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Welcome to Biochemistry and Molecular Genetics
Julia Promisel Cooper, Chair
As biochemists and molecular geneticists, we are in the midst of an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell’s machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.
Maximal synergy and depth of thinking require an open, vibrant research environment in which people of all backgrounds thrive. We are passionately devoted to enhancing diversity and upholding uncompromised equity and anti-racism. These principles, along with the close proximity of BMG to other outstanding basic and clinical departments as well as several hospitals, vastly enhance our opportunities for collaboration and translation of paradigm-shifting basic discoveries to the clinic and beyond.
Research Areas
Highlighted Recent Publications
Vögeli and Kieft Lab
Vögeli Lab
Structural and mechanistic bases for a potent HIV-1 capsid inhibitor
Asturias Lab
Physiologic RNA Targets and Refined Sequence Specificity of Coronavirus EndoU
Hesselberth Lab
Kieft Lab
Comprehensive Chromosome End Remodeling during Programmed DNA Elimination
Davis Lab
A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution
DeGregori Lab
COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status
D’Alessandro and Hansen Lab
Zhao Lab
A unified mechanism for intron and exon definition and back-splicing
Zhao Lab
Zhao Lab
A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
Asturias Lab
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Friday Research Talks
| 11:00 AM - 12:00 PM
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BMG Seminar - Manny Ascano
| 12:00 PM - 01:00 PM
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Friday Research Talks
| 11:00 AM - 12:00 PM
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BMG Chalk Talk - Jay Hesselberth
| 12:00 PM - 01:00 PM
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Embodying Equity Workshop
| 10:00 AM - 12:30 PM
News
Congratulations to all recent postdoc and graduate student awardees!
 | February 2021 James DeGregori’s research was highlighted in the CU Anschutz Medical Campus news - “The Impacts of Aging on Cancer” |
 | February 2021 David Pollock’s COVID-19 research was highlighted in the CU Anschutz Medical Campus news - “Coronavirus Mutates Fast; New Strain Can Arise in Single Patient” |
 | February 2021 Steve Bonilla (Postdoctoral Scholar, Kieft Lab) was awarded the Howard Hughes Medical Institute Hanna Grey Fellowship. Congratulations! |
| December 2020 Quentin Vicens (Research Asst. Prof.) and Jeffrey Kieft were awarded an NIH R21 from NIAID to study xrRNAs in the alphavirus supergroup. Congratulations! |
 | November 2020 Angelo D’Alessandro’s COVID-19 red blood cell research was highlighted in the CU Anschutz Medical Campus news - “Attack on Red Blood Cells a Prime Suspect in COVID’s Debilitating Effects” |
 | November 2020 Welcome to BMG, Casey Greene! Dr. Greene will be the Director of the new Center for Health Artificial Intelligence and Chair of the Department of Biomedical Informatics, both of which will be forming over the next year. |
 | October 2020 Travis Nemkov’s (postdoc D'Alessandro lab) recent publication was highlighted in the CU Anschutz Medical Campus news - “Metabolomics: The Science Behind a Tour de France Winner” |
 | October 2020 Suja Jagannathan was awarded an RNA Society Colorado RNA Club grant. Congratulations! |
 | October 2020 Angelo D’Alessandro’s recent publication on the cover of Small was highlighted in Technology Networks - “New Technology Diagnoses Sickle Cell Disease in Record Time” |
 | October 2020 Jay Hesselberth was awarded a R01 NIH Director's Transformative Research grant. Congratulations! |
| September 2020 James DeGregori was awarded a shared R01 NICHD grant with Andrew Thorburn (Dept. of Pharmacology). Congratulations! |
 | September 2020 Francisco Asturias was awarded a shared R01 NIAID grant with Mamuka Kvaratskhelia (Division of Infectious Diseases). Congratulations! |
| September 2020 Angelo D’Alessandro won the 2020 Innovation Award from the National Blood Foundation. Congratulations! |
 | September 2020 Dick Davis lab’s recent publication was highlighted in the Sept. 2020 issue of Cell Current Biology - "Genomes: Programmed DNA Elimination in a Parasitic Nematode" |
 | August 2020 Congrats to Lena Steckelberg from the Kieft lab on joining the faculty of Columbia University Med Center Biochemistry and Mol. Biophysics Dept.! |
| » More News |
