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Welcome to Biochemistry and Molecular Genetics


Julia Promisel Cooper -- 500 x 600

Julia Promisel Cooper, Chair

As biochemists and molecular geneticists, we are in the midst of an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell’s machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.

Maximal synergy and depth of thinking require an open, vibrant research environment in which people of all backgrounds thrive. We are passionately devoted to enhancing diversity and upholding uncompromised equity and anti-racism. These principles, along with the close proximity of BMG to other outstanding basic and clinical departments as well as several hospitals, vastly enhance our opportunities for collaboration and translation of paradigm-shifting basic discoveries to the clinic and beyond.



Research Areas



Highlighted Recent Publications


Establishing RNA-RNA interactions remodels lncRNA structure and promotes PRC2 activity

Johnson Lab – April 2021 – Science Advances

 

Cooperative binding between distant transcription factors is a hallmark of active enhancers

Ramachandran Lab – April 2021 – Molecular Cell

 

Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8

Cooper Lab – March 2021 - Nature

 

Alternative RNA structures formed during transcription depend on elongation rate and modify RNA processing

Bentley Lab – February 2021 – Molecular Cell

 

Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions

Vögeli Lab - February 2021 - Nature Communications

 

The disordered Spindly C-terminus interacts with RZZ subunits ROD-1 and ZWL-1 in the kinetochore through the same sites in C. elegans

Vögeli Lab - February 2021 - JMB

 

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

Asturias Lab - October 2020 - Science

 

Physiologic RNA Targets and Refined Sequence Specificity of Coronavirus EndoU

Hesselberth Lab - September 2020 - RNA Journal

 

Comprehensive Chromosome End Remodeling during Programmed DNA Elimination
Davis Lab - September 2020 - Current Biology

 

The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold

Kieft Lab - August 2020 - RNA Journal


A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution
DeGregori Lab - July 2020 - Scientific Reports

The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition
Rissland Lab - June 2020 - eLife

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status
D’Alessandro Lab - June 2020 - JCI Insight

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences
Taliaferro Lab - June 2020 - eLife

Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis

Zhao Lab - June 2020 - Cancer Research 

» More Publications


Outdoor sphere sculpture on CU Anschutz campus

Prospective Postdoctoral Scholars

 

Outdoor sculpture on CU Anschutz during the fall

Prospective Graduate Students

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Diversity, Equity & Inclusion

 

News


Congratulations to all recent postdoc and graduate student awardees!

  

Ramachandran 60 x 90

Rao.Satya

April 2021

Srinivas Ramachandran and Satyanarayan Rao’s Molecular Cell publication was highlighted in the CU Anschutz Medical Campus News – “How transcription factors work together in cancer formation

CU Cancer Center Logo

April 2021

Multiple BMG CU Cancer Center Member's PNAS publication was highlighted in the CU Anschutz Medical Campus News - "A drug that can stop tumors from growing"

James Sikela -- 60 x 70

April 2021

Jim Sikela was awarded an Autism Speaks grant. Congratulations!

Melissa Haendel

March 2021

Welcome to BMG, Melissa Haendel! Dr. Haendel will be the Chief Research Informatics Officer for the Anschutz Medical Campus as well as a Professor in BMG.

David Pollock -- 60 x 70

March 2021

David Pollock contributed scientific expertise to the Washington Post article “An Accelerated cauldron of evolution: Covid-19 patients with cancer, HIV, may play a role in emergence of variant”.

DzieciatkowskaM

hainesJulie

March 2021

Monika Dzieciatkowska, Julie Haines, and Angelo D’Alessandro’s research was highlighted in the CU Anschutz Medical Campus News – “Scientists Discover Ways of Making Old Blood New Again

Elan Eisenmesser -- 60 x 75

March 2021

Elan Eisenmesser’s COVID-19 research was highlighted in the CU Anschutz Medical Campus news – “Researchers Target Nucleocapsid Protein to Combat COVID-19

James DeGregori -- 60 x 75

February 2021

James DeGregori’s research was highlighted in the CU Anschutz Medical Campus news - “The Impacts of Aging on Cancer

David Pollock -- 60 x 70

February 2021

David Pollock’s COVID-19 research was highlighted in the CU Anschutz Medical Campus news - “Coronavirus Mutates Fast; New Strain Can Arise in Single Patient

Steve Bonilla

February 2021

Steve Bonilla (Postdoctoral Scholar, Kieft Lab) was awarded the Howard Hughes Medical Institute Hanna Grey Fellowship. Congratulations!

Elan Eisenmesser -- 60 x 75

January 2021

Elan Eisenmesser’s recent streptococcus pneumoniae publication was highlighted in Nature Communications Focus Structural biology, biochemistry and biophysics.

Quentin Vicens 60x70

Jeff Kieft -- 60 x 75

December 2020

Quentin Vicens (Research Asst. Prof.) and Jeffrey Kieft were awarded an NIH R21 from NIAID to study xrRNAs in the alphavirus supergroup. Congratulations! 

 » More News