Regulatory RNAs

The Regulatory RNA Group within the RNA Bioscience Initiative investigates the foundational molecular mechanisms that regulate the diverse and essential roles of RNA in biology.

Members of the group seek to understand how different RNAs exert control over an ever-expanding number of cellular activities—from translation to chromatin modification to genome editing. Studies encompass how RNA is made, maintained, localized and ultimately degraded in the cell, how RNA interacts with other cellular molecules, the structure of RNA and its ability to drive function, and many others. Using approaches as diverse as molecular biology, bioinformatics, structural biology, cell biology, virology, biochemistry, and biophysics, we work toward a comprehensive understanding of the mechanisms by which non-coding RNA operate to control biology, with the long-term goal of translating this understanding into the clinic to benefit human health.