| Name | Department | Lab Website | Research Interests |
| Caitlin Bell, MD | Medicine | Bell Lab | Extensive population-level evidence demonstrates that patients with cancer have significantly increased cardiovascular morbidity and mortality, and, conversely, patients with CVD have significantly increased risk of incident cancer. The bidirectional
associations extend beyond simple shared risk factors and cardiotoxicity from cancer therapies to include shared molecular mechanisms and disease cross-communication, both of which are poorly defined. One example of this is the observation
that colorectal cancer (CRC) survivors have higher rates of hypertension and atherosclerosis even when attempting to control for age, shared risk factors, and therapy received. As such, one of the Bell Lab's projects focuses on how CRC
itself may lead to vascular remodeling and worsening of CVDs using mouse models, cell culture assays, and computational data. The goal is to identify causal pathways for treatment and prevention of accelerated CVD in cancer survivors. |
| Benjamin Bitler, PhD | OB-GYN | Bitler Lab | Investigating novel DNA damage repair mechanisms that can be targeted to overcome therapy resistant ovarian cancer. |
| Andrea Bonetto, PhD | Pathology | Bonetto Lab | Molecular mechanisms related to the onset of cachexia (i.e. musculoskeletal wasting) in colorectal cancer. |
| Virginia Borges, MD, MMSc | Medicine - Medical Oncology | Borges Lab | Determining the reasons why young women's breast cancer has worse recurrence and survival outcomes, with a focus on human translational research, extra cellular vesicles, the influence of parity status and large database research. |
| Alessandra Brambati, PhD | Pharmacology | Brambati Lab | We will study the molecular mechanisms that regulate microhomology-mediated end-joining (MMEJ), a poorly understood DNA double-strand break repair pathway. The mutational signature associated with MMEJ is frequently observed in cancer genomes.
When the two canonical DSB repair pathways-non-homologous end joining and homologous recombination-are compromised, cells become dependent on MMEJ for survival. This dependency makes MMEJ an attractive therapeutic target, particularly
for treating cancers with homologous recombination deficiencies, either as a monotherapy or in combination with PARP inhibitors. |
| Cecilia Caino, PhD | Pharmacology | Caino Lab | My lab is interested in liver metastasis. |
| Zachary Clayton, PhD | Medicine - Geriatrics | | We employ preclinical to clinical translational experimental approaches to determine the influence of cancer and cancer therapy on cardiovascular disease risk through the lens of large artery health. In mouse models, we are currently assessing
the influence of breast cancer on large artery health and the potential therapeutic efficacy of various exercise and dietary interventions for mitigating declines in large artery health with breast cancer. Clinically, we are currently
assessing cardiovascular health in lymphoma survivors relative to age- and sex-matched healthy counterparts and the underlying role of cellular senescence. |
| Kyle Concannon, MD | Medicine - Medical Oncology | Concannon Lab | We study targetable resistance mechanisms to tyrosine kinase inhibitors in lung cancer with current projects aimed at overcoming resistance using cell surface targeting strategies like antibody-drug conjugates and cellular therapies in collaboration
with the Fecci lab. |
| James DeGregori, PhD | Biochemistry and Molecular Genetics (BMG)
| DeGregori Lab | Our research will focus either on mutational patterns in normal lung or on hematologic malignancies. |
| Elan Eisenmesser, PhD | Biochemistry and Molecular Genetics (BMG) | Eisenmesser Lab | Biochemical and structural studies on metabolic enzymes and their super assemblies. Students will learn fundamental biochemistry, learn how to purify enzymes, probe enzymes, and ultimately use atomic-resolution methods to determine how they
function.
|
| Patricia Ernst, PhD | Pediatrics and Pharmacology | Ernst Lab | Our lab studies epigenetic mechanisms regulating normal hematopoiesis and leukemia focusing on histone methyltransferases. Specific projects range from biochemical, immunology, gene expression or cell biological approaches to understanding
particular pathways in high-risk pediatric leukemia. |
| Xiying Fan, PhD | Dermatology | | My laboratory focuses on utilizing large-scale sequencing tools to better understand the mechanisms of cancer immunoediting. My primary focus of interest lies in studying the functions and interactions of innate immune cells and hair follicles in cancer immunoediting during skin cancer progression. The overarching goal of my research is to advance the development of immunotherapies aimed at treating cancer patients. |
Daysha Ferrer Torres, PhD | Medicine-GI | Ferrer Torres Lab | The Ferrer-Torres Lab studies how the esophagus repairs itself after injury and how these processes differ across racial and genetic backgrounds, focusing on conditions like GERD, Barrett’s esophagus, and esophageal cancer. The lab explores
the role of the protective enzyme GSTT2 and has developed advanced organoid models that mimic esophageal tissue, including both epithelial and mesenchymal layers, to study development and repair. By using these tools, the lab aims to discover
new treatments and improve personalized care for diverse populations. |
| Craig Forester, MD, PhD | Pediatric Hematology/Oncology | Forester Lab | Our lab seeks to define out epitranscriptomic changes impact specificity in protein synthesis across an array of contexts including pediatric bone marrow failure and oncogenesis predisposition. |
| Michael Graner, MS, PhD | Neurosurgery | Graner Lab | Understanding how tumor/host immune responses in immune suppression and immunotherapy development. Extracellular vesicles in neurologic diseases. Canine cancer vaccine development. |
| Adam Green, MD | Pediatrics | Green Lab | Our lab investigates pediatric high-grade glioma, a challenging childhood brain tumor that currently has poor treatment options and survival. We use genomic, functional genomic, and drug screening methods to find novel targets in these tumors,
and then we study treatments against these targets in lab models to find promising therapies to take to early-phase pediatric clinical trials. We have several potential projects available across the translational spectrum and studying
various subtypes of these tumors. |
| Curtis Henry, PhD | | Henry Lab | Obesity is associated with immune dysfunction, which increases susceptibility to infections, cancer, and other diseases. Interestingly, research in our lab has discovered that obesity reduces global actin levels in T-cells and increased lipid content in the cell membrane. Furthermore, we have discovered that these obesity-induced biophysical changes in T-cell compromises binding to targets, including immunotherapies which are used to treat blood cancers. We will continue to characterize obesity induced T-cell function using a variety of biophysical and bioengineering assays to assess overall structure of T-cells, their movement through simulated blood and lymphatic vessels, and their ability to bind and kill cancer cells. |
| Rebecca Ihrie, PhD | Pediatrics - Child Neurology | | My laboratory focuses on brain tumors across the lifespan and their relationship to stem cells of the developing and adult brain. We do a large amount of flow cytometry, imaging cytometry, and advanced data analysis. A typical summer research
project would involve learning immunostaining techniques with supervision from lab members, and then implementing a quantitative workflow to analyze the data. For students with a particular interest in computational analyses, we do offer
advanced projects analyzing high dimensional data (35+ channels on tens of thousands to millions of cells) supported by an Image Data Science Manager in the group. |
| Craig Jordan, PhD | Medicine | Jordan Lab | Evaluation of leukemia stem cell biology and therapeutic vulnerabilities. |
| Miria Kano, PhD | Community and Behavioral Health | | We have two potential projects for a summer student - survivorship care for people diagnosed with breast cancer and barriers and facilitators to clinical trial enrollment for those diagnosed with ovarian cancer. |
| Laurel Lenz, PhD | Immunology and Microbiology | | Our group is doing basic research geared towards improving the activation and impact of natural killer (NK) cells in the context of cancer and other diseases. Mature NK cells can recognize and kill tumor cells, but their ability to do is enhanced
(or possibly impaired) by external stimuli they are exposed to. We have identified bacterial products that engage with the immune system in a way that strongly induces NK cell activation. Ongoing work in the lab seeks to better understand
how these products work in hopes of developing new therapies. The summer project will involve testing if tumor cell products might suppress the activation of NK cells and whether stimulation of NK cells with bacterial products can overcome
or block these effects to improve NK cell anti-tumor responses. |
| Traci Lyons, PhD | Medicine - Medical Oncology | | The relationship between semaphorin 7a and mesenchymal and macrophage related phenotypes. |
| Siddhartha Mitra, PhD | Pediatrics and Neurosurgery | | I lead an independent laboratory focused on researching tumor immunology and exploring the crucial role of oncogenes in controlling tumor immune surveillance. |
| Joe Nassour, PhD | Biochemistry and Molecular Genetics (BMG) | Nassour Lab | We study how activation of the RAS pathway triggers the senescence program, causing cells to permanently stop dividing. In particular, we focus on how oncogenic RAS signaling induces DNA damage at telomeres, leading to activation of the DNA
damage response and establishment of cellular senescence. Our goal is to understand how these mechanisms link oncogenic signaling, telomere dysfunction, and tumor suppression. |
| Mike Oliphant, PhD | Pharmacology | Oliphant Lab | The Oliphant Lab integrates single-cell genomics, patient-derived organoids and high-throughput drug screening to understand how breast cancers begin and how they rewire their metabolism to become resistant to therapy. |
| Eric Pietras, PhD | Medicine | | Metabolic targeting of pre-leukemic stem cells in clonal hematopoiesis and myelodysplastic syndrome |
| Todd Pitts, PhD | Medicine | Pitts Lab | The Pitts (GI Translational Research) Lab is focused on developing new novel therapies for colorectal and pancreatic cancers. The lab is interested in finding rational combination partners for molecularly-targeted anticancer and immunotherapy
agents. The Pitts lab has a special interest in predictive biomarker and resistance mechanisms using correlative biological assays for early phase clinical trials. |
| Jennifer Richer, PhD | Pathology | Richer Lab | Dr. Richer’s expertise in steroid hormone receptors in cancer spans over 25 years. Her laboratory uses contemporary cell and molecular biology techniques to elucidate mechanisms of endocrine therapy resistance in women’s cancers
and identify targetable proteins involved in tumor progression. |
| Rebecca Schweppe, PhD | Endocrinology-Medicine | Schweppe Lab | Activating mutations of the MAP kinase (MAPK) pathway, especially mutations in BRAF-V600E, are common in thyroid cancer. Although a combination of BRAF and MEK1/2 inhibition (dabrafenib and trametinib) was recently approved for BRAF-mutant
thyroid cancer, it is clear that new, more effective therapies are needed. We have recently identified the androgen receptor (AR) as a potential mechanism of resistance to BRAF-directed therapies. The goals of the summer research project
will be determine how AR mediates resistance to BRAF inhibition using innovative in vitro approaches. |
| Natalie Serkova, PhD | Radiology | Serkova Lab | The student will be involved in a multi-team project (including Animal Imaging team, Pediatric Neurooncology Team, and Radiation Oncology team) to apply advancer MRI imaging protocols at a 9.4T MRI scanner to detect, characterize and differentiate three distinct brain tumor subtypes of orthotopic patient-derived xenograft (PDX) mouse models. Particularly, she/he will be involved in MRI analysis to characterize pediatric debilitating brain tumors such as high-grade gliomas/ diffuse intrinsic pontine gliomas, medulloblastomas and ependymomas. The student will have an independent, well-defined summer fellowship project and learn to work in a collaborative multi-team environment. He/she will receive extended training in brain tumor biology, oncologic imaging, image analysis and how to present their results and prepare scientific reports. |
| Dan Sherbenou, MD-PhD | Medicine | Sherbenou Lab | The immediate goal of our research is to improve the treatment and outcomes of patients with multiple myeloma, especially for patients who have developed difficult-to-treat multi-drug resistant disease. Our approach is to utilize primary bone
marrow biopsies in developing new therapies, personalizing the application of current drugs, and designing novel drug combinations to treat acquired resistance. |
| Meredith Tennis, PhD | Medicine | | Investigate a molecular profile of persistence in lung premalignant lesions for mechanistic connections to activity to a lung cancer prevention agent. |
| Linda van Dyk, PhD | Immunology and Microbiology | | My lab's research interests center around cancer biology, gene regulation, and microbiology virology. |
| Rajeev Vibhakar, MD, PhD | Pediatrics | | Investigation of mechanisms of resistance in pediatric brain tumors using patient derived cells and advanced molecular techniques such as ChIP-Seq, single cell RNA Seq. |