RNA Biology



Modern biology has been revolutionized by the discovery that many processes of fundamental importance are regulated by RNA in addition to the role of RNA in generating the protein constituents of cells. Current research has only scratched the tip of the iceberg in understanding the contribution of RNA and RNA regulatory mechanisms in biology. RNA biology is advancing medicine through development of new RNA therapeutics with the potential to target virtually any disease or process through a common target, RNA.

Major knowledge gaps remain in the basic, diagnostic and therapeutic areas of RNA biology and much remains to be discovered about mechanisms of RNA function, regulation, and its role and impact on biology and disease. Research in the RNA Biology Group is aimed at understanding the contribution and role of RNA in biology, disease, and therapy. These include studies on RNA biogenesis (transcription and RNA processing); identifying and understanding RNA structure-function; analysis of RNA translation, stability, surveillance, and localization; RNA regulatory networks; identifying and characterization of the roles of non-coding regulatory RNAs (small RNAs and long non-coding RNAs); RNA informatics and RNA technologies; the contribution of errors in RNA and its biogenesis to disease; and the potential development and use of novel RNA therapeutics.


Faculty with Research in this Area


Francisco Asturias -- 500 x 600

Francisco Asturias, PhD

Characterization large macromolecular complexes

David Bentley -- 500 x 600

David Bentley, PhD

Messenger RNA Production by RNA polymerase II

Richard Davis -- 500 x 600

Richard Davis, PhD

Programmed DNA elimination, novel RNAs, and RNA metabolism

Elan Eisenmesser -- 500 x 600

Elan Eisenmesser, PhD

Viral protein/host protein interactions and enzyme motions

Jay Hesselberth -- 500 x 600

Jay Hesselberth, PhD

Nucleic acid repair

Suja Jagannathan -- 500 x 600

Sujatha Jagannathan, PhD

mRNA surveillance in health and disease

Aaron Johnson -- 500 x 600

Aaron Johnson, PhD

Mechanisms of chromatin-mediated gene silencing

Jeff Kieft -- 500 x 600

Jeffrey Kieft, PhD

Complex RNA structure and how RNA controls diverse biological processes

Neel Mukherjee -- 500 x 600

Neelanjan Mukherjee, PhD

The dynamics of RNA regulatory networks

Catherine Musselman -- 500 x 600

Catherine Musselman, PhD

Structural mechanisms of chromatin signaling

Olivia Rissland -- 500 x 600

Olivia Rissland, PhD

RNA stability and translation

Matt Taliaferro -- 500 x 600

Matthew Taliaferro, PhD

Subcellular RNA localization

Beat Vogeli -- 500 x 600

Beat Vögeli, PhD

NMR spectroscopy for the elucidation of conformation and communication networks within and between proteins and nucleic acids

Rui Zhao -- 500 x 600

Rui Zhao, PhD

Molecular mechanism of pre-mRNA splicing; drug design targeting transcriptional complex in breast cancer