Sujatha Jagannathan, PhD

Assistant Professor and Vice Chair for Equity



Jagannathan

Education

Ph.D., Duke University

Contact Information

Phone: (303) 724-3309
E-mail: sujatha.jagannathan@cuanschutz.edu​

​mRNA surveillance in health and disease

Robustness in biological systems relies on quality control. While errors in the DNA are repaired to maintain fidelity in the flow of genetic information, errors in mRNA are dealt with by degrading the erroneous molecules via surveillance processes such as nonsense-mediated mRNA decay (NMD). Though all mRNAs degraded by NMD follow a set of canonical rules, the converse – that every mRNA that follows the rule is subject to NMD – is not true. This variation in RNA quality control is a major confounding factor in interpreting the clinical impact of human genetic variants. 

An NMD target may degrade and generate no protein, or escape degradation and result in the production of a full-length or truncated protein – each scenario associated with a potentially different outcome for the cell. The long-term goal of our research program is to understand the molecular logic governing the varying efficiency in RNA quality control and its impact on gene expression, and in turn, cellular phenotypes.  To this end, we will apply computational and experimental tools to understand how RNA surveillance shapes gene expression and contributes to disease processes.

Jagannathan Labpragyan.singh@cuanschutz.edu
PictureFirst NameLast NameJob TitleEmail
Amy CampbellAmyCampbellResearch Instructoramy.e.campbell@cuanschutz.edu 
Michael Cortazar
MichaelCortazarPostdoctoral Scholarmichael.cortazarosorio@cuanschutz.edu 
Divya Kolakada
DivyaRaoGraduate Studentdivya.kolakada@cuanschutz.edu 
Zhongyou Li
ZhongyouLiPostdoctoral Scholarzhongyou.li@cuanschutz.edu
Oscar Munoz
OscarMunozGraduate Studentoscar.munoz@cuanschutz.edu
GregoryPoterewiczGraduate Studentgregory.poterewicz@cuanschutz.edu
MlanaLoreGraduate Studentmlana.lore@cuanschutz.edu
KelleenMcEnteeRSPkelleen.mcentee@cuanschutz.edu
PragyanSingh Postdocpragyan.singh@cuanschutz.edu

Biochemistry and Molecular Genetics

CU Anschutz

Research I South

12801 East 17th Avenue

Mail Stop 8101

Aurora, CO 80045


303-724-3201

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