Translational Clinical Research in the Department of Neurosurgery
| Trial Type | Title | Principal Investigator | Eligibility & Information |
| Advanced Parkinson's Disease with Motor Fluctuations (Interventional) | RESTORE | Steven Ojemann, MD | Pamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu |
| Arteriovenous Malformations | Apollo TM Onyx Delivery Micro Catheter Post Market Safety Study | Joshua Seinfeld, MD | Jen Maitlen, RN 303-724-1995 https://clinicaltrials.gov/ct2/show/NCT02378883?term=apollo+onyx&rank=1 |
| Brain Injury Device (interventional) | Physiological Effects of Intrathoracic Pressure Regulation in Patients With Decreased Cerebral Perfusion Due to Brain Injury or Intracranial Pathology | Robert Neumann, MD | Jen Maitlen, RN 303-724-1995 |
| Brain Surgery BioBanking | Central Nervous System Biorepository Protocol | Kevin O. Lillehei, MD | Jen Maitlen, RN 303-724-1995 |
| Brain Tumor | A Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects with Advanced Solid Tumors, Including Glioma, with an IDH1 Mutation | Lia Gore, MD | Monica Robischon, RN 720-848-0663 https://clinicaltrials.gov/ct2/show/NCT02073994?term=A+Phase+1%2C+Multicenter%2C+Open-Label%2C+Dose-Escalation%2C+Safety%2C+Pharmacokinetic%2C+Pharmacodynamic%2C+and+Clinical+Activity+Study+of+Orally+Administered+AG-120+in+Subjects+with+Advanced+Solid+Tum |
| Brain Tumor | An Expanded Access Protocol for the Treatement of Glioblastoma Multiforme in Patiens with Already Manufactured DCVax®-L, Autologous Dendritic Cells Pulsed with Tumor Lysate Antigen Who Have Screen-Failed Protocol 020221 | Kevin O. Lillehei, MD | Monica Robischon, RN 720-848-0661 https://clinicaltrials.gov/ct2/show/NCT02146066?term=DCvax&rank=4 |
| Brain Tumor Drug vs Radiation with Drug (interventional) | Phase III Intergroup Study of Temozolomide Alone Versus Radiotherapy with Concomitant and Adjuvant Temozolomide Versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma | Brian Kavanagh | |
| Brain Tumor Drug, Radiation (interventional) | Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma | Laurie Gaspar, MD | Monica Robischon, RN 720-848-0661 |
| Brain Tumor Observational | Frailty as a Predictor of Neurosurgical Outcomes in Brain Tumor Patients | D. Ryan Ormond, MD | Jen Maitlen, RN 303-724-1995 |
| Cerebral Hemorrhage | Minimally invasive Subcortical Parafascicular Access for Clot Evacuation (MiSPACE) Registry | Samy Youssef, MD | Jen Maitlen, RN 303-724-1995 https://clinicaltrials.gov/ct2/show/NCT02331719?term=NCT02331719&rank=1 |
| Electrophysiology during Deep Brain Stimulation Surgery (Research) | Using Parkinson’s disease to study the role of Substantia nigra pars reticulata in movement initiation and perception | Aviva Abosch, MD, PhD | Pamela David Gerecht, PhD 303-724-4134 |
| Electrophysiology during Deep Brain Stimulation Surgery (Research) | Local Field Potentials Recorded from Deep Brain Stimulating Electrodes Implanted for the Treatment of Parkinson’s Disease, Essential Tremor or Dystonia | Aviva Abosch, MD, PhD | Pamela David Gerecht, PhD 303-724-4134 |
| Electrophysiology during Deep Brain Stimulation Surgery (Research) | Sensory Gating Measured with Microelectrode Recording During Deep Brain Stimulation Surgery | Aviva Abosch, MD, PhD | Pamela David Gerecht, PhD 303-724-4134 More Info |
| Epilespy (interventional) | Stereotactic Laser Ablation for Temporal Lobe Epilepsy | Steven Ojemann, MD | Pamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu |
| Neuropsychology Observational | University of Colorado School of Medicine Neuropsychology Database | Brian Hoyt, PhD | Jen Maitlen, RN 303-724-1995 |
Clinical Trials
| Title | Trial Type | Principal Investigator | Eligibility & Information |
| RESTORE | Advanced Parkinson's Disease with Motor Fluctuations (Interventional) | Steven Ojemann, MD | Pamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu |
| Physiological Effects of Intrathoracic Pressure Regulation in Patients With Decreased Cerebral Perfusion Due to Brain Injury or Intracranial Pathology | Brain Injury Device (interventional) | Robert Neumann, MD | Jen Maitlen, RN 303-724-1995 |
| Phase III Intergroup Study of Temozolomide Alone Versus Radiotherapy with Concomitant and Adjuvant Temozolomide Versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma | Brain Tumor Drug vs Radiation with Drug (interventional) | Brian Kavanagh | |
| Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma | Brain Tumor Drug, Radiation (interventional) | Laurie Gaspar, MD | Monica Robischon, RN 720-848-0661 |
| Stereotactic Laser Ablation for Temporal Lobe Epilepsy | Epilespy (interventional) | Steven Ojemann, MD | Pamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu |
Clinical Research
Meet the Vice Chair, Research
Cristin Welle, PhD, Associate Professor
BIOElectrics Lab
Cristin.Welle@CUAnschutz.edu
303-724-9116
Meet the Research Administrator
Sophie Eggert, MPH
Sophie.Eggert@CUAnschutz.edu
303-724-4305