A multidisciplinary team of clinicians, educators, and scientists working to improve the prevention and treatment of infectious diseases
Mamuka presented quite novel findings on the intranuclear mechanism of action of the exceptionally potent, long-acting, new antiretroviral drug lenacapavir. His lab discovered that this HIV-1 capsid-binding drug acts mainly after viral nuclear entry, by hyper-stabilizing and functionally compromising the pliability of the capsid. Previously the mechanism was thought to be interfering with binding of cellular factors in the cytoplasm or nucleus.
Katharine reviewed the rationale and supporting data for the effectiveness of this important preventive intervention, as well as practical aspects of implementation and use. Health care disparities and their relationships to care barriers and outcomes were also illuminated. The PrEP Program newsletters are provided at a separate link on this page.
The award from the University of Colorado Hospital recognizes an employee for outstanding contributions as a productive member of the care team or for consistently offering amazing service to the medical staff through the course of their job duties.
Mary Bessesen has been awarded a 2021 Golden Stethescope award for her leadership during the COVID-19 pandemic at the Rocky Mountain Regional VA Medical Center. Her nominator, Medical student Lauren Heery, wrote: "As I begin the process of applying
to Internal Medicine residency this year, I hope that I can model my career after Dr. Bessesen's leadership. Her attentive and compassionate teaching, patient care, and leadership are all skills I hope to emulate in my training. The impact of
Dr. Bessesen's leadership and mentorship extends to so many students, colleagues, and patients, and this award is well-deserved!" More information on the Golden Stethescope Awards can be found here.
Assistant Professor of Medicine Lorna Allen, FNP, has won this year's Annual DOM Shark Tank Competition for her Quality Improvement project "VECTORS: Vancomycin Errors Corrected Through Optimizing OPAT Med Reconciliation and AVS Standardization." Congratulations to her on this achievement. The Division also thanks her for all her superb, fastidious, and very hard work to make our outpatient antimicrobial therapy (OPAT) program a success. The project has identified and proposes specific solutions for common, important issues related to delivery of the antibiotic vancomycin to outpatients. As this year's Shark Tank winner, she will receive one year of quality coaching, project management, data collection and Epic analyst support, and stakeholder support. This project has great potential to optimize patient care and simplify logistics for our providers.
Dr. Mann's award-winning abstract is entitled "Lower Cumulative Antiretroviral Exposure in People Living with HIV and Diabetes." Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is a novel pharmacologic measure of cumulative ART adherence predictive of viral suppression and future viremia. Her findings, also published in J AIDS, revealed that patients who have diabetes mellitus have 25% lower concentrations of TFV-DP in DBS compared to those without diabetes.
This Department of Medicine award is given to those who have gone above and beyond during the COVID-19 pandemic. Dr. Chauhan has worked tirelessly and with much skill and wisdom to manage our division's response. Her efforts have included but are not limited to enabling and organizing two new ID services, formulating our treatment guidelines, participating in clinical trials, advising the University of Colorado Hospital, and seeing many extra patients herself. This is an exceptionally well-deserved award.
Mamuka Kvaratskelia, PhD and colleagues have recently published in Nature Microbiology, their discovery that a cytoplasmic protein, Sec24C, helps the HIV-1 core to maintain its integrity to successfully reach the nucleus. More can be read about their research here.
This singular distinction is awarded for an outstanding record of community-centered scholarship, outreach, and service, especially for those who experience adversity. A nominator wrote: “Her passion for equity and social justice has led her to seek opportunities to help people in our community most in need. For many years she has provided pro bono exams for people seeking asylum. Originally, she would conduct exams after hours in the Denver Metro Tuberculosis clinic. Recognizing that this was not optimal, she worked with other physician leaders at Denver Health to found the Denver Health Human Rights Clinic…providing complete support for patients and their families including connecting people with legal support if needed.”
His talk was entitled "Emerging SARS-CoV-2 Variants: Implications for the Pandemic, the Vaccines and our Patients." He reviewed the viral properties of the variants and their epidemiological origins and behaviors inside and outside the U.S. He also discussed pathogenic features, evidence for immune evasion and likely impacts on vaccines and treatments. A recording of the full talk is available here. Recordings of previous town halls hosted by the Department of Medicine are available here.
In July 2021 Physician Educator Dr. Frasca will take on the Program Director role, with Dr. Brian Montague continuing as an Associate Program Director. We look forward to their leadership and extend many thanks to Caros Franco-Paredes for his excellent stewardship these past few years and to Dave Beckham and Kristine Erlandson before that. Thanks also to Kelly Rico for her able service as our Education Administrator.
Virologist Mamuka Kvaratskhelia, Ph.D. and colleagues in the Division of Infectious Diseases have published in Nature Microbiology their discovery that a human cellular protein – Sec24c – critically regulates HIV-1. Sec24c, binds to the outer shell (capsid core) of an incoming virus and is necessary for proper infectivity. First authors are Stephanie Rebensburg, PhD and Guochao Wei, PhD. Other collaborators included the Melikyan, Poeschla, and Kewalramani laboratories. Understanding the dependency of HIV-1 on this protein may have implications for therapeutic intervention. Notably the discovery follows on their recent report in Science on an ultra-potent new antiviral drug that also binds to a similar region on the incoming capsid.
Sarah Rowan has been selected for the position of Associate Director of the Mentored Scholarly Activity Program for the University of Colorado School of Medicine. The MSA program is designed to foster self-directed, life-long learning. Students are required to identify and work with a mentor to design and implement a scholarly project. This longitudinal program culminates with students completing a mentored scholarly project, written manuscript, poster, and oral presentation. Sarah will supervise the epidemiology, community, and public health branch of the program. If you are in the Division of Infectious Diseases, expect to hear from Sarah soon about mentoring students and judging the oral presentations.
Dr. Erlandson recently went on the CU on the Air podcast to discuss her work as co-PI on the AFTER Study - a new research study actively recruiting COVID-19 survivors to explore how different personalized physical therapies aid in recovery from the illness. More information can be found at the study website.
“We have also come to this hallowed spot to remind America of the fierce urgency of now…. I have a dream that one day this nation will rise up and live out the true meaning of its creed…”
The full talk, titled "Implications of Genetic Variants of SARS-CoV-2: The Worrying Prospect of a New Pandemic Phase", can be viewed here.
Invasive mucormycosis (IM) is a dire infectious complication in immunocompromised people. ID pharmacists Matt Miller and Kyle Molina and Transplant ID physician Maheen Abidi led a multi-center study that showed survival in hematopoietic stem cell recipients with this opportunistic mold infection continues to be poor, but suggested potential benefits of combined treatment -- amphotericin, 3rd generation azoles, and surgical excision -- that should be prospectively studied further.
SARS-CoV-2 vaccines are now being administered to frontline health care workers on the Anschutz Medical Campus, as well as at Denver Health and the VA Medical Center. Mutiple Division members continue to take care of COVID-19 patients across the city and have participated both in vaccine science and in enabling the local implementation of the historic national vaccine campaign. Thomas Campbell, MD was featured in the most recent episode of the CU on the Air podcast, discussing clinical trials of potential SARS-CoV-2 vaccines, with special attention to the Anschutz Medical Campus participation in the Moderna trial which has now received FDA emergency use authorization along with the Pfizer-BioNTech vaccine. He said that collaboration by many was the key to the success of this effort, noting that the Colorado Clinical and Translational Sciences Institute offered important structure and that UCHealth’s electronic health records made it easier to identify volunteers to participate in the trial. “There is light at the end of tunnel" he said. It’s been less than 12 months since this illness was first detected in humans and in less than 12 months we now have two vaccines that have proven to be highly efficacious and that’s unheard of.”
As we focus on COVID-19, we know that additional pandemics are certain to occur when more viruses cross species barriers from animals to humans. In addition to SARS-CoV-2, no virus illustrates this risk more than HIV-1, for which chimpanzees were the proximate source about a century ago. Dr. Mamuka Kvaratskhelia, Professor of Medicine in the Division of Infectious Diseases, has now led a team of researchers in seven U.S. laboratories in uncovering the underlying mechanism of action of a strikingly innovative addition to the HIV therapeutic armamentarium. The research was published in Science on October 16. It concerns the first in class, ultra-potent HIV-1 capsid inhibitor, GS-6207 (Lenacapavir, Gilead). GS-6207 heralds an entirely new way of treating HIV-1. Its remarkable potency and other advantageous features have led to current clinical trials with very long dosing intervals (six months). Combining molecular biology, virology, structural biology, high resolution imaging of HIV in cells, and an array of biochemical and biophysical methods, the paper reveals the key mechanism: blocking HIV’s ability to complete infection by hyper-stabilizing and thereby preventing disassembly of the virion capsid shell in infected cells. The work has strong potential to lead to further treatment advances, but it also illuminates what is still the most mysterious part of the HIV-1 life cycle: the post-entry fate of the virus capsid core as it traverses the cytoplasm and enters the nucleus. Other contributors on our campus were the Asturias and Poeschla laboratories. Mamuka was also just awarded a new 5-year NIH R01 grant to take this work forward.
Carlos Franco-Paredes MD, Associate Professor of Medicine, is a recipient of the 14th Annual Faculty Professionalism Award. The Faculty Professionalism Award recognizes a School of Medicine faculty member who has served as a role model for professionalism as defined in the School of Medicine Rules. From the nomination letter: “Carlos advocates for the right thing both within and outside our institution, taking a stand, even when unpopular, to make sure our we are all consistently honoring the core traditions of the profession of medicine.”
has launched a new service, the TelePrEP/HIV Prevention Program. This entirely virtual service allows at-risk people – especially in rural and underserved areas of the state – to confidentially receive medical care for HIV prevention
from trained medical personnel via their computers, smart phones, and tablets. This program is an extension of the existing in-person PrEP Clinic at the Infectious Diseases Group Practice at UCHealth University of Colorado Hospital. Read more at UCHealth Today.
Early during virus infection, our bodies produce Interferons (IFNs). These antiviral agents are highly diverse, with 12 distinct IFNa subtypes and IFNb being the most highly expressed. Of these, only two, IFNa2 and IFNb, are approved for clinical use, and in fact are being tested against COVID-19 in ongoing clinical trials. However, Interferons need to be administered with care, as they cause adverse effects. In PLOS Pathogens, a team led by Drs. Mario Santiago and Cara Wilson now report that IFNa2 is not the most potent antiviral interferon against HIV-1. In a critical target, helper T cells in the gut, IFNa8, IFNa14 and IFNb inhibited HIV-1 more than IFNa2. Using unbiased transcriptomics, the team then showed that distinct IFNa subtypes and IFNb triggered common and unique gene sets and cellular pathways, suggesting that these diverse Interferons have both redundant and nonredundant functions. Specifically, IFNb altered 3-times more genes than any IFNa subtype. Interestingly, in the gut of persons with chronic HIV-1 infection, IFNb, but not IFNa, was induced. Genes specifically induced by IFNb were decreased during HIV-1 infection and altered pathways that could promote inflammation and depletion of CD4 T cells, both critical features of AIDS. The work suggests that we should not limit ourselves to the 2 clinically available Interferons to combat viral epidemics and pandemics; evolution has given us a diverse range of antiviral Interferons to choose and improve upon.
Bats have been primary reservoirs for multiple lethal human viral pathogens, such as SARS, MERS, rabies, Henipa viruses, and most recently, SARS-CoV-2. The probability that further zoonoses will emerge from them is high and the COVID-19 pandemic suggests that bat innate immune systems are insufficiently characterized relative to the medical importance of these mammals. Restriction factors are main innate immune effectors, limit viral host switching/emergence, and exert strong selection pressure when it occurs. HIV-1 exemplifies how retroviruses can also be severe pathogens when they cross species barriers, and bats harbor many endogenous and also at least one exogenous retrovirus. The Poeschla lab has now identified and characterized a retroviral restriction in bats. Working with colleagues in Singapore and Australia, they studied the large bat Pteropus alecto, which is the reservoir species for Nipah virus. Primate lentiviruses are specifically restricted while nonprimate lentiviruses are entirely unrestricted. The particular retroviral restriction pattern has singular features, but is dependent on viral capsid interactions with cyclophilin A, a cellular protein known to complexly regulate HIV and SIV replication, including restriction.
Dr. Carlos Franco-Paredes was the subject of a feature article in CU Medicine Today about his work inspecting county jails, advising state prison leaders, and advocating for safer conditions for people held in immigration detention centers. His activities have been multifaceted, and included traveling coast-to-coast to inspect jails and prisons, serving as the court-appointed inspector of the Prince George’s County Jail in Maryland, and inspecting facilities in Oakland and for the Los Angeles County jail system. He also has issued advocacy letters used in court hearings seeking to create safer conditions for those held in custody. Collaborating with the Southern Poverty Law Center, the University of Texas School of Law’s Civil Rights Clinic, and other groups, he has produced declarations on behalf of detainees in Immigration and Customs Enforcement detention centers. He has been actively publishing in peer-reviewed journals, including The New England Journal of Medicine and the Lancet.
This innovator award recognizes three responders in the department who were instrumental during the critical phase of the COVID-19 pandemic in the spring of 2020. Dr. Johnson cared for many COVID-19 patients and contributed on several levels to formulating the division and institutional responses. He helped devise evidence-based COVID-19 treatment guidelines and served on the NIH guidelines panel as well. The award will be presented October 29. Zoom link
Women living with HIV often have larger, high-grade lesions (HSIL) or multifocal lesions resulting in incomplete removal of HSIL. Up to 50% of women living with HIV treated with after treatment with Loop electrosurgical excision procedure (LEEP) had persistent or recurrent HSIL compared to 5-10% of HIV negative. The cervical cancer screening and treatment team at the Helen Joseph Hospital in Johannesburg implemented a double blinded placebo controlled randomized clinical trial in 180 HIV-1 infected women with biopsied proven HSIL. Women received the quadrivalent HPV vaccine at baseline, week 4 and 26 during the study. LEEP was done at week 4. The primary endpoint was a composite of HSIL on cervical histology or cytology at week 26 or week 52, and there were a number of secondary measures. The primary endpoint was not significantly different between the vaccine and placebo arms with cytologic or histologic HSIL. Thus, this study did not support HPV vaccination in this setting. Recurrent HSIL was high despite virologic suppression. This work highlights how earlier and improved access to cervical cancer screening and treatment is necessary to prevent the significant burden of cervical cancer in HIV infected women.
Advances in Infectious Disease (TAI) - launched in 2013 - is a peer-reviewed open-access journal with a strong clinical and pharmacological focus. TAI delivers the highest quality peer-reviewed open access original research articles, reviews,
and scholarly comment on pioneering efforts and innovative studies in the medical treatment of infectious diseases. TAI welcomes original research articles across all areas of infectious disease. The journal publishes original research articles
and reviews articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports are also considered. The journal is listed in PubMed and indexed
in Web of Science, Emerging Sources Citation Index (ESCI) and Scopus). One of the goals as Editor-in-Chief is to increase the volume of submissions and to index the journal in Thomson Reuters' Science Citation Index Expanded (SCIE)".
The United States has extraordinarily high incarceration rates compared to other major developed countries. SARS-CoV-2 is a particularly destructive addition to a stew of correctional system factors that include extreme sentence durations, disproportionate impacts on racial minorities and other historically disadvantaged populations, resistance to paroling elderly individuals for whom recidivism risks are low, crowding, poor ventilation systems, inadequate preventive measures, lower quality medical care and limited treatment access. In The Lancet Infectious Diseases, multiple ID division members recently joined with The Sentencing Project to review the issues and make recommendations for systematic, rational decarceration policies to reduce morbidity and mortality from COVID-19. Dr. Franco-Paredes also gave Department of Medicine Grand Rounds on September 30 on “The Triumph of Despair: Health Inequities and Structural Racism”.
Treatment of latent tuberculosis infection (LTBI) with short course regimens is now favored over longer traditional regimens such as daily INH for 9 months. Dr. Michelle Haas and her colleagues (Kaylynn Aiona, Kristine Erlandson and Robert Belknap) have now published their analysis of 2 different short course rifamycin-based LTBI regimens from their recent retrospective cohort study. The study was carried out at the Denver Metro Tuberculosis Clinic. They found that INH-rifapentine self-administered once weekly for 3 months (3HP-SAT) was associated with higher completion rates and fewer adverse events than daily rifampin for 4 (4R) months. Importantly, this finding was also seen among adults aged 50 and older in whom safer options for LTBI treatment are needed. They conclude that expanding 3HP-SAT may enhance tuberculosis prevention in the U.S.
National HIV/AIDS and Aging Awareness Day is September 18. Physician-scientist Kristine Erlandson works on understanding physical function impairments in older adults with HIV and improving physical function and disability with physical activity. This work has expanded to encompass impacts of ART-associated weight gain. Among her numerous grants, her current R01 investigates the impact of statins on physical function and she and a co-PI recently received an R01 to investigate High-intensity Interval Training in older HIV patients. Her work in theses areas are highlighted by the following 2020 publications so far (these are half of the total of 12 this calendar year; see the rest in the Publications window). Congratulations to Kristine!
In a recent commentary, Drs. Shanta Zimmer and Janet Gilsdorf review the history of gender disparities within the Infectious Disease Society of America (IDSA) and describe progress toward
equity as well as next steps to maintain efforts with the goal of achieving healthier outcomes for patients. They note that women have played an increasing role since the formation of the IDSA Women’s Committee in 1992. Later task forces
have emphasized the importance of women and other unrepresented minorities, to the success of IDSA core missions. Ongoing efforts in the Society to maintain the presence of women and their unique talents, experiences, and understandings are
Adherence to ART is central to quality HIV care and to the prevention of transmission. Dr. Jose Castillo-Mancilla has recently published a major study of five hundred and twenty-seven persons living with HIV (1150 person-visits).Working with a creative set of analytical methods that measure drug concentrations in dried blood spots,he and his colleagues determined patient characteristics that predict the concentrations of tenofovir diphosphate, the active anabolite to the antiretroviral agent tenofovir. This study complements previous analyses that have established the association of this adherence measure with viral suppression (PMID: 30137238) and its utility as a predictor of future viremia (PMID: 30942881) in PWH. Future research to incorporate these predictors into the interpretation of this ART adherence biomarker, and to establish whether these associations extend to PWH taking tenofovir alafenamide-containing ART are ongoing.
JAK-STAT inhibitors are powerful immunosuppressive agents with good uses in inflammatory and autoimmune diseases. They are also being studied intensively around the world for use in treating COVID-19-associated inflammation. Dr. Esther Benamu recently reviewed these drugs, along with complement (C5) inhibitors in Infectious Disease Clinics of North America.
The study, published in JAMA Open Network, established a clear annual risk of cardiomyopathy among asymptomatic individuals in endemic regions. His team found a yearly rate of cardiomyopathy of approximately 5% among patients with acute Chagas infection and 2% among patients with indeterminate chronic Chagas disease. These findings promise to enforce the urgency to diagnose and treat early patients living with Chagas Disease. CU Anschutz News also covered this study in a recent press release.
Dr. Dinarello discovered IL-1 as a key mediator of fever and he has gone on to develop therapeutics that block this important cytokine. Now he and colleagues in France report in PNAS that
anakinra, an IL-1 receptor antagonist, can ameliorate destructive hyper-inflammation in COVID-19.
Andrés F. Henao-Martínez, MD and Carlos Franco-Paredes, MD, MPH, are co-authors of a perspective article, “Racial Disproportionality in Covid Clinical Trials,” published last Tuesday by The New England Journal of Medicine. Andrés, Carlos, and their co-authors call out the underrepresentation of minority groups in COVID-19 clinical trials, and in some cases the failure of some studies to disclose racial and ethnic data. “It is alarming that long-standing racial health disparities have been extended to Covid-19 clinical trials when racial and ethnic minority groups have so much to gain from this research, including the opportunity to receive lifesaving treatment,” the authors write.
Thomas Campbell, MD, Professor of Medicine in the ID Division, has been named Chief Clinical Research Officer for UCHealth and Associate Dean of Adult Health Research. Tom has abundant experience with clinical trials, most recently for COVID-19 interventions, and is the site leader of the Colorado ACTU. He will be responsible for assuring an effective environment for conducting clinical research that complies with federal and state regulatory requirements. The position will foster infrastructure, processes, informatics and analytics to promote high quality UCH and University of Colorado clinical research. Tom succeeds Thomas Flaig, MD, professor of medicine in the Division of Medical Oncology, who was named the University’s Vice Chancellor for Research earlier this year. The division is delighted to see him take on this important role.
The ID Division stands foursquare with Dean Reilly in his July 20th statement of principle on Dr. Anthony Fauci
and reiterates his call for commitment to science in the COVID-19 crisis and in all other infectious disease policy:
"The number of cases of COVID-19 has been rising significantly across the country and, while the numbers in Colorado have not been increasing as quickly as in other places, we have seen cases here trending upward. The trajectory is a cause for concern and a reminder that we must remain diligent in our efforts to limit the spread of the coronavirus. It is also clear that willful ignorance and persistent efforts to divide us from one another are not solving the problem. At the Anschutz Medical Campus, we are committed to the pursuit of evidence, the gathering of data, and the application of that knowledge to lead us to improved understanding of human health and better care for all. That is why the disparagement of Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, is so alarming. He is one of our country’s leading champions of pursuing facts for the common good, and he has come under attack recently for doing his work with clear-eyed purpose.
"With those attacks in mind, I encourage you to read a letter released last Tuesday, by Howard Bauchner, MD, editor in chief of JAMA and the JAMA Network, stating in part: “As we have learned the coronavirus does not respect state lines – Maine or Alabama, or political parties – Republican or Democrat. The undermining of science – and the unprecedented attacks on scientists and public health officials – risk lives in every corner of our country. . . . So to all who are reading this – wherever you live and whatever your political affiliation – please wash your hands, keep your distance from others when appropriate, wear your masks, and please join me in showing respect for Dr. Anthony Fauci and his many colleagues at the NIH, CDC, and throughout the country who are our best hope in these challenging times.”
"It is disheartening that such a plea needs to be made during the most widespread public health crisis of our lives, but Dr. Bauchner’s message is clear: science matters. You and your colleagues at the CU School of Medicine are also among those professionals who are our best hope to get through these trying times. We must reject distractions, continue to guard against falsehoods, and remain focused on our common purpose: conquering the coronavirus as soon as possible so that we can pursue all the other work on this campus that matters. The work you’re doing is too important to be discouraged or diverted. Thank you for your extraordinary efforts to improve our health and safety."
Dr. Katherine Frasca starts today as Associate Program Director (APD) of the ID Fellowship Program. Katherine will take over Dr. Kristine Erlandson’s role. We welcome Katherine and express our deepest gratitude to Kristine for her many contributions to the training and mentorship of multiple generations of infectious disease fellows. Dr. Carlos Franco-Paredes is Program Director (PD) and Katherine and Dr. Brian Montague are the two APDs. Katherine brings a wealth of clinical & educational experience to our program. She has a stellar record in Education and the Scholarship of Teaching. She is locally and regionally recognized as a leader in medical education on HIV prevention. During the first year of her promotion to assistant professor, she was one of four recipients of the prestigious Program Academic Clinician Educator (PACE) grant, which provides scholarly support for medical education research. During that same year, she also completed the Teaching Scholars Program, learning skills in curriculum development, evaluation and medical education research. In assembling both of these programs, she has created and directed a comprehensive clinical and educational program on HIV prevention. She has developed a novel virtual curriculum on HIV pre-exposure prophylaxis (PrEP). Additionally, Katherine has been coordinating the schedule and teaching activities for the Fellows Clinic at Anschutz Medical Center Infectious Diseases Division since 2017.
The Division is pleased to announce that Sarah Rowan and Whitney Starr have each been promoted to Associate Professor. We congratulate them for their well-deserved promotions and recognize our good fortune in having such superb, dedicated faculty. Among their many accomplishments, both Sarah and Whitney are key contributors to the division’s deep expertise in chronic viral diseases. Each has been very active in HIV medicine, and Sarah also in the area of HCV. They have been active since February in the division’s vigorous response to COVID-19 as well.
Recruited from the Tufts University Division of Infectious Diseases in 2017, Dr. Krsak has been active in numerous clinical and scholarly activities related to the COVID-19 efforts of our medical school. The CU Doctors homepage can be found here.
“Our site here at University of Colorado Hospital is part of a nationwide network called the COVID Prevention Network, which is set up so that it has a cohort of sites that are available to sequentially enroll into multiple vaccine studies,” said Dr. Thomas Campbell, an infectious disease physician at the CU School of Medicine and University of Colorado Hospital. “If it works, the Moderna vaccine could be a real game-changer for the pandemic.” Watch the full interview with Dr. Campbell featured in the UCHealth Today article covering the vaccine trial launch.
The award was announced by graduating fellows at their virtual graduation party. Fond tributes were made by many faculty for graduating fellows Angela Budgin, Shelly Kon, Sarah Mann, and Sias Scherger. The fellows cited Dr. Colbert’s dedication to teaching and emphasis on understanding evidence-based rationales for testing, diagnosis and therapies.
From Dean Reilly’s weekly message July 6, “CPR News featured Sarah Rowan, MD, assistant professor of medicine in the Division of Infectious Diseases, in a recent report about finding a creative and meaningful way to take a break from the non-stop cycle of work our colleagues have been facing this year. Sarah, who practices at Denver Health and is an artist in her free time, was inspired to create art that features women of color who have been providing care in the time of COVID-19. She emailed friends at local hospitals, including Shanta Zimmer, MD, senior associate dean for education, associate dean for diversity and inclusion, and professor of medicine, to ask for selfies that could be turned into portraits, which are now featured on a specially created website, Women of Color on the Front Lines. “I hope that it serves as a visual representation that our society values women and racial diversity in medicine, and their commitment is worth recording with artwork,” Sarah said. “I hope that people feel honored and appreciated. I also feel hopeful that this will inspire young people to go into medicine, particularly young Black people or Latinx people.””
Dr. Charles Dinarello in the Division of Infectious Diseases has been awarded the 2020 Tang Prize in Biopharmaceutical Sciences. The prize was awarded for “the development of cytokine-targeting
biological therapies for the treatment of inflammatory diseases.” See also the CU Anschutz Today article.
He shares this year’s prize with two colleagues, Marc Feldmann and Tadamitsu Kishimoto. Charles discovered Interleukin-1 and is an author of over 1,000 scientific papers. His work has applications to diverse fields and most recently
his laboratory has been working on treatments for the hyper-inflammatory problems seen in COVID-19. More about the Tang Prize, which is awarded every two years to two to three distinguished scientists, can be found here.
Charles has previously been awarded a University Distinguished Professorship, which is the highest honor that the University of Colorado bestows on its own faculty
members. Congratulations to Dr. Dinarello on this extraordinary recognition and on all his scientific achievements.
The Division is delighted to welcome four new ID fellows, who started July 1, 2020. They bring to us a wealth of education, experience and talent from diverse backgrounds. Biographies are coming soon to the Education page.
Dr. David Fraulino
David joins us from the University of Connecticut internal medicine residency and is graduate of the University of New England College of Osteopathic Medicine.
Dr. José Henao
Jose joins us from the University of Minnesota internal medicine residency and is a graduate of the Universidad de Ciencias Medicas Andrés Vesalio Guzmán (UCIMED) Escuela de Medicina, Costa Rica.
Dr. Zachary Shepard
Zachary joins us from the University of Michigan internal medicine residency and is a graduate of the Baylor College of Medicine.
Dr. Lilian Vargas
Lilian joins us from the Houston Methodist Hospital internal medicine residency and is a graduate of the Universidad Nacional Autónoma de Honduras Facultad de Ciencias Médicas, Honduras.
Dr. Barron is Professor of Medicine in the ID Division and Medical Director of Infection Control and prevention. On January 8, 2020, she emailed her colleagues: “Hello. Happy New Year! Never a dull day in infection prevention. There is a severe respiratory disease due to a novel coronavirus that is causing an outbreak in the Wuhan province of China.” The full article, "A fearless protector: Meet the top infectious disease expert in Colorado", can be found at UCHealth Today. Drs. Barron and Larissa Pisney are the point persons for Infection Control in our main academic hospital, UCH.
The Division of Infectious Diseases will be home to a new T32 program for postdoctoral training in Antiretroviral Discovery, Evaluation and Application Research (ADEAR). ADEAR will provide postdoctoral scientists with mentored research training under the direction of faculty at the University of Colorado, Colorado State University and the University of Denver who are who engaged in research related to the discovery and evaluation of new antiretroviral drugs or the application of existing antiretrovirals for the treatment and prevention of HIV/AIDS. The program is expected to kick off in July 2020 and will support 3 trainees per year through June 2025. A request for applications will be released in early July.
The full article can be read here.
Their recommendations can be read in full here.
Read about our role in developing antiviral medications and working to attenuate the virus's inflammatory response here.
Dr. Frasca recently attended to numerous COVID-19 inpatients and has compiled this very helpful and practical resource which can be found in our COVID-19 document collection on our division's COVID-19 resources page. Stay tuned for expansions and refinements by her and our other physicians of this living document.
Dr. Beckham was featured in a recent news report about how researchers and clinicians are working together on our campus to make a serum test available. The University of Colorado Hospital was the first in the state to treat COVID-19 patients with convalescent serum. This work is supported in part by a CCTSI pilot award.
Dr. Carlos Franco-Paredes works with a national network of physicians dedicated to provide medical care for immigrants under ICE custody. Dr. Michelle Haas has been volunteering in the Human Rights Clinic (HRC) at Denver Health. Janine Young and Jaime Moo-Young lead the HRC. In response to COVID-19, Carlos has actively collaborated with RMAIN, ACLU, Southern Poverty Law Center, and numerous immigration attorneys to promote the release of detained immigrants on humanitarian parole. Implementing interventions such as social distancing and infection prevention is a major challenge in for-profit overcrowded detention centers.
The "Faces of the ID Division" card below provides a photo panel showing our faculty arranged in order of year of appointment to the CU SOM faculty. The 72 faculty distribute as follows: AMC-51, Denver Health-15, Veterans' Affairs-4 (7 counting joint roles), NJH-2. On the AMC (UCH), there are 40 ID clinicians who staff our inpatient and outpatient ID services (32 physicians, 8 APPs). Fourteen of our faculty have laboratory-based programs in Research Complex 2 (RC2).
In response to COVID-19, the Division’s weekly Case Conference is now a virtual series that will focus on this new infectious disease and engage the campus and the broader Colorado medical community. Fellows and faculty present and discuss COVID-19 cases and medical students provide a literature review. This is a joint collaboration between CU Anschutz, Denver Health, Colorado IDSA, and ECHO Colorado.
Professor Shanta Zimmer Rolls Out New COVID-19 Course at the CU School of Medicine
Professor Zimmer, Senior Associate Dean for Education, has led a team of educators and students in setting up the COVID-19 Pandemic Response Elective Course in record time. It is also posted at the iCollaborative website of the AAMC.
Their grand rounds [video link] presentation on April 1 gave an overview of epidemiological modeling, origins and properties of SARS-CoV-2, clinical features, and treatment. They were joined by Professor Jonathan Samet from the CU School of Public Health.
On 24 March, the Division activated a 5th inpatient ID service (Green) to meet the needs of COVID-19 patients. The pre-existing services are Gold ID, Blue ID, Ortho-ID and Transplant ID. In addition, faculty are participating in several COVID-19 clinical trials, organizing outpatient follow-up visits, providing updated treatment and monitoring guidelines, and supervising hospital infection control.
The Division is Growing. In July we will be 72 faculty members strong. A fifth inpatient service will soon start at University of Colorado Hospital. We are delighted to officially announce five new ID Division faculty members who will join us
in mid-2020. They collectively bring a wealth of talent, training and diverse experiences to our three-shield missions:
Yiannis Koullias, MD comes to us from the Partners ID fellowship at Harvard Medical School/Brigham & Women’s Hospital/MGH, with subspecialty training in Transplant ID at Dana-Farber/Brigham and Women’s Cancer Center. He is a graduate of Harvard College, Duke Medical School, and the Brigham’s Internal Medicine Residency Program. His has broad interests in Transplant ID, including viral and fungal infections in heme-onc/BMT populations.
Sarah Mann, MD joins us from our ID fellowship here at the University of Colorado School of Medicine. She is a graduate of Cornell University, George Washington University Medical School and the Harbor UCLA internal medicine residency. She has interests in HIV Medicine and works on stewardship of anti-retroviral agents.
Aakriti Pandita, MD joins us from the Infectious Disease Fellowship at Warren Alpert Medical School of Brown University. She is a graduate of the Sher-i-Kashmir Institute of Medical Sciences in Srinagar, India, and the SUNY Upstate Medical University internal medicine residency. She is jointly appointed with the Division of Hospital Medicine. She is currently working on a meta-analysis of decades-long time trends in Staphylococcus aureus bacteremia. She also has a strong interest in tuberculosis and advocacy.
Rebecca Rwubusisi MSN, BSN, is our new APP for the Transplant ID (TID) service on the AMC. She is an Acute Care Nurse Practitioner whose valuable experience includes 15 years of bedside experience as an RN in the Department of Surgery, on the UC Health Inpatient Transplant Unit. She also has medical experience in East Africa and is fluent in Spanish.
Sias Scherger, MD also joins the division from our ID fellowship. He is a graduate of the University of Nebraska, the University of Nebraska College of Medicine and the Wake Forest internal medicine residency. He has interests in transplant ID and is working on understanding associations between anti-cytokine antibodies and endemic fungal infections.
Drs. Michelle Barron and Larissa Pisney (University of Colorado Hospital Infection Control and Prevention) are at the head of a multi-faceted campaign to ready our UCH providers and trainees and have been coordinating with state and national authorities. Drs. Mary Bessesen and Heather Young have been performing similar roles at the VA Medical Center and Denver Health. Dr. Brian Montague is involved in managing employee health for both the School of Medicine and UCH. Numerous other ID faculty members have participated in patient care, screening and testing, contingency planning, guidelines preparation, communications and community outreach, scientific discussions, idea generation, and teaching. Division scientists are working on various research aspects of understanding, preventing and treating viral infections. The Infectious Disease Fellows are involved in consulting on COVID-19 issues and they will also be working with the Colorado Dept. of Public Health in the coming month to learn about the role of epidemiologists and about public health policy. The Division website aggregator contains much practical information, both local and international.
Dr. Barron, Medical Director of Infection Control and Prevention, discussed COVID-19 basics, screening and treatment guidelines, and infection control measures. The entire town hall can be watched here.
Their participation is part of the important role that Denver Health ID faculty continue to play in M. tuberculosis treatment and control, in Colorado and internationally. See Sterling et al. in MMWR in "Recent Publications" below for full details of the team's report.
Dr. Chauhan was awarded for her outpatient stewardship project “Approaches to Decrease Inappropriate Antibiotic use in Acute Respiratory Conditions in a Geriatric Clinic.” She will present her project on March 11, 2020. Her goals are to work with the antimicrobial stewardship team to help expand outpatient stewardship programs to other UCH clinics. Quality improvement projects such as this are important areas for academic contribution and grant funding opportunities in the division.
Dr. Rowan spoke about her work on a local HIV task force to expand testing and treatment of the virus and about other efforts by the Colorado medical community to combat HIV.
Drs. Canfield and Mann published their results in Clinical Infectious Diseases. The case exhibited numerous interesting features including the classic - and in this case, quite developed - verrucous lesion with raised, sharply demarcated borders.
Dr. Hillary Dunlevy, Assistant Professor of Medicine, was awarded the Annual University of Colorado Hospital Full-time Physician Medical Staff Award on January 30, 2020. Recipients of this award exemplify the mission and vision of UCH and are recognized for achievement in one or more of the following areas: Amazing patient care; Outstanding teaching of student physicians; Improvements in services offered/collaboration with other specialties; Community service.
Her appointment will provide significant assistance to our physician providers and facilitate the patient care, education and research missions of the TID focus group. Rebecca received her BSN Magna Cum Laude from the University of Colorado Denver in 2005. She is an Acute Care Nurse Practitioner whose extensive experience includes 15 years of bedside experience as an RN in the Department of Surgery, on the UC Health Inpatient Transplant Unit. There she gained an in-depth understanding of the multi-faceted transplantation process and close working relationships with transplant providers. She developed a passion for Infectious Diseases as well, prompting her to transition to our Division. During three months in Rwanda, Rebecca also saw and treated patients with multiple infectious problems, including HIV/AIDS. Moreover, she is fluent in Spanish.
She will begin her role on Monday, February 3rd, 2020.
Dr. Wilson will transition into the director role on July 1, 2020. Our MD-PhD program is a critical linchpin in the education of physician-scientists, allowing top-notch students to obtain their PhD alongside their MD. The program provides tuition as well as an annual stipend.
Michelle Barron, UCHealth University of Colorado Hospital’s medical director of infection prevention and professor of medicine at CU School of Medicine was recently interviewed by the Daily Camera. She discussed how Boulder County has managed to avoid the worst of a state and nationwide Hepatitis A outbreak.
Dr. Tom Campbell has been nominated to lead the new Section Review Group of the NIH-CDC-HIVMA-/IDSA Guidelines for Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV.
The University of Colorado Department of Medicine has selected the 2017 recipients for its Outstanding Early Career Scholar Program, HIV/AIDS researcher Kristine Erlandson, MD, and cardiology researcher Kunhua Song, PhD. The program aims to accelerate the careers of promising researchers in the Department of Medicine.
Quiros-Gomez O, Segura-Cardona Á, Flórez PA, et al. Risk factors and spatial analysis for domiciliary infestation with the Chagas disease vector Triatoma venosa in Colombia. Ther Adv Infect Dis. 2022;9:20499361221084164. doi:10.1177/20499361221084164
Frost HM, Sebastian T, Keith A, et al. COVID-19 and Acute Otitis Media in Children: A Case Series. J Prim Care Community Health. 2022;13:21501319221082350. doi:10.1177/21501319221082351
Dillon SM, Mickens KL, Thompson TA, et al. Granzyme B(+) CD4 T cells accumulate in the colon during chronic HIV-1 infection. Gut Microbes. 2022;14(1):2045852. doi:10.1080/19490976.2022.2045852
Chastain DB, Osae SP, Thomas GM, et al. Clinical Severity on Hospital Admission for COVID-19: An Analysis of Social Determinants of Health From an Early Hot Spot in the Southeastern U.S. J Prim Care Community Health. 2022;13:21501319221092244. doi:10.1177/21501319221092244
Chastain DB, Henao-Martínez AF, Dykes AC, et al. Missed opportunities to identify cryptococcosis in COVID-19 patients: a case report and literature review. Ther Adv Infect Dis. 2022;9:20499361211066364. doi:10.1177/20499361211066363
Castleman MJ, Stumpf MM, Therrien NR, et al. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022;219(6):e20212553. doi:10.1084/jem.20212553
Higuita NA, Suarez JA, Millender E, et al. U.S. bound journey of migrant peoples InTransit across Dante’s Inferno and Purgatory in the Americas. Travel Med Infect Dis. 2022;47:102317. doi:10.1016/j.tmaid.2022.102317
Ballandras-Colas A, Chivukula V, Gruszka DT, et al. Multivalent interactions essential for lentiviral integrase function. Nat Commun. 2022;13(1):2416. doi:10.1038/s41467-022-29928-8
McWhirter L, Lou Y, Reingold S, et al. Rates of Appropriate Treatment and Follow-Up Testing After a Gonorrhea and/or Chlamydia Infection in an Urban Network of Federally Qualified Health Center Systems. Sex Transm Dis. 2022;49(5):319-324. doi:10.1097/OLQ.0000000000001600
Pandey S, Hu Y, Bushman LR, Castillo-Mancilla J, Anderson PL, Cooks RG. Miniature mass spectrometer-based point-of-care assay for cabotegravir and rilpivirine in whole blood. Anal Bioanal Chem. 2022;414(11):3387-3395. doi:10.1007/s00216-022-03954-3
Hoover RK, Krsak M, Molina KC, Shah K, Redell M. Kimyrsa, An Oritavancin-Containing Product: Clinical Study and Review of Properties. Open Forum Infect Dis. 2022;9(5):ofac090. doi:10.1093/ofid/ofac090
Castillo-Mancilla JR, Musinguzi N, Asiimwe S, et al. High residual inflammation despite HIV viral suppression: Lessons learned from real-time adherence monitoring among people with HIV in Africa. HIV Med. 2022;23(5):465-473. doi:10.1111/hiv.13200
Brooks KM, Castillo-Mancilla JR, Morrow M, et al. Predictors of 007 triphosphate concentrations in dried blood spots in persons with hepatitis C and active drug or alcohol use. J Antimicrob Chemother. 2022;77(5):1396-1403. doi:10.1093/jac/dkac051
Haukoos JS, Rowan SE, Galbraith JW, et al. The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Screening Trial: rationale and design of a multi-center pragmatic randomized clinical trial of hepatitis C screening in emergency departments. Trials. 2022;23(1):354. doi:10.1186/s13063-022-06265-1
Bowman ER, Wilson M, Riedl KM, et al. Lipidome Alterations with Exercise Among People With and Without HIV: An Exploratory Study. AIDS Res Hum Retroviruses. Published online April 21, 2022. doi:10.1089/AID.2021.0154
Bai X, Buckle AM, Vladar EK, et al. Author Correction: Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022;12(1):6466. doi:10.1038/s41598-022-10890-w
Cook P, Jankowski C, Erlandson KM, Reeder B, Starr W, Flynn Makic MB. Low- and High-Intensity Physical Activity Among People with HIV: Multilevel Modeling Analysis Using Sensor- and Survey-Based Predictors. JMIR Mhealth Uhealth. 2022;10(4):e33938. doi:10.2196/33938
Bago B, Kovacs M, Protzko J, et al. Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample. Nat Hum Behav. Published online April 14, 2022. doi:10.1038/s41562-022-01319-5
Beatty NL, Forsyth CJ, Gilman RH, et al. Neglected Testing for Neglected Tropical Diseases at the CDC. Am J Trop Med Hyg. Published online April 12, 2022:tpmd220222. doi:10.4269/ajtmh.22-0222
Oliveira VHF, Erlandson KM, Cook PF, et al. The High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults With HIV (HEALTH): A Research Protocol. J Assoc Nurses AIDS Care. 2022;33(2):178-188. doi:10.1097/JNC.0000000000000276
Masters MC, Yang J, Lake JE, et al. Diabetes mellitus is associated with declines in physical function among men with and without HIV. AIDS. 2022;36(5):637-646. doi:10.1097/QAD.0000000000003160
Hauschild BC, Burnside HC, Gray BA, et al. Characteristics of the Audience Reached by the National Network of Sexually Transmitted Disease Clinical Prevention Training Centers and Correlation With Sexually Transmitted Infection Rates, 2015 to 2020. Sex Transm Dis. 2022;49(4):313-317. doi:10.1097/OLQ.0000000000001590
Deminice R, Oliveira VHF, Webel AR, Erlandson KM. Sarcopenia Related to Human Immunodeficiency Virus: Protective Effects of Exercise. Exerc Sport Sci Rev. 2022;50(2):73-80. doi:10.1249/JES.0000000000000282
Barr EA, Raybin JL, Dunlevy H, Abuogi L, Jones J. Transition From Pediatric and Adolescent HIV Care to Adult HIV Care and the Patient-Provider Relationship: A Qualitative Metasynthesis. J Assoc Nurses AIDS Care. 2022;33(2):132-154. doi:10.1097/JNC.0000000000000239
Solomon SS, Wagner-Cardoso S, Smeaton L, et al. A minimal monitoring approach for the treatment of hepatitis C virus infection (ACTG A5360 [MINMON]): a phase 4, open-label, single-arm trial. Lancet Gastroenterol Hepatol. 2022;7(4):307-317. doi:10.1016/S2468-1253(21)00397-6
Nakayama T, Lee IT, Le W, et al. Inflammatory molecular endotypes of nasal polyps derived from White and Japanese populations. J Allergy Clin Immunol. 2022;149(4):1296-1308.e6. doi:10.1016/j.jaci.2021.11.017
Molina KC, Bajrovic V, Bonomo RA. Carbapenemase-producing Enterobacterales in solid organ transplantation: Tip of the iceberg? Transpl Infect Dis. 2022;24(2):e13780. doi:10.1111/tid.13780
Miller EK, Goldberg AM, Janoff EN, et al. Designing and implementing methodology for double-blind, placebo-controlled clinical trials using blood products within the Department of Veterans Affairs. Clin Trials. 2022;19(2):137-145. doi:10.1177/17407745211069703
Goodman A, Patten L, Castillo-Mancilla J, Zimmer S, Madinger N, Frasca K. Factors Associated with Retention and Adherence in a Comprehensive, Diverse HIV Pre-Exposure Prophylaxis Clinic. AIDS Res Hum Retroviruses. 2022;38(4):327-335. doi:10.1089/AID.2021.0130
de Graaf DM, Teufel LU, Joosten LAB, Dinarello CA. Interleukin-38 in Health and Disease. Cytokine. 2022;152:155824. doi:10.1016/j.cyto.2022.155824
Aronsohn AI, Bhattacharya D, Morgan TR, Wyles DL, Chung RT, McQuillen DP. Reply. Hepatology. 2022;75(4):1055-1056. doi:10.1002/hep.32257
Capin JJ, Wilson MP, Hare K, et al. Prospective telehealth analysis of functional performance, frailty, quality of life, and mental health after COVID-19 hospitalization. BMC Geriatr. 2022;22(1):251. doi:10.1186/s12877-022-02854-6
Psomas CK, Hoover DR, Shi Q, et al. POLYPHARMACY IS ASSOCIATED WITH FALLS IN WOMEN WITH AND WITHOUT HIV. J Acquir Immune Defic Syndr. Published online March 25, 2022. doi:10.1097/QAI.0000000000002955
Bai X, Buckle AM, Vladar EK, et al. Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022;12(1):5207. doi:10.1038/s41598-022-09133-9
Davis AJ, Greene M, Siegler E, et al. Strengths and Challenges of Various Models of Geriatric Consultation for Older Adults Living With Human Immunodeficiency Virus. Clin Infect Dis. 2022;74(6):1101-1106. doi:10.1093/cid/ciab682
Wilkin T, Chen H, Sahasrabuddhe V, et al. A randomized clinical trial of HPV test-and-treat as compared to cytology-based screening for prevention of cervical cancer among women living with HIV: AIDS Clinical Trials Group Protocol A5282. Clin Infect Dis. Published online March 16, 2022:ciac213. doi:10.1093/cid/ciac213
Galbraith MD, Kinning KT, Sullivan KD, et al. Specialized interferon action in COVID-19. Proc Natl Acad Sci U S A. 2022;119(11). doi:10.1073/pnas.2116730119
O’Brien KK, Brown DA, Bergin C, et al. Long COVID and episodic disability: advancing the conceptualisation, measurement and knowledge of episodic disability among people living with Long COVID - protocol for a mixed-methods study. BMJ Open. 2022;12(3):e060826. doi:10.1136/bmjopen-2022-060826
Diaz Del Valle F, Zakrajsek JK, Min SJ, et al. Impact of Airline Secondhand Tobacco Smoke Exposure on Respiratory Health and Lung Function Decades After Exposure Cessation. Chest. Published online March 7, 2022:S0012-3692(22)00416-0. doi:10.1016/j.chest.2022.02.049
Looby SE, Kantor A, Burdo TH, et al. Factors Associated with Systemic Immune Activation Indices in a Global Primary Cardiovascular Disease Prevention Cohort of People with HIV on Antiretroviral Therapy. Clin Infect Dis. Published online March 2, 2022:ciac166. doi:10.1093/cid/ciac166
Gorse GJ, Rattigan SM, Kirpich A, et al. Influence of Preseason Antibodies Against Influenza Virus on Risk of Influenza Infection Among Healthcare Personnel. J Infect Dis. 2022;225(5):891-902. doi:10.1093/infdis/jiab468
Abuogi LL, Castillo-Mancilla J, Hampanda K, et al. Tenofovir Diphosphate in Dried Blood Spots in Pregnant and Postpartum Women With HIV in Kenya: A Novel Approach to Measuring Peripartum Adherence. J Acquir Immune Defic Syndr. 2022;89(3):310-317. doi:10.1097/QAI.0000000000002859
Smith L, Letendre S, Erlandson KM, Ma Q, Ellis RJ, Farhadian SF. Polypharmacy in older adults with HIV infection: Effects on the brain. J Am Geriatr Soc. 2022;70(3):924-927. doi:10.1111/jgs.17569
Schröder A, Lunding LP, Zissler UM, et al. IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33. Allergy. 2022;77(3):856-869. doi:10.1111/all.15072
Satyanarayana G, Enriquez KT, Sun T, et al. Coinfections in Patients With Cancer and COVID-19: A COVID-19 and Cancer Consortium (CCC19) Study. Open Forum Infect Dis. 2022;9(3):ofac037. doi:10.1093/ofid/ofac037
Molina KC, Miller MA, Mueller SW, Van Matre ET, Krsak M, Kiser TH. Clinical Pharmacokinetics and Pharmacodynamics of Dalbavancin. Clin Pharmacokinet. 2022;61(3):363-374. doi:10.1007/s40262-021-01088-w
Lunding LP, Skouras DB, Vock C, Dinarello CA, Wegmann M. The NLRP3 inflammasome inhibitor, OLT1177(®) , ameliorates experimental allergic asthma in mice. Allergy. 2022;77(3):1035-1038. doi:10.1111/all.15164
Freddo AM, Mathur S, Dunlevy H, Jaggers J, Khanna A. Endocarditis Caused by Candida parapsilosis Presenting With Severe Thrombocytopenia in a Patient With Tetralogy of Fallot. World J Pediatr Congenit Heart Surg. 2022;13(2):245-247. doi:10.1177/21501351211008839
Winglee K, Hill AN, Belknap R, Stout JE, Ayers TL. Variability of interferon-γ release assays in people at high risk of tuberculosis infection or progression to tuberculosis disease living in the United States. Clin Microbiol Infect. Published online February 18, 2022:S1198-743X(22)00094-5. doi:10.1016/j.cmi.2022.02.020
Montague BT, Wipperman MF, Hooper AT, et al. Anti-SARS-CoV-2 IgA Identifies Asymptomatic Infection in First Responders. J Infect Dis. 2022;225(4):578-586. doi:10.1093/infdis/jiab524
Jennings L, Robbins RN, Nguyen N, et al. Tenofovir diphosphate in dried blood spots predicts future viremia in persons with HIV taking antiretroviral therapy in south africa. AIDS. Published online February 15, 2022. doi:10.1097/QAD.0000000000003185
Erlandson KM, Fitch KV, McCallum SA, et al. Geographical Differences in the Self-Reported Functional Impairment of People with HIV and Associations with Cardiometabolic Risk. Clin Infect Dis. Published online February 15, 2022:ciac098. doi:10.1093/cid/ciac098
Adu-Ampratwum D, Pan Y, Koneru PC, et al. Identification and Optimization of a Novel HIV-1 Integrase Inhibitor. ACS Omega. 2022;7(5):4482-4491. doi:10.1021/acsomega.1c06378
Hoke KL, Zimmer SL, Roddy AB, Ondrechen MJ, Williamson CE, Buan NR. Reintegrating Biology Through the Nexus of Energy, Information, and Matter. Integr Comp Biol. 2022;61(6):2082-2094. doi:10.1093/icb/icab174
Chastain DB, Rao A, Yaseyyedi A, Henao-Martínez AF, Borges T, Franco-Paredes C. Cerebral Cryptococcomas: A Systematic Scoping Review of Available Evidence to Facilitate Diagnosis and Treatment. Pathogens. 2022;11(2). doi:10.3390/pathogens11020205
Abdo M, Wu X, Sharma A, et al. Regional Differences in Risk of Recurrent Falls Among Older U.S. Women and Men with HIV in the HIV Infection, Aging, and Immune Function Long-Term Observational Study. AIDS Res Hum Retroviruses. Published online February 2, 2022. doi:10.1089/AID.2021.0162
Ren DM, Abrams A, Banigan M, et al. Evaluation of Communication and Safety Behaviors During Hospital-Wide Code Response Simulation. Simul Healthc. 2022;17(1):e45-e50. doi:10.1097/SIH.0000000000000575
Ortiz-Martínez Y, Rodríguez-Morales AJ, Henao-Martínez AF. Decreased notification of TB cases during the COVID-19 pandemic. Int J Tuberc Lung Dis. 2022;26(2):177-178. doi:10.5588/ijtld.21.0651
Dhindsa S, Ghanim H, Jenkins T, et al. High prevalence of subnormal testosterone in obese adolescent males: reversal with bariatric surgery. Eur J Endocrinol. 2022;186(3):319-327. doi:10.1530/EJE-21-0545
Chai PR, Mohamed Y, Bustamante MJ, et al. DigiPrEP: A Pilot Trial to Evaluate the Feasibility, Acceptability, and Accuracy of a Digital Pill System to Measure PrEP Adherence in Men Who Have Sex With Men Who Use Substances. J Acquir Immune Defic Syndr. 2022;89(2):e5-e15. doi:10.1097/QAI.0000000000002854
Teufel LU, Arts RJW, Netea MG, Dinarello CA, Joosten LAB. IL-1 family cytokines as drivers and inhibitors of trained immunity. Cytokine. 2022;150:155773. doi:10.1016/j.cyto.2021.155773
Summer SS, Jenkins T, Inge T, Deka R, Khoury JC. Association of diet quality, physical activity, and abdominal obesity with metabolic syndrome z-score in black and white adolescents in the US. Nutr Metab Cardiovasc Dis. 2022;32(2):346-354. doi:10.1016/j.numecd.2021.10.021
Novak AR, Krsak M, Kiser TH, et al. Pharmacokinetic Evaluation of Cefazolin in the Cerebrospinal Fluid of Critically Ill Patients. Open Forum Infect Dis. 2022;9(2):ofab649. doi:10.1093/ofid/ofab649
Lundgren JD, Grund B, Barkauskas CE, et al. Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial. Ann Intern Med. 2022;175(2):234-243. doi:10.7326/M21-3507
Kamis KF, Wyles DL, Minturn MS, et al. Hepatitis C Testing and Linkage to Care Among Adults on Probation in a Large US City. Open Forum Infect Dis. 2022;9(2):ofab636. doi:10.1093/ofid/ofab636
Jolley S, Nordon-Craft A, Wilson MP, et al. Disparities in the allocation of inpatient physical and occupational therapy services for patients with COVID-19. J Hosp Med. 2022;17(2):88-95. doi:10.1002/jhm.12785
Frost HM, Munsiff SS, Lou Y, Jenkins TC. Simplifying outpatient antibiotic stewardship. Infect Control Hosp Epidemiol. 2022;43(2):260-261. doi:10.1017/ice.2020.1409
Frank DN, Qiu Y, Cao Y, et al. A dysbiotic microbiome promotes head and neck squamous cell carcinoma. Oncogene. 2022;41(9):1269-1280. doi:10.1038/s41388-021-02137-1
van de Veerdonk FL, Renga G, Pariano M, et al. Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy. J Clin Invest. 2022;132(2). doi:10.1172/JCI144983
Rowan SE, McCormick DW, Wendel KA, et al. Lower Prevalence of SARS-CoV-2 Infection Among People Experiencing Homelessness Tested in Outdoor Encampments Compared with Overnight Shelters - Denver, Colorado, June - July 2020. Clin Infect Dis. Published online January 18, 2022. doi:10.1093/cid/ciac039
Barrett B, Nguyen DH, Xu J, et al. SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide. J Immunol. 2022;208(2):444-453. doi:10.4049/jimmunol.2001389
Brijkumar J, Edwards JA, Johnson BA, et al. Comparing effectiveness of first-line antiretroviral therapy between peri-urban and rural clinics in KwaZulu-Natal, South Africa. HIV Med. Published online January 12, 2022. doi:10.1111/hiv.13231
Dyamenahalli K, Choy K, Frank DN, et al. Age and injury size influence the magnitude of fecal dysbiosis in adult burn patients. J Burn Care Res. Published online January 10, 2022:irac001. doi:10.1093/jbcr/irac001
Windsor WJ, Knight V, Merkel PA, et al. COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method. Am J Trop Med Hyg. 2022;106(2):562-565. doi:10.4269/ajtmh.21-1036
Odayar J, Orrell C, Phillips TK, et al. Use of tenofovir diphosphate levels to predict viremia during the postpartum period in women living with HIV: a nested case-control study. Clin Infect Dis. Published online January 3, 2022:ciab1068. doi:10.1093/cid/ciab1068
Windham S, Hirsch K, Peterson R, et al. The Predictive Potential of Elevated Serum Inflammatory Markers in Determining the Need for Intubation in CoVID-19 Patients. J Crit Care Med (Targu Mures). 2022;8(1):14-22. doi:10.2478/jccm-2021-0035
Wandling M, Cuschieri J, Kozar R, et al. Multi-center validation of the Bowel Injury Predictive Score (BIPS) for the early identification of need to operate in blunt bowel and mesenteric injuries. Injury. 2022;53(1):122-128. doi:10.1016/j.injury.2021.07.026
Shepard Z, Skorupa T, Espinoza L, Erlandson K, Damioli L. Coxiella burnetii Infection Associated With Thromboangiitis Obliterans-like Phenomena With Digital Autoamputation: A Case Report and Review of Q Fever-Associated Autoimmunity. Open Forum Infect Dis. 2022;9(1):ofab637. doi:10.1093/ofid/ofab637
Haukoos JS, White DAE, Rowan SE, et al. Development of a 2-step algorithm to identify emergency department patients for HIV pre-exposure prophylaxis. Am J Emerg Med. 2022;51:6-12. doi:10.1016/j.ajem.2021.09.084
Frost HM, Lou Y, Keith A, Byars A, Jenkins TC. Increasing Guideline-Concordant Durations of Antibiotic Therapy for Acute Otitis Media. J Pediatr. 2022;240:221-227.e9. doi:10.1016/j.jpeds.2021.07.016
Franco-Paredes C. Transmissibility of SARS-CoV-2 among fully vaccinated individuals. Lancet Infect Dis. 2022;22(1):16. doi:10.1016/S1473-3099(21)00768-4
Embi PJ, Levy ME, Naleway AL, et al. Effectiveness of two-dose vaccination with mRNA COVID-19 vaccines against COVID-19-associated hospitalizations among immunocompromised adults-Nine States, January-September 2021. Am J Transplant. 2022;22(1):306-314. doi:10.1111/ajt.16641
Amo-Aparicio J, Garcia-Garcia J, Puigdomenech M, et al. Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury. Exp Neurol. 2022;347:113889. doi:10.1016/j.expneurol.2021.113889
Vicente-Alcalde N, Ruescas-Escolano E, Franco-Paredes C, Tuells J. Control of a COVID-19 Outbreak in a Spanish Prison: Lessons Learned in Outbreak Control. Front Med (Lausanne). 2022;9:806438. doi:10.3389/fmed.2022.806438
McMahan RH, Hulsebus HJ, Najarro KM, et al. Age-Related Intestinal Dysbiosis and Enrichment of Gut-specific Bacteria in the Lung Are Associated With Increased Susceptibility to Streptococcus pneumoniae Infection in Mice. Front Aging. 2022;3:859991. doi:10.3389/fragi.2022.859991
Guo K, Barrett BS, Mickens KL, et al. Interferon Resistance of Emerging SARS-CoV-2 Variants. bioRxiv. Published online December 10, 2021:2021.03.20.436257. doi:10.1101/2021.03.20.436257
Kates OS, Haydel BM, Florman SS, et al. Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study. Clin Infect Dis. 2021;73(11):e4090-e4099. doi:10.1093/cid/ciaa1097
Cummings DAT, Radonovich LJ, Gorse GJ, et al. Risk Factors for Healthcare Personnel Infection With Endemic Coronaviruses (HKU1, OC43, NL63, 229E): Results from the Respiratory Protection Effectiveness Clinical Trial (ResPECT). Clin Infect Dis. 2021;73(11):e4428-e4432. doi:10.1093/cid/ciaa900
Yager JL, Brooks KM, Castillo-Mancilla JR, et al. Tenofovir-diphosphate in peripheral blood mononuclear cells during low, medium and high adherence to emtricitabine/ tenofovir alafenamide vs. emtricitabine/ tenofovir disoproxil fumarate. AIDS. 2021;35(15):2481-2487. doi:10.1097/QAD.0000000000003062
Wendel KA, Mauk K, Amsterdam L, et al. Enhancing Gonococcal Antimicrobial Resistance Surveillance in Cisgender Women, Strengthening the US Response to Resistant Gonorrhea, 2018 to 2019. Sex Transm Dis. 2021;48(12S Suppl 2):S104-S110. doi:10.1097/OLQ.0000000000001554
Schlanger K, Learner ER, Pham CD, et al. Strengthening the US Response to Resistant Gonorrhea: An Overview of a Multisite Program to Enhance Local Response Capacity for Antibiotic-Resistant Neisseria gonorrhoeae. Sex Transm Dis. 2021;48(12S Suppl 2):S97-S103. doi:10.1097/OLQ.0000000000001545
Rietmeijer CA, Hauschild BC, Burnside HC, Wendel KA. Medicaid Expansion and Rates of Reportable Sexually Transmitted Infections in the United States: A County-Level Analysis. Sex Transm Dis. 2021;48(12):e190-e191. doi:10.1097/OLQ.0000000000001422
Maragh-Bass AC, Parker S, Thompson G, et al. “Ending the HIV epidemic”: where are African American women in the plan? AIDS. 2021;35(15):2541-2544. doi:10.1097/QAD.0000000000003037
Kousari A, Moser C, Olefsky M, et al. Poorer Muscle Quality and Quantity With ART Initiation Is Associated With Greater Inflammation and Immune Activation. J Acquir Immune Defic Syndr. 2021;88(4):399-405. doi:10.1097/QAI.0000000000002776
Wyles DL, Kang M, Matining RM, Murphy RL, Peters MG. Continued Low Rates of Hepatitis C Virus (HCV) Recurrence in HCV/HIV- and HCV-Infected Participants Who Achieved Sustained Virologic Response After Direct-Acting Antiviral Treatment: Final Results From the AIDS Clinical Trials Group A5320 Viral Hepatitis C Infection Long-term Cohort Study (V-HICS). Open Forum Infect Dis. 2021;8(12):ofab511. doi:10.1093/ofid/ofab511
Windham S, Wilson MP, Fling C, et al. Elevated glycohemoglobin is linked to critical illness in CoVID-19: a retrospective analysis. Ther Adv Infect Dis. 2021;8:20499361211027390. doi:10.1177/20499361211027390
Viszlayová D, Sojka M, Dobrodenková S, et al. SARS-CoV-2 RNA in the Cerebrospinal Fluid of a Patient with Long COVID. Ther Adv Infect Dis. 2021;8:20499361211048572. doi:10.1177/20499361211048572
Semitala FC, Kadota JL, Musinguzi A, et al. Completion of isoniazid-rifapentine (3HP) for tuberculosis prevention among people living with HIV: Interim analysis of a hybrid type 3 effectiveness-implementation randomized trial. PLoS Med. 2021;18(12):e1003875. doi:10.1371/journal.pmed.1003875
Rosolanka R, Henao-Martinez AF, Pisney L, Franco-Paredes C, Krsak M. COVID-19: a review of current knowledge regarding exposure, quarantine, isolation and other preventive measures. Ther Adv Infect Dis. 2021;8:20499361211032040. doi:10.1177/20499361211032039
Rodriguez-Morales AJ, Sah R, Millan-Oñate J, et al. COVID-19 associated mucormycosis: the urgent need to reconsider the indiscriminate use of immunosuppressive drugs. Ther Adv Infect Dis. 2021;8:20499361211027064. doi:10.1177/20499361211027065
Rodríguez-Morales AJ, Bonilla-Aldana DK, Suárez JA, et al. Yellow fever reemergence in Venezuela - Implications for international travelers and Latin American countries during the COVID-19 pandemic. Travel Med Infect Dis. 2021;44:102192. doi:10.1016/j.tmaid.2021.102192
Quan NG, Latif H, Krsak M, et al. Benefits of COVID-19 viral screening of formerly incarcerated individuals during community reentry. Ther Adv Infect Dis. 2021;8:2049936120985951. doi:10.1177/2049936120985951
Marcus R, Henao-Martínez AF, Nolan M, et al. Recognition and screening for Chagas disease in the USA. Ther Adv Infect Dis. 2021;8:20499361211046090. doi:10.1177/20499361211046086
Kristofich M, Anderson PL, Castillo-Mancilla JR. Beyond HIV viral load: application of pharmacologic measures to identify ART adherence mismatch. Ther Adv Infect Dis. 2021;8:20499361211010596. doi:10.1177/20499361211010596
Kalil AC, Mehta AK, Patterson TF, et al. Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial. Lancet Respir Med. 2021;9(12):1365-1376. doi:10.1016/S2213-2600(21)00384-2
Gharamti AA, Mundo W, Chastain DB, Franco-Paredes C, Henao-Martínez AF, Shapiro L. Pneumocystis jirovecii pneumonia: a proposed novel model of corticosteroid benefit. Ther Adv Infect Dis. 2021;8:20499361211032030. doi:10.1177/20499361211032034
García Oronoz G, Pedraza-Arévalo LC, Henao-Martínez AF, Franco-Paredes C, Suarez JA. Visceral leishmaniasis in the island of Margarita, Venezuela: a neglected parasitic infection in the Caribbean. Ther Adv Infect Dis. 2021;8:20499361211031710. doi:10.1177/20499361211031714
Gabster A, Jhangimal M, Erausquin JT, et al. Rapid health evaluation in migrant peoples in transit through Darien, Panama: protocol for a multimethod qualitative and quantitative study. Ther Adv Infect Dis. 2021;8:20499361211066190. doi:10.1177/20499361211066190
Frost HM, Sebastian T, Durfee J, Jenkins TC. Ophthalmic antibiotic use for acute infectious conjunctivitis in children. J AAPOS. 2021;25(6):350.e1-350.e7. doi:10.1016/j.jaapos.2021.06.006
Erlandson KM, Liu J, Johnson R, et al. An exercise intervention alters stool microbiota and metabolites among older, sedentary adults. Ther Adv Infect Dis. 2021;8:20499361211027068. doi:10.1177/20499361211027067
Chadalawada S, Rassi AJ, Samara O, et al. Mortality risk in chronic Chagas cardiomyopathy: a systematic review and meta-analysis. ESC Heart Fail. 2021;8(6):5466-5481. doi:10.1002/ehf2.13648
Castillo-Mancilla JR, Edwards JA, Brijkumar J, et al. Tenofovir diphosphate levels in dried blood spots are associated with virologic failure and resistance to first-line therapy in South Africa: a case-control cohort study. J Int AIDS Soc. 2021;24(12):e25849. doi:10.1002/jia2.25849
Archuleta S, Gharamti AA, Sillau S, et al. Increased mortality associated with uncontrolled diabetes mellitus in patients with pulmonary cryptococcosis: a single US cohort study. Ther Adv Infect Dis. 2021;8:20499361211004370. doi:10.1177/20499361211004367
Agudelo-Higuita NI, Rodriguez-Morales AJ, Henao-Martinez AF, Franco-Paredes C, Gabster A. The treacherous journey of hundreds of migrants from Cameroon to reach the United States. Travel Med Infect Dis. 2021;44:102172. doi:10.1016/j.tmaid.2021.102172
Agudelo Higuita NI, White BP, Franco-Paredes C, McGhee MA. An update on prevention of malaria in travelers. Ther Adv Infect Dis. 2021;8:20499361211040690. doi:10.1177/20499361211040690
Naranjo L, Carrillo-Villaseñor F, D’Suze G, et al. Ischemic Stroke in a Child after a Probable Scorpion Sting. Am J Trop Med Hyg. 2021;106(3):959-961. doi:10.4269/ajtmh.21-0880
Liu S, Koneru PC, Li W, et al. HIV-1 integrase binding to genomic RNA 5’-UTR induces local structural changes in vitro and in virio. Retrovirology. 2021;18(1):37. doi:10.1186/s12977-021-00582-0
O’Brien KK, Bayoumi AM, Chan Carusone S, et al. Disability and self-care living strategies among adults living with HIV during the COVID-19 pandemic. AIDS Res Ther. 2021;18(1):87. doi:10.1186/s12981-021-00413-4
Radtke KK, Ernest JP, Zhang N, et al. Comparative Efficacy of Rifapentine Alone and in Combination with Isoniazid for Latent Tuberculosis Infection: a Translational Pharmacokinetic-Pharmacodynamic Modeling Study. Antimicrob Agents Chemother. 2021;65(12):e0170521. doi:10.1128/AAC.01705-21
Sulkowski M, Wyles D. Déjà vu All Over Again: Retreatment of HCV Direct Acting Antivirals Failures-Same Satisfactory Results, Same Unanswered Questions. Clin Infect Dis. 2021;73(9):e3296-e3299. doi:10.1093/cid/ciaa1329
Haas MK, Aiona K, Erlandson KM, Belknap RW. Higher Completion Rates With Self-administered Once-weekly Isoniazid-rifapentine Versus Daily Rifampin in Adults With Latent Tuberculosis. Clin Infect Dis. 2021;73(9):e3459-e3467. doi:10.1093/cid/ciaa1364
Kamis KF, Barbera L, Abdo M, et al. Risk Factors for Hospitalization in People With HIV and COVID-19. J Acquir Immune Defic Syndr. 2021;88(3):e22. doi:10.1097/QAI.0000000000002780
Quandelacy TM, Zimmer S, Lessler J, et al. Predicting virologically confirmed influenza using school absences in Allegheny County, Pennsylvania, USA during the 2007-2015 influenza seasons. Influenza Other Respir Viruses. 2021;15(6):757-766. doi:10.1111/irv.12865
Krsak M, Harry BL, Palmer BE, Franco-Paredes C. Response to Mishra et al. re “Postinfectious Immunity After COVID-19 and Vaccination Against SARS-CoV-2”. Viral Immunol. 2021;34(9):659-660. doi:10.1089/vim.2021.0147
Kamkwalala AR, Garg A, Roy U, et al. Current Considerations for Clinical Management and Care of People with HIV: Findings from the 11th Annual International HIV and Aging Workshop. AIDS Res Hum Retroviruses. 2021;37(11):807-820. doi:10.1089/AID.2021.0059
Hirsch SD, Elling CL, Bootpetch TC, et al. The role of CDHR3 in susceptibility to otitis media. J Mol Med (Berl). 2021;99(11):1571-1583. doi:10.1007/s00109-021-02118-7
Hernández-Favela CG, Hernández-Ruiz VA, Bello-Chavolla OY, et al. Higher Veterans Aging Cohort Study 2.0 Index Score Predicts Functional Decline Among Older Adults Living with HIV. AIDS Res Hum Retroviruses. 2021;37(11):878-883. doi:10.1089/AID.2020.0295
de Graaf DM, Teufel LU, van de Veerdonk FL, et al. IL-38 prevents induction of trained immunity by inhibition of mTOR signaling. J Leukoc Biol. 2021;110(5):907-915. doi:10.1002/JLB.3A0220-143RRR
Cooper MM, Preslaski CR, Shihadeh KC, Hawkins KL, Jenkins TC. Multiple-Dose Dalbavancin Regimens as the Predominant Treatment of Deep-Seated or Endovascular Infections: A Scoping Review. Open Forum Infect Dis. 2021;8(11):ofab486. doi:10.1093/ofid/ofab486
Carriger JF, Thompson M, Barron MG. Causal Bayesian networks in assessments of wildfire risks: Opportunities for ecological risk assessment and management. Integr Environ Assess Manag. 2021;17(6):1168-1178. doi:10.1002/ieam.4443
Campbell TW, Wilson MP, Roder H, et al. Predicting prognosis in COVID-19 patients using machine learning and readily available clinical data. Int J Med Inform. 2021;155:104594. doi:10.1016/j.ijmedinf.2021.104594
Bessesen MT, Rattigan S, Frederick J, et al. Outpatient healthcare personnel knowledge and attitudes towards infection prevention measures for protection from respiratory infections. Am J Infect Control. 2021;49(11):1369-1375. doi:10.1016/j.ajic.2021.06.011
Molteni R, Biavasco R, Stefanoni D, et al. Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease. Blood. 2021;138(17):1554-1569. doi:10.1182/blood.2020009594
Erlandson KM, Carter CC, Melbourne K, et al. Weight Change Following Antiretroviral Therapy Switch in People With Viral Suppression: Pooled Data from Randomized Clinical Trials. Clin Infect Dis. 2021;73(8):1440-1451. doi:10.1093/cid/ciab444
Thompson MG, Stenehjem E, Grannis S, et al. Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings. N Engl J Med. 2021;385(15):1355-1371. doi:10.1056/NEJMoa2110362
Pettit AC, Stout JE, Belknap R, et al. Optimal Testing Choice and Diagnostic Strategies for Latent Tuberculosis Infection Among US-Born People Living with Human Immunodeficiency Virus (HIV). Clin Infect Dis. 2021;73(7):e2278-e2284. doi:10.1093/cid/ciaa1135
Firnhaber C, Swarts A, Jezile V, et al. Human Papillomavirus Vaccination Prior to Loop Electroexcision Procedure Does Not Prevent Recurrent Cervical High-grade Squamous Intraepithelial Lesions in Women Living With Human Immunodeficiency Virus: A Randomized, Double-blind, Placebo-controlled Trial. Clin Infect Dis. 2021;73(7):e2211-e2216. doi:10.1093/cid/ciaa1456
Morrow M, MaWhinney S, Coyle RP, et al. Emtricitabine triphosphate in dried blood spots predicts future viremia in persons with HIV and identifies mismatch with self-reported adherence. AIDS. 2021;35(12):1949-1956. doi:10.1097/QAD.0000000000002981
Rumbaut Castillo R, Hurtado Gascón LC, Ruiz-Fuentes JL, et al. Leprosy in children in Cuba: Epidemiological and clinical description of 50 cases from 2012-2019. PLoS Negl Trop Dis. 2021;15(10):e0009910. doi:10.1371/journal.pntd.0009910
Krsak M, Harry BL, Palmer BE, Franco-Paredes C. Postinfectious Immunity After COVID-19 and Vaccination Against SARS-CoV-2. Viral Immunol. 2021;34(8):504-509. doi:10.1089/vim.2021.0054
Heil EL, Bork JT, Abbo LM, et al. Optimizing the Management of Uncomplicated Gram-Negative Bloodstream Infections: Consensus Guidance Using a Modified Delphi Process. Open Forum Infect Dis. 2021;8(10):ofab434. doi:10.1093/ofid/ofab434
Francis J, Mngqibisa R, McIlleron H, et al. A Semimechanistic Pharmacokinetic Model for Depot Medroxyprogesterone Acetate and Drug-Drug Interactions With Antiretroviral and Antituberculosis Treatment. Clin Pharmacol Ther. 2021;110(4):1057-1065. doi:10.1002/cpt.2324
Chu NM, Chen X, Gross AL, et al. Cognitive impairment burden in older and younger adults across the kidney transplant care continuum. Clin Transplant. 2021;35(10):e14425. doi:10.1111/ctr.14425
Chauhan L, Pattee J, Ford J, et al. A Multi-center, Prospective, Observational-cohort controlled study of Clinical Outcomes following COVID-19 Convalescent plasma therapy in hospitalized COVID-19 patients. Clin Infect Dis. Published online September 21, 2021:ciab834. doi:10.1093/cid/ciab834
Stanislawski MA, Frank DN, Borengasser SJ, et al. The Gut Microbiota during a Behavioral Weight Loss Intervention. Nutrients. 2021;13(9). doi:10.3390/nu13093248
Valença-Pereira F, Fang Q, Marié IJ, et al. IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca(2+) through the noncanonical STAT3 pathway. Proc Natl Acad Sci U S A. 2021;118(37). doi:10.1073/pnas.2103444118
Karoor V, Strassheim D, Sullivan T, et al. The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension. Int J Mol Sci. 2021;22(18). doi:10.3390/ijms22189916
Sungar WG, Angerhofer C, McCormick T, et al. Implementation of holistic review into emergency medicine residency application screening to improve recruitment of underrepresented in medicine applicants. AEM Educ Train. 2021;5(Suppl 1):S10-S18. doi:10.1002/aet2.10662
Ryan PP, Hawkins KL, Altman S, et al. A novel virtual hospital at home model during the coronavirus disease 2019 (COVID-19) pandemic. Infect Control Hosp Epidemiol. 2021;42(9):1140-1142. doi:10.1017/ice.2020.435
Kibbie JJ, Dillon SM, Thompson TA, Purba CM, McCarter MD, Wilson CC. Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling. Immunobiology. 2021;226(5):152126. doi:10.1016/j.imbio.2021.152126
Castillo-Mancilla JR, Morrow M, Coyle RP, et al. Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV. Open Forum Infect Dis. 2021;8(9):ofab463. doi:10.1093/ofid/ofab463
Hasenkrug KJ, Feldmann F, Myers L, et al. Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques. mBio. 2021;12(4):e0150321. doi:10.1128/mBio.01503-21
Javan H, Li L, Schaaf CL, et al. Interleukin-1 Receptor Antagonism Abrogates Acute Pressure Overload-Induced Murine Heart Failure. Ann Thorac Surg. Published online August 19, 2021:S0003-4975(21)01434-X. doi:10.1016/j.athoracsur.2021.07.044
Lange-Maia BS, Buchman AS, Leurgans SE, et al. Racial Differences in the Effect of HIV Status on Motor and Pulmonary Function and Mobility Disability in Older Adults. J Racial Ethn Health Disparities. Published online August 17, 2021. doi:10.1007/s40615-021-01126-0
Masters MC, Perez J, Wu K, et al. Baseline Neurocognitive Impairment (NCI) Is Associated With Incident Frailty but Baseline Frailty Does Not Predict Incident NCI in Older Persons With Human Immunodeficiency Virus (HIV). Clin Infect Dis. 2021;73(4):680-688. doi:10.1093/cid/ciab122
Jankowski CM, Wilson MP, MaWhinney S, et al. Blunted Muscle Mitochondrial Responses to Exercise Training in Older Adults With HIV. J Infect Dis. 2021;224(4):679-683. doi:10.1093/infdis/jiaa799
Shah AS, Helmrath MA, Inge TH, et al. Study protocol: a prospective controlled clinical trial to assess surgical or medical treatment for paediatric type 2 diabetes (ST(2)OMP). BMJ Open. 2021;11(8):e047766. doi:10.1136/bmjopen-2020-047766
Gharamti A, Samara O, Monzon A, et al. Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol. BMJ Open. 2021;11(8):e048476. doi:10.1136/bmjopen-2020-048476
Simberkoff MS, Rattigan SM, Gaydos CA, et al. Impact of mandatory vaccination of healthcare personnel on rates of influenza and other viral respiratory pathogens. Infect Control Hosp Epidemiol. Published online August 5, 2021:1-5. doi:10.1017/ice.2021.324
Johnson TM, Molina KC, Howard AH, et al. Real-World Comparison of Bezlotoxumab to Standard of Care Therapy for Prevention of Recurrent Clostridioides difficile Infection in Patients at High Risk for Recurrence. Clin Infect Dis. Published online August 4, 2021:ciab674. doi:10.1093/cid/ciab674
Hileman CO, Kalayjian RC, Azzam S, et al. Plasma Citrate and Succinate Are Associated With Neurocognitive Impairment in Older People With HIV. Clin Infect Dis. 2021;73(3):e765-e772. doi:10.1093/cid/ciab107
Scarpato S, Pell J, Baduashvili A, et al. Controlling Chaos: How to Construct Electronically Integrated Inpatient Clinical Pathways That Can Disseminate Best Practice Rapidly in Times of Crisis. Am J Med Qual. 2021;36(4):287-289. doi:10.1097/01.JMQ.0000741988.67405.df
Zimmer AJ, Heitkamp P, Malar J, et al. Facility-based directly observed therapy (DOT) for tuberculosis during COVID-19: A community perspective. J Clin Tuberc Other Mycobact Dis. 2021;24:100248. doi:10.1016/j.jctube.2021.100248
Zhao P, Yao Q, Zhang PJ, et al. Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery-on-a-chip. Sci Adv. 2021;7(34). doi:10.1126/sciadv.abg1694
Tan S, Kasperbauer S. Nontuberculous Mycobacteria. Semin Respir Crit Care Med. 2021;42(4):567-586. doi:10.1055/s-0041-1730997
Sartain E, Schoeppler K, Crowther B, et al. Perioperative anidulafungin combined with triazole prophylaxis for the prevention of early invasive candidiasis in lung transplant recipients. Transpl Infect Dis. 2021;23(4):e13692. doi:10.1111/tid.13692
Koo S, Bold TD, Cheng MP, et al. A eulogy for Dr Francisco Miguel Marty Forero. Transpl Infect Dis. 2021;23(4):e13645. doi:10.1111/tid.13645
Briukhovetska D, Dörr J, Endres S, Libby P, Dinarello CA, Kobold S. Interleukins in cancer: from biology to therapy. Nat Rev Cancer. 2021;21(8):481-499. doi:10.1038/s41568-021-00363-z
Barbera LK, Kamis KF, Rowan SE, et al. HIV and COVID-19: review of clinical course and outcomes. HIV Res Clin Pract. 2021;22(4):102-118. doi:10.1080/25787489.2021.1975608
Badii M, Gaal OI, Cleophas MC, et al. Urate-induced epigenetic modifications in myeloid cells. Arthritis Res Ther. 2021;23(1):202. doi:10.1186/s13075-021-02580-1
Pandita A, Gil RM, Farmakiotis D. Call for Action: Racial Disparities in Clinical Research. Clin Infect Dis. 2021;73(2):356-357. doi:10.1093/cid/ciaa1349
Marx GE, Biggerstaff BJ, Nawrocki CC, et al. Detection of Severe Acute Respiratory Syndrome Coronavirus 2 on Self-Collected Saliva or Anterior Nasal Specimens Compared With Healthcare Personnel-Collected Nasopharyngeal Specimens. Clin Infect Dis. 2021;73(Suppl 1):S65-S73. doi:10.1093/cid/ciab330
Lake JE, La K, Erlandson KM, et al. Tesamorelin improves fat quality independent of changes in fat quantity. AIDS. 2021;35(9):1395-1402. doi:10.1097/QAD.0000000000002897
Akiyama BM, Graham ME, O Donoghue Z, Beckham JD, Kieft JS. Three-dimensional structure of a flavivirus dumbbell RNA reveals molecular details of an RNA regulator of replication. Nucleic Acids Res. 2021;49(12):7122-7138. doi:10.1093/nar/gkab462
Cohen MS, Nirula A, Mulligan MJ, et al. Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial. JAMA. 2021;326(1):46-55. doi:10.1001/jama.2021.8828
van Ingen J, Aliberti S, Andrejak C, et al. Management of Drug Toxicity in Mycobacterium avium Complex Pulmonary Disease: An Expert Panel Survey. Clin Infect Dis. 2021;73(1):e256-e259. doi:10.1093/cid/ciaa1361
Kelly SG, Wu K, Tassiopoulos K, Erlandson KM, Koletar SL, Palella FJJ. Incorporating Frailty Into the Pooled Cohort Equations to Predict Cardiovascular Disease Among Persons With HIV. J Acquir Immune Defic Syndr. 2021;87(3):971-977. doi:10.1097/QAI.0000000000002662
Haukoos JS, Lyons MS, Rothman RE, et al. Comparison of HIV Screening Strategies in the Emergency Department: A Randomized Clinical Trial. JAMA Netw Open. 2021;4(7):e2117763. doi:10.1001/jamanetworkopen.2021.17763
Gardner EM, Hawkins KL. Same-day Start of Antiretroviral Therapy Demonstrates the Potential To Lessen Disparities in Human Immunodeficiency Virus Treatment Outcomes. Clin Infect Dis. 2021;73(1):e129-e131. doi:10.1093/cid/ciaa618
Vazquez Deida AA, Shihadeh KC, Aragon D, Knepper BC, Jenkins TC. Factors Associated With Longer Than Recommended Durations of Antibiotic Therapy for Uncomplicated Ambulatory Infections in an Integrated Healthcare System. Open Forum Infect Dis. 2021;8(7):ofab324. doi:10.1093/ofid/ofab324
Mueller SW, Kedzior SK, Miller MA, et al. An overview of current and emerging antifungal pharmacotherapy for invasive fungal infections. Expert Opin Pharmacother. 2021;22(10):1355-1371. doi:10.1080/14656566.2021.1892075
Maehigashi T, Ahn S, Kim UI, et al. A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site. PLoS Pathog. 2021;17(7):e1009671. doi:10.1371/journal.ppat.1009671
Luetkemeyer AF, Wyles DL. CROI 2021: Viral Hepatitis and Other Forms of Liver Injury Impacting People with HIV. Top Antivir Med. 2021;29(3):379-385.
Los J, Gaydos CA, Gibert CL, et al. Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial. Am J Infect Control. 2021;49(7):893-899. doi:10.1016/j.ajic.2021.02.001
Lofgren SM, Nicol MR, Kandole TK, et al. Short Communication: A Descriptive Analysis of Dried Blood Spot Adherence Testing Among Ugandans with HIV Presenting with Cryptococcal Meningitis. AIDS Res Hum Retroviruses. 2021;37(7):529-533. doi:10.1089/AID.2020.0202
Johnson TM, Howard AH, Miller MA, et al. Effectiveness of Bezlotoxumab for Prevention of Recurrent Clostridioides difficile Infection Among Transplant Recipients. Open Forum Infect Dis. 2021;8(7):ofab294. doi:10.1093/ofid/ofab294
Johnson KA, Niu X, Glidden DV, et al. Lower Urine Tenofovir Concentrations Among Individuals Taking Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate: Implications for Point-of-Care Testing. Open Forum Infect Dis. 2021;8(7):ofab200. doi:10.1093/ofid/ofab200
Frank DN, Giese APJ, Hafren L, et al. Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants. J Med Genet. 2021;58(7):442-452. doi:10.1136/jmedgenet-2020-106844
Dillon SM, Abdo MH, Wilson MP, et al. A Unique Gut Microbiome-Physical Function Axis Exists in Older People with HIV: An Exploratory Study. AIDS Res Hum Retroviruses. 2021;37(7):542-550. doi:10.1089/AID.2020.0283
Coleman KJ, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of Jamestown Canyon Virus Disease. Neurohospitalist. 2021;11(3):277-278. doi:10.1177/19418744211005948
Niemeyer BF, Miller CM, Ledesma-Feliciano C, et al. Broad antiviral and anti-inflammatory efficacy of nafamostat against SARS-CoV-2 and seasonal coronaviruses in primary human bronchiolar epithelia. Nano Sel. Published online June 30, 2021. doi:10.1002/nano.202100123
Abbott R, Abbott TD, Abraham S, et al. Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run. Phys Rev Lett. 2021;126(24):241102. doi:10.1103/PhysRevLett.126.241102
Castleman MJ, Dillon SM, Thompson TA, et al. Gut Bacteria Induce Granzyme B Expression in Human Colonic ILC3s In Vitro in an IL-15-Dependent Manner. J Immunol. 2021;206(12):3043-3052. doi:10.4049/jimmunol.2000239
Schultz JS, Sparks H, Beckham JD. Arboviral central nervous system infections. Curr Opin Infect Dis. 2021;34(3):264-271. doi:10.1097/QCO.0000000000000729
Costello A, Pandita A, Devitt J. Case Report: Thrombotic Thrombocytopenia after COVID-19 Janssen Vaccination. Am Fam Physician. 2021;103(11):646-647.
Vickery TW, Armstrong M, Kofonow JM, et al. Specialized pro-resolving mediator lipidome and 16S rRNA bacterial microbiome data associated with human chronic rhinosinusitis. Data Brief. 2021;36:107023. doi:10.1016/j.dib.2021.107023
Shepard Z, Rios M, Solis J, et al. Common Dermatologic Conditions in Returning Travelers. Curr Trop Med Rep. 2021;8(2):104-111. doi:10.1007/s40475-021-00231-8
Mundo W, Berning A, Koullias Y, et al. Disseminated Cryptococcal Disease in A Patient With Chronic Chylothorax and a Pleurovenous Catheter, a Case Report With Autopsy Findings. Open Forum Infect Dis. 2021;8(6):ofab258. doi:10.1093/ofid/ofab258
Mortaji P, Corbisiero MF, Vrolijk MA, Henao-Martínez AF, Franco-Paredes C. Chronicle of Jails and Prisons COVID-19 Deaths Foretold. Am J Med Sci. 2021;361(6):801-802. doi:10.1016/j.amjms.2021.01.002
McCormick DW, Rowan SE, Pappert R, et al. Bartonella Seroreactivity Among Persons Experiencing Homelessness During an Outbreak of Bartonella quintana in Denver, Colorado, 2020. Open Forum Infect Dis. 2021;8(6):ofab230. doi:10.1093/ofid/ofab230
Macias Gil R, Touzard-Romo F, Sanchez MC, et al. Characteristics and outcomes of Hispanic/Latinx patients with coronavirus disease 19 (COVID-19) requiring hospitalization in Rhode Island: a retrospective cohort study. Ann Epidemiol. 2021;58:64-68. doi:10.1016/j.annepidem.2021.03.003
Li S, Jiang L, Beckmann K, et al. A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling. J Biol Chem. 2021;296:100630. doi:10.1016/j.jbc.2021.100630
Ibrahim ME, Castillo-Mancilla JR, Yager J, et al. Individualized Adherence Benchmarks for HIV Pre-Exposure Prophylaxis. AIDS Res Hum Retroviruses. 2021;37(6):421-428. doi:10.1089/AID.2020.0108
Haukoos JS, White DAE, Rowan SE, et al. HIV Risk and Pre-Exposure Prophylaxis Eligibility Among Emergency Department Patients. AIDS Patient Care STDS. 2021;35(6):211-219. doi:10.1089/apc.2021.0012
Grivas P, Khaki AR, Wise-Draper TM, et al. Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer Consortium. Ann Oncol. 2021;32(6):787-800. doi:10.1016/j.annonc.2021.02.024
Gharamti AA, Mei F, Jankousky KC, et al. Diagnostic Utility of a Ferritin-to-Procalcitonin Ratio to Differentiate Patients With COVID-19 From Those With Bacterial Pneumonia: A Multicenter Study. Open Forum Infect Dis. 2021;8(6):ofab124. doi:10.1093/ofid/ofab124
Erlandson KM, Piggott DA. Frailty and HIV: Moving from Characterization to Intervention. Curr HIV/AIDS Rep. 2021;18(3):157-175. doi:10.1007/s11904-021-00554-1
Cordero JH, Shepard Z, Schultz J, et al. Dermatologic Manifestations of Tick-borne Diseases in Travelers. Curr Trop Med Rep. 2021;8(2):99-103. doi:10.1007/s40475-021-00230-9
Chai PR, Goodman G, Bustamante MJ, et al. Long-Term Stability of the Electronic Sensor Component of a Digital Pill System in Real-World Storage Settings. J Pharm Technol. 2021;37(3):135-139. doi:10.1177/8755122520985219
Hyson P, Barahona LV, Pedraza-Arévalo LC, et al. Experiences with Diagnosis and Treatment of Chagas Disease at a United States Teaching Hospital-Clinical Features of Patients with Positive Screening Serologic Testing. Trop Med Infect Dis. 2021;6(2). doi:10.3390/tropicalmed6020093
Alvarado-Socarras JL, Vargas-Soler JA, Franco-Paredes C, Villegas-Lamus KC, Rojas-Torres JP, Rodriguez-Morales AJ. A Cluster of Neonatal Infections Caused by Candida auris at a Large Referral Center in Colombia. J Pediatric Infect Dis Soc. 2021;10(5):549-555. doi:10.1093/jpids/piaa152
van Deuren RC, Arts P, Cavalli G, et al. Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses. Genome Med. 2021;13(1):94. doi:10.1186/s13073-021-00907-w
Jha V, Nicholson LK, Gardner EM, et al. Impact of HIV-1 Infection and Antigen Class on T Follicular Helper Cell Responses to Pneumococcal Polysaccharide-Protein Conjugate Vaccine-13. J Immunol. 2021;206(10):2402-2411. doi:10.4049/jimmunol.2001133
Falutz J, Brañas F, Erlandson KM. Frailty: the current challenge for aging people with HIV. Curr Opin HIV AIDS. 2021;16(3):133-140. doi:10.1097/COH.0000000000000677
Siebert JC, Stanislawski MA, Zaman A, et al. Multiomic Predictors of Short-Term Weight Loss and Clinical Outcomes During a Behavioral-Based Weight Loss Intervention. Obesity (Silver Spring). 2021;29(5):859-869. doi:10.1002/oby.23127
Schultz J, Beeson A, Newton T, et al. Impact of An Internal Medicine-Pediatrics Residency Quality Improvement Project to Increase Latent Tuberculosis Screening. Am J Med Sci. 2021;361(5):670-672. doi:10.1016/j.amjms.2020.10.033
Li Z, Wang-Heaton H, Cartwright BM, et al. ATR prevents Ca(2+) overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling. FASEB J. 2021;35(5):e21373. doi:10.1096/fj.202001636RRR
Jenkins TC, Tamma PD. Thinking Beyond the “Core” Antibiotic Stewardship Interventions: Shifting the Onus for Appropriate Antibiotic Use from Stewardship Teams to Prescribing Clinicians. Clin Infect Dis. 2021;72(8):1457-1462. doi:10.1093/cid/ciaa1003
Chai PR, Bustamante MJ, Goodman G, et al. A Brief Training Program to Support the Use of a Digital Pill System for Medication Adherence: Pilot Descriptive Study. JMIR Form Res. 2021;5(4):e26213. doi:10.2196/26213
Feng PJ, Wu Y, Ho CS, et al. Impact of T-Cell Xtend on T-SPOT.TB Assay in High-Risk Individuals after Delayed Blood Sample Processing. J Clin Microbiol. 2021;59(5). doi:10.1128/JCM.00120-21
Benamu E, Gajurel K, Anderson JN, et al. Plasma Microbial Cell-free DNA Next Generation Sequencing in the Diagnosis and Management of Febrile Neutropenia. Clin Infect Dis. Published online April 19, 2021:ciab324. doi:10.1093/cid/ciab324
Nicholson LT, Pidgeon TS, Lauder A, Rellan I, Richard MJ, Ruch DS. Lunate Revascularization With Temporary Internal Radiocarpal Spanning Fixation for Kienböck Disease. Hand (N Y). Published online April 15, 2021:15589447211006858. doi:10.1177/15589447211006858
Malik SA, Zhu C, Li J, et al. Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections. World J Gastroenterol. 2021;27(14):1465-1482. doi:10.3748/wjg.v27.i14.1465
van der Heijden WA, Van de Wijer L, Keramati F, et al. Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells. JCI Insight. 2021;6(7):145928. doi:10.1172/jci.insight.145928
Erlandson KM, Wilson MP, MaWhinney S, et al. The Impact of Moderate or High-Intensity Combined Exercise on Systemic Inflammation Among Older Persons With and Without HIV. J Infect Dis. 2021;223(7):1161-1170. doi:10.1093/infdis/jiaa494
Cavalli G, Tengesdal IW, Gresnigt M, et al. The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity. Cell Rep. 2021;35(1):108955. doi:10.1016/j.celrep.2021.108955
Hasenkrug KJ, Feldmann F, Myers L, et al. Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques. bioRxiv. Published online April 4, 2021:2021.04.02.438262. doi:10.1101/2021.04.02.438262
Oliveira VHF, Borsari AL, Cárdenas JDG, et al. Low Agreement Between Initial and Revised European Consensus on Definition and Diagnosis of Sarcopenia Applied to People Living With HIV. J Acquir Immune Defic Syndr. 2021;86(4):e106-e113. doi:10.1097/QAI.0000000000002576
Abdo M, Langan SJ, MaWhinney S, et al. Effect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr. 2021;86(4):455-462. doi:10.1097/QAI.0000000000002579
Taimur S, Pouch SM, Zubizarreta N, et al. Impact of pre-transplant carbapenem-resistant Enterobacterales colonization and/or infection on solid organ transplant outcomes. Clin Transplant. 2021;35(4):e14239. doi:10.1111/ctr.14239
Rebensburg SV, Wei G, Larue RC, et al. Sec24C is an HIV-1 host dependency factor crucial for virus replication. Nat Microbiol. 2021;6(4):435-444. doi:10.1038/s41564-021-00868-1
Krsak M, Wada NI, Plankey MW, et al. Self-Reported Cannabis Use and Markers of Inflammation in Men Who Have Sex With Men With and Without HIV. Cannabis Cannabinoid Res. 2021;6(2):165-173. doi:10.1089/can.2019.0083
Krsak M, Henao-Martínez AF, Franco-Paredes C. COVID-19: Way Forward With Serosurveillance Without Overemphasizing Neutralizing Antibodies. Viral Immunol. 2021;34(3):130-133. doi:10.1089/vim.2020.0246
Goldschmidt AB, Khoury JC, Mitchell JE, et al. Loss of Control Eating and Health Indicators Over 6 Years in Adolescents Undergoing Metabolic and Bariatric Surgery. Obesity (Silver Spring). 2021;29(4):740-747. doi:10.1002/oby.23126
Franco-Paredes C, Suarez JA, Henao-Martínez AF. Global COVID-19 vaccine equity should precede requiring travelers proof of vaccination. Int J Infect Dis. 2021;105:243-244. doi:10.1016/j.ijid.2021.02.061
Dillon SM, Wilson CC. Gut Innate Immunity and HIV Pathogenesis. Curr HIV/AIDS Rep. 2021;18(2):128-138. doi:10.1007/s11904-021-00544-3
Auma AWN, Shive C, Damjanovska S, et al. T-cell Activation Is Correlated With Monocyte Activation in HCV/HIV Coinfection and Declines During HCV Direct-Acting Antiviral Therapy. Open Forum Infect Dis. 2021;8(4):ofab079. doi:10.1093/ofid/ofab079
Allan R, Wiebe SA, Johnson SM, Piaseckyj O, Campbell TL. Practicing Emotionally Focused Therapy online: Calling all relationships. J Marital Fam Ther. 2021;47(2):424-439. doi:10.1111/jmft.12507
Read JM, Zimmer S, Vukotich CJ, et al. Influenza and other respiratory viral infections associated with absence from school among schoolchildren in Pittsburgh, Pennsylvania, USA: a cohort study. BMC Infect Dis. 2021;21(1):291. doi:10.1186/s12879-021-05922-1
Eller KA, Aunins TR, Courtney CM, et al. Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria. Commun Biol. 2021;4(1):331. doi:10.1038/s42003-021-01856-1
Lundgren JD, Grund B, Barkauskas CE, et al. A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19. N Engl J Med. 2021;384(10):905-914. doi:10.1056/NEJMoa2033130
Tengesdal IW, Menon DR, Osborne DG, et al. Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion. Proc Natl Acad Sci U S A. 2021;118(10). doi:10.1073/pnas.2000915118
Sabourin KR, Schultz J, Romero J, et al. Risk Factors of SARS-CoV-2 Antibodies in Arapahoe County First Responders-The COVID-19 Arapahoe SErosurveillance Study (CASES) Project. J Occup Environ Med. 2021;63(3):191-198. doi:10.1097/JOM.0000000000002099
Erlandson KM, Wu K, Lake JE, et al. Mitochondrial DNA haplogroups and weight gain following switch to integrase strand transfer inhibitor-based antiretroviral therapy. AIDS. 2021;35(3):439-445. doi:10.1097/QAD.0000000000002771
Canfield GS, Chatterjee A, Espinosa J, et al. Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium. Antimicrob Agents Chemother. 2021;65(5):AAC.00143-21. doi:10.1128/AAC.00143-21
Zeller MH, Kidwell KM, Reiter-Purtill J, et al. Cigarette Use and Adolescent Metabolic and Bariatric Surgery. Obesity (Silver Spring). 2021;29(3):579-586. doi:10.1002/oby.23084