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Welcome to Biochemistry and Molecular Genetics

Julia Promisel Cooper -- 500 x 600

Julia Promisel Cooper, Chair

As biochemists and molecular geneticists, we are in the midst of an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell’s machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.

Maximal synergy and depth of thinking require an open, vibrant research environment in which people of all backgrounds thrive. We are passionately devoted to enhancing diversity and upholding uncompromised equity and anti-racism. These principles, along with the close proximity of BMG to other outstanding basic and clinical departments as well as several hospitals, vastly enhance our opportunities for collaboration and translation of paradigm-shifting basic discoveries to the clinic and beyond.



Research Areas



Highlighted Recent Publications


Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation

Hae Park, Jeff Kieft, Mark Gregory, & James DeGregori - October 2022 - NIH

 

SAM1 domain of SASH1 harbors distinctive structural heterogeneity

Morkos Henen & Beat Vögeli - October 2022 - ScienceDirect

 

Atomic resolution protein allostery from the multi-state structure of a PDZ domain

Beat Vögeli - October 2022 - Nature Communications 

 

Promiscuity of response regulators for thioredoxin steers bacterial virulence

Morkos Henen & Beat Vögeli - October 2022 - Nature Communications 

 

Ligand-specific conformational change drives interdomain allostery in Pin1

Morkos Henen & Beat Vögeli - October 2022 - Nature Communications 

 

The pausing zone and control of RNA polymerase II elongation by Spt5: implications for the pause-release model 

Nova Fong, Ryan Sheridan, Srinivas Ramachandran, & David Bentley - October 2022 - ScienceDirect

 

High-throughput identification of RNA localization elements in neuronal cells

Ankita Arora, Matthew Taliaferro, & Charlie Moffatt - September 2022 - Oxford Academic

 

Ligand-specific conformational change drives interdomain allostery in Pin1

Morkos Henen & Beat Vogeli - August 2022 - Nature Communications 

 

Thoughts on how to think (and talk) about RNA structure

Quentin Vicens & Jeff Kieft - April 2022 - PNAS

» More Publications


More Information

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Prospective Postdoctoral Scholars

 

Outdoor sculpture on CU Anschutz during the fall

Prospective Graduate Students

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Diversity, Equity & Inclusion

 

News - 2022


Congratulations to all recent facultypostdoc, and graduate student awardees!

  
Rui Zhao -- 500 x 600

November 2022
Rui Zhao and Heide Ford received a 2022 AB Nexus Award with Dr. Wang (CU Boulder).

Jay Hesselberth -- 500 x 600November 2022
Jay Hesselberth
 received a 2022 AB Nexus Award with Dr. Kostov (CU Boulder).

James DeGregori -- 500 x 600

Harry Park -- 750 x 700

November 2022
AML research by James DeGregori, Harry Park, and the DeGregori Lab was highlighted in CU Anschutz Today.
Screen Shot 2022-06-17 at 3.57.43 PMSeptember 2022
Rachel Culp-Hill (D’Alessandro Lab) received a 2022 CU Anschutz Research Award for Trainee Research Excellence. Congratulations!
Jay Hesselberth -- 500 x 600September 2022
Jay Hesselberth received a 2022 CU Anschutz Research Award for Research Faculty Collaborator. Congratulations!

Quentin Vicens 60x70

Beat Vogeli -- 60 x 75

September 2022
Quentin Vicens and Beat Vogeli were awarded an NSF grant to study the structure and mechanism of Z-RNA recognition by ADAR1Congratulations!

Catherine Mussleman Crop compress 60x70

September 2022
Catherine Musselman and Christian Mosimann were awarded an NSF grant that was highlighted in the SOM NewsroomCongratulations!

Neelanjan Mukherjee -- 60 x 75August 2022
Neel Mukherjee has been awarded an NIGMS MIRA award. Congratulations!

Rishi Nageshan

Rahul Thadani

Julia Promisel Cooper -- 500 x 600

August 2022
Rishi Nageshan, Rahul Thadani, and Julie Cooper, Cooper Lab, were highlighted in a recent article with the SEA-PHAGES Summer Program. Congratulations! 
Jay Hesselberth -- 500 x 600July 2022
Jay Hesselberth and his team were awarded a 2022 ASPIRE Program Team Award for their research on Mechanisms of immune protection and pathology by lymph node stromal cells. Congratulations!

MorkosHenen

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Beat5

June 2022
Morkos Henen, Quentin Vicens, and Beat Vögeli were co-guest editors for a collection of articles aimed to present novel approaches, technologies, targets, and therapeutics in the area of drug discovery. Congratulations!

Elan Eisenmesser -- 500 x 600

Beat5

June 2022
Elan Eisenmesser and Beat Vogeli were awarded an R21 "The SARS-CoV-2 Nucleocapsid interactions with RNA and host cell cyclophilin-A". Congratulations!
 » More News