Dr. Mamuka Kvaratskhelia and Colleagues Publish Groundbreaking HIV Research in Science

3D closeup of Virus DNAAs we focus on COVID-19, we know that additional pandemics are certain to occur when more viruses cross species barriers from animals to humans. In addition to SARS-CoV-2, no virus illustrates this risk more than HIV-1, for which chimpanzees were the proximate source about a century ago. Dr. Mamuka Kvaratskhelia, Professor of Medicine in the Division of Infectious Diseases, has now led a team of researchers in seven U.S. laboratories in uncovering the underlying mechanism of action of a strikingly innovative addition to the HIV therapeutic armamentarium. The research was published in Science on October 16. It concerns the first in class, ultra-potent HIV-1 capsid inhibitor, GS-6207 (Lenacapavir, Gilead). GS-6207 heralds an entirely new way of treating HIV-1. Its remarkable potency and other advantageous features have led to current clinical trials with very long dosing intervals (six months). Combining molecular biology, virology, structural biology, high resolution imaging of HIV in cells, and an array of biochemical and biophysical methods, the paper reveals the key mechanism: blocking HIV’s ability to complete infection by hyper-stabilizing and thereby preventing disassembly of the virion capsid shell in infected cells. The work has strong potential to lead to further treatment advances, but it also illuminates what is still the most mysterious part of the HIV-1 life cycle: the post-entry fate of the virus capsid core as it traverses the cytoplasm and enters the nucleus. Other contributors on our campus were the Asturias and Poeschla laboratories. Mamuka was also just awarded a new 5-year NIH R01 grant to take this work forward.

Katherine Frasca and Donna McGregor Lead New Virtual TelePrEP/HIV Prevention Program

Picture of two men wearing surgical masksUCHealth has launched a new service, the TelePrEP/HIV Prevention Program. This entirely virtual service allows at-risk people – especially in rural and underserved areas of the state – to confidentially receive medical care for HIV prevention from trained medical personnel via their computers, smart phones, and tablets. This program is an extension of the existing in-person PrEP Clinic at the Infectious Diseases Group Practice at UCHealth University of Colorado Hospital. Read more at UCHealth Today.

Santiago and Wilson Labs Decipher Functional Differences Between the Antiviral Interferons

Diagram of interferomes in gut cd4+ T cellsEarly during virus infection, our bodies produce Interferons (IFNs). These antiviral agents are highly diverse, with 12 distinct IFNa subtypes and IFNb being the most highly expressed. Of these, only two, IFNa2 and IFNb, are approved for clinical use, and in fact are being tested against COVID-19 in ongoing clinical trials. However, Interferons need to be administered with care, as they cause adverse effects. In PLOS Pathogens, a team led by Drs. Mario Santiago and Cara Wilson now report that IFNa2 is not the most potent antiviral interferon against HIV-1. In a critical target, helper T cells in the gut, IFNa8, IFNa14 and IFNb inhibited HIV-1 more than IFNa2. Using unbiased transcriptomics, the team then showed that distinct IFNa subtypes and IFNb triggered common and unique gene sets and cellular pathways, suggesting that these diverse Interferons have both redundant and nonredundant functions. Specifically, IFNb altered 3-times more genes than any IFNa subtype. Interestingly, in the gut of persons with chronic HIV-1 infection, IFNb, but not IFNa, was induced. Genes specifically induced by IFNb were decreased during HIV-1 infection and altered pathways that could promote inflammation and depletion of CD4 T cells, both critical features of AIDS. The work suggests that we should not limit ourselves to the 2 clinically available Interferons to combat viral epidemics and pandemics; evolution has given us a diverse range of antiviral Interferons to choose and improve upon.

Understanding How Bats are Recurrent Sources of Lethal Human Viruses

Picture of Yinpterochiroptera bat flying Bats have been primary reservoirs for multiple lethal human viral pathogens, such as SARS, MERS, rabies, Henipa viruses, and most recently, SARS-CoV-2. The probability that further zoonoses will emerge from them is high and the COVID-19 pandemic suggests that bat innate immune systems are insufficiently characterized relative to the medical importance of these mammals. Restriction factors are main innate immune effectors, limit viral host switching/emergence, and exert strong selection pressure when it occurs. HIV-1 exemplifies how retroviruses can also be severe pathogens when they cross species barriers, and bats harbor many endogenous and also at least one exogenous retrovirus. The Poeschla lab has now identified and characterized a retroviral restriction in bats. Working with colleagues in Singapore and Australia, they studied the large bat Pteropus alecto, which is the reservoir species for Nipah virus. Primate lentiviruses are specifically restricted while nonprimate lentiviruses are entirely unrestricted. The particular retroviral restriction pattern has singular features, but is dependent on viral capsid interactions with cyclophilin A, a cellular protein known to complexly regulate HIV and SIV replication, including restriction. 

Women of Color on the Front Lines: Portraits of Unsung Heroes

Art depicting WOC frontline medical workers

Dr. Sarah Rowan was featured in CU Medicine Today in an article about her project, Women of Color on the front lines.  Artworks by her and fellow artists have been turned into an online gallery  that show the strength and determination of health care providers and the creativity and talent of the artists.  Dr. Rowan has long painted portraits to relax but in the midst of the pandemic, her hobby took on newfound importance, and prompted her to find a way to celebrate an overlooked community of frontline workers emerging during the crisis.  She and her fellow artists seek to honor all health care workers who are on the front lines of the health care response. To raise the profile of women of color, she asked physician friends to send selfies so that she could make portraits. Those friends contacted other friends and within days, Rowan had 150 photos from physicians across the country and has attracted national attention for the project. Over 75 other artists have signed up. 

Protecting detainees from COVID-19

Picture of Dr. Franco-Paredes on AMC circa 2020Dr. Carlos Franco-Paredes was the subject of a feature article in CU Medicine Today about his work inspecting county jails, advising state prison leaders, and advocating for safer conditions for people held in immigration detention centers. His activities have been multifaceted, and included traveling coast-to-coast to inspect jails and prisons, serving as the court-appointed inspector of the Prince George’s County Jail in Maryland, and inspecting facilities in Oakland and for the Los Angeles County jail system. He also has issued advocacy letters used in court hearings seeking to create safer conditions for those held in custody. Collaborating with the Southern Poverty Law Center, the University of Texas School of Law’s Civil Rights Clinic, and other groups, he has produced declarations on behalf of detainees in Immigration and Customs Enforcement detention centers. He has been actively publishing in peer-reviewed journals, including The New England Journal of Medicine and the Lancet.

Professor Steven Johnson Receives the DOM COVID-19 Pandemic Leadership Response Team Award

DOM Pandemic Response Team Award Poster

This innovator award recognizes three responders in the department who were instrumental during the critical phase of the COVID-19 pandemic in the spring of 2020. Dr. Johnson cared for many COVID-19 patients and contributed on several levels to formulating the division and institutional responses. He helped devise evidence-based COVID-19 treatment guidelines and served on the NIH guidelines panel as well. The award will be presented October 29. Zoom link 

Congratulations to Jennifer Doudna (who was at CU Boulder from 1991-1994) and Emmanuelle Charpentier on one of the most deserved Nobel Prizes ever. What a Year. Our ID Division scientists use CRISPR all the time now.

Poster of Jennifer Doudna and Emmanuelle Charpentier - 2020 Chemistry Nobel Laureates

A killer pandemic virus, evidence-based cures from deeply creative basic research, amazing scientists. Perfect for 2020. Perfect for any year's prize.

2020 Nobel laureates in medicine poster

Dr. Cindy Firnhaber and colleagues in South Africa report the outcome of a trial of HPV vaccination in women with HIV and high-grade cervical dysplasia

Women living with HIV often have larger, high-grade lesions (HSIL) or multifocal lesions resulting in incomplete removal of HSIL. Up to 50% of women living with HIV treated with after treatment with Loop electrosurgical excision procedure (LEEP) had persistent or recurrent HSIL compared to 5-10% of HIV negative. The cervical cancer screening and treatment team at the Helen Joseph Hospital in Johannesburg implemented a double blinded placebo controlled randomized clinical trial in 180 HIV-1 infected women with biopsied proven HSIL. Women received the quadrivalent HPV vaccine at baseline, week 4 and 26 during the study. LEEP was done at week 4. The primary endpoint was a composite of HSIL on cervical histology or cytology at week 26 or week 52, and there were a number of secondary measures. The primary endpoint was not significantly different between the vaccine and placebo arms with cytologic or histologic HSIL. Thus, this study did not support HPV vaccination in this setting. Recurrent HSIL was high despite virologic suppression. This work highlights how earlier and improved access to cervical cancer screening and treatment is necessary to prevent the significant burden of cervical cancer in HIV infected women.

Dr. Andrés Henao-Martinez named Editor-in-Chief of Therapeutic Advances in Infectious Diseases. Andrés describes the focus of the journal and his goals:

Andres Henao Martinez"Therapeutic Advances in Infectious Disease (TAI) - launched in 2013 - is a peer-reviewed open-access journal with a strong clinical and pharmacological focus. TAI delivers the highest quality peer-reviewed open access original research articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of infectious diseases. TAI welcomes original research articles across all areas of infectious disease. The journal publishes original research articles and reviews articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports are also considered. The journal is listed in PubMed and indexed in Web of Science, Emerging Sources Citation Index (ESCI) and Scopus). One of the goals as Editor-in-Chief is to increase the volume of submissions and to index the journal in Thomson Reuters' Science Citation Index Expanded (SCIE)".

Prisons, the Cycle of Despair, and COVID-19

The United States has extraordinarily high incarceration rates compared to other major developed countries. SARS-CoV-2 is a particularly destructive addition to a stew of correctional system factors that include extreme sentence durations, disproportionate impacts on racial minorities and other historically disadvantaged populations, resistance to paroling elderly individuals for whom recidivism risks are low, crowding, poor ventilation systems, inadequate preventive measures, lower quality medical care and limited treatment access. In The Lancet Infectious Diseases, multiple ID division members recently joined with The Sentencing Project to review the issues and make recommendations for systematic, rational decarceration policies to reduce morbidity and mortality from COVID-19. Dr. Franco-Paredes also gave Department of Medicine Grand Rounds on September 30 on “The Triumph of Despair: Health Inequities and Structural Racism”. 

Dr. Haas and colleagues publish encouraging data on a new latent tuberculosis treatment strategy 

Treatment of latent tuberculosis infection (LTBI) with short course regimens is now favored over longer traditional regimens such as daily INH for 9 months. Dr. Michelle Haas and her colleagues (Kaylynn Aiona, Kristine Erlandson and Robert Belknap) have now published their analysis of 2 different short course rifamycin-based LTBI regimens from their recent retrospective cohort study. The study was carried out at the Denver Metro Tuberculosis Clinic. They found that INH-rifapentine self-administered once weekly for 3 months (3HP-SAT) was associated with higher completion rates and fewer adverse events than daily rifampin for 4 (4R) months.  Importantly, this finding was also seen among adults aged 50 and older in whom safer options for LTBI treatment are needed.  They conclude that expanding 3HP-SAT may enhance tuberculosis prevention in the U.S. 

Dr. Kristine Erlandson: 12 primary research papers so far in 2020 (and it’s still only September)

National HIV/AIDS and Aging Awareness Day is September 18. Physician-scientist Kristine Erlandson works on understanding physical function impairments in older adults with HIV and improving physical function and disability with physical activity. This work has expanded to encompass impacts of ART-associated weight gain. Among her numerous grants, her current R01 investigates the impact of statins on physical function and she and a co-PI recently received an R01 to investigate High-intensity Interval Training in older HIV patients. Her work in theses areas are highlighted by the following 2020 publications so far (these are half of the total of 12 this calendar year; see the rest in the Publications window). Congratulations to Kristine!

Women in the IDSA: Progress, Future Opportunities

In a recent commentary, Drs. Shanta Zimmer and Janet Gilsdorf review the history of gender disparities within the Infectious Disease Society of America (IDSA) and describe progress toward equity as well as next steps to maintain efforts with the goal of achieving healthier outcomes for patients. They note that women have played an increasing role since the formation of the IDSA Women’s Committee in 1992. Later task forces have emphasized the importance of women and other unrepresented minorities, to the success of IDSA core missions. Ongoing efforts in the Society to maintain the presence of women and their unique talents, experiences, and understandings are important. 

Dr. Castillo-Mancilla’s Work on Quantifying Adherence to ART

Adherence to ART is central to quality HIV care and to the prevention of transmission. Dr. Jose Castillo-Mancilla has recently published a major study of five hundred and twenty-seven persons living with HIV (1150 person-visits).Working with a creative set of analytical methods that measure drug concentrations in dried blood spots,he and his colleagues determined patient characteristics that predict the concentrations of tenofovir diphosphate, the active anabolite to the antiretroviral agent tenofovir. This study complements previous analyses that have established the association of this adherence measure with viral suppression (PMID: 30137238) and its utility as a predictor of future viremia (PMID: 30942881) in PWH. Future research to incorporate these predictors into the interpretation of this ART adherence biomarker, and to establish whether these associations extend to PWH taking tenofovir alafenamide-containing ART are ongoing. 

Dr. Esther Benamu Provides Expert Opinion on the Roles of JAK-STAT Inhibitors

JAK-STAT inhibitors are powerful immunosuppressive agents with good uses in inflammatory and autoimmune diseases. They are also being studied intensively around the world for use in treating COVID-19-associated inflammation. Dr. Esther Benamu recently reviewed these drugs, along with complement (C5) inhibitors in Infectious Disease Clinics of North America

Dr. Henao-Martínez and team publish outcome of an extensive systematic review and meta-analysis on the natural history of Chagas disease. 

The study, published in  JAMA Open Network, established a clear annual risk of cardiomyopathy among asymptomatic individuals in endemic regions. His team found a yearly rate of cardiomyopathy of approximately 5% among patients with acute Chagas infection and 2% among patients with indeterminate chronic Chagas disease. These findings promise to enforce the urgency to diagnose and treat early patients living with Chagas Disease. CU Anschutz News also covered this study in a recent press release.

Dr. Charles Dinarello and colleagues publish clinical trial results on IL-1 receptor blockade in COVID-19 in the Proceedings of the National Academy of Sciences

Dr. Dinarello discovered IL-1 as a key mediator of fever and he has gone on to develop therapeutics that block this important cytokine. Now he and colleagues in France report in PNAS that anakinra, an IL-1 receptor antagonist, can ameliorate destructive hyper-inflammation in COVID-19.

Drs. Henao-Martínez and Franco-Paredes provide an important perspective on racial inequity and COVID19 in the New England Journal of Medicine

Andrés F. Henao-Martínez, MD and Carlos Franco-Paredes, MD, MPH, are co-authors of a perspective article, “Racial Disproportionality in Covid Clinical Trials,” published last Tuesday by The New England Journal of Medicine. Andrés, Carlos, and their co-authors call out the underrepresentation of minority groups in COVID-19 clinical trials, and in some cases the failure of some studies to disclose racial and ethnic data. “It is alarming that long-standing racial health disparities have been extended to Covid-19 clinical trials when racial and ethnic minority groups have so much to gain from this research, including the opportunity to receive lifesaving treatment,” the authors write.

Dr. Thomas Campbell appointed Chief Clinical Research Officer for UCH Health and Associate Dean of Adult Health Research

Thomas Campbell, MD, Professor of Medicine in the ID Division, has been named Chief Clinical Research Officer for UCHealth and Associate Dean of Adult Health Research. Tom has abundant experience with clinical trials, most recently for COVID-19 interventions, and is the site leader of the Colorado ACTU. He will be responsible for assuring an effective environment for conducting clinical research that complies with federal and state regulatory requirements. The position will foster infrastructure, processes, informatics and analytics to promote high quality UCH and University of Colorado clinical research. Tom succeeds Thomas Flaig, MD, professor of medicine in the Division of Medical Oncology, who was named the University’s Vice Chancellor for Research earlier this year. The division is delighted to see him take on this important role.

Supporting Dr. Fauci

The ID Division stands foursquare with Dean Reilly in his July 20th statement of principle on Dr. Anthony Fauci and reiterates his call for commitment to science in the COVID-19 crisis and in all other infectious disease policy:

"The number of cases of COVID-19 has been rising significantly across the country and, while the numbers in Colorado have not been increasing as quickly as in other places, we have seen cases here trending upward. The trajectory is a cause for concern and a reminder that we must remain diligent in our efforts to limit the spread of the coronavirus. It is also clear that willful ignorance and persistent efforts to divide us from one another are not solving the problem. At the Anschutz Medical Campus, we are committed to the pursuit of evidence, the gathering of data, and the application of that knowledge to lead us to improved understanding of human health and better care for all. That is why the disparagement of Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, is so alarming. He is one of our country’s leading champions of pursuing facts for the common good, and he has come under attack recently for doing his work with clear-eyed purpose.

"With those attacks in mind, I encourage you to read a letter released last Tuesday, by Howard Bauchner, MD, editor in chief of JAMA and the JAMA Network, stating in part: “As we have learned the coronavirus does not respect state lines – Maine or Alabama, or political parties – Republican or Democrat. The undermining of science – and the unprecedented attacks on scientists and public health officials – risk lives in every corner of our country. . . . So to all who are reading this – wherever you live and whatever your political affiliation – please wash your hands, keep your distance from others when appropriate, wear your masks, and please join me in showing respect for Dr. Anthony Fauci and his many colleagues at the NIH, CDC, and throughout the country who are our best hope in these challenging times.”

"It is disheartening that such a plea needs to be made during the most widespread public health crisis of our lives, but Dr. Bauchner’s message is clear: science matters. You and your colleagues at the CU School of Medicine are also among those professionals who are our best hope to get through these trying times. We must reject distractions, continue to guard against falsehoods, and remain focused on our common purpose: conquering the coronavirus as soon as possible so that we can pursue all the other work on this campus that matters. The work you’re doing is too important to be discouraged or diverted. Thank you for your extraordinary efforts to improve our health and safety."

Dr. Katherine Frasca Assumes Associate Fellowship Program Director Role

Dr. Katherine Frasca starts today as Associate Program Director (APD) of the ID Fellowship Program. Katherine will take over Dr. Kristine Erlandson’s role.  We welcome Katherine and express our deepest gratitude to Kristine for her many contributions to the training and mentorship of multiple generations of infectious disease fellows. Dr. Carlos Franco-Paredes is Program Director (PD) and Katherine and Dr. Brian Montague are the two APDs. Katherine brings a wealth of clinical & educational experience to our program. She has a stellar record in Education and the Scholarship of Teaching. She is locally and regionally recognized as a leader in medical education on HIV prevention. During the first year of her promotion to assistant professor, she was one of four recipients of the prestigious Program Academic Clinician Educator (PACE) grant, which provides scholarly support for medical education research. During that same year, she also completed the Teaching Scholars Program, learning skills in curriculum development, evaluation and medical education research. In assembling both of these programs, she has created and directed a comprehensive clinical and educational program on HIV prevention. She has developed a novel virtual curriculum on HIV pre-exposure prophylaxis (PrEP). Additionally, Katherine has been coordinating the schedule and teaching activities for the Fellows Clinic at Anschutz Medical Center Infectious Diseases Division since 2017.

Sarah Rowan MD and Whitney Starr NP, MSN Promoted to Associate Professors

The Division is pleased to announce that Sarah Rowan and Whitney Starr have each been promoted to Associate Professor. We congratulate them for their well-deserved promotions and recognize our good fortune in having such superb, dedicated faculty. Among their many accomplishments, both Sarah and Whitney are key contributors to the division’s deep expertise in chronic viral diseases. Each has been very active in HIV medicine, and Sarah also in the area of HCV. They have been active since February in the division’s vigorous response to COVID-19 as well.

Dr. Martin Krsak Selected in July 2020 to be the Featured Provider for the CU Doctors Web Page.

Recruited from the Tufts University Division of Infectious Diseases in 2017, Dr. Krsak has been active in numerous clinical and scholarly activities related to the COVID-19 efforts of our medical school. The CU Doctors homepage can be found  here.

Campus Participates in COVID-19 Moderna mRNA SARS-CoV-2 Vaccine Trial Under Leadership of PI Tom Campbell

“Our site here at University of Colorado Hospital is part of a nationwide network called the COVID Prevention Network, which is set up so that it has a cohort of sites that are available to sequentially enroll into multiple vaccine studies,” said Dr. Thomas Campbell, an infectious disease physician at the CU School of Medicine and University of Colorado Hospital. “If it works, the Moderna vaccine could be a real game-changer for the pandemic.” Watch the full interview with Dr. Campbell featured in the UCHealth Today article covering the vaccine trial launch.

James Colbert, MD Awarded the Golden Apple Teaching Award

The award was announced by graduating fellows at their virtual graduation party. Fond tributes were made by many faculty for graduating fellows Angela Budgin, Shelly Kon, Sarah Mann, and Sias Scherger. The fellows cited Dr. Colbert’s dedication to teaching and emphasis on understanding evidence-based rationales for testing, diagnosis and therapies.

Sara Rowan, MD Featured in Colorado Public Radio News for her Recent Work on a Creative Portrait Series Honoring Women of Color on the Medical Front Lines

From Dean Reilly’s weekly message July 6, “CPR News featured Sarah Rowan, MD, assistant professor of medicine in the Division of Infectious Diseases, in a recent report about finding a creative and meaningful way to take a break from the non-stop cycle of work our colleagues have been facing this year. Sarah, who practices at Denver Health and is an artist in her free time, was inspired to create art that features women of color who have been providing care in the time of COVID-19. She emailed friends at local hospitals, including Shanta Zimmer, MD, senior associate dean for education, associate dean for diversity and inclusion, and professor of medicine, to ask for selfies that could be turned into portraits, which are now featured on a specially created website, Women of Color on the Front Lines. “I hope that it serves as a visual representation that our society values women and racial diversity in medicine, and their commitment is worth recording with artwork,” Sarah said. “I hope that people feel honored and appreciated. I also feel hopeful that this will inspire young people to go into medicine, particularly young Black people or Latinx people.””

Dr. Charles Dinarello Awarded the 2020 Tang Prize

Dr. Charles Dinarello in the Division of Infectious Diseases has been awarded the 2020 Tang Prize in Biopharmaceutical Sciences. The prize was awarded for “the development of cytokine-targeting biological therapies for the treatment of inflammatory diseases.” See also the CU Anschutz Today article. He shares this year’s prize with two colleagues, Marc Feldmann and Tadamitsu Kishimoto. Charles discovered Interleukin-1 and is an author of over 1,000 scientific papers. His work has applications to diverse fields and most recently his laboratory has been working on treatments for the hyper-inflammatory problems seen in COVID-19. More about the Tang Prize, which is awarded every two years to two to three distinguished scientists, can be found here. Charles has previously been awarded a University Distinguished Professorship, which is the highest honor that the University of Colorado bestows on its own faculty members. Congratulations to Dr. Dinarello on this extraordinary recognition and on all his scientific achievements.

The Division Welcomes 4 New ID Fellows

The Division is delighted to welcome four new ID fellows, who started July 1, 2020. They bring to us a wealth of education, experience and talent from diverse backgrounds. Biographies are coming soon to the Education page.

Dr. David Fraulino

David joins us from the University of Connecticut internal medicine residency and is graduate of the University of New England College of Osteopathic Medicine.

Dr. José Henao

Jose joins us from the University of Minnesota internal medicine residency and is a graduate of the Universidad de Ciencias Medicas Andrés Vesalio Guzmán (UCIMED) Escuela de Medicina, Costa Rica. 

Dr. Zachary Shepard

Zachary joins us from the University of Michigan internal medicine residency and is a graduate of the Baylor College of Medicine.

Dr. Lilian Vargas

Lilian joins us from the Houston Methodist Hospital internal medicine residency and is a graduate of the Universidad Nacional Autónoma de Honduras Facultad de Ciencias Médicas, Honduras.

Read all about Dr. Michelle Barron’s Inspiring Life Story and Career

Dr. Barron is Professor of Medicine in the ID Division and Medical Director of Infection Control and prevention. On January 8, 2020, she emailed her colleagues: “Hello. Happy New Year! Never a dull day in infection prevention. There is a severe respiratory disease due to a novel coronavirus that is causing an outbreak in the Wuhan province of China.” The full article, "A fearless protector: Meet the top infectious disease expert in Colorado", can be found at UCHealth Today. Drs. Barron and Larissa Pisney are the point persons for Infection Control in our main academic hospital, UCH.

HIV Training Grant Awarded

The Division of Infectious Diseases will be home to a new T32 program for postdoctoral training in Antiretroviral Discovery, Evaluation and Application Research (ADEAR).  ADEAR will provide postdoctoral scientists with mentored research training under the direction of faculty at the University of Colorado, Colorado State University and the University of Denver who are who engaged in research related to the discovery and evaluation of new antiretroviral drugs or the application of existing antiretrovirals for the treatment and prevention of HIV/AIDS.  The program is expected to kick off in July 2020 and will support 3 trainees per year through June 2025.  A request for applications will be released in early July.

Dr. Franco-Paredes Interviewed by the New York Times on the Worsening Problem of COVID-19 in Prisons

The full article can be read here.

Drs. Krsak, Henao-Martinez, and Franco-Paredes Advocate in the NEJM for Serological Testing in Correctional Facilities

Their recommendations can be read in full here.

Multiple Division Faculty are Contributing to COVID-19 Clinical Trials Research

Read about our role in developing antiviral medications and working to attenuate the virus's inflammatory response here.

Dr. Katherine Frasca Has Created a COVID-19 TipSheet/Survival Guide Based on Her and Our Other ID Physicians' First-hand Experience

Dr. Frasca recently attended to numerous COVID-19 inpatients and has compiled this very helpful and practical resource which can be found in our COVID-19 document collection on our division's COVID-19 resources page. Stay tuned for expansions and refinements by her and our other physicians of this living document. 

Associate Professor David Beckham, MD Has Been at the Forefront of Efforts to Deploy Convalescent Plasma for COVID-19 Patients in Colorado

Dr. Beckham was featured in a recent news report about how researchers and clinicians are working together on our campus to make a serum test available. The University of Colorado Hospital was the first in the state to treat COVID-19 patients with convalescent serum. This work is supported in part by a CCTSI pilot award.

Division Faculty Advocate for Immigrant and Disadvantaged Populations

Dr. Carlos Franco-Paredes works with a national network of physicians dedicated to provide medical care for immigrants under ICE custody. Dr. Michelle Haas has been volunteering in the Human Rights Clinic (HRC) at Denver Health. Janine Young and Jaime Moo-Young lead the HRC.  In response to COVID-19, Carlos has actively collaborated with RMAIN, ACLU, Southern Poverty Law Center, and numerous immigration attorneys to promote the release of detained immigrants on humanitarian parole. Implementing interventions such as social distancing and infection prevention is a major challenge in for-profit overcrowded detention centers.

ID Faculty Photo Panel Now Available on ID Division Website

The "Faces of the ID Division" card below provides a photo panel showing our faculty arranged in order of year of appointment to the CU SOM faculty. The 72 faculty distribute as follows: AMC-51, Denver Health-15, Veterans' Affairs-4 (7 counting joint roles), NJH-2. On the AMC (UCH), there are 40 ID clinicians who staff our inpatient and outpatient ID services (32 physicians, 8 APPs). Fourteen of our faculty have laboratory-based programs in Research Complex 2 (RC2).

Weekly Division Case Conferences Have Moved to a Virtual Format

In response to COVID-19, the Division’s weekly Case Conference is now a virtual series that will focus on this new infectious disease and engage the campus and the broader Colorado medical community. Fellows and faculty present and discuss COVID-19 cases and medical students provide a literature review. This is a joint collaboration between CU Anschutz, Denver Health, Colorado IDSA, and ECHO Colorado.

Professor Shanta Zimmer Rolls Out New COVID-19 Course at the CU School of Medicine

Professor Zimmer, Senior Associate Dean for Education, has led a team of educators and students in setting up the COVID-19 Pandemic Response Elective Course in record time. It is also posted at the iCollaborative website of the AAMC.

Professors Eric Poeschla, Steven Johnson, and Thomas Campbell Present COVID-19 Grand Rounds

Their grand rounds [video link]  presentation on April 1 gave an overview of epidemiological modeling, origins and properties of SARS-CoV-2, clinical features, and treatment. They were joined by Professor Jonathan Samet from the CU School of Public Health.

Division Activates Additional Inpatient ID Service in Response to COVID-19

On 24 March, the Division activated a 5th inpatient ID service (Green) to meet the needs of COVID-19 patients. The pre-existing services are Gold ID, Blue ID, Ortho-ID and Transplant ID. In addition, faculty are participating in several COVID-19 clinical trials, organizing outpatient follow-up visits, providing updated treatment and monitoring guidelines, and supervising hospital infection control.

We Welcome Five Incoming Faculty Members

The Division is Growing. In July we will be 72 faculty members strong. A fifth inpatient service will soon start at University of Colorado Hospital. We are delighted to officially announce five new ID Division faculty members who will join us in mid-2020. They collectively bring a wealth of talent, training and diverse experiences to our three-shield missions:

Yiannis Koullias, MD comes to us from the Partners ID fellowship at Harvard Medical School/Brigham & Women’s Hospital/MGH, with subspecialty training in Transplant ID at Dana-Farber/Brigham and Women’s Cancer Center. He is a graduate of Harvard College, Duke Medical School, and the Brigham’s Internal Medicine Residency Program. His has broad interests in Transplant ID, including viral and fungal infections in heme-onc/BMT populations.

Sarah Mann, MD joins us from our ID fellowship here at the University of Colorado School of Medicine. She is a graduate of Cornell University, George Washington University Medical School and the Harbor UCLA internal medicine residency. She has interests in HIV Medicine and works on stewardship of anti-retroviral agents.

Aakriti Pandita, MD joins us from the Infectious Disease Fellowship at Warren Alpert Medical School of Brown University. She is a graduate of the Sher-i-Kashmir Institute of Medical Sciences in Srinagar, India, and the SUNY Upstate Medical University internal medicine residency. She is jointly appointed with the Division of Hospital Medicine. She is currently working on a meta-analysis of decades-long time trends in Staphylococcus aureus bacteremia. She also has a strong interest in tuberculosis and advocacy.

Rebecca Rwubusisi MSN, BSN, is our new APP for the Transplant ID (TID) service on the AMC. She is an Acute Care Nurse Practitioner whose valuable experience includes 15 years of bedside experience as an RN in the Department of Surgery, on the UC Health Inpatient Transplant Unit. She also has medical experience in East Africa and is fluent in Spanish.

Sias Scherger, MD also joins the division from our ID fellowship. He is a graduate of the University of Nebraska, the University of Nebraska College of Medicine and the Wake Forest internal medicine residency. He has interests in transplant ID and is working on understanding associations between anti-cytokine antibodies and endemic fungal infections.

Responding to COVID-19. The CU Infectious Diseases Division Continues to be Deeply Involved in Institutional Preparations for the Coronavirus Pandemic

Drs. Michelle Barron and Larissa Pisney (University of Colorado Hospital Infection Control and Prevention) are at the head of a multi-faceted campaign to ready our UCH providers and trainees and have been coordinating with state and national authorities. Drs. Mary Bessesen and Heather Young have been performing similar roles at the VA Medical Center and Denver Health. Dr. Brian Montague is involved in managing employee health for both the School of Medicine and UCH. Numerous other ID faculty members have participated in patient care, screening and testing, contingency planning, guidelines preparation, communications and community outreach, scientific discussions, idea generation, and teaching.  Division scientists are working on various research aspects of understanding, preventing and treating viral infections. The Infectious Disease Fellows are involved in consulting on COVID-19 issues and they will also be working with the Colorado Dept. of Public Health in the coming month to learn about the role of epidemiologists and about public health policy.  The Division website aggregator contains much practical information, both local and international.

Dr. Michelle Barron Speaks at UCHealth Town Hall on COVID-19 Response

Dr. Barron, Medical Director of Infection Control and Prevention, discussed COVID-19 basics, screening and treatment guidelines, and infection control measures. The entire town hall can be watched here.

Drs. Robert Belknap, David Cohn and Randall Reves Participate in Multi-institutional Team to Update Guidelines for Treatment of Latent Tuberculosis.

Their participation is part of the important role that Denver Health ID faculty continue to play in M. tuberculosis treatment and control, in Colorado and internationally. See Sterling et al. in MMWR in "Recent Publications" below for full details of the team's report.

Dr. Lakshmi Chauhan Receives the Outstanding Quality Award at 2nd Annual UCH Quality & Safety Symposium

Dr. Chauhan was awarded for her outpatient stewardship project “Approaches to Decrease Inappropriate Antibiotic use in Acute Respiratory Conditions in a Geriatric Clinic.” She will present her project on March 11, 2020. Her goals are to work with the antimicrobial stewardship team to help expand outpatient stewardship programs to other UCH clinics. Quality improvement projects such as this are important areas for academic contribution and grant funding opportunities in the division.

Dr. Sarah Rowan Discusses Colorado's Ongoing Fight to End HIV with 5280 Magazine.

Dr. Rowan spoke about her work on a local HIV task force to expand testing and treatment of the virus and about other efforts by the Colorado medical community to combat HIV.

Congratulations to Fellowship Program Director Dr. Carlos Franco-Paredes and Education Coordinator Kelly Rico for Highly Positive ACGME Annual Program Review.  

The Review Committee found no concerns and commended the program for its demonstrated excellent compliance with the ACGME's Program Requirements.

ID Fellows Greg Canfield and Sarah Mann Publish a Striking Example of Cutaneous Blastomycosis.

Drs. Canfield and Mann published their results in Clinical Infectious Diseases.  The case exhibited numerous interesting features including the classic - and in this case, quite developed - verrucous lesion with raised, sharply demarcated borders. 

Dr. Hillary Dunlevy Awarded Annual CU Hospital Physician Medical Staff Award

Dr. Hillary Dunlevy, Assistant Professor of Medicine, was awarded the Annual University of Colorado Hospital Full-time Physician Medical Staff Award on January 30, 2020. Recipients of this award exemplify the mission and vision of UCH and are recognized for achievement in one or more of the following areas:  Amazing patient care; Outstanding teaching of student physicians; Improvements in services offered/collaboration with other specialties; Community service.

Rebecca Rwubusisi MSN, BSN, RN, CCTN Joins Our Team as the New APP for Transplant ID Service

Her appointment will provide significant assistance to our physician providers and facilitate the patient care, education and research missions of the TID focus group. Rebecca received her BSN Magna Cum Laude from the University of Colorado Denver in 2005. She is an Acute Care Nurse Practitioner whose extensive experience includes 15 years of bedside experience as an RN in the Department of Surgery, on the UC Health Inpatient Transplant Unit. There she gained an in-depth understanding of the multi-faceted transplantation process and close working relationships with transplant providers. She developed a passion for Infectious Diseases as well, prompting her to transition to our Division. During three months in Rwanda, Rebecca also saw and treated patients with multiple infectious problems, including HIV/AIDS. Moreover, she is fluent in Spanish.

Debra Best Joins Our Division as Our New Post-Award Administrator

She will begin her role on Monday, February 3rd, 2020.

Dr. Cara Wilson has been appointed Associate Director of the Medical Scientist Training Program

Dr. Wilson will transition into the director role on July 1, 2020. Our MD-PhD program is a critical linchpin in the education of physician-scientists, allowing top-notch students to obtain their PhD alongside their MD. The program provides tuition as well as an annual stipend.

Dr. Michelle Barron Discusses Infection Prevention with Boulder Daily Camera

Michelle Barron, UCHealth University of Colorado Hospital’s medical director of infection prevention and professor of medicine at CU School of Medicine was recently interviewed by  the Daily Camera. She discussed how Boulder County has managed to avoid the worst of a state and nationwide Hepatitis A outbreak.

Dr. Tom Campbell to lead scientific review group on HIV

Dr. Tom Campbell has been nominated to lead the new Section Review Group of the NIH-CDC-HIVMA-/IDSA Guidelines for Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV.

Dr. Kristine Erlandson Announced as Outstanding Early Career Scholar

The University of Colorado Department of Medicine has selected the 2017 recipients for its Outstanding Early Career Scholar Program, HIV/AIDS researcher Kristine Erlandson, MD, and cardiology researcher Kunhua Song, PhD. The program aims to accelerate the careers of promising researchers in the Department of Medicine.

Santiago and Wilson labs frame the gene expression landscape of HIV-1 infected gut T cells exposed to enteric bacteria February 2017

Broncos fever is spreading through Denver and beyond! Have you been exposed? Dr. Michelle Barron talks about the fandemic

Dr. David Beckham discusses his role in the fight against the Zika Virus with the Aurora Sentinel

Dr. Kejun Guo highlighted as being a successful international scholar

Dr. David Wyles, New ID Division Chief at Denver Health

Professor Dinarello publishes review on inflammation and arthritis in Nature Reviews Rheumatology.
Dr. Kristine Erlandson received 2016 ACTG John Carey Young Investigator Award

Dr. David Beckham discusses details surrounding the Zika virus

Arjun Srinivasan, MD, of the CDC, presented a national update on antibiotic stewardship. Dr. Norihiro Yogo, diretor of antimicrobial stewardship at UCH, and Matt Miller, PharmD, were mentioned due to their involvement in developing guidelines for treating common infections

Dr. Michelle Barron discusses mosquito prevention in an article featured in the Denver Post

Q & A with Dr. Michelle Barron- featured on CU Medicine Today through the School of Medicine

Dr. Jose Castillo-Mancilla selected as a Department of Medicine 2016 Rising Star

Dr. Bill Burman, Director of Denver Public Health, named interim CEO of Denver Health

Poeschla laboratory reports newtransgenic model of stably augmented innate immunity in PLoS Pathogens

Dr. Connnie Price named CMO at Denver Health

DOM’s Richard Johnson and Dr.Eric Poeschla Elected to the Association of American Physicians

Beckham Lab discovers that alpha-synuclein, the protein that causes Parkinson’s disease, functions as a neuron-specific restriction factor to inhibit viral infections in the brain

Connick Lab reports novel findings on the roles of follicular regulatory T cells in HIV and SIV disease in Nature Communications

Dr. Elizabeth Connick invited to serve on the Office of AIDS Research Advisory Council

Wilson lab reports in Mucosal Immunology that gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection

Santiago and Wilson Labs report on the role of Interferon-α Subtypes in mucosal HIV-1 Infection

Dr. Cara Wilson appointed DOM Vice Chair for Faculty Development

Dr. Charles Dinarello Named University Distinguished Professor

Dr. Thomas Campbell Awarded Excellence in Global Health

Dr. Charles Dinarello Receives Lifetime Achievement Award

Charles Dinarello Receives Honorary Doctorate

Welcome to the Division of Infectious Diseases at the University of Colorado School of Medicine. This message is addressed to our colleagues, patients and members of the public with an interest in the problems and challenges of infectious diseases.

Our faculty, more than 70 and growing, take care of patients with infectious diseases in the mountain west and across the world, do scientific research on major infectious disease (ID) health problems, and educate the next generation of physicians and scientists in our field.

We work mainly at three sites located across the Denver metropolitan area:

1. The Anschutz Medical Campus (AMC). The AMC, which contains the School of Medicine (SOM) and is located in Aurora, just east of the Denver city line, was built to accommodate the growth of the SOM and fulfill its need for cutting edge facilities for research, education, and clinical missions. Many of the Infectious Diseases Division faculty are located physically in Research Complex 2 in the research quadrangle, where we have state of the art laboratories and bio-containment facilities for work with infectious agents. AMC ID physicians, physician assistants and nurse... practitioners take care of hospitalized patients in the University of Colorado Hospital (UCH). We take care of outpatients in our Infectious Disease Group Practice (IDGP) in the UCH outpatient pavilion.

2. Denver Health (DH). This municipal, integrated model public health care system serves a broad range of patients in Colorado, with education and research as two of its strategic pillars. DH is comprised of the Denver Health Medical Center (DHMC), a community health program with 8 centers and 16 school-based clinics in Denver, and the City and County health department (Denver Public Health, DPH). Infectious Diseases faculty are located in both DPH and the Department of Medicine of DHMC. Denver Public Health clinics include the ID Clinic and Center for Positive Health (HIV), the Denver Metro Tuberculosis (TB) Clinic serving the 7-county Metro area for diagnosis and treatment of TB and latent TB infection, and the Immunization and Travel Clinic (over 21,000 vaccinations to 10,000 patients per year). DHMC, in partnership with the Colorado Department of Health and Environment, is one of nine designated regional Ebola and other special pathogen treatment centers in the U.S.

Factors associated with tenofovir diphosphate concentrations in dried blood spots in persons living with HIV.
Coyle RP, Morrow M, Coleman SS, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, MaWhinney S, Anderson PL, Castillo-Mancilla JR.  J Antimicrob Chemother. 2020 Jun 1;75(6):1591-1598.   

IL-18 and infections: Is there a role for targeted therapies?

Vecchié A, Bonaventura A, Toldo S, Dagna L, Dinarello CA, Abbate A.

J Cell Physiol. 2020 Aug 13. doi: 10.1002/jcp.30008. Online ahead of print.

PMID: 32794180 Review.

 

Use of a Standardized Dalbavancin Approach to Facilitate Earlier Hospital Discharge for Vulnerable Patients Receiving Prolonged Inpatient Antibiotic Therapy.

Vazquez Deida AA, Shihadeh KC, Preslaski CR, Young HL, Wyles DL, Jenkins TC.

Open Forum Infect Dis. 2020 Jul 13;7(8):ofaa293. doi: 10.1093/ofid/ofaa293. eCollection 2020 Aug.

PMID: 32793767 Free PMC article.

 

Protocol for the 3HP Options Trial: a hybrid type 3 implementation-effectiveness randomized trial of delivery strategies for short-course tuberculosis preventive therapy among people living with HIV in Uganda.

Kadota JL, Musinguzi A, Nabunje J, Welishe F, Ssemata JL, Bishop O, Berger CA, Patel D, Sammann A, Katahoire A, Nahid P, Belknap R, Phillips PPJ, Namusobya J, Kamya M, Handley MA, Kiwanuka N, Katamba A, Dowdy D, Semitala FC, Cattamanchi A.

Implement Sci. 2020 Aug 12;15(1):65. doi: 10.1186/s13012-020-01025-8.

PMID: 32787925

 
Outpatient Antimicrobial Treatment for People Who Inject Drugs.

Hurley H, Sikka M, Jenkins T, Cari EV, Thornton A.

Infect Dis Clin North Am. 2020 Sep;34(3):525-538. doi: 10.1016/j.idc.2020.06.009.

PMID: 32782100 Review.

 

Racial Disproportionality in Covid Clinical Trials.

Chastain DB, Osae SP, Henao-Martínez AF, Franco-Paredes C, Chastain JS, Young HN.

N Engl J Med. 2020 Aug 11. doi: 10.1056/NEJMp2021971. Online ahead of print.

PMID: 32780573 No abstract available.

 

The Impact of Moderate or High-Intensity Combined Exercise on Systemic Inflammation among Older Persons with and without HIV.

Erlandson KM, Wilson MP, MaWhinney S, Rapaport E, Liu J, Wilson CC, Rahkola JT, Janoff EN, Brown TT, Campbell TB, Jankowski CM.

J Infect Dis. 2020 Aug 11:jiaa494. doi: 10.1093/infdis/jiaa494. Online ahead of print.

PMID: 32779711

 

COVID-19 in solid organ transplant: A multi-center cohort study.

Kates OS, Haydel BM, Florman SS, Rana MM, Chaudhry ZS, Ramesh MS, Safa K, Kotton CN, Blumberg EA, Besharatian BD, Tanna SD, Ison MG, Malinis M, Azar MM, Rakita RM, Morillas JA, Majeed A, Sait AS, Spaggiari M, Hemmige V, Mehta SA, Neumann H, Badami A, Goldman JD, Lala A, Hemmersbach-Miller M, McCort ME, Bajrovic V, Ortiz-Bautista C, Friedman-Moraco R, Sehgal S, Lease ED, Fisher CE, Limaye AP; UW COVID-19 SOT Study Team.

Clin Infect Dis. 2020 Aug 7:ciaa1097. doi: 10.1093/cid/ciaa1097. Online ahead of print.

PMID: 32766815

 

Pharmacokinetics and renal safety of tenofovir alafenamide with boosted protease inhibitors and ledipasvir/sofosbuvir.

Brooks KM, Castillo-Mancilla JR, Morrow M, MaWhinney S, Blum J, Wyles DL, Rowan SE, Ibrahim ME, Zheng JH, Johnson B, Gomez J, Choi YJ, Cendali F, Haas H, Roon L, Bushman LR, Anderson PL, Kiser JJ.

J Antimicrob Chemother. 2020 Aug 7:dkaa299. doi: 10.1093/jac/dkaa299. Online ahead of print.

PMID: 32766700

 


Ensuring the Safety of Yellow Fever Vaccination in Travelers-The Experience at a Large U.S. Academic Medical Center in Colorado.

Bandali M, Schultz J, Than K, McGregor D, Archuleta S, Chadalawada S, Mundo W, Chastain D, Franco-Paredes C, Reno E, Henao-Martínez AF.

Trop Med Infect Dis. 2020 Jul 29;5(3):E125. doi: 10.3390/tropicalmed5030125.

PMID: 32751094

 

Rethinking interleukin-6 blockade for treatment of COVID-19.

Scherger S, Henao-Martínez A, Franco-Paredes C, Shapiro L.

Med Hypotheses. 2020 Jun 27;144:110053. doi: 10.1016/j.mehy.2020.110053. Online ahead of print.

PMID: 32758889 Free PMC article.

 

Lower Cumulative Antiretroviral Exposure in People Living with Hiv and Diabetes Mellitus.

Mann SC, Morrow M, Coyle RP, Coleman SS, Saderup A, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Mawhinney S, Anderson PL, Castillo-Mancilla JR.

J Acquir Immune Defic Syndr. 2020 Jul 22. doi: 10.1097/QAI.0000000000002460. Online ahead of print.

PMID: 32740367

 

Guidelines for COVID-19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients.

Waghmare A, Abidi MZ, Boeckh M, Chemaly RF, Dadwal S, El Boghdadly Z, Kamboj M, Papanicolaou GA, Pergam SA, Shahid Z.

Biol Blood Marrow Transplant. 2020 Jul 28:S1083-8791(20)30460-2. doi: 10.1016/j.bbmt.2020.07.027. Online ahead of print.

PMID: 32736007 Free PMC article.

 


Physical Function and Frailty Tools in Mortality Prediction of Middle-Aged Adults with HIV.

Pelloquin R, Abdo M, MaWhinney S, Jankowski CM, Erlandson KM.

J Acquir Immune Defic Syndr. 2020 Jul 23. doi: 10.1097/QAI.0000000000002455. Online ahead of print.

PMID: 32732769

 


Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants.

Frank DN, Giese APJ, Hafren L, Bootpetch TC, Yarza TKL, Steritz MJ, Pedro M, Labra PJ, Daly KA, Tantoco MLC, Szeremeta W, Reyes-Quintos MRT, Ahankoob N, Llanes EGDV, Pine HS, Yousaf S, Ir D, Einarsdottir E, de la Cruz RAR, Lee NR, Nonato RMA, Robertson CE, Ong KMC, Magno JPM, Chiong ANE, Espiritu-Chiong MC, San Agustin ML, Cruz TLG, Abes GT, Bamshad MJ, Cutiongco-de la Paz EM, Kere J, Nickerson DA, Mohlke KL, Riazuddin S, Chan A, Mattila PS, Leal SM, Ryan AF, Ahmed ZM, Chonmaitree T, Sale MM, Chiong CM, Santos-Cortez RLP.

J Med Genet. 2020 Jul 24:jmedgenet-2020-106844. doi: 10.1136/jmedgenet-2020-106844. Online ahead of print.

PMID: 32709676

 

Body Composition Changes in Response to Moderate or High-Intensity Exercise Among Older Adults with or without HIV Infection.

Jankowski CM, Mawhinney S, Wilson MP, Campbell TB, Kohrt WM, Schwartz RS, Brown TT, Erlandson KM.

J Acquir Immune Defic Syndr. 2020 Jul 16. doi: 10.1097/QAI.0000000000002443. Online ahead of print.

PMID: 32701826

 

Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19.

Cauchois R, Koubi M, Delarbre D, Manet C, Carvelli J, Blasco VB, Jean R, Fouche L, Bornet C, Pauly V, Mazodier K, Pestre V, Jarrot PA, Dinarello CA, Kaplanski G.

Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):18951-18953. doi: 10.1073/pnas.2009017117. Epub 2020 Jul 22.

PMID: 32699149

 

Countermeasures to Coronavirus Disease 2019: Are Immunomodulators Rational Treatment Options-A Critical Review of the Evidence.

Chastain DB, Stitt TM, Ly PT, Henao-Martínez AF, Franco-Paredes C, Osae SP.

Open Forum Infect Dis. 2020 Jun 5;7(7):ofaa219. doi: 10.1093/ofid/ofaa219. eCollection 2020 Jul.

PMID: 32691007 Free PMC article.  Review.

 

Increased cryptococcal meningitis mortality among HIV negative, non-transplant patients: a single US center cohort study.

Motoa G, Pate A, Chastain D, Mann S, Canfield GS, Franco-Paredes C, Henao-Martínez AF.

Ther Adv Infect Dis. 2020 Jul 8;7:2049936120940881. doi: 10.1177/2049936120940881. eCollection 2020 Jan-Dec.

PMID: 32685148 Free PMC article.

 

Thinking Beyond the "Core" Antibiotic Stewardship Interventions: Shifting the Onus for Appropriate Antibiotic Use from Stewardship Teams to Prescribing Clinicians.

Jenkins TC, Tamma PD.

Clin Infect Dis. 2020 Jul 15:ciaa1003. doi: 10.1093/cid/ciaa1003. Online ahead of print.

PMID: 32667974

 

A pooled analysis to compare the clinical characteristics of human papillomavirus-positive and -negative cervical precancers.

Castle PE, Pierz AJ, Adcock R, Aslam S, Basu PS, Belinson JL, Cuzick J, El-Zein M, Ferreccio C, Firnhaber C, Franco EL, Gravitt PE, Isidean SD, Lin J, Mahmud SM, Monsonego J, Muwonge R, Ratnam S, Mahboobeh Safaeian M, Schiffman M, Smith JS, Swarts A, Wright T, Van De Wyngard V, Xi LF.

Cancer Prev Res (Phila). 2020 Jul 12:canprevres.0182.2020. doi: 10.1158/1940-6207.CAPR-20-0182. Online ahead of print.

PMID: 32655005

 

Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE.

Umbleja T, Brown TT, Overton ET, Ribaudo HJ, Schrack JA, Fitch KV, Douglas PS, Grinspoon SK, Henn S, Arduino RC, Rodriguez B, Benson CA, Erlandson KM.

J Infect Dis. 2020 Jul 9;222(Supplement_1):S52-S62. doi: 10.1093/infdis/jiaa249.

PMID: 32645163

 

Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline.

Daley CL, Iaccarino JM, Lange C, Cambau E, Wallace RJ Jr, Andrejak C, Böttger EC, Brozek J, Griffith DE, Guglielmetti L, Huitt GA, Knight SL, Leitman P, Marras TK, Olivier KN, Santin M, Stout JE, Tortoli E, van Ingen J, Wagner D, Winthrop KL.

Eur Respir J. 2020 Jul 7;56(1):2000535. doi: 10.1183/13993003.00535-2020. Print 2020 Jul.

PMID: 32636299

 

Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline: Executive Summary.

Daley CL, Iaccarino JM, Lange C, Cambau E, Wallace RJ, Andrejak C, Böttger EC, Brozek J, Griffith DE, Guglielmetti L, Huitt GA, Knight SL, Leitman P, Marras TK, Olivier KN, Santin M, Stout JE, Tortoli E, van Ingen J, Wagner D, Winthrop KL.

Clin Infect Dis. 2020 Jul 6:ciaa241. doi: 10.1093/cid/ciaa241. Online ahead of print.

PMID: 32628747

 

Treatment of osteoarticular, cardiovascular, intravascular-catheter-related and other complicated infections with dalbavancin and oritavancin: A systematic review.

Thomas G, Henao-Martínez AF, Franco-Paredes C, Chastain DB.

Int J Antimicrob Agents. 2020 Jun 27:106069. doi: 10.1016/j.ijantimicag.2020.106069. Online ahead of print.

PMID: 32603683 Review.

 

Empiric Therapies for COVID-19: Destined to Fail by Ignoring the Lessons of History.

Canfield GS, Schultz JS, Windham S, Scherger S, Henao-Martinez AF, Shapiro L, Franco-Paredes C, Chastain DB, Wand T, Krsak M.

J Hosp Med. 2020 Jul 1;15(7):434-436. doi: 10.12788/jhm.3469. Epub 2020 Jun 17.

PMID: 32584243 No abstract available.

 


Preventing SARS-CoV-2 infection by blocking a tissue serine protease.

Jankousky KC, Schultz J, Windham S, Henao-Martínez AF, Franco-Paredes C, Shapiro L.

Ther Adv Infect Dis. 2020 Jun 10;7:2049936120933076. doi: 10.1177/2049936120933076. eCollection 2020 Jan-Dec.

PMID: 32577236 Free PMC article.

 

COVID-19 in jails and prisons: A neglected infection in a marginalized population.

Franco-Paredes C, Jankousky K, Schultz J, Bernfeld J, Cullen K, Quan NG, Kon S, Hotez P, Henao-Martínez AF, Krsak M.

PLoS Negl Trop Dis. 2020 Jun 22;14(6):e0008409. doi: 10.1371/journal.pntd.0008409. eCollection 2020 Jun.

PMID: 32569274 Free PMC article. No abstract available.

 

Splenic Complications of Babesia microti Infection in Humans: A Systematic Review.

Dumic I, Madrid C, Rueda Prada L, Nordstrom CW, Taweesedt PT, Ramanan P.

Can J Infect Dis Med Microbiol. 2020 May 27;2020:6934149. doi: 10.1155/2020/6934149. eCollection 2020.

PMID: 32566058 Free PMC article. Review.

 

An Overview of Eastern Equine Encephalitis (EEE).

Kapadia RK, Chauhan L, Piquet AL, Tyler KL, Pastula DM.

Neurohospitalist. 2020 Jul;10(3):161-162. doi: 10.1177/1941874420905762. Epub 2020 Feb 17.

PMID: 32549937 No abstract available.

 

Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots Following Tenofovir Alafenamide: The TAF-DBS Study.

Yager J, Castillo-Mancilla J, Ibrahim ME, Brooks KM, McHugh C, Morrow M, McCallister S, Bushman LR, MaWhinney S, Kiser JJ, Anderson PL.

J Acquir Immune Defic Syndr. 2020 Jul 1;84(3):323-330. doi: 10.1097/QAI.0000000000002354.

PMID: 32539288

 

Cryptococcal pericarditis in a heart transplant recipient.

Mann S, Tobolowsky F, Purohit S, Henao-Martínez A, Bajrovic V, Ramanan P, Wolfel E, Khazanie P, Barron M, Madinger N, Benamu E.

Transpl Infect Dis. 2020 Jun 13:e13366. doi: 10.1111/tid.13366. Online ahead of print.

PMID: 32533755

 

Heparin as a therapy for COVID-19: current evidence and future possibilities.

Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP.

Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L211-L217. doi: 10.1152/ajplung.00199.2020. Epub 2020 Jun 10.

PMID: 32519894 Free PMC article. Review.

 

MABp1 targeting interleukin-1α in hidradenitis suppurativa ineligible for adalimumab treatment: results of the open-label extension period.

Kanni T, Argyropoulou M, Dinarello CA, Simard J, Giamarellos-Bourboulis EJ.

Clin Exp Dermatol. 2020 Jun 9. doi: 10.1111/ced.14333. Online ahead of print.

PMID: 32516832 No abstract available.

 

Screening for Covid-19 in Skilled Nursing Facilities.

Krsak M, Henao-Martínez AF, Franco-Paredes C.

N Engl J Med. 2020 Jul 9;383(2):190-191. doi: 10.1056/NEJMc2017362. Epub 2020 May 29.

PMID: 32469480 No abstract available.

 

The Long Journey inside Immigration Detention Centers in the U.S.

Bonfiglio G, Rosal K, Henao-Martínez A, Franco-Paredes C, Poeschla E, Moo-Young J, Seefeldt T, Dunlevy H, Haas M, Young J.

J Travel Med. 2020 May 28:taaa083. doi: 10.1093/jtm/taaa083. Online ahead of print.

PMID: 32463091 Free PMC article. No abstract available.

 


Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans.

Grander C, Schaefer B, Schwärzler J, Grabherr F, de Graaf DM, Enrich B, Oberhuber G, Mayr L, Sangineto M, Jaschke N, Adolph TE, Effenberger M, Moschen AR, Dinarello CA, Zoller H, Tilg H.

Gut. 2020 Jul 22:gutjnl-2020-321375. doi: 10.1136/gutjnl-2020-321375. Online ahead of print.

PMID: 32699098

 


Infectious Risks Associated with Biologics Targeting Janus Kinase-Signal Transducer and Activator of Transcription Signaling and Complement Pathway for Inflammatory Diseases.

Benamu E.

Infect Dis Clin North Am. 2020 Jun;34(2):271-310. doi: 10.1016/j.idc.2020.02.014.

PMID: 32444011 Review.

 

Same Day Start of Antiretroviral Therapy Demonstrates the Potential to Lessen Disparities in HIV Treatment Outcomes.

Gardner EM, Hawkins KL.

Clin Infect Dis. 2020 May 25:ciaa618. doi: 10.1093/cid/ciaa618. Online ahead of print.

PMID: 32449902 No abstract available.

 

Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions.

Spinelli MA, Haberer JE, Chai PR, Castillo-Mancilla J, Anderson PL, Gandhi M.

Curr HIV/AIDS Rep. 2020 Aug;17(4):301-314. doi: 10.1007/s11904-020-00502-5.

PMID: 32424549 Review.

 

 

Impact of an automated hand hygiene monitoring system combined with a performance improvement intervention on hospital-acquired infections.

Knepper BC, Miller AM, Young HL.

Infect Control Hosp Epidemiol . 2020 May 28:1-7. doi: 10.1017/ice.2020.182.

 

Cryptococcal pericarditis in a heart transplant recipient.

Mann S, Tobolowsky F, Purohit S, Henao-Martínez A, Bajrovic V, Ramanan P, Wolfel E, Khazanie P, Barron M, Madinger N, Benamu E.

Transpl Infect Dis. 2020 Jun 13:e13366. doi: 10.1111/tid.13366.

PMID: 32533755

 

Heparin as a Therapy for COVID-19: Current Evidence and Future Possibilities.

Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP.

Am J Physiol Lung Cell Mol Physiol . 2020 Jun 10. doi: 10.1152/ajplung.00199.2020.

PMID: 32519894

 

MABp1 targeting interleukin-1alpha in hidradenitis suppurativa non-eligible for adalimumab treatment: Results of the open-label extension period.

Kanni T, Argyropoulou M, Dinarello CA, Simard J, Giamarellos-Bourboulis EJ.

Clin Exp Dermatol. 2020 Jun 9. doi: 10.1111/ced.14333. [Epub ahead of print]

PMID: 32516832

 

Screening for Covid-19 in Skilled Nursing Facilities.

Krsak M, Henao-Martínez AF, Franco-Paredes C.

N Engl J Med. 2020 May 29;382. pii: 10.1056/NEJMc2017362#sa1. doi: 10.1056/NEJMc2017362. [Epub ahead of print] No abstract available.

PMID: 32469480

 

Crohn's Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria.

Shahir NM, Wang JR, Wolber EA, Schaner MS, Frank DN, Ir D, Robertson CE, Chaumont N, Sadiq TS, Koruda MJ, Rahbar R, Nix BD, Newberry RD, Sartor RB, Sheikh SZ, Furey TS.

Inflamm Bowel Dis. 2020 May 29. pii: izaa103. doi: 10.1093/ibd/izaa103. [Epub ahead of print]

PMID: 32469069

 

The Long Journey inside Immigration Detention Centers in the U.S.

Bonfiglio G, Rosal K, Henao-Martínez A, Franco-Paredes C, Poeschla E, Moo-Young J, Seefeldt T, Dunlevy H, Haas M, Young J.

J Travel Med. 2020 May 28. pii: taaa083. doi: 10.1093/jtm/taaa083. [Epub ahead of print] No abstract available.

PMID: 32463091

 

Impact of an automated hand hygiene monitoring system combined with a performance improvement intervention on hospital-acquired infections.

Knepper BC, Miller AM, Young HL.

Infect Control Hosp Epidemiol. 2020 May 28:1-7. doi: 10.1017/ice.2020.182. [Epub ahead of print]

PMID: 32460928

 

Same Day Start of Antiretroviral Therapy Demonstrates the Potential to Lessen Disparities in HIV Treatment Outcomes.

Gardner EM, Hawkins KL.

Clin Infect Dis. 2020 May 25. pii: ciaa618. doi: 10.1093/cid/ciaa618. [Epub ahead of print] No abstract available.

PMID: 32449902

 

Infectious Risks Associated with Biologics Targeting Janus Kinase-Signal Transducer and Activator of Transcription Signaling and Complement Pathway for Inflammatory Diseases.

Benamu E.

Infect Dis Clin North Am. 2020 Jun;34(2):271-310. doi: 10.1016/j.idc.2020.02.014. Review.

PMID: 32444011

 

Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions.

Spinelli MA, Haberer JE, Chai PR, Castillo-Mancilla J, Anderson PL, Gandhi M.

Curr HIV/AIDS Rep. 2020 May 19. doi: 10.1007/s11904-020-00502-5. [Epub ahead of print] Review.

PMID:32424549

 

HCV DAA Therapy in Persons with HIV-HCV Genotype 1 Coinfection Results in High Rate of Sustained Virologic Response and Heterogeneity in Normalization of Soluble Markers of Immune Activation.

Anthony DD, Sulkowski MS, Smeaton LM, Damjanovska S, Shive CL, Kowal CM, Cohen DE, Bhattacharya D, Alston-Smith BL, Balagopal A, Wyles DL.

J Infect Dis. 2020 May 15. pii: jiaa254. doi: 10.1093/infdis/jiaa254. [Epub ahead of print]

PMID: 32406487

 

Insights into the L,D-transpeptidases and D,D-carboxypeptidase of Mycobacterium abscessus: ceftaroline, imipenem and novel diazabicyclooctanes inhibitors.

Dousa KM, Kurz SG, Taracila MA, Bonfield T, Bethel CR, Barnes MD, Selvaraju S, Abdelhamed AM, Kreiswirth BN, Boom WH, Kasperbauer SH, Daley CL, Bonomo RA.

Antimicrob Agents Chemother. 2020 May 11. pii: AAC.00098-20. doi: 10.1128/AAC.00098-20. [Epub ahead of print]

PMID: 32393499

 

Prevention of yellow fever in travellers: an update.

Reno E, Quan NG, Franco-Paredes C, Chastain DB, Chauhan L, Rodriguez-Morales AJ, Henao-Martínez AF.

Lancet Infect Dis. 2020 Jun;20(6):e129-e137. doi: 10.1016/S1473-3099(20)30170-5. Epub 2020 May 7. Review.

PMID: 32386609

 

Muc5ac Expression Protects the Colonic Barrier in Experimental Colitis.

Olli KE, Rapp C, O'Connell L, Collins CB, McNamee EN, Jensen O, Jedlicka P, Allison KC, Goldberg MS, Gerich ME, Frank DN, Ir D, Robertson CE, Evans CM, Aherne CM.

Inflamm Bowel Dis. 2020 May 9. pii: izaa064. doi: 10.1093/ibd/izaa064. [Epub ahead of print]

PMID: 32385500

 

Structural Vulnerability in the United States Revealed in Three Waves of Novel Coronavirus Disease (COVID-19).

Solis J, Franco-Paredes C, Henao-Martínez AF, Krsak M, Zimmer SM.

Am J Trop Med Hyg. 2020 May 7. doi: 10.4269/ajtmh.20-0391. [Epub ahead of print]

PMID: 32383432

 

Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis.

Oliveira VHF, Borsari AL, Webel AR, Erlandson KM, Deminice R.

Eur J Clin Nutr. 2020 Apr 27. doi: 10.1038/s41430-020-0637-0. [Epub ahead of print] Review.    

PMID: 32341489

 

COVID-19 Serosurveillance May Facilitate Return-to-Work Decisions.

Krsak M, Johnson SC, Poeschla EM.

Am J Trop Med Hyg. 2020 Jun;102(6):1189-1190. doi: 10.4269/ajtmh.20-0302.

PMID: 32329432

 

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease.

Abbate A, Toldo S, Marchetti C, Kron J, Van Tassell BW, Dinarello CA.

Circ Res. 2020 Apr 24;126(9):1260-1280. doi: 10.1161/CIRCRESAHA.120.315937. Epub 2020 Apr 23.

PMID: 32324502

 

Novel Coronavirus Disease (COVID-19) Serosurveillance May Facilitate Return-to-Work Decisions.

Krsak M, Johnson SC, Poeschla EM.

Am J Trop Med Hyg. 2020 Apr 23. doi: 10.4269/ajtmh.20-0302. [Epub ahead of print]

PMID: 32329432

 

Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation.

Bankers L, Miller C, Liu G, Thongkittidilok C, Morrison J, Poeschla EM.

J Immunol. 2020 Apr 10. pii: ji1901421. doi: 10.4049/jimmunol.1901421. [Epub ahead of print]

PMID: 32277054

 

Partial Normalization of Biomarkers of Inflammation and Immune Activation Among Virally Suppressed Men With HIV Infection and High ART Adherence.

Castillo-Mancilla JR, Brown TT, Palella FJ Jr, Macatangay BJC, Breen EC, Jacobson LP, Wada NI.

Open Forum Infect Dis. 2020 Mar 23;7(4):ofaa099. doi: 10.1093/ofid/ofaa099. eCollection 2020 Apr.

PMID: 32322603

 

Cutaneous Leishmaniasis due to  Leishmania (Viannia) panamensis in Two Travelers Successfully Treated with Miltefosine.

Mann S, Phupitakphol T, Davis B, Newman S, Suarez JA, Henao-Martínez A, Franco-Paredes C.

Am J Trop Med Hyg. 2020 Apr 20. doi: 10.4269/ajtmh.20-0086. [Epub ahead of print]

PMID: 32314693

 

Application of Selected Muscle Strength and Body Mass Cut-Points for the Diagnosis of Sarcopenia in Men and Women with or at risk for HIV Infection.

Erlandson KM, Travison TG, Zhu H, Magaziner J, Correa-de-Araujo R, Cawthon PM, Bhasin S, Manini T, Fielding RA, Palella FJ, Kingsley L, Lake JE, Sharma A, Tien PC, Weber KM, Yin MT, Brown TT.

J Gerontol A Biol Sci Med Sci. 2020 Apr 7. pii: glaa083. doi: 10.1093/gerona/glaa083. [Epub ahead of print]

PMID: 32301484

 

Re-treatment of Hepatitis C Infection After Multiple Failures of Direct-Acting Antiviral Therapy.

Fierer DS, Wyles DL.

Open Forum Infect Dis. 2020 Mar 16;7(4):ofaa095. doi: 10.1093/ofid/ofaa095. eCollection 2020 Apr.

PMID: 32296728

Reply to: Trials of Tuberculosis Preventive Therapy in People with HIV Infection.

Stout JE, Turner NA, Belknap RW, Horsburgh CR, Sterling TR, Phillips PPJ.

Am J Respir Crit Care Med. 2020 Apr 13. doi: 10.1164/rccm.202003-0855LE. [Epub ahead of print] No abstract available.

PMID: 32282235

 

Early progression and immune reconstitution inflammatory syndrome during treatment of mild-to-moderate Kaposi sarcoma in sub-Saharan Africa and South America: Incidence, long-term outcomes and effects of early chemotherapy.

Nyirenda M, Ngongondo M, Kang M, Umbleja T, Krown SE, Godfrey C, Samaneka W, Mngqibisa R, Hoagland B, Mwelase N, Caruso S, Martinez-Maza O, Dittmer DP, Borok M, Hosseinipour MC, Campbell TB; A5264/AMC-067 team.

J Acquir Immune Defic Syndr. 2020 Apr 4. doi: 10.1097/QAI.0000000000002361. [Epub ahead of print]

PMID: 32265361

 

Albert Camus' 'The COVID-19 Plague' Revisited. 
Franco-Paredes C.Clin Infect Dis. 2020 Apr 17:ciaa454. doi: 10.1093/cid/ciaa454. Online ahead of print.PMID: 32301966 No abstract available

 

COVID-19 and the coming epidemic in US immigration detention centres. 
Meyer JP, Franco-Paredes C, Parmar P, Yasin F, Gartland M.Lancet Infect Dis. 2020 Apr 15:S1473-3099(20)30295-4. doi: 10.1016/S1473-3099(20)30295-4. Online ahead of print.PMID: 32304631 No abstract available.

 

Unexpected etiology of a pleural empyema in a patient with chronic lymphocytic leukemia (CLL): Capnocytophaga ochracea. 
Basco SA, Steele GM, Henao-Martínez AF, Franco-Paredes C, Chastain DB.IDCases. 2020 Mar 20;20:e00747. doi: 10.1016/j.idcr.2020.e00747. eCollection 2020.PMID: 32300526 Free PMC article.

 

CMV myocarditis in solid organ transplant recipients: A case series and review of literature.

Scherger S, Mathur S, Bajrovic V, Johnson SC, Benamu E, Ramanan P, Wolfel E, Levi ME, Abidi MZ.

Transpl Infect Dis. 2020 Mar 30:e13282. doi: 10.1111/tid.13282.  Review. PMID: 32232951

 

Five-year kidney outcomes of bariatric surgery differ in severely obese adolescents and adults with and without type 2 diabetes.

 

Bjornstad P, Nehus E, Jenkins T, Mitsnefes M, Moxey-Mims M, Dixon JB, Inge TH.

Kidney Int. 2020 Feb 3. pii: S0085-2538(20)30114-9. doi: 10.1016/j.kint.2020.01.016. PMID: 32229096

 

Advantages of Outpatient Treatment with Long-Acting Lipoglycopeptides for Serious Gram-Positive Infections: A Review.

Krsak M, Morrisette T, Miller M, Molina K, Huang M, Damioli L, Pisney L, Wong M, Poeschla E.

Pharmacotherapy. 2020 Apr 2. doi: 10.1002/phar.2389. Epub ahead PMID: 32239771

 

Intramedullary spinal cord lesions in an immunocompromised host due to  Mycobacterium haemophilum.

Kon S, Franco-Paredes C, Hawkins KL.

IDCases. 2019 Nov 22;19:e00674. doi: 10.1016/j.idcr.2019.e00674. eCollection 2020. PMID: 32226763

 

Factors associated with tenofovir diphosphate concentrations in dried blood spots in persons living with HIV.

Coyle RP, Morrow M, Coleman SS, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, MaWhinney S, Anderson PL, Castillo-Mancilla JR.

J Antimicrob Chemother. 2020 Mar 24. pii: dkaa070. doi: 10.1093/jac/dkaa070. PMID: 32211787

 

Intrahepatic Viral Kinetics during Direct-Acting Antivirals for Hepatitis C in HIV Co-infection:The ACTG A5335S Substudy.

Balagopal A, Smeaton LM, Quinn J, Venuto CS, Morse GD, Vu V, Alston-Smith B, Cohen DE, Santana-Bagur JL, Anthony DD, Sulkowski MS, Wyles DL, Talal AH.

J Infect Dis. 2020 Mar 23. pii: jiaa126. doi: 10.1093/infdis/jiaa126.  PMID: 32201883

 

Advances in Long-Acting Agents for the Treatment of HIV Infection.

Rana AI, Castillo-Mancilla JR, Tashima KT, Landovitz RL.

Drugs. 2020 Mar 16. doi: 10.1007/s40265-020-01284-1.  PMID: 32180205

 

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis.

Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, Alvarado-Arnez LE, Bonilla-Aldana DK, Franco-Paredes C, Henao-Martinez AF, Paniz-Mondolfi A, Lagos-Grisales GJ, Ramírez-Vallejo E, Suárez JA, Zambrano LI, Villamil-Gómez WE, Balbin-Ramon GJ, Rabaan AA, Harapan H, Dhama K, Nishiura H, Kataoka H, Ahmad T, Sah R; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). Electronic address: https://www.lancovid.org.

Travel Med Infect Dis. 2020 Mar 13:101623. doi: 10.1016/j.tmaid.2020.101623.  Review. PMID: 32179124

 

The Struggling Infectious Diseases Fellow: Remediation Challenges and Opportunities.

Melia MT, Paez A, Reid G, Chirch LM, Luther VP, Blackburn BG, Perez F, Abdoler E, Kaul DR, Rehm S, Harik N, Barsoumian A, Person AK, Yun H, Beckham JD, Boruchoff S, Cariello PF, Cutrell JB, Graber CJ, Lee DH, Maziarz E, Paras ML, Razonable RR, Ressner R, Chen A, Chow B, Escota G, Herc E, Johnson A, Maves RC, Nnedu O, Clauss H, Kulkarni P, Pottinger PS, Serpa JA, Bhowmick T, Bittner M, Wooten D, Casanas B, Shnekendorf R, Blumberg EA.

Open Forum Infect Dis. 2020 Feb 18;7(3):ofaa058. doi: 10.1093/ofid/ofaa058. eCollection 2020 Mar. Review. PMID: 32166097

 

Serial Sputum Induction in Nontuberculous Mycobacterial Pulmonary Disease.

Holt MR, Kasperbauer SH, Daley CL.

Eur Respir J. 2020 Mar 12. pii: 1902196. doi: 10.1183/13993003.02196-2019. PMID: 32165404

 

Treatment of advanced AIDS-associated Kaposi sarcoma in resource-limited settings: a three-arm, open-label, randomised, non-inferiority trial.

Krown SE, Moser CB, MacPhail P, Matining RM, Godfrey C, Caruso SR, Hosseinipour MC, Samaneka W, Nyirenda M, Busakhala NW, Okuku FM, Kosgei J, Hoagland B, Mwelase N, Oliver VO, Burger H, Mngqibisa R, Nokta M, Campbell TB, Borok MZ; A5263/AMC066 protocol team.

Lancet. 2020 Mar 5. pii: S0140-6736(19)33222-2. doi: 10.1016/S0140-6736(19)33222-2. PMID: 32145827

 

Gastrointestinal symptoms in relation to quality of life after metabolic surgery in adolescents.

Dewberry L, Khoury J, Schmiege S, Jenkins T, Boles R, Inge T.

Surg Obes Relat Dis. 2020 Jan 3. pii: S1550-7289(19)31163-3. doi: 10.1016/j.soard.2019.12.025. PMID: 32122816

 

Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.

Klück V, van Deuren RC, Cavalli G, Shaukat A, Arts P, Cleophas MC, CriÈ™an TO, Tausche AK, Riches P, Dalbeth N, Stamp LK, Hindmarsh JH, Jansen TLTA, Janssen M, Steehouwer M, Lelieveld S, van de Vorst M, Gilissen C, Dagna L, Van de Veerdonk FL, Eisenmesser EZ, Kim S, Merriman TR, Hoischen A, Netea MG, Dinarello CA, Joosten LA.

Ann Rheum Dis. 2020 Apr;79(4):536-544. doi: 10.1136/annrheumdis-2019-216233. Epub 2020 Feb 29. PMID: 32114511

 

Use of Procalcitonin to Guide Discontinuation of Antimicrobial Therapy in Patients with Persistent Intra-Abdominal Collections: A Case Series.  Motoa G, Pate A, Franco-Paredes C, Chastain DB, Henao-Martínez AF, Hojat L. Case Rep Infect Dis. 2020 Jan 9;2020:6342180. doi: 10.1155/2020/6342180. eCollection 2020.PMID: 32158570

 

COVID-19 in Latin America: The implications of the first confirmed case in Brazil. 
Rodriguez-Morales AJ, Gallego V, Escalera-Antezana JP, Méndez CA, Zambrano LI, Franco-Paredes C, Suárez JA, Rodriguez-Enciso HD, Balbin-Ramon GJ, Savio-Larriera E, Risquez A, Cimerman S. Travel Med Infect Dis. 2020 Feb 29:101613. doi: 10.1016/j.tmaid.2020.101613. [Epub ahead of print] No abstract available. PMID: 32126292

 

Antibiotic Prescribing Patterns for Acute Otitis Media for Children 2 Years and Older. 
Frost HM, Becker LF, Knepper BC, Shihadeh KC, Jenkins TC. J Pediatr. 2020 Feb 25. pii: S0022-3476(20)30116-5. doi: 10.1016/j.jpeds.2020.01.045. [Epub ahead of print] PMID: 32111379 [PubMed - as supplied by publisher]

 

Antiretroviral therapy initiation is associated with decreased visceral and subcutaneous adipose tissue density in people living with HIV. 
Debroy P, Lake JE, Moser C, Olefsky M, Erlandson KM, Scherzinger A, Stein JH, Currier JS, Brown TT, McComsey GA. Clin Infect Dis. 2020 Feb 28. pii: ciaa196. doi: 10.1093/cid/ciaa196. [Epub ahead of print]. PMID: 32107532

 

Risk Factors for Weight Gain Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy. 
Lake JE, Wu K, Bares SH, Debroy P, Godfrey C, Koethe JR, McComsey GA, Palella FJ Jr, Tassiopoulos K, Erlandson KM; ACTG A5322 Study Team. Clin Infect Dis. 2020 Feb 26. pii: ciaa177. doi: 10.1093/cid/ciaa177. [Epub ahead of print] PMID: 32099991

 


 

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