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Welcome to Biochemistry and Molecular Genetics
Julia Promisel Cooper, Chair
As biochemists and molecular geneticists, we are in the midst of an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell’s machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.
Maximal synergy and depth of thinking require an open, vibrant research environment in which people of all backgrounds thrive. We are passionately devoted to enhancing diversity and upholding uncompromised equity and anti-racism. These principles, along with the close proximity of BMG to other outstanding basic and clinical departments as well as several hospitals, vastly enhance our opportunities for collaboration and translation of paradigm-shifting basic discoveries to the clinic and beyond.
Research Areas
Highlighted Recent Publications
A viral RNA hijacks host machinery using dynamic conformational changes of a tRNA-like structure
Kieft Lab – November 2021 - Science
Identification and Development of Therapeutics for COVID-19
Greene Lab – November 2021 – mSystems
Greene Lab – October 2021 – mSystems
Cells with cancer-associated mutations overtake our tissues as we age
DeGregori Lab – October 2021 – Aging and Cancer
Vögeli Lab – September 2021 – Journal of the American Chemical Society
Shared properties and singularities of exoribonuclease-resistant RNAs in viruses
Kieft Lab – July 2021 – Computational and Structural Biotechnology Journal
Jagannathan Lab – July 2021 – RNA Journal
DeGregori Lab – June 2021 – Journal of Experimental Medicine
RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells
Mukherjee Lab – June 2021 – RNA Journal
The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region
Eisenmesser Lab – June 2021 – Journal of Molecular Biology
Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B
Eisenmesser Lab – May 2021 – Frontiers in Molecular Biosciences
Establishing RNA-RNA interactions remodels lncRNA structure and promotes PRC2 activity
Johnson Lab – April 2021 – Science Advances
Cooperative binding between distant transcription factors is a hallmark of active enhancers
Ramachandran Lab – April 2021 – Molecular Cell
Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8
Cooper Lab – March 2021 - Nature
Bentley Lab – February 2021 – Molecular Cell
Vögeli Lab - February 2021 - Nature Communications
Vögeli Lab - February 2021 - JMB
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News
Congratulations to all recent postdoc and graduate student awardees!
 | March 2022 Allison Porman Swain, Johnson Lab, has been awarded the K99/R00 Pathway to Independence Award from the NIH/NIDCR for her project “N6-methyladenosine in Candida white-opaque switching and oral infection”. Congratulations! |
 | December 2021 Jillian Ramos, Kieft Lab, has been awarded the 2022 RNA Society / Cold Spring Harbor Laboratory Press Award for Research Excellence by an Underrepresented Scientist! Congratulations! |
.jpeg?sfvrsn=e9e0e8b9_2 "CostantinoD (1)") | December 2021 David Costantino, Kieft Lab, was selected as the 2021 Steven Fadul Award winner! Congratulations! |
| November 2021 Jeff Kieft and Steve Bonilla were highlighted in the CU Anschutz Medical Campus News – “CU Anschutz Researchers Examine How a Viral RNA Changes Shape to Hijack Host Cells” |
 | November 2021 Elan Eisenmesser was awarded an R01 – "The oxidative state of the coenzyme modulates global dynamics and function within an enzyme family" – Congratulations! |
 | August 2021 Casey Greene was highlighted in the CU Anschutz Medical Campus News – “CU Researcher and Colleagues Offer Standards for Studies Using Machine Learning” |
 | July 2021 Matt Taliaferro and Chad Pearson (CDB) were awarded a $1 million research grant from the W. M. Keck Foundation. Congratulations! |
 | July 2021 Evan Morrison, Rissland Lab, was awarded the HHMI Gilliam fellowship. Congratulations! |
 | July 2021 Suja Jagannathan was awarded a FSHD Society grant. Congratulations! |
 | July 2021 Eric Pietras (Division of Hematology) and James DeGregori's publications were highlighted in the CU Anschutz Medical Campus News – “Two Studies by CU Cancer Center Researchers Explore Link Between Inflammation and Leukemia” |
 | June 2021 Natalie Davidson's, Greene Lab, publication - "Analysis of scientific journalism in Nature reveals gender and regional disparities in coverage" - was highlighted in a Nature editorial. |
 | June 2021 Olivia Rissland was awarded the NSF CAREER. Congratulations! |
 | June 2021 Jeff Kieft was awarded a CCTSI Pilot grant. Congratulations! |
| June 2021 Srinivas Ramachandran and James DeGregori were awarded a CU Cancer Center grant. Congratulations! |
 | June 2021 David Bentley shared his knowledge of mRNA technology in an interview with 9News – “After what scientists learned from COVID vaccines, a look at the future of mRNA technology” |
| May 2021 The Johnson, Mukherjee and Zhao labs were highlighted in the CU Anschutz Medical Campus News – “Are the COVID-19 Vaccines Good News for Cancer Care?” |
 | May 2021 Zoe O’Donoghue, Kieft Lab, has been selected to be one of the prestigious AAAS Science and Technology Policy Fellows in DC, starting this fall. Zoe has also been awarded the Graduate School Student Award for Distinguished Service. Congratulations! |
| May 2021 Melissa Haendel and Casey Greene were highlighted in the CU Anschutz Medical Campus News – “With a treasure trove of data, CU Anschutz gears up to strike gold” |
| » More News |
