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Welcome to Biochemistry and Molecular Genetics
Julia Promisel Cooper, Chair
As biochemists and molecular geneticists, we are in the midst of an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell’s machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.
Maximal synergy and depth of thinking require an open, vibrant research environment in which people of all backgrounds thrive. We are passionately devoted to enhancing diversity and upholding uncompromised equity and anti-racism. These principles, along with the close proximity of BMG to other outstanding basic and clinical departments as well as several hospitals, vastly enhance our opportunities for collaboration and translation of paradigm-shifting basic discoveries to the clinic and beyond.
Research Areas
Highlighted Recent Publications
Establishing RNA-RNA interactions remodels lncRNA structure and promotes PRC2 activity
Johnson Lab – April 2021 – Science Advances
Cooperative binding between distant transcription factors is a hallmark of active enhancers
Ramachandran Lab – April 2021 – Molecular Cell
Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8
Cooper Lab – March 2021 - Nature
Bentley Lab – February 2021 – Molecular Cell
Vögeli Lab - February 2021 - Nature Communications
Vögeli Lab - February 2021 - JMB
Structural and mechanistic bases for a potent HIV-1 capsid inhibitor
Asturias Lab - October 2020 - Science
Physiologic RNA Targets and Refined Sequence Specificity of Coronavirus EndoU
Hesselberth Lab - September 2020 - RNA Journal
Comprehensive Chromosome End Remodeling during Programmed DNA Elimination
Davis Lab - September 2020 - Current Biology
Kieft Lab - August 2020 - RNA Journal
A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution
DeGregori Lab - July 2020 - Scientific Reports
The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition
Rissland Lab - June 2020 - eLife
COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status
D’Alessandro Lab - June 2020 - JCI Insight
FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences
Taliaferro Lab - June 2020 - eLife
Zhao Lab - June 2020 - Cancer Research
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End of Year DEAR Committee Meeting
| 10:30 AM - 12:00 PM
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Friday Research Talks
| 11:00 AM - 12:00 PM
News
Congratulations to all recent postdoc and graduate student awardees!
 | June 2021 David Bentley shared his knowledge of mRNA technology in an interview with 9News – “After what scientists learned from COVID vaccines, a look at the future of mRNA technology” |
| May 2021 The Johnson, Mukherjee and Zhao labs were highlighted in the CU Anschutz Medical Campus News – “Are the COVID-19 Vaccines Good News for Cancer Care?” |
 | May 2021 Zoe O’Donoghue, Kieft Lab, has been selected to be one of the prestigious AAAS Science and Technology Policy Fellows in DC, starting this fall. Zoe has also been awarded the Graduate School Student Award for Distinguished Service. Congratulations! |
| May 2021 Melissa Haendel and Casey Greene were highlighted in the CU Anschutz Medical Campus News – “With a treasure trove of data, CU Anschutz gears up to strike gold” |
| April 2021 Srinivas Ramachandran and Satyanarayan Rao’s Molecular Cell publication was highlighted in the CU Anschutz Medical Campus News – “How transcription factors work together in cancer formation” |
 | April 2021 Multiple BMG CU Cancer Center Member's PNAS publication was highlighted in the CU Anschutz Medical Campus News - "A drug that can stop tumors from growing" |
 | April 2021 Jim Sikela was awarded an Autism Speaks grant. Congratulations! |
 | March 2021 Welcome to BMG, Melissa Haendel! Dr. Haendel will be the Chief Research Informatics Officer for the Anschutz Medical Campus as well as a Professor in BMG. |
 | March 2021 David Pollock contributed scientific expertise to the Washington Post article “An Accelerated cauldron of evolution: Covid-19 patients with cancer, HIV, may play a role in emergence of variant”. |
| March 2021 Monika Dzieciatkowska, Julie Haines, and Angelo D’Alessandro’s research was highlighted in the CU Anschutz Medical Campus News – “Scientists Discover Ways of Making Old Blood New Again” |
 | March 2021 Elan Eisenmesser’s COVID-19 research was highlighted in the CU Anschutz Medical Campus news – “Researchers Target Nucleocapsid Protein to Combat COVID-19” |
 | February 2021 James DeGregori’s research was highlighted in the CU Anschutz Medical Campus news - “The Impacts of Aging on Cancer” |
| February 2021 David Pollock’s COVID-19 research was highlighted in the CU Anschutz Medical Campus news - “Coronavirus Mutates Fast; New Strain Can Arise in Single Patient” |
 | February 2021 Steve Bonilla (Postdoctoral Scholar, Kieft Lab) was awarded the Howard Hughes Medical Institute Hanna Grey Fellowship. Congratulations! |
| » More News |
