Colorado Head and Neck Cancer SPORE


The main goal of the Colorado (CO) Head and Neck Cancer (HNC) SPORE is to advance translational research to improve survival and quality of life for HNC patients. The CO HNC SPORE takes advantage of our expertise in basic and clinical sciences, and uses unique model systems to identify novel molecular and cellular mechanisms of HNC pathogenesis targetable by therapeutic interventions to treat all cancer types arising from head and neck anatomic sites.

The Developmental Research Program is designed to attract current HNC researchers and researchers from other fields to conduct innovative research in all types of cancers arising from head and neck tissues. The Career Enhancement Program is designed to solicit junior researchers to develop research projects to transition into independent HNC researchers. We encourage underrepresented minority (URM) and people with disabilities to apply for DRP and CEP projects. The CO HNC SPORE also includes Biospecimen/Pathology, Data Science, and Administrative Cores to provide support. 

Leaders


Biospecimen/Pathology Core


Scott Lucia, MD 100 x 150

Core Director

Scott Lucia, MD
Pathology
Scott.Lucia@cuanschutz.edu

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Adrie van Bokhoven, PhD 100 x 150

Core Director

Adrie van Bokhoven, PhD
Pathology
Adrie.vanBokhoven@cuanschutz.edu

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The Biospecimen/Pathology Core (BPC) is essential to the success of the Colorado Head and Neck Cancer SPORE. The BPC is a central service that obtains tissues and information from patients with head and neck cancer. The collected tissue and information is stored and processed so that researchers have the best possible materials and information for their projects. In addition, the BPC provides unique skills and expertise in pathology and analysis technology to be successful in the execution of their projects.

Career Enhancement Program


Daniel Bowles, MD 100 x 150

Clinical Science Leader

Daniel Bowles, MD
Medical Oncology
Daniel.Bowles@cuanschutz.edu

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Raphael Nemenoff, PhD 100 x 150

Basic Science Leader

Raphael Nemenoff, PhD
Renal Med-Diseases/Hypertension
Raphael.Nemenoff@cuanschutz.edu

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The Career Enhancement Program (CEP) will encourage promising candidates at the University of Colorado Cancer Center to pursue translational research careers in head and neck cancer (HNC). The CEP will provide these investigators with financial support, mentorship for scientific projects and career development, and opportunities for collaboration. The long-term goal is to foster these individuals into successful independent research careers and to incorporate them and their new ideas/projects into the Colorado HNC SPORE. 

Data Science Core


Dexiang Gao, PhD

Core Director

Dexiang Gao, PhD
Endocrinology
Dexiang.Gao@cuanschutz.edu

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The University of Colorado Head and Neck Cancer (CO HNC) SPORE Data Science Core (DSC) provides services for biostatistics, informatics, bioinformatics, and other data science related analyses. The core includes a comprehensive team of biostatisticians, bioinformaticians, and an epidemiologist, that form a hub of researchers with the common denominator of being engaged in HNC research through existing collaborations. The DSC will provide assistance with research hypotheses formulation, clinical trial designs, sample size determination, analytical and database design, data collection, analyses, management and storage. This support will continue through management and coordination of accumulating research and clinical data analyses, assistance with manuscript preparation and clinical trial reports in relation to key quantitative findings and rigorous scientific conclusions. 

Developmental Research Program


Bryan Haugen, MD 100 x 150

Clinical Science Leader

Bryan Haugen, MD
Endocrinology/Metabolism/Diabetes
Bryan.Haugen@cuanschutz.edu

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Mary Reyland, PhD 100 x 150

Basic Science Leader

Mary Reyland, PhD
School of Dental Medicine/Hypertension
Mary.Reyland@cuanschutz.edu

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The premise of the Developmental Research Program within the Colorado HNC SPORE application is that innovative, high-risk research from existing head and neck cancer researchers, and an influx of research from investigators with expertise outside of, but that can be applied to head and neck cancer, will catalyze significant advances in the understanding and treatment of HNC.   

Administrative Core


Antonio Jimeno, MD, PhD 100 x 150

Director

Antonio Jimeno, MD, PhD
Medical Oncology
Antonio.Jimeno@cuanschutz.edu

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Xiao-Jing Wang, MD, PhD 100 x 150

Director

Xiao-Jing Wang, MD, PhD
Pathology
XJ.Wang@cuanschutz.edu

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The goal of the Administrative Core of the Colorado Head and Neck Cancer (HNC) SPORE is to facilitate innovative translational science that will accelerate the application of new discoveries to the clinic for HNC patients. The primary objective of the Administrative Core is to provide scientific leadership, administrative services and financial oversight, and to function as a communication hub for all SPORE-related activities. The Administrative Core will support investigators and personnel in projects 1-3, the Biospecimen/Pathology Core, the Developmental Research Program (DRP), the Career Enhancement Program (CEP), and the Tissue Use Committee.

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