We Welcome Five Incoming Faculty Members

The Division is Growing. In July we will be 72 faculty members strong. A fifth inpatient service will soon start at University of Colorado Hospital. We are delighted to officially announce five new ID Division faculty members who will join us in mid-2020. They collectively bring a wealth of talent, training and diverse experiences to our three-shield missions:

Yiannis Koullias, MD comes to us from the Partners ID fellowship at Harvard Medical School/Brigham & Women’s Hospital/MGH, with subspecialty training in Transplant ID at Dana-Farber/Brigham and Women’s Cancer Center. He is a graduate of Harvard College, Duke Medical School, and the Brigham’s Internal Medicine Residency Program. His has broad interests in Transplant ID, including viral and fungal infections in heme-onc/BMT populations.

Sarah Mann, MD joins us from our ID fellowship here at the University of Colorado School of Medicine. She is a graduate of Cornell University, George Washington University Medical School and the Harbor UCLA internal medicine residency. She has interests in HIV Medicine and works on stewardship of anti-retroviral agents.

Aakriti Pandita, MD joins us from the Infectious Disease Fellowship at Warren Alpert Medical School of Brown University. She is a graduate of the Sher-i-Kashmir Institute of Medical Sciences in Srinagar, India, and the SUNY Upstate Medical University internal medicine residency. She is jointly appointed with the Division of Hospital Medicine. She is currently working on a meta-analysis of decades-long time trends in Staphylococcus aureus bacteremia. She also has a strong interest in tuberculosis and advocacy.

Rebecca Rwubusisi MSN, BSN, is our new APP for the Transplant ID (TID) service on the AMC. She is an Acute Care Nurse Practitioner whose valuable experience includes 15 years of bedside experience as an RN in the Department of Surgery, on the UC Health Inpatient Transplant Unit. She also has medical experience in East Africa and is fluent in Spanish.

Sias Scherger, MD also joins the division from our ID fellowship. He is a graduate of the University of Nebraska, the University of Nebraska College of Medicine and the Wake Forest internal medicine residency. He has interests in transplant ID and is working on understanding associations between anti-cytokine antibodies and endemic fungal infections.

Responding to COVID-19. The CU Infectious Diseases Division Continues to be Deeply Involved in Institutional Preparations for the Coronavirus Pandemic

Drs. Michelle Barron and Larissa Pisney (University of Colorado Hospital Infection Control and Prevention) are at the head of a multi-faceted campaign to ready our UCH providers and trainees and have been coordinating with state and national authorities. Drs. Mary Bessesen and Heather Young have been performing similar roles at the VA Medical Center and Denver Health. Dr. Brian Montague is involved in managing employee health for both the School of Medicine and UCH. Numerous other ID faculty members have participated in patient care, screening and testing, contingency planning, guidelines preparation, communications and community outreach, scientific discussions, idea generation, and teaching.  Division scientists are working on various research aspects of understanding, preventing and treating viral infections. The Infectious Disease Fellows are involved in consulting on COVID-19 issues and they will also be working with the Colorado Dept. of Public Health in the coming month to learn about the role of epidemiologists and about public health policy.  The Division website aggregator contains much practical information, both local and international.

Dr. Michelle Barron Speaks at UCHealth Town Hall on COVID-19 Response

Dr. Barron, Medical Director of Infection Control and Prevention, discussed COVID-19 basics, screening and treatment guidelines, and infection control measures. The entire town hall can be watched here.

Drs. Robert Belknap, David Cohn and Randall Reves Participate in Multi-institutional Team to Update Guidelines for Treatment of Latent Tuberculosis.

Their participation is part of the important role that Denver Health ID faculty continue to play in M. tuberculosis treatment and control, in Colorado and internationally. See Sterling et al. in MMWR in "Recent Publications" below for full details of the team's report.

Dr. Lakshmi Chauhan Receives the Outstanding Quality Award at 2nd Annual UCH Quality & Safety Symposium

Dr. Chauhan was awarded for her outpatient stewardship project “Approaches to Decrease Inappropriate Antibiotic use in Acute Respiratory Conditions in a Geriatric Clinic.” She will present her project on March 11, 2020. Her goals are to work with the antimicrobial stewardship team to help expand outpatient stewardship programs to other UCH clinics. Quality improvement projects such as this are important areas for academic contribution and grant funding opportunities in the division.

Dr. Sarah Rowan Discusses Colorado's Ongoing Fight to End HIV with 5280 Magazine.

Dr. Rowan spoke about her work on a local HIV task force to expand testing and treatment of the virus and about other efforts by the Colorado medical community to combat HIV.

Congratulations to Fellowship Program Director Dr. Carlos Franco-Paredes and Education Coordinator Kelly Rico for Highly Positive ACGME Annual Program Review.  

The Review Committee found no concerns and commended the program for its demonstrated excellent compliance with the ACGME's Program Requirements.

ID Fellows Greg Canfield and Sarah Mann Publish a Striking Example of Cutaneous Blastomycosis.

Drs. Canfield and Mann published their results in Clinical Infectious Diseases.  The case exhibited numerous interesting features including the classic - and in this case, quite developed - verrucous lesion with raised, sharply demarcated borders. 

 

Dr. Hillary Dunlevy Awarded Annual CU Hospital Physician Medical Staff Award

Dr. Hillary Dunlevy, Assistant Professor of Medicine, was awarded the Annual University of Colorado Hospital Full-time Physician Medical Staff Award on January 30, 2020. Recipients of this award exemplify the mission and vision of UCH and are recognized for achievement in one or more of the following areas:  Amazing patient care; Outstanding teaching of student physicians; Improvements in services offered/collaboration with other specialties; Community service.

Rebecca Rwubusisi MSN, BSN, RN, CCTN Joins Our Team as the New APP for Transplant ID Service

Her appointment will provide significant assistance to our physician providers and facilitate the patient care, education and research missions of the TID focus group. Rebecca received her BSN Magna Cum Laude from the University of Colorado Denver in 2005. She is an Acute Care Nurse Practitioner whose extensive experience includes 15 years of bedside experience as an RN in the Department of Surgery, on the UC Health Inpatient Transplant Unit. There she gained an in-depth understanding of the multi-faceted transplantation process and close working relationships with transplant providers. She developed a passion for Infectious Diseases as well, prompting her to transition to our Division. During three months in Rwanda, Rebecca also saw and treated patients with multiple infectious problems, including HIV/AIDS. Moreover, she is fluent in Spanish.

 

Debra Best Joins Our Division as Our New Post-Award Administrator

She will begin her role on Monday, February 3rd, 2020.

Dr. Cara Wilson has been appointed Associate Director of the Medical Scientist Training Program

Dr. Wilson will transition into the director role on July 1, 2020. Our MD-PhD program is a critical linchpin in the education of physician-scientists, allowing top-notch students to obtain their PhD alongside their MD. The program provides tuition as well as an annual stipend.

Dr. Michelle Barron Discusses Infection Prevention with Boulder Daily Camera

Michelle Barron, UCHealth University of Colorado Hospital’s medical director of infection prevention and professor of medicine at CU School of Medicine was recently interviewed by  the Daily Camera. She discussed how Boulder County has managed to avoid the worst of a state and nationwide Hepatitis A outbreak.

Dr. Tom Campbell to lead scientific review group on HIV

Dr. Tom Campbell has been nominated to lead the new Section Review Group of the NIH-CDC-HIVMA-/IDSA Guidelines for Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV.

Dr. Kristine Erlandson Announced as Outstanding Early Career Scholar

The University of Colorado Department of Medicine has selected the 2017 recipients for its Outstanding Early Career Scholar Program, HIV/AIDS researcher Kristine Erlandson, MD, and cardiology researcher Kunhua Song, PhD. The program aims to accelerate the careers of promising researchers in the Department of Medicine.

Santiago and Wilson labs frame the gene expression landscape of HIV-1 infected gut T cells exposed to enteric bacteria February 2017

Broncos fever is spreading through Denver and beyond! Have you been exposed? Dr. Michelle Barron talks about the fandemic

Dr. David Beckham discusses his role in the fight against the Zika Virus with the Aurora Sentinel

Dr. Kejun Guo highlighted as being a successful international scholar

Dr. David Wyles, New ID Division Chief at Denver Health

Professor Dinarello publishes review on inflammation and arthritis in Nature Reviews Rheumatology.
Dr. Kristine Erlandson received 2016 ACTG John Carey Young Investigator Award

Dr. David Beckham discusses details surrounding the Zika virus

Arjun Srinivasan, MD, of the CDC, presented a national update on antibiotic stewardship. Dr. Norihiro Yogo, diretor of antimicrobial stewardship at UCH, and Matt Miller, PharmD, were mentioned due to their involvement in developing guidelines for treating common infections

Dr. Michelle Barron discusses mosquito prevention in an article featured in the Denver Post

Q & A with Dr. Michelle Barron- featured on CU Medicine Today through the School of Medicine

Dr. Jose Castillo-Mancilla selected as a Department of Medicine 2016 Rising Star

Dr. Bill Burman, Director of Denver Public Health, named interim CEO of Denver Health

Poeschla laboratory reports newtransgenic model of stably augmented innate immunity in PLoS Pathogens

Dr. Connnie Price named CMO at Denver Health

DOM’s Richard Johnson and Dr.Eric Poeschla Elected to the Association of American Physicians

Beckham Lab discovers that alpha-synuclein, the protein that causes Parkinson’s disease, functions as a neuron-specific restriction factor to inhibit viral infections in the brain

Connick Lab reports novel findings on the roles of follicular regulatory T cells in HIV and SIV disease in Nature Communications

Dr. Elizabeth Connick invited to serve on the Office of AIDS Research Advisory Council

Wilson lab reports in Mucosal Immunology that gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection

Santiago and Wilson Labs report on the role of Interferon-α Subtypes in mucosal HIV-1 Infection

Dr. Cara Wilson appointed DOM Vice Chair for Faculty Development

Dr. Charles Dinarello Named University Distinguished Professor

Dr. Thomas Campbell Awarded Excellence in Global Health

Dr. Charles Dinarello Receives Lifetime Achievement Award

Charles Dinarello Receives Honorary Doctorate

Welcome to the Division of Infectious Diseases at the University of Colorado School of Medicine. This message is addressed to our colleagues, patients and members of the public with an interest in the problems and challenges of infectious diseases.

Our faculty, more than 70 and growing, take care of patients with infectious diseases in the mountain west and across the world, do scientific research on major infectious disease (ID) health problems, and educate the next generation of physicians and scientists in our field.

We work mainly at three sites located across the Denver metropolitan area:

1. The Anschutz Medical Campus (AMC). The AMC, which contains the School of Medicine (SOM) and is located in Aurora, just east of the Denver city line, was built to accommodate the growth of the SOM and fulfill its need for cutting edge facilities for research, education, and clinical missions. Many of the Infectious Diseases Division faculty are located physically in Research Complex 2 in the research quadrangle, where we have state of the art laboratories and bio-containment facilities for work with infectious agents. AMC ID physicians, physician assistants and nurse... practitioners take care of hospitalized patients in the University of Colorado Hospital (UCH). We take care of outpatients in our Infectious Disease Group Practice (IDGP) in the UCH outpatient pavilion.

2. Denver Health (DH). This municipal, integrated model public health care system serves a broad range of patients in Colorado, with education and research as two of its strategic pillars. DH is comprised of the Denver Health Medical Center (DHMC), a community health program with 8 centers and 16 school-based clinics in Denver, and the City and County health department (Denver Public Health, DPH). Infectious Diseases faculty are located in both DPH and the Department of Medicine of DHMC. Denver Public Health clinics include the ID Clinic and Center for Positive Health (HIV), the Denver Metro Tuberculosis (TB) Clinic serving the 7-county Metro area for diagnosis and treatment of TB and latent TB infection, and the Immunization and Travel Clinic (over 21,000 vaccinations to 10,000 patients per year). DHMC, in partnership with the Colorado Department of Health and Environment, is one of nine designated regional Ebola and other special pathogen treatment centers in the U.S.

Recent Publications

Use of Procalcitonin to Guide Discontinuation of Antimicrobial Therapy in Patients with Persistent Intra-Abdominal Collections: A Case Series. Motoa G, Pate A, Franco-Paredes C, Chastain DB, Henao-Martínez AF, Hojat L. Case Rep Infect Dis. 2020 Jan 9;2020:6342180. doi: 10.1155/2020/6342180. eCollection 2020.PMID: 32158570

COVID-19 in Latin America: The implications of the first confirmed case in Brazil.
Rodriguez-Morales AJ, Gallego V, Escalera-Antezana JP, Méndez CA, Zambrano LI, Franco-Paredes C, Suárez JA, Rodriguez-Enciso HD, Balbin-Ramon GJ, Savio-Larriera E, Risquez A, Cimerman S. Travel Med Infect Dis. 2020 Feb 29:101613. doi: 10.1016/j.tmaid.2020.101613. [Epub ahead of print] No abstract available. PMID: 32126292

Antibiotic Prescribing Patterns for Acute Otitis Media for Children 2 Years and Older.
Frost HM, Becker LF, Knepper BC, Shihadeh KC, Jenkins TC. J Pediatr. 2020 Feb 25. pii: S0022-3476(20)30116-5. doi: 10.1016/j.jpeds.2020.01.045. [Epub ahead of print] PMID: 32111379 [PubMed - as supplied by publisher]

Antiretroviral therapy initiation is associated with decreased visceral and subcutaneous adipose tissue density in people living with HIV.
Debroy P, Lake JE, Moser C, Olefsky M, Erlandson KM, Scherzinger A, Stein JH, Currier JS, Brown TT, McComsey GA. Clin Infect Dis. 2020 Feb 28. pii: ciaa196. doi: 10.1093/cid/ciaa196. [Epub ahead of print]. PMID: 32107532

Risk Factors for Weight Gain Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy.
Lake JE, Wu K, Bares SH, Debroy P, Godfrey C, Koethe JR, McComsey GA, Palella FJ Jr, Tassiopoulos K, Erlandson KM; ACTG A5322 Study Team. Clin Infect Dis. 2020 Feb 26. pii: ciaa177. doi: 10.1093/cid/ciaa177. [Epub ahead of print] PMID: 32099991

The Impact of a Structured, Supervised Exercise Program on Daily Step Count in Sedentary Older Adults With and Without HIV.
Stabell AC, Wilson M, Jankowski CM, MaWhinney S, Erlandson KM. J Acquir Immune Defic Syndr. 2020 Feb 20. doi: 10.1097/QAI.0000000000002326. [Epub ahead of print] PMID: 32084050

Bile Acid Sequestration Reverses Liver Injury and Prevents Progression of NASH in Western Diet-Fed Mice.
Takahashi S, Luo Y, Ranjit S, Xie C, Libby AE, Orlicky DJ, Dvornikov A, Wang XX, Myakala K, Jones BA, Bhasin K, Wang D, McManaman JL, Krausz KW, Gratton E, Ir D, Robertson CE, Frank DN, Gonzalez FJ, Levi M. J Biol Chem. 2020 Feb 19. pii: jbc.RA119.011913. doi: 10.1074/jbc.RA119.011913. [Epub ahead of print] PMID: 32075905

Guidelines for the treatment of latent tuberculosis infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020.
Sterling TR, Njie G, Zenner D, Cohn DL, Reves R, Ahmed A, Menzies D, Horsburgh CR,  Crane CM, Burgos M, LoBue P, Winston CA, Belknap R.   MMWR Recomm Rep 2020;69(No. RR-1):1–11.

A 31-year-old Micronesian Man With Shoulder Fungating Mass.
Canfield GS, Bock A, Mann S, Zimmer S, Somerset H, Franco-Paredes C, Wilson CC, Metter RB. Clin Infect Dis. 2020 Feb 14;70(5):973-975. doi: 10.1093/cid/ciz591. No abstract available.

Systemic Expression of a Viral RdRP Protects Against Retrovirus Infection and Disease.
Miller CM, Barrett BS, Chen J, Morrison JH, Radomile C, Santiago ML, Poeschla EM. J Virol. 2020 Feb 12. pii: JVI.00071-20. doi: 10.1128/JVI.00071-20. [Epub ahead of print]

A deadly feast: Elucidating the burden of orally acquired acute Chagas disease in Latin America - Public health and travel medicine importance.
Franco-Paredes C, Villamil-Gómez WE, Schultz J, Henao-Martínez AF, Parra-Henao G, Rassi A Jr, Rodríguez-Morales AJ, Suarez JA. Travel Med Infect Dis. 2020 Jan 29:101565. doi: 10.1016/j.tmaid.2020.101565. [Epub ahead of print] Review.

Preventing paralytic polio caused by vaccine-derived poliovirus type 2.
Franco-Paredes C, Santos-Preciado JI, Henao-Martinez AF, Rodriguez-Morales AJ, Carrasco P.< Lancet Infect Dis. 2020 Jan;20(1):21-22. doi: 10.1016/S1473-3099(19)30692-9. No abstract available. PMID:31 876491

Quantifying HIV-1-Mediated Gut CD4+ T Cell Death in the Lamina Propria Aggregate Culture (LPAC) Model.
Dillon, S. M., Guo, K., Castleman, M. J., Santiago, M. L. and Wilson, C. C. (2020). Bio-protocol. 10(2): e3486. DOI: 10.21769/BioProtoc.3486.

End-of-Life Planning Prior to Death Among People Living With HIV.
Abdo M, Ressler A, MaWhinney S, Jankowski C, Johnson SC, Erlandson KM. J Assoc Nurses AIDS Care. 2020 Feb 13. doi: 10.1097/JNC.0000000000000162. [Epub ahead of print]

Can gut microbiota of men who have sex with men influence HIV transmission?

Coleman SL, Neff CP, Li SX, Armstrong AJS, Schneider JM, Sen S, Fennimore B, Campbell TB, Lozupone CA, Palmer BE. Gut Microbes. 2020 Feb 10:1-10. doi: 10.1080/19490976.2019.1700756. [Epub ahead of print]

Physical activity and exercise to improve cardiovascular health for adults living with HIV.
Ozemek C, Erlandson KM, Jankowski CM. Prog Cardiovasc Dis. 2020 Jan 31. pii: S0033-0620(20)30027-X. doi: 10.1016/j.pcad.2020.01.005. [Epub ahead of print] Review.

Identification of Novel Genes and Biological Pathways That Overlap in Infectious and Nonallergic Diseases of the Upper and Lower Airways Using Network Analyses.
Baschal EE, Larson ED, Bootpetch Roberts TC, Pathak S, Frank G, Handley E, Dinwiddie J, Moloney M, Yoon PJ, Gubbels SP, Scholes MA, Cass SP, Jenkins HA, Frank DN, Yang IV, Schwartz DA, Ramakrishnan VR, Santos-Cortez RLP. Front Genet. 2020 Jan 17;10:1352. doi: 10.3389/fgene.2019.01352. eCollection 2019.

Falling Through the Cracks: Risk Factors for Becoming Lost to HIV Care After Incarceration in a Southern Jail.
Tiruneh YM, Li X, Bovell-Ammon B, Iroh P, Flanigan TP, Montague BT, Rich JD, Nijhawan AE. AIDS Behav. 2020 Jan 31. doi: 10.1007/s10461-020-02803-7. [Epub ahead of print]

Editorial: Forging new frontiers in HIV and aging.
Masters MC, Erlandson KM. Curr Opin HIV AIDS. 2020 Mar;15(2):81-82. doi: 10.1097/COH.0000000000000610. No abstract available.

Fusobacterium necrophorum subsp. necrophorum Liver Abscess with Pylephlebitis: An Abdominal Variant of Lemierre's Syndrome.
Radovanovic N, Dumic I, Veselinovic M, Burger S, Milovanovic T, Nordstrom CW, Niendorf E, Ramanan P. Case Rep Infect Dis. 2020 Jan 13;2020:9237267. doi: 10.1155/2020/9237267. eCollection 2020.

Nutrimetabolomics reveals food-specific compounds in urine of adults consuming a DASH-style diet.
Reisdorph NA, Hendricks AE, Tang M, Doenges KA, Reisdorph RM, Tooker BC, Quinn K, Borengasser SJ, Nkrumah-Elie Y, Frank DN, Campbell WW, Krebs NF. Sci Rep. 2020 Jan 24;10(1):1157. doi: 10.1038/s41598-020-57979-8.

HIV, aging, and adherence: an update and future directions.
Mann SC, Castillo-Mancilla JR. Curr Opin HIV AIDS. 2020 Mar;15(2):134-141. doi: 10.1097/COH.0000000000000615.

Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint.
Giron LB, Papasavvas E, Azzoni L, Yin X, Anzurez A, Damra M, Mounzer K, Kostman JR, Sanne I, Firnhaber CS, Tateno H, Liu Q, Montaner LJ, Abdel-Mohsen M. AIDS. 2020 Jan 17. doi: 10.1097/QAD.0000000000002476. [Epub ahead of print]

Obese adolescents with PCOS have altered biodiversity and relative abundance in gastrointestinal microbiota.
Jobira B, Frank DN, Pyle L, Silveira LJ, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. J Clin Endocrinol Metab. 2020 Jan 23. pii: dgz263. doi: 10.1210/clinem/dgz263. [Epub ahead of print]

Roles of Candida albicans Mig1 and Mig2 in glucose repression, pathogenicity traits, and SNF1 essentiality.
Lagree K, Woolford CA, Huang MY, May G, McManus CJ, Solis NV, Filler SG, Mitchell AP. PLoS Genet. 2020 Jan 21;16(1):e1008582. doi: 10.1371/journal.pgen.1008582. eCollection 2020 Jan.

 

Liver Transplantation for Decompensated Cirrhosis Secondary to Telomerase Reverse Transcriptase (TERT) Mutation.
Kolb JM, Conzen K, Wachs M, Crossno J Jr, McMahon B, Abidi MZ, Pomfret EA, Kriss M. Hepatology. 2020 Jan 14. doi: 10.1002/hep.31111. [Epub ahead of print]

HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cells.
Ickler J, Francois S, Widera M, Santiago ML, Dittmer U, Sutter K. PLoS One. 2020 Jan 14;15(1):e0218905. doi: 10.1371/journal.pone.0218905. eCollection 2020.

A multicenter randomized placebo controlled trial of rifampin to reduce pedal amputations for osteomyelitis in veterans with diabetes (VA INTREPID).
Bessesen MT, Doros G, Henrie AM, Harrington KM, Hermos JA, Bonomo RA, Ferguson RE, Huang GD, Brown ST. BMC Infect Dis. 2020 Jan 8;20(1):23. doi: 10.1186/s12879-019-4751-3.

Higher acuity resource utilization with older age and poorer HIV control in adolescents and young adults in the HIV Research Network.
Neilan AM, Lu F, Gebo KA, Diaz-Reyes R, Huang M, Parker RA, Karalius B, Patel K, Voss C, Ciaranello AL, Agwu AL. J Acquir Immune Defic Syndr. 2020 Jan 3. doi: 10.1097/QAI.0000000000002280. [Epub ahead of print]

What is the collective effect of aging and HIV on the gut microbiome?
Dillon SM, Wilson CC. Curr Opin HIV AIDS. 2020 Mar;15(2):94-100. doi: 10.1097/COH.0000000000000611.

Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019.
Chand S, Thapa S, Kon S, Johnson SC, Poeschla EM, Franco-Paredes C, Rodríguez-Morales AJ, Mattar S, Henao-Martínez AF. Emerg Infect Dis. 2020 Feb;26(2):383-385. doi: 10.3201/eid2602.191349. PMID: 31961310

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