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The mission of the RNA Bioscience Initiative (RBI) is to cultivate a vibrant center of discovery and innovation in RNA biology, informatics, diagnostics, and therapy. Our goal is to provide a fluid pipeline from basic to clinical RNA research at the Anschutz Medical Campus.
RNA in the News
Squid Use RNA Editing to Adapt to Fluctuating Ocean Temperatures
Winter 2023
University of California, San Diego molecular biologists recently showed that RNA editing occurs naturally in squid kinesin transcripts in response to cold. Kinesin proteins produced from these modified transcripts bound to microtublules more frequently, and held on longer, than their unmodified warm water counterparts, allowing squid to rapidly adapt to cold water. This study demonstrates the power and flexibility imparted by on-demand changes to mRNA, rather than permanent changes to DNA.
Long Non-Coding RNA, FEDORA, Potential Key to Thwarting Depression in Women
Winter 2023
Researchers at the Icahn School of Medicine at Mount Sinai in New York have discovered a lncRNA that is expressed at higher levels in the brains of women diagnosed with major depressive disorder (MDD) as compared to healthy women or men or depressed men. The study explores the presence of this molecule, in postmortem samples, and modified mice, as well as levels of FEDORA in the bloodstream of patients before and after treatment with a fast-acting antidepressant.RBI Spotlight
SAVE THE DATE! 2nd Annual Rocky Mountain RNA Symposium to be Held Friday, April 14, 2023
January 3, 2023
RBI has partnered with the Colorado RNA Club to revive the annual Rocky Mountain RNA Symposium that was derailed by the COVID19 pandemic. The 2023 symposium will be held on Friday, April 14th in the Elliman Conference Center on the CU Anschutz Medical Campus. This one day event will feature rising stars in the RNA world – Ariel Bazzini, PhD (Stowers Institute), Susan Shao, PhD (Harvard), Siggy Nachtergaele, PhD (Yale), and Derrick Morton, PhD (USC). Registration for this FREE meeting is now OPEN!
Jeff Kieft, PhD, Announces move to the New York Structural Biology Center (NYSBC) to Assume the Role of Executive Director
January 1, 2023
RBI's Dr. Jeff Kieft will begin his next great scientific adventure May 1, 2023. Jeff's contributions to RBI are innumerable and he will be greatly missed! Thanks so much for your scientific brilliance, patient teaching, and active leadership. Best always!
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RBI's Neel Mukherjee, PhD, Featured in New State of Research at CU Anschutz Video
December 20, 2022
Learn how the University of Colorado Anschutz Medical Campus is working across institutions, medical specialties and communities to advance research that's changing the world. Dr. Mukherjee does a fantastic job narrating large portions of the video. Congratulations
Neel!
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Kieft Lab Mints Another Fantastic PhD Scientist
December 1, 2022
The highest of high fives to RBI's latest DOCTOR, Rachel Jones, PhD! Dr. Jones successfully defended her thesis "Uncovering the rules of resistant RNA knots: lessons from the Tamana Bat Virus xrRNA" in front of colleagues, friends and family. Congratulations!
On Tap
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The RBI has made CU Anschutz a clear hub of RNA biology expertise, raising the status of the university and its researchers in the eyes of scientists at institutions around the country and the world. The RBI sets CU Anschutz up as a leader in the exciting and groundbreaking field of RNA biology.
.jpg?sfvrsn=60498fb9_4 "Amy Campbell, PhD")
Amy Campbell, PhD
RBI Co-Director Discusses the Future of mRNA Technology on 9News
RBI Co-Director, David Bentley, PhD, was interviewed by 9News reporter Anusha Roy and featured on Next with Kyle Clark. In this piece Dr. Bentley expertly describes the future of mRNA technology and its possible therapeutic uses beyond the COVID vaccine.