Rapid and Rigorous Patient-centered Program (R2P2)
Keywords
Pragmatic research; rapid research; patient-centered tools; decision aids; implementation science; research methods, user centered design
Type of Research
Community-based participatory; Research methods development/testing; Dissemination and implementation research; Practice based research; Clinical research; Shared decision making
Summary
This comprehensive patient-centered personalization program will develop patient-centered decision support tools across various clinical domains, with a strong emphasis on rapid and rigorous development, sustainable processes and equity in engagement. Initially, the team will embark on four distinct projects: primary care for patients with multiple chronic conditions; specialty care – carotid stenting decision aid; tertiary care – heart transplant decision aid; and late life care for patients with dementia. Four to six additional pilot projects will be funded during the five years of the program, for a total of 8-10 projects designed to improve healthcare decision-making and outcomes in various clinical domains, benefiting patients, providers and healthcare systems.
We have the following specific aims:
- Rapidly and rigorously Design a host of tools to improve the patient-centeredness of care.
- Rapidly and rigorously Implement & Test interventions in real-world settings using pragmatic research.
- Rapidly and rigorously Disseminate and Sustain project delivery and outcomes.
Significance
Will develop and test both a) broadly applicable patient-centered tools such as decision aids to enhance patient-physician interactions across the disease and life course spectrums and b) resources to enhance rapid and rigorous pragmatic research. A variety of projects will be supported to apply these resources and tools to improve healthcare and healthcare research.
Impact
- Accelerate rapid and rigorous pragmatic research
- Enhance patient and clinician shared decision making
- Improve patient healthcare experience by developing, providing and testing personalized, patient centered ‘whole health’ interventions
- Rapidly co-develop and implement feasible programs with clinical, community, and patient partners that are effective, efficient, equitable and sustainable
Translational Science Benefits Model* Benefits | ||
| Demonstrated: Benefits are those that have been observed and verifiable. Potential: Benefits are those logically expected with moderate to high confidence | ||
| Increased patient engagement and satisfaction. Potential |  | Software technologies; Tested decision aids |
| Cost effectiveness and reduced health care expenditures. Potential |
| Implementation and engagement costs; Healthcare quality and delivery |
| Higher quality, more relevant research. Demonstrated |  | Number of publications and tools on these topics; documented use of R2P2 resources |
| Enhanced disease prevention and management (in relatively short term). Demonstrated | | Measures of health behaviors and quality of care |
*The Translational Science Benefits Model is a framework designed to help public health and clinical scientists demonstrate the impact of their work in the real world. The Translational Science Benefits Model and Translating for Impact Toolkit © 2017-2023, created by the Institute of Clinical and Translational Sciences at Washington University in St. Louis and available at translationalsciencebenefitsmodel.wustl.edu, is licensed under Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0).
Implications for Reducing Health Disparities
Increased reach to and engagement of groups often left out of both research and health care innovations
Lessons Learned
- Patient, healthcare system, and clinician engagement are critical- and can be very time consuming and expensive. It is important to understand these costs
- There is a need for resources and examples of patient-centered tools and successful rapid projects
- Traditional healthcare research views rapid research as being antithetical to health quality
- It is challenging to accelerate research in academic settings
- Tools to enhance pragmatic research should be developed for two audiences: 1) those not familiar with such research for practical applications and 2) implementation and outcomes research teams interested in collecting rigorous data for publications or grant proposals
References
1. Jolles MP, Glasgow RE, Gomes R, Huebschmann AG, Kessler ER. Method to engage invested partners to co-create feasible and sustainable approaches to design and implement cancer prevention and control tools. Res Involv Engagem. 2026 Apr 11;12(1):53. doi: 10.1186/s40900-026-00877-6. PMID: 41965810; PMCID: PMC13112691.
2. Trinkley KE, Glasgow RE. From Automation to Action in Heart Failure: Digital Solutions, Pragmatic Evidence, and the Integrative Role of Implementation Science. Circ Heart Fail. 2026 Feb;19(2):e013900. doi: 10.1161/CIRCHEARTFAILURE.125.013900. Epub 2026 Jan 29. PMID: 41608797; PMCID: PMC13178591.
3. Creel LM, Cronin J, Matlock DD, Glasgow RE, Rubio S, Perez Jolles M. The costs of partner engagement in research: Opportunities for pragmatic research, implementation science, and the science of engagement. J Clin Transl Sci. 2026;10(1):e118. doi:10.1017/cts.2026.10784
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