The Davila Lab aims to understand the cellular and molecular signals that promote the generation of potent and long-lasting tumor-specific T cell responses. Early preclinical studies demonstrated that formulating vaccines to include toll like receptor agonists together with peptides representing tumor antigens induced potent CD8 cytotoxic T cell responses and were effective at treating tumors in a prophylactic and therapeutic setting. We continue to exploit the T cell’s ability to recognize and destroy tumors.
Jitao Guo, Elena Muse, Allison J. Christians, Steven J. Swanson, and Eduardo Davila. Using an anticancer drug cocktail of MK2206, Nut7441, and tramatenib to improve dendritic cell-based cancer vaccines. Cancer Immunol Res. Accepted May 2019
Suk Lee Y, Davila E, Zhang T, Milmoe HP, Vogel SN, Bromberg JS, Scalea JR. Myeloid-derived suppressor cells are bound and inhibited by anti-thymocyte globulin. Innate Immun. 2019 Jan;25(1):46-59. doi: 10.1177/1753425918820427. PMID: 30782043; PMCID: PMC6830891.
Geng D, Ciavattone N, Lasola JJ, Shrestha R, Sanchez A, Guo J, Vlk A, Younis R, Wang L, Brown AJ, Zhang Y, Velasco-Gonzalez C, Tan AC, Davila E. Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels. Commun Biol. 2020 Jun 12;3(1):306. doi: 10.1038/s42003-020-1033-y. PMID: 32533049.
Neuwelt A, Al-Juhaishi T, Davila E, Haverkos B. Enhancing antitumor immunity through checkpoint blockade as a therapeutic strategy in T-cell lymphomas. Blood Adv. 2020 Sep 8;4(17):4256-4266. doi: 10.1182/bloodadvances.2020001966. PMID: 32898250; PMCID.
Xander graduated from CU Boulder with a B.A in Molecular, Cellular, and Developmental Biology (summa cum laude), and a B.A in Neuroscience. He completed his undergraduate research in a neuroscience lab looking to identify the neuronal substrates of pair-bonding in the monogamous prairie vole.
Xander's current research is focused on identifying novel chemotherapeutics that sensitize T Cell Lymphomas to CD8+ CTL-mediated killing and aims to find FDA-approved compounds that can be repurposed to treat T-Cell malignancies.
In his free time Xander enjoys singing with his old A Capella group, the CU Buffoons, hiking and playing with his cat, Cleo.
Phoebe is a PhD student and NSF fellow in the Cancer Biology Program. She obtained her B.S. in Cell and Developmental Biology at the University of California, Santa Barbara and went on to become an R&D assay development researcher at Visby Medical for several years where she helped develop rapid handheld PCR-based medical diagnostic devices for various infectious diseases.
Phoebe's main interest is on developing T-cell based therapies for treating solid tumors and she is specifically working to understand the molecular mechanisms underlying CD8:MyD88 T-cell improved anti-tumor efficacy.
An avid fan of the outdoors, Phoebe often goes hiking, camping, and snowboarding in the winter. She is an avid podcast listener and consumes a whole range of topics from US foreign policy to true crime.
Jiangli received his PhD in 1996 from the Chinese Academy of Agricultural Sciences in Beijing, China. His current project involves engineering TILs to improve antitumor efficacy and persistence. He also aims to characterize the safety of engineered TILs through the use of syngeneic and humanized mouse models.
Outside of the Davila Lab, Jiangli enjoys fishing and playing ping pong.
Allie is a Master's candidate in the BSBT/Microbiology & Immunology Program. She earned her B.A. in Molecular, Cellular, and Developmental Biology with a Certificate in Public Health from CU Boulder.
In the lab, Allie is the manager of the Cytek Aurora Flow Cytometer. Currently, she is characterizing the TCR repertoire and functional response of tumor-infiltrating lymphocytes in response to chemotherapies in melanoma mouse models.
Winter is Allie's favorite season; she loves walking her dog in the snow and watching hockey. In the summer she looks forward to hiking and wildflower photography! She also enjoys volunteering with the DAWN Clinic, a local medical non-profit serving uninsured individuals in Aurora.
Eman is a second year Pediatric Hematology/Oncology/Transplant fellow at Children’s Hospital Colorado on the Anschutz Medical Campus. She Received her MD/MSc from Mansoura University Medical School, Egypt after which she joined the transplant unit at the Texas Children's Hospital, Baylor College of Medicine as a clinical research fellow.
Outside of her clinical and laboratory work, Eman enjoys being outdoors and travelling, playing ping pong, squash, and tennis, and sharing food! Pictured, Eman in Amsterdam in 2019 before the pandemic where she was awarded to travel to present her poster in EHA 2019.
Daniela is an undergraduate student researcher in her senior year at the University of Colorado Denver, where she will obtain her bachelors degree in Biology. A MARC-U STAR Scholar, Daniela is most recently a EUReCA Fellow. Her work in the Davila Lab focuses on the effect that IL-1 receptor associated kinase-M (IRAK-M) has on melanomas and its ability to metastasize.
In her free time, Daniela enjoys hiking and loves dogs, especially her own! She also developed a new found love for puzzles during quarantine.
Jitao is a research associate with the Davila lab and received his PhD in Microbiology from Peking University. His current research is focused on developing synthetic cell signaling modules to customize T cell responses for cancer therapy.
Outside the lab, he enjoys writing scientific stories and handiworks. The photo shown here is of Jitao biking in Tibet.