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Welcome to Biochemistry and Molecular Genetics


Julia Promisel Cooper -- 500 x 600

Julia Promisel Cooper, Chair

As biochemists and molecular geneticists, we are in the midst of an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell’s machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.

Maximal synergy and depth of thinking require an open, vibrant research environment in which people of all backgrounds thrive. We are passionately devoted to enhancing diversity and upholding uncompromised equity and anti-racism. These principles, along with the close proximity of BMG to other outstanding basic and clinical departments as well as several hospitals, vastly enhance our opportunities for collaboration and translation of paradigm-shifting basic discoveries to the clinic and beyond.



Research Areas



Highlighted Recent Publications


A viral RNA hijacks host machinery using dynamic conformational changes of a tRNA-like structure

Kieft Lab – November 2021 - Science

 

Identification and Development of Therapeutics for COVID-19

Greene Lab – November 2021 – mSystems

 

Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure

Greene Lab – October 2021 – mSystems

 

Cells with cancer-associated mutations overtake our tissues as we age

DeGregori Lab – October 2021 – Aging and Cancer

 

Reconstruction of Coupled Intra- and Interdomain Protein Motion from Nuclear and Electron Magnetic Resonance

Vögeli Lab – September 2021 – Journal of the American Chemical Society

 

Shared properties and singularities of exoribonuclease-resistant RNAs in viruses

Kieft Lab – July 2021 – Computational and Structural Biotechnology Journal

 

Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules

Jagannathan Lab – July 2021 – RNA Journal

 

Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors

DeGregori Lab – June 2021 – Journal of Experimental Medicine

 

RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells

Mukherjee Lab – June 2021 – RNA Journal

 

The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region

Eisenmesser Lab – June 2021 – Journal of Molecular Biology

 

Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B

Eisenmesser Lab – May 2021 – Frontiers in Molecular Biosciences

 

Establishing RNA-RNA interactions remodels lncRNA structure and promotes PRC2 activity

Johnson Lab – April 2021 – Science Advances

 

Cooperative binding between distant transcription factors is a hallmark of active enhancers

Ramachandran Lab – April 2021 – Molecular Cell

 

Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8

Cooper Lab – March 2021 - Nature

 

Alternative RNA structures formed during transcription depend on elongation rate and modify RNA processing

Bentley Lab – February 2021 – Molecular Cell

 

Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions

Vögeli Lab - February 2021 - Nature Communications

 

The disordered Spindly C-terminus interacts with RZZ subunits ROD-1 and ZWL-1 in the kinetochore through the same sites in C. elegans

Vögeli Lab - February 2021 - JMB



» More Publications


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Prospective Postdoctoral Scholars

 

Outdoor sculpture on CU Anschutz during the fall

Prospective Graduate Students

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Diversity, Equity & Inclusion

 

News


Congratulations to all recent postdoc and graduate student awardees!

  
Elan Eisenmesser

November 2021

Elan Eisenmesser was awarded an R01 – "The oxidative state of the coenzyme modulates global dynamics and function within an enzyme family" – Congratulations!

Casey Greene

August 2021

Casey Greene was highlighted in the CU Anschutz Medical Campus News – “CU Researcher and Colleagues Offer Standards for Studies Using Machine Learning

Matt Taliaferro -- 60 x 75

July 2021

Matt Taliaferro and Chad Pearson (CDB) were awarded a $1 million research grant from the W. M. Keck Foundation. Congratulations!

Evan Morrison

July 2021

Evan Morrison, Rissland Lab, was awarded the HHMI Gilliam fellowship. Congratulations!

Suja Jagannathan -- 60 x 75

July 2021

Suja Jagannathan was awarded a FSHD Society grant. Congratulations!

James DeGregori -- 60 x 75

July 2021

Eric Pietras (Division of Hematology) and James DeGregori's publications were highlighted in the CU Anschutz Medical Campus News – “Two Studies by CU Cancer Center Researchers Explore Link Between Inflammation and Leukemia

Natalie Davidson

June 2021

Natalie Davidson's, Greene Labpublication - "Analysis of scientific journalism in Nature reveals gender and regional disparities in coverage" - was highlighted in a Nature editorial.

Olivia Rissland -- 60 x 75

June 2021

Olivia Rissland was awarded the NSF CAREER. Congratulations!
Jeff Kieft -- 60 x 75

June 2021

Jeff Kieft was awarded a CCTSI Pilot grant. Congratulations!

Ramachandran 60 x 90

James DeGregori -- 60 x 75

June 2021

Srinivas Ramachandran and James DeGregori were awarded a CU Cancer Center grant. Congratulations!

David Bentley -- 60 x 80

June 2021

David Bentley shared his knowledge of mRNA technology in an interview with 9News – “After what scientists learned from COVID vaccines, a look at the future of mRNA technology

Aaron Johnson -- 60 x 70

Neelanjan Mukherjee -- 60 x 75

Rui Zhao -- 60 x 75

May 2021

The Johnson, Mukherjee and Zhao labs were highlighted in the CU Anschutz Medical Campus News – “Are the COVID-19 Vaccines Good News for Cancer Care?

odonoghueZoe

May 2021

Zoe O’Donoghue, Kieft Lab, has been selected to be one of the prestigious AAAS Science and Technology Policy Fellows in DC, starting this fall. Zoe has also been awarded the Graduate School Student Award for Distinguished Service. Congratulations!

Melissa Haendel

Casey Greene

May 2021

Melissa Haendel and Casey Greene were highlighted in the CU Anschutz Medical Campus News – “With a treasure trove of data, CU Anschutz gears up to strike gold

 » More News