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Welcome to Biochemistry and Molecular Genetics


Julia Promisel Cooper -- 500 x 600

Julia Promisel Cooper, Chair

As biochemists and molecular geneticists, we are in the midst of an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell’s machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.

Maximal synergy and depth of thinking require an open, vibrant research environment in which people of all backgrounds thrive. We are passionately devoted to enhancing diversity and upholding uncompromised equity and anti-racism. These principles, along with the close proximity of BMG to other outstanding basic and clinical departments as well as several hospitals, vastly enhance our opportunities for collaboration and translation of paradigm-shifting basic discoveries to the clinic and beyond.



Research Areas



Highlighted Recent Publications


Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

Asturias Lab

 

Physiologic RNA Targets and Refined Sequence Specificity of Coronavirus EndoU

Hesselberth Lab

 

The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold

Kieft Lab

 

Comprehensive Chromosome End Remodeling during Programmed DNA Elimination
Davis Lab

A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution
DeGregori Lab

The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition
Rissland Lab

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status
D’Alessandro and Hansen Lab

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences
Taliaferro Lab

Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis

Zhao Lab

The Driver of Extreme Human-Specific Olduvai Repeat Expansion Remains Highly Active in the Human Genome
Sikela Lab

Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism
Bentley Lab

A unified mechanism for intron and exon definition and back-splicing
Zhao Lab

Structural and functional analyses of an allosteric Eya2 phosphatase inhibitor that has on target effects in human lung cancer cells

Zhao Lab

A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
Asturias Lab

Solution NMR backbone assignment reveals interaction-free tumbling of human lineage-specific Olduvai protein domains
Vogeli Lab

» More Publications

News


Congratulations to all recent postdoc and graduate student fellowship awardees!

  
Casey Greene

November 2020

Welcome to BMG, Casey Greene! Dr. Greene will be the Director of the new Center for Health Artificial Intelligence and Chair of the Department of Biomedical Informatics, both of which will be forming over the next year.
Travis Nemkov

October 2020

Travis Nemkov’s (postdoc D'Alessandro lab) recent publication was highlighted in the CU Anschutz Medical Campus news - “Metabolomics: The Science Behind a Tour de France Winner

Angelo D'Alessandro

October 2020

Angelo D’Alessandro’s recent publication on the cover of Small was highlighted in Technology Networks - “New Technology Diagnoses Sickle Cell Disease in Record Time

Jay Hesselberth -- 60 x 70

October 2020

Jay Hesselberth was awarded a R01 NIH Director's Transformative Research Grant.

Angelo D'Alessandro

September 2020

Angelo D’Alessandro won the 2020 Innovation Award from the National Blood Foundation. Congratulations!

Richard Davis

September 2020

Dick Davis lab’s recent publication was highlighted in the Sept. 2020 issue of Cell Current Biology - "Genomes: Programmed DNA Elimination in a Parasitic Nematode"

Anna-Lena Steckelberg

August 2020

Congrats to Lena Steckelberg from the Kieft lab on joining the faculty of Columbia University Med Center Biochemistry and Mol. Biophysics Dept.!

Jay HesselberthJuly 2020
Jay Hesselberth was awarded an Advanced Industries Accelerator Spark Grant.
Matt TaliaferroJuly 2020
Matthew Taliaferro was awarded a Cancer League of Colorado Research Grant.
Angelo D'AlessandroJuly 2020
Angelo D’Alessandro’s research on COVID-19 was highlighted in Reuters.
Srinivas Ramachandran

June 2020
Srinivas Ramachandran was named a Pew-Stewart Scholar for Cancer Research.

Suja Jagannathan

June 2020
Suja Jagannathan was awarded the FSHD Society Young Investigator Award, honoring Suja’s ground-breaking work on the molecular mechanisms underlying this genetic muscle disease.

Hongjin ZhengApril 2020
Hongjin Zheng was awarded a R21 NIA grant.

Giovana Breda Veronezi

Allison Porman Swain

April 2020
Giovana Maria Breda Veronezi (Davis Lab) interviewed Allison Porman Swain (Johnson Lab) for the blog "Ciência pelos olhos delas" (“Science through her eyes”), linked to the University of Campinas, in Brazil.

 » More News

 


Outdoor sculpture on CU Anschutz during the fall

Prospective Graduate Students

Outdoor sphere sculpture on CU Anschutz campus

Prospective Postdoctoral Fellows