The Davila Lab aims to understand the cellular and molecular signals that promote the generation of potent and long-lasting tumor-specific T cell responses. Early preclinical studies demonstrated that formulating vaccines to include toll like receptor agonists together with peptides representing tumor antigens induced potent CD8 cytotoxic T cell responses and were effective at treating tumors in a prophylactic and therapeutic setting. We continue to exploit the T cell’s ability to recognize and destroy tumors.
Geng D, Kaczanowska S, Tsai A, Younger K, Ochoa A, Davila E. TLR5 ligand-secreting T cells reshape the tumor microenvironment and enhance antitumor activity. Cancer Res. 2015 Mar 20;PubMed PMID: 25795705.
Kaczanowska S, Joseph AM, Guo J, Tsai AK, Lasola JJ, Younger K, Zhang Y, Gonzales CV, Davila E. A Synthetic CD8α:MyD88 Coreceptor Enhances CD8+ T-cell Responses to Weakly Immunogenic and Lowly Expressed Tumor Antigens. Cancer Res. 2017 Dec 15;77(24):7049-7058.
Jitao Guo, Elena Muse, Allison J. Christians, Steven J. Swanson, and Eduardo Davila. Using an anticancer drug cocktail of MK2206, Nut7441, and tramatenib to improve dendritic cell-based cancer vaccines. Cancer Immunol Res. Accepted May 2019
I am a PhD student and NSF fellow in the Cancer Biology Program. I obtained my B.S. in Cell and Developmental Biology at the University of California, Santa Barbara. After my B.S., I was an R&D assay development researcher at Visby Medical for several years where I helped develop rapid handheld PCR-based medical diagnostic devices for various infectious diseases. I love the outdoors so I often go hiking, camping, and snowboarding in the winter. In my spare time, I'm an avid podcast listener and I consume a whole range of topics from US foreign policy and politics to true crime and real estate investing.
My main interest is on developing T-cell based therapies for treating solid tumors. I'm specifically working to understand the molecular mechanisms underlying CD8:MyD88 T-cell improved anti-tumor efficacy.
I am Research Associate with the Davila lab and received my PhD in Microbiology from Peking University. My research is focused on developing synthetic cell signaling modules to customize T cell responses for cancer therapy.
Outside the lab, I enjoy writing scientific stories and handiworks. The photo shown here is of me biking hard in Tibet, just like I am pursing a dream receptor now in Colorado.