investigation of molecular mechanisms and targeted therapies is
critical to help us understand the causes of thyroid cancer, how the
tumor grows and spreads, and how we can find new ways to treat advanced
disease for which there is currently no cure. The deregulation of
protein kinases plays a major role in promoting tumorigenesis in the
majority of human cancers, including thyroid cancer, and targeting this
deregulated activity has led to major breakthroughs in cancer therapy.
The goals of Dr. Rebecca Schweppe’s
are to understand the regulation and function of deregulated kinase
pathways in thyroid cancer in order to develop more effective
therapies. We use translational approaches using cell lines derived
from thyroid tumors to understand why some tumors are sensitive or
resistant to different kinase-directed therapies, with the goal of
identifying predictive biomarkers of response, and improving clinical
responses. Ultimately, these studies will identify rational and more
specific therapies for patients with advanced thyroid cancer.