Genomics, Proteomics and Metabolomics



DNA has the blueprint of life. Enumerating the bases that make up the genomes of all organisms continues to be a monumental effort in biology, in a quest to understand life better. The ability to read out sequences cheaply and in a massively parallel manner has changed the way we do biology. Fundamentally, it gives us the ultimate picture of our makeup and our relationships with all the other species. Genomes are a snapshot of evolving species, helping us understand the evolutionary processes and adaptation. Mutations lead to many human diseases. Sequencing can not only help diagnose diseases, but also aid in understanding the molecular mechanisms underlying disease states.

Perhaps the most unexpected use of genomics has been its use as a counting device for DNA and RNA, furthering the study of molecular biology at a systems scale. Apart from counting RNA by converting them into DNA, genomics also has been instrumental in characterizing genomic protection by proteins that control which regions of the genome are active. Sensitive measurement of RNA has enabled catching RNA polymerases in the act of transcribing the genome . Research in our Department has pushed genomics beyond usual molecular biology applications by developing methods to sensitively measure enzyme activity in single cells . Our department is at the cutting edge in developing genomic technologies with applications ranging from structural epigenomics to how RNA modifications affect the aggressiveness of a cancer cell, to RNA stability, function, and structure.

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Faculty with Research in this Area


David Bentley -- 500 x 600

David Bentley, PhD

Messenger RNA Production by RNA polymerase II

Julia Promisel Cooper -- 500 x 600

Julia Promisel Cooper, PhD

An expanded view of telomeres and their roles in safeguarding genome stability

Angelo DAlessandro -- 500 x 600

Angelo D'Alessandro, PhD

Cancer metabolism and (red) blood cell biology

Richard Davis -- 500 x 600

Richard Davis, PhD

Programmed DNA elimination, novel RNAs, and RNA metabolism

James DeGregori -- 500 x 600

James DeGregori, PhD

Cancer: understanding its evolution and targeting its dependencies

Kirk Hansen -- 500 x 600

Kirk Hansen, PhD

Quantitative and functional proteomics, extracellular matrix processing and organization

Jay Hesselberth -- 500 x 600

Jay Hesselberth, PhD

Nucleic acid repair

Suja Jagannathan -- 500 x 600

Sujatha Jagannathan, PhD

mRNA surveillance in health and disease

Aaron Johnson -- 500 x 600

Aaron Johnson, PhD

Mechanisms of chromatin-mediated gene silencing

Neel Mukherjee -- 500 x 600

Neelanjan Mukherjee, PhD

The dynamics of RNA regulatory networks

David Pollock -- 500 x 600

David Pollock, PhD

Protein structure, function and sequence evolution

Srinivas Ramachandran -- 500 x 600

Srinivas Ramachandran, PhD

In vivo nucleosome structure and dynamics

Olivia Rissland -- 500 x 600

Olivia Rissland, PhD

RNA stability and translation

James Sikela -- 500 x 600

James Sikela, PhD

Genome variation in human evolution and disease

Matt Taliaferro -- 500 x 600

Matthew Taliaferro, PhD

Subcellular RNA localization