I am a physician scientist and our research spans from basic to translational to clinical research projects focused on neuroendocrinology, the reproductive system and endocrine neoplasia including pituitary and adrenal tumors.
Basic research studies: Our lab is interested in the control of the
reproductive axis. We study the development and function of the GnRH
neuronal system, control by peptide and steroid hormones, regulation of
neuronal migration and epigenetic modulation. Insight into this system
will give clues to understanding the normal control of puberty and
causes of hypogonadism in men and amenorrhea and infertility in women.
These studies will lead to better understanding of how hormones work and
new treatment options for our patients.
A new translational area of interest for the lab is to understand
what causes pituitary and adrenal tumors and cancer. Pituitary tumors
present with hormone excess or hormone deficiencies, cause vision
problems, are locally invasive and recur. Using gene arrays we have
identified novel genes involved in pituitary tumors causing
proliferation, migration and invasion. Study of human tumors and use of
mouse models and cell systems may give new clinical biomarkers for
aggressiveness and lead to new treatments for our patients. Adrenal
cancer is a rare but devastating disease and our new interdisciplinary
research to study human tumor samples, develop new cell lines and models
will bring new therapies for our patients.
Additional clinical research projects focus on new treatments for hormone deficiencies or excess including: weekly Growth hormone therapy, new treatments for pituitary tumors and adrenal tumors.