain stimulation effect on olfactory dysfunction in Parkinson’s diseaseJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinson's DiseaseUnderstanding the role of subcortical oscillations in human sleep dysregulationJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinson's DiseaseSubthalamic nucleus activity during habitual versus controlled movementJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinson's DiseaseRESTORE-1: A Randomized, Placebo Surgery Controlled, Double-blinded, Multi-center, Phase 2 Clinical Trial, Evaluating the Efficacy and Safety of VY-AADC02 in Advanced Parkinson’s Disease with Motor FluctuationsSteven Ojemann, MDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinson's DiseaseA Randomized, Sham Surgery Controlled, Double-blind, Multi-center, Phase 2 Clinical Trial, Evaluating the Efficacy and Safety of VY-AADC02 in Moderate to Advanced Parkinson’s Disease Patients with Motor FluctuationsSteven Ojemann, MDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Spine A Double Blinded Randomized control trial in Outcomes for Lumbar Decompressions with use of Liposomal BupivicainePeter Witt, MDTERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970
Status EpilepticusA double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus Dave Case, MDTERRA.ORNELAS@CUANSCHUTZ.EDU
303-724-7970
StrokeEvaluation of ultra-early biomarkers in acute ischemic strokeRobert G. Kowalski, MD, MS

ROBERT.2.KOWALSKI@CUANSCHUUTZ.EDU
303-724-4136
443-651-4506

Stroke
Medtronic Embolization of the Middle Meningeal Artery with ONYXTM Liquid Embolic System In the Treatment of Subacute and Chronic Subdural HEmatoma (EMBOLISE) Christopher Roark, MDTERRA.ORNELAS@CUANSCHUTZ.EDU
303-724-7970
Stroke
EvaLuateEndoVascular treatment of Acutely ruptured shallow intradural aneurysms with the Pipeline™ Flex embolization device with Shield TEchnology (ELEVATE)David E. Case, MDTERRA.ORNELAS@CUANSCHUTZ.EDU
303-724-7970