Translational Clinical Research in the Department of Neurosurgery

Treatment AreaTitlePrincipal InvestigatorEligibility and Information
Peripheral Nerve InjuryA Phase 2a, Multicenter, Randomized, Patient and Evaluator Blinded, Controlled Study Evaluating the Safety and Efficacy of NTX-001 Compared to Standard of Care in the Treatment of Acute Single Transected Peripheral Nerve Injury Occurring below the Distal Border of the Brachial Plexus Requiring Surgical RepairKevin Lillehei, MDJENNIFER.MAITLEN@CUANSCHUTZ.EDU
303-724-1995
Status Epilepticus

A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus Dave Case, MDTERRA.ORNELAS@CUANSCHUTZ.EDU
303-724-7970
BiobankingNervous System Biorepository ProtocolKevin Lillehei, MDARIN.GRANER@CUANSCHUTZ.EDU
303-724-4136
Brain InjuryUniversity of Colorado Department of Neurosurgery Exosomes in Traumatic Brain Injury (TBI) Protocol Kevin Lillehei, MD

TERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970

Brain Injury, StrokeImpact of Fever Prevention in Brain Injured Patients (INTREPID)Luis Cava, MDTERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970
Brain and Nervous System CancerAdditional cancer clinical trials for patients with brain and nervous system cancer
Multiplehttps://researchstudies.cuanschutz.edu/
Brain TumorVigilant ObservatIon of GlIadeL WAfer ImplaNT (VIGILANT) Registry: A Multicenter, Observational Registry to
Collect Information on the Safety and Effectiveness of Gliadel® Wafer (Carmustine Implant) Used in Usual
Medical Practice
Kevin Lillehei, MDTERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970
Chiari/SyringomyeliaPark Reeves Syringomyelia Research SymposiumBrent O’Neill, MD

KIM.POPPLETON@childrenscolorado.org;
720-777-5281

CraniopharyngiomaAdvancing Treatment for Pediatric Craniopharyngioma (ATPC): Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical TherapyTodd Hankinson, MD

SUSAN.STAULCUP@CUANSCHUTZ.EDU; 
720-777-4377

Epilepsy

Pediatric Brain Lesions Associated with Intractable Epilepsy: Molecular Biology in Comparison to Aggressive Brain Tumors

Additional Information

Allyson Alexander, MDKIM.POPPLETON@childrenscolorado.org;
720-777-5281
EpilepsyUsing chronic epilepsy monitoring to study the role of parietal and occipital cortex in movement initiation and perceptionJohn Thompson, PhD

PAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134

EpilepsySLATE- Stereotactic Laser Ablation for Medial Temporal Lobe EpilepsySteven Ojemann, MDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
EpilepsyIdentifying relevant seizure biomarkers from RNS® System recorded electrocorticography for the development of optimized seizure detection algorithms.John Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
EpilepsyAssociation of depth recordings from the temporal cortex with sleep pattern detection and characterization of sleep dysfunction in patients with refractory epilepsy John Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
EpilepsyImpact of Surgical intervention treatment on sleep dysfunction in patients with refractory epilepsy.John Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Epilepsy

Barriers to Epilepsy Surgery- Survey

Additional Information

Steven Ojemann, MDQR code for Barriers to Epilepsy Surgery trial
Epilepsy Neurophysiological investigation of epistemic veracity in the context of ambiguous videographic evidenceJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Hydrocephalus
Endoscopic versus Shunt Treatment of Hydrocephalus in Infants (ESTHI) 

Todd Hankinson, MD SUSAN.STAULCUP@CUANSCHUTZ.EDU
720-777-4377
HydrocephalusHCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)  

Todd Hankinson, MD 
SUSAN.STAULCUP@CUANSCHUTZ.EDU; 
720-777-4377
MeningiomaCorrelation of pre-operative MRI for olfactory tract imaging with intraoperative findings and olfaction outcome Samy Youssef, MD
Movement DisordersSensory Gating Measured with Microelectrode Recording during Deep Brain Stimulation SurgeryJudith Gault, PhDJUDITH.GAULT@CUANSCHUTZ.EDU;
303-724-4132
Movement DisordersAutomatic measurement of hand movements toward development of an objective assessment of primary motor symptoms in Parkinson’s disease and Essential TremorJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
NeurospychologyUniversity of Colorado School of Medicine Neuropsychology Database Brian Hoyt, PhD

JENNIFER.MAITLEN@CUANSCHUTZ.EDU;
303-724-1995

Parkinson’s disease and schizophreniaLeveraging ethical dissection among capacity, beneficence, and justice in clinical trials of neurotherapeutics in the severely disabledJudith Gault, PhD

JUDITH.GAULT@CUANSCHUTZ.EDU;
303-724-4132

Parkinson's DiseaseSubthalamic nucleus deep brain stimulation effect on olfactory dysfunction in Parkinson’s diseaseJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinson's DiseaseUnderstanding the role of subcortical oscillations in human sleep dysregulationJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinson's DiseaseSubthalamic nucleus activity during habitual versus controlled movementJohn Thompson, PhDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinson's DiseaseRESTORE-1: A Randomized, Placebo Surgery Controlled, Double-blinded, Multi-center, Phase 2 Clinical Trial, Evaluating the Efficacy and Safety of VY-AADC02 in Advanced Parkinson’s Disease with Motor FluctuationsSteven Ojemann, MDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Parkinson's DiseaseA Randomized, Sham Surgery Controlled, Double-blind, Multi-center, Phase 2 Clinical Trial, Evaluating the Efficacy and Safety of VY-AADC02 in Moderate to Advanced Parkinson’s Disease Patients with Motor FluctuationsSteven Ojemann, MDPAMELA.DAVIDGERECHT@CUANSCHUTZ.EDU;
303-724-4134
Spine A Double Blinded Randomized control trial in Outcomes for Lumbar Decompressions with use of Liposomal BupivicainePeter Witt, MDTERRA.ORNELAS@CUANSCHUTZ.EDU;
303-724-7970