Kirk Hansen, PhD

Professor



Kirk Hansen

Education

Ph.D., California Institute of Technology

Contact Information

Phone: (303) 724-5544
Email: Kirk.Hansen@cuanschutz.edu

We are focused on developing strategies for the detection and characterization of extracellular proteins in health and disease. Our goal is to understand underlying mechanisms of tissue microenvironments, including innate immunity, in disease processes using mass spectrometry.

One of our main focuses is improving characterization of tissue extracellular matrices (ECM). We have been refining traditional biochemical extraction and digestion methods to improve proteomic coverage of insoluble and crosslinked proteins of the ECM. These methods are being used to obtain a more detailed view of tissue remodeling in wound healing, aging, cancer and fibrotic diseases in general. New methods to identify protein crosslinks are allowing for the study of enzymatic specificity of the crosslinking enzymes at a resolution previously not available. 

Similar methods are being developed to characterize fibrin clot structures with the goal of identifying mediators of thrombosis and coagulopathies. This work is being supported by rapid ion mobility mass spectrometry for quantitative plasma proteome characterization. These approaches, in addition to metabolomic methods (D'Alessandro Lab), will be the foundation of a personalized medicine platform that has the potential to revolutionize clinical diagnostics.

Degregori Lab 2024

PicturesFirst NameLast NameJob TitleEmail
Lilyrose BahrabadiLilyroseBahrabadiResearch Service Professionallilyrose.bahrabadi@cuanschutz.edu
David Ceja Galindo
DavidCeja GalindoResearch Service Professionaldavid.cejagalindo@cuanschutz.edu
 AlexandraCrookResearch Associatealexandra.crook@ucdenver.edu
Monika	 Dzieciatkowska
MonikaDzieciatkowskaSenior Instructormonika.dzieciatkowska@cuanschutz.edu 
FranklynFranklynIheagwamPostdoctoral Scholarfranklyn.iheagwam@cuanschutz.edu
Lopez, KeiraKeiraLopezResearch Service Professionalkeira.lopez@cuanschutz.edu
Sean MaroneySeanMaroneyResearch Service Professionalsean.maroney@ucdenver.edu
Mark MaslankaMarkMaslankaGraduate Studentmark.maslanka@cuanschutz.edu
Max McCabe
MaxMcCabeResearch Associatemaxwell.mccabe@cuanschutz.edu 
Anthony SaviolaAnthonySaviolaResearch Assistant Professor

anthony.saviola@cuanschutz.edu

cara smithCara SmithPostdoctoral Scholarcara.2.smith@cuanschutz.edu

Biochemistry and Molecular Genetics

CU Anschutz

Research I South

12801 East 17th Avenue

Mail Stop 8101

Aurora, CO 80045


303-724-3201

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