Highlighted Publications Archive

The Driver of Extreme Human-Specific Olduvai Repeat Expansion Remains Highly Active in the Human Genome

Sikela Lab - January 2020 - Genetics

Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism

Bentley Lab - December 2019 - Molecular Cell

A unified mechanism for intron and exon definition and back-splicing

Zhao Lab - September 2019 – Nature

Structural and functional analyses of an allosteric Eya2 phosphatase inhibitor that has on target effects in human lung cancer cells

Zhao Lab - September 2019 - Mol Cancer Ther

A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
Asturias Lab - August 2019 - Cell 

Solution NMR backbone assignment reveals interaction-free tumbling of human lineage-specific Olduvai protein domains

Vögeli Lab - July 2019 - Biomolecular NMR Assignments

Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism
Bentley Lab

A unified mechanism for intron and exon definition and back-splicing
Zhao Lab

Structural and functional analyses of an allosteric Eya2 phosphatase inhibitor that has on target effects in human lung cancer cells

Zhao Lab

A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
Asturias Lab

Solution NMR backbone assignment reveals interaction-free tumbling of human lineage-specific Olduvai protein domains
Vögeli Lab

​Coding regions affect mRNA stability in human cells
Rissland Lab

​Widespread backtracking by RNA Pol II is a major effector of gene activation, 5’ pause release, termination, and transcription elongation rate
Bentley Lab

​Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response
Hesselberth Lab

​Anti-Aging Discovery Could Lead to Restorative Skin Treatments
DeGregori Lab

​Paired involvement of human-specific Olduvai domains and NOTCH2NL genes in human brain evolution
Davis and Sikela Labs

​A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport
Vögeli Lab

The comparative genomics and complex population history of Papio baboons​
Sikela Lab

A Third Linear Association Between Olduvai (DUF1220) Copy Number and Severity of the Classic Symptoms of Inherited Autism​
Davis and Sikela Labs

Scientists are untangling our bodies’ genetic “double-edged swords”
Sikela Lab

Comparative genome analysis of programmed DNA elimination in nematodes
Davis Lab

Mitochondrial accumulation of amyloid beta (Aβ) peptides requires TOMM22 as a main Aβ receptor in yeast.​
Zheng Lab

Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression

Zhao Lab

Transcription elongation rate affects nascent histone pre-mRNA folding and 3' end processing
Bentley Lab

Genomic trade‑ofs: are autism and schizophrenia the steep price of the human brain?
Sikela Lab

Recruitment and allosteric stimulation of a histone-deubiquitinating enzyme during heterochromatin assembly.
Johnson Lab

The interplay of histone H2B ubiquitination with budding and fission yeast heterochromatin.
Johnson Lab

Sequence entropy of folding and the absolute rate of amino acid substitutions​
Pollock Lab

Structure of the yeast spliceosomal postcatalytic P complex​
Zhao​ Lab

NOE-Derived Methyl Distances from a 360 kDa Proteasome Complex​
Vögeli Lab

Genetic bypass of essential RNA repair enzymes in budding yeast
Hesselberth Lab

Localization of Cdc7 Protein Kinase During DNA Replication in Saccharomyces cerevisiae​
Sclafani and Hesselberth​​ Labs

Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease​
Kieft​ Lab

Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling
Kieft​ Lab

Mediator structure and rearrangements required for holoenzyme formation
Asturias Lab

RNA Pol II Dynamics Modulate Co-transcriptional Chromatin Modification, CTD Phosphorylation, and Transcriptional Direction
Bentley Lab

A novel role for yeast casein kinases in glucose sensing and signaling
Johnston Lab

Changing mutational and adaptive landscapes and the genesis of cancer​​
DeGregori Lab

Networks of Dynamic Allostery Regulate Enzyme Function​
Eisenmesser Lab

​​Silencing of Germline-Expressed Genes by DNA Elimination in Somatic Cells
Davis Lab

An RNA matchmaker protein re​gulates the activity of the long noncoding RNA HOTAIR
Johnson Lab

Selectable one-step PCR-mediated integration of a degron for rapid depletion of endogenous human proteins.
Bentley Lab

Three-way junction conformation dictates self-association of phage packaging RNAs.
Kieft Lab

How to write titles that ​tempt
Johnson Lab

DUF1220 copy number is associated with schizophrenia risk and severity: implications for understanding autism and schizophrenia as related diseases
Sikela​​  Lab