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The mission of the RNA Bioscience Initiative (RBI) is to cultivate a vibrant center of discovery and innovation in RNA biology, informatics, diagnostics, and therapy. Our goal is to provide a fluid pipeline from basic to clinical RNA research at the Anschutz Medical Campus.
University of California, San Diego molecular biologists recently showed that RNA editing occurs naturally in squid kinesin transcripts in response to cold. Kinesin proteins produced from these modified transcripts bound to microtublules more frequently, and held on longer, than their unmodified warm water counterparts, allowing squid to rapidly adapt to cold water. This study demonstrates the power and flexibility imparted by on-demand changes to mRNA, rather than permanent changes to DNA.
Winter 2023Researchers at the Icahn School of Medicine at Mount Sinai in New York have discovered a lncRNA that is expressed at higher levels in the brains of women diagnosed with major depressive disorder (MDD) as compared to healthy women or men or depressed men. The study explores the presence of this molecule, in postmortem samples, and modified mice, as well as levels of FEDORA in the bloodstream of patients before and after treatment with a fast-acting antidepressant.
The RBI has made CU Anschutz a clear hub of RNA biology expertise, raising the status of the university and its researchers in the eyes of scientists at institutions around the country and the world. The RBI sets CU Anschutz up as a leader in the exciting and groundbreaking field of RNA biology.
Amy Campbell, PhD
RBI Co-Director, David Bentley, PhD, was interviewed by 9News reporter Anusha Roy and featured on Next with Kyle Clark. In this piece Dr. Bentley expertly describes the future of mRNA technology and its possible therapeutic uses beyond the COVID vaccine.