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Welcome to Biochemistry and Molecular Genetics


Julia Promisel Cooper -- 500 x 600

Julia Promisel Cooper, Chair

As biochemists and molecular geneticists, we are in the midst of an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell’s machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.

Maximal synergy and depth of thinking require an open, vibrant research environment in which people of all backgrounds thrive. We are passionately devoted to enhancing diversity and upholding uncompromised equity and anti-racism. These principles, along with the close proximity of BMG to other outstanding basic and clinical departments as well as several hospitals, vastly enhance our opportunities for collaboration and translation of paradigm-shifting basic discoveries to the clinic and beyond.



Research Areas



Highlighted Recent Publications


The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold

Kieft Lab

 

Comprehensive Chromosome End Remodeling during Programmed DNA Elimination
Davis Lab

A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution
DeGregori Lab

The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition
Rissland Lab

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status
D’Alessandro and Hansen Lab

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences
Taliaferro Lab

Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis

Zhao Lab

The Driver of Extreme Human-Specific Olduvai Repeat Expansion Remains Highly Active in the Human Genome
Sikela Lab

Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism
Bentley Lab

A unified mechanism for intron and exon definition and back-splicing
Zhao Lab

Structural and functional analyses of an allosteric Eya2 phosphatase inhibitor that has on target effects in human lung cancer cells

Zhao Lab

A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
Asturias Lab

Solution NMR backbone assignment reveals interaction-free tumbling of human lineage-specific Olduvai protein domains
Vogeli Lab

» More Publications

Upcoming Events


Friday Research Talks

September 25, 2020 | 11AM - 12PM 


Seminar Series

Coming Soon - October 2020!

News


Congratulations to all recent postdoc and graduate student fellowship awardees!

  
Richard Davis

September 2020

Dick Davis lab’s recent publication was highlighted in the Sept. 2020 issue of Current Biology.

Anna-Lena Steckelberg

August 2020

Congrats to Lena Steckelberg from the Kieft lab on joining the faculty of Columbia University Med Center Biochemistry and Mol. Biophysics Dept.!

Jay HesselberthJuly 2020
Jay Hesselberth was awarded an Advanced Industries Accelerator Spark Grant.
Matt TaliaferroJuly 2020
Matthew Taliaferro was awarded a Cancer League of Colorado Research Grant.
Angelo D'AlessandroJuly 2020
Angelo D’Alessandro’s research on COVID-19 was highlighted in Reuters.
Srinivas Ramachandran

June 2020
Srinivas Ramachandran was named a Pew-Stewart Scholar for Cancer Research.

Suja Jagannathan

June 2020
Suja Jagannathan was awarded the FSHD Society Young Investigator Award, honoring Suja’s ground-breaking work on the molecular mechanisms underlying this genetic muscle disease.

Hongjin ZhengApril 2020
Hongjin Zheng was awarded an R21 NIA grant.

Giovana Breda Veronezi

Allison Porman Swain

April 2020
Giovana Maria Breda Veronezi (Davis Lab) interviewed Allison Porman Swain (Johnson Lab) for the blog "Ciência pelos olhos delas" (“Science through her eyes”), linked to the University of Campinas, in Brazil.

Olivia Rissland

March 2020
Olivia Rissland was awarded an R21 NIAID grant.

DAlessandro -- 60 x 70March 2020
Angelo D'Alessandro was awarded an R21 NHLBI grant and an R01 NHLBI grant.
Aaron Johnson

March 2020
Aaron Johnson was awarded an NSF grant.

 » More News

 


Outdoor sculpture on CU Anschutz during the fall

Prospective Graduate Students

Outdoor sphere sculpture on CU Anschutz campus

Prospective Postdoctoral Fellows