1
To test the novel combination therapy of taxanes and inhibitors of the spindle assembly checkpoint pathway in preclinical models of anaplastic thyroid cancer
This lab is currently NIH funded - R01 CA233546
Haugen/French Lab
Professor
Dr. Haugen is a physician-scientist who sees patients with thyroid cancer and does basic/translational and clinical research on thyroid cancer therapeutics. More recently, his research group and collaborators have been using multi-omic approaches and single cell RNA sequencing to better understand advanced thyroid cancer in humans and animal models.
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Associate Professor
Dr. French in an immunologist who investigates the immune response in advanced thyroid cancers using both human tumors and mouse models.
Research Topics
Here are the research topics for the Haugen Lab:
2
To determine the effects of metabolism and sex in thyroid cancer progression using human studies and animal models.
3
To explore complementary therapies to BRAF inihibitor + MEK inhibitor (in BRAF mutated tumors) and MEK inhibitor in (in RAS mutated tumors) to improve efficacy of these therapies
The experiments use transgenic mouse models and single cell sequencing approaches.
Here are the research topics for the French Lab:
1
Characterizing the T cell response in human thyroid tumors. We expand tumor-infiltrating T cells from thyroid tumors for TCR clonality and antigen specificity studies
2
Investigating immune-modulating therapies for advanced thyroid cancers in preclinical mouse models and clinical trials
Lab Personnel
| Haugen/French Lab Personnel | |
Vibha Sharma, PhD Research Associate | |
|
Uma Pugazhenthi Research Laboratory Intermediate Professional |
Jacob Calhoun Research Laboratory Intermediate Professional | |
Amanda LaGreca, MD Assistant Professor | |
Nikita Pozdeyev, MD, PhD Assistant Professor | |
 |
Min-Ji Jeon, MD, PhD Visiting Research Scholar |