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APPLICATIONS FOR THE FALL 2022 RBI PILOT GRANT PROGRAM ARE CLOSED!
CHECK BACK IN JANUARY 2023 FOR OUR NEXT RFA.
Thanks for the support! It truly was “transformative”. Data from our 2017 RBI Pilot Grant project supported 2 publications and an NIH R35 for $6,904,527 in total costs.
Bruce Appel, PhD
Section Head, Professor of Pediatrics, Diane G. Wallach Chair of Pediatric Stem Cell BiologyShared Content Block:
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RECIPIENT | DEPARTMENT | AWARD | PROJECT |
Santos Franco, PhD | Pediatrics- Developmental Biology | Spatial Transcriptomics | Elucidating the spatiotemporal mechanisms of neural stem cell fate specification in the developing brain |
Katharina Hopp, PhD | Medicine- Renal Diseases and Hypertension | Spatial Transcriptomics | Utilizing spatial transcriptomic profiling to understand the heterogenous histopathology of polycystic kidney disease |
Eric Clambey, PhD | Immunology & Microbiology | mRNA-LNP | mRNA-LNP vaccination against chronic gammaherpesvirus infection |
Heide Ford, PhD | Pharmacology | Ribosome Profiling | Determining the Mechanism of Action of 8430, a Novel Inhibitor of Metastasis |
Matthew Gailbraith, PhD | Pharmacology | Nanopore | Long-read RNA-sequencing to discover novel transcriptome features in Down syndrome |
Jeffrey Kieft, PhD | BMG | Nanopore | Using long-read NGS to interrogate flavivirus noncoding RNA structure and modifications |
Matthew Taliaferro, PhD | BMG | Nanopore | Nanopore-based detection of 8-oxoguanosine for RNA localization analysis |
RECIPIENT | DEPARTMENT | AWARD | PROJECT |
David Bentley | BMG | RNA-seq | Determination of nascent RNA folding in vivo by psoralen cross-linking |
James Maloney | Medicine- Pulmonary Sciences and Critical Care | RNA-seq | Gene expression changes in human T-regs in response to the SARS-CoV-2 nsp15 protein |
Tania Reis | Medicine- Endocrinology, Metabolism, and Diabetes | RNA-seq | Dissecting m6A's role in metabolism |
Chandra Tucker | Pharmacology | RNA-seq | Probing RNA transcriptional responses to sudden appearance or dissolution of biomolecular condensates |
Ethan Hughes | CDB | scRNA-seq | Determine the transcriptomics profile of mature oligodendrocytes participating in remyelination |
Elena Hsieh | Pediatrics-Allergy/Immunology | scRNA-seq | Understanding SARS-CoV-2 B cell responses derived from COVID-19 immunization |
Suja Jagannathan | BMG | scRNA-seq | Singe cell long-read CaptureSeq to characterize isoform structure of DUX4 transcripts |
Matt Kennedy | Pharmacology | scRNA-seq | Profiling amyloid-beta binding cells of the central nervous system |
Tem Morrison | Immunology and Microbiology | scRNA-seq | Mechanisms of chronic chikungunya virus infection and joint disease |
Holger Russ | BDC; Immunology and Microbiology | scRNA-seq | Cellular heterogeneity and function in thymi of patients with Down syndrome |
Charles Sagerstrom | Pediatrics-Developmental Biology | scRNA-seq | Adaptation of single-cell calling card technology to test TF function in zebrafish embryogenesis |
Rebecca Schweppe | Medicine- Endocrinology, Metabolism, and Diabetes | scRNA-seq | Deregulation of the transcriptome promotes the transformation of anaplastic thyroid cancer |
Lori Sussel | BDC | scRNA-seq | Identification of pancreatic islet cell-type specific splicing events |
Benjamin Bitler | OBGYN | Spatial Transcriptomics | Spatial analysis of the ovarian cancer tumor microenvironment |
Nicholas Foreman | Pediatrics-Hematology, Oncology, and Bone Marrow Transplantation | Spatial Transcriptomics | Spatial lineage trajectory analysis in childhood brain tumor medulloblastoma |
Wendy Macklin | CDB | Spatial Transcriptomics | Spatiotemporal analysis of microglial contribution to immune-mediated demyelinating lesion formation |
Rebecca McCullough | Pharmaceutical Sciences | Spatial Transcriptomics | The neuroimmune landscape of the aging brain: Dissecting the impact of alcohol |
Julie Siegenthaler | Pediatrics- Developmental Biology | Spatial Transcriptomics | Spatial transcriptomics to study mechanisms of meninges development |
Carmen Sucharov | Medicine- Cardiology | Spatial Transcriptomics | Spatial transcriptomics in the failing pediatric heart |
Kelly Sullivan | Pediatrics- Developmental Biology | Spatial Transcriptomics | Defining the impact of interferon receptor copy number on neuroinflammation in a mouse model of Alzheimer’s disease in Down syndrome |
RECIPIENT | DEPARTMENT | AWARD | PROJECT |
Kristin Artinger | Craniofacial Biology | RNA-seq | Using RNA-seq to identify molecular interactions among different cell populations during neural crest cell migration |
Adela Cota-Gomez | Pulmonary Sciences and Critical Care | RNA-seq | Nrf2 activator PB125 as a potential therapeutic agent against coronavirus (COVID related) |
Tom Evans | CDB | RNA-seq | Discovering direct RNA targets of novel ncRNAs |
Wendy Macklin | CDB | RNA-seq | Developmental RNAseq analysis of the translatome in axons with conditional neuronal Raptor deletion |
Nidia Quillinan | Anesthesiology | RNA-seq | Distinct firing properties of thalamic neurons receiving cerebellar input |
Olivia Rissland | BMG | RNA-seq | COVID genomic sequencing and tracking |
Rebecca Schweppe | Pathology | RNA-seq | Nuclear FAK alters the transcriptome to promote thyroid cancer growth and survival |
Linda van Dyk | Barbara Davis Center | RNA-seq | Identification of host and viral ncRNA interatcing with La and RIF-I during gammaherpesvirus infection |
Natalia (Maria) Vergara | Opthamology | RNA-seq | Unraveling the molecular basis of retinal abnormalities in Down syndrome |
Quentin Vicens | BMG | RNA-seq | Using RNA-seq to determine the biological role of the Z-RNA binding domain of ADAR1 during the interferon response |
Rocky Baker | Immunology and Microbiology | scRNA-seq | Combined TCR and gene expression profile of HIP-reactive T cells in islet grafts after induction of tolerance with 2.5HIP PLG-NPs |
David Beckham | Infectious Disease | scRNA-seq | Defining innate immune responses to SARS-CoV2 with single cell resolution |
Melanie Koenigshoff | Pulmonary Sciences and Critical Care | scRNA-seq | Unraveling the molecular mechanisms of distal lung epithelial stem cell impairment in COPD |
Liyen Loh | Immunology and Microbiology | scRNA-seq | Deciphering the development of innate T cells in the human thymus |
James Nichols | Craniofacial Biology | scRNA-seq | Clonal dominance in appendage development |
Matthew Sikora | Pathology | scRNA-seq | Functional heterogeneity in estrogen receptor co-regulator activity |
Mary Weiser-Evans | Renal Diseases and Hypertension | scRNA-seq | SMC-derived AdvSca-SM cell contribution to cardiac fibrosis |
Timothy McKinsey | Cardiology | scRNA-seq | Exploring the therapeutic potential of HDAC inhibition in HFpEF |
Howard Davidson | Barbara Davis Center | scTech Development | Monitoring alternative splicing in single human T cells by ScISOr-Seq plus |
Peter Dempsey | Gastroenterology, Hepatology, and Nutrition | scTech Development | Population-based analysis of intestinal organoid heterogeneity using CellTagging and scRNAseq |
James Dylewski | Renal Diseases and Hypertension | scTech Development | The role of FcRn in antigen presentation by glomerular endothelial cells in immune mediated kidney disease |
Rachel Friedman | Barbara Davis Center | scTech Development | Myeloid cells in the islets |
Kirk Hansen | BMG | scTech Development | Development of an ECM atlas to guide regenerative medicine therapies using MULTI-seq |
Elena Hsieh | Pediatric Allergy and Immunology | scTech Development | Understanding IL-15/IL-2RB interactions in a hypomorphic IL-2RB mouse model |
Katja Kiseljak-Vassiliades | Endocrinology, Metabolism, and Diabetes | scTech Development | In situ reconstruction of distinct cell populations within the human adrenal gland |
Christian Mosimann | Pediatrics | scTech Development | Charting cardiovascular progenitor clonality and developmental trajectories in toto |
Eric Pietras | Hematology | scTech Development | Clonal tracking and expression analysis in a mouse model of human clonal hematopoiesis of indeterminate potential (CHIP) |
Stephen Santoro | Peds-Developmental Biology | scTech Development | Lineage tracing the odorant receptor fates of olfactory sensory neurons |
Eszter Vladar | Pulmonary Sciences | scTech Development | WNT4 signaling specifies ciliated cell fate in the airway epithelium |
Tuoqi Wu | Immunology and Microbiology | scTech Development | Identify the transcriptional and protein expression signatures of CAR T cells with long-term antitumor immunity using endogenous TCR sequences as molecular barcodes |
RECIPIENT | DEPARTMENT | AWARD | PROJECT |
Howard Davidson | Barbara Davis Center | Bioinformatics Support | Using CITE-seq to define immune biomarkers of the honeymoon period in type 1 diabetes |
Joshua Black | Pharmacology | RNA Biology | Enrichment detection and discovery of repeat element-gene mRNA fusion transcripts |
Tom Evans | Cell and Developmental Biology | RNA Biology | Control of RNP co-assembly dynamics in early development |
Tania Reis | Endocrinology, Metabolism, and Diabetes | RNA Biology | Mechanisms of control of Drosophila fat storage by conserved RNA-binding protein Nito |
Douglas Shepherd & Diego Restrepo | Pharmacology | RNA Biology | High-throughput spatial quantification of RNA expression in mouse olfaction after exposure to viral agents |
Jianbin Wang | BMG | RNA Biology | Transcription and transcription-replication collision and R-loop formationduring programmed DNA elimination |
Diana Cittelly | Pathology | RNA-seq | Transcriptional profile of reactive astrocytes at early and late stages of brain metastatic progression |
Katherine Fantauzzo | Craniofacial Biology | RNA-seq | Srsf3-mediated alternative RNA splicing downstream of PDGFRalpha signaling in the palatal mesenchyme |
Jeffrey Kieft | BMG | RNA-seq | Identification of cellular exoribonuclease-resistant RNAs by xrRNA-seq |
Traci Lyons | Oncology | RNA-seq | Investigating SEMA7A-regulated mechanisms of endocrine resistance in ER+ breast cancer |
Michael McMurray | CDB | RNA-seq | Defining the maternal contribution of RNAs in yeast gametes |
Chad Pearson | CDB | RNA-seq | Identifying centriolar RNAs in Tetrahymena thermophila |
Rytis Prekeris | CDB | RNA-seq | Identification of midbody-associated RNA |
Eszter Vladar | Pulmonary Sciences | RNA-seq | Molecular, physiological and health outcome impacts of triple combination therapy in cystic fibrosis airway disease |
Trevor Williams | Craniofacial Biology | RNA-seq | Functional analysis of differential splicing by Rbm10 – the gene mutated in human TARP Syndrome |
Rocky Baker | Immunology and Microbiology | scRNA-seq | Monitor phenotype and TCR of HIP-reactive T cells over time in a subject at risk for T1D |
Joseph Brzezinski | Opthamology | scRNA-seq | Regulation of human cone photoreceptor development |
Eric Clambey | Anesthesiology | scRNA-seq | CD4 T cell lineage tracing by scRNA-seq |
Nicholas Foreman | Pediatrics | scRNA-seq | To investigate the feasibility of single-nuclei RNAseq analysis of pediatric brain tumors |
Dany Gaillard | CDB | scRNA-seq | Single cell RNA-seq of irradiated mouse CVP |
Ross Kedl | Immunology and Microbiology | scRNA-seq | In search of Tvacs: single cell RNAseq comparison between vaccine-elicited and infection elicited CD8+ T cell responses |
T. Rajendra Kumar | OB/GYN | scRNA-seq | Single cell RNA-seq analysis of pituitary gonadotropes |
Wendy Macklin | CDB | scRNA-seq | scRNAseq of oligodendrocytes during development with conditional rictor deletion in neurons |
Karen Moulton | Cardiology | scRNA-seq | Translating vascular cell phenotypes of human coronary artery disease |
Holger Russ | Barbara Davis Center | scRNA-seq | Elucidating AIRE dependent expression of tissue-restricted antigens in stem cell derived organotypic thymus cultures from healthy and autoimmune patients |
Daniel Sherbenou | Hematology | scRNA-seq | Tracking resistant multiple myeloma cells in residual disease by single-cell RNA-seq |
Tamara Terzian | Oncology | scRNA-seq | Molecular determinants of lymphangiogenesis |
RECIPIENT | DEPARTMENT | AWARD | PROJECT |
Lori Sussel | Barbara Davis Center | Bioinformatics Support | Identification of IncRNAs associated with obesity-induced diabetes |
Kristin Artinger & David Bentley | Craniofacial Biology & BMG | RNA-seq | Developmental control of co-transcriptional splicing in zebrafish |
Sue Kinnamon | Otolaryngology | RNA-seq | Transcriptome analysis of GAD65-expressing taste receptor cells |
Suchitra Rao | Infectious Diseases | RNA-seq | Measures of immune responses to influenza infection in children |
Lori Sussel | Barbara Davis Center | RNA-seq | Determine the effect of zinc deficiency on the islet transcriptome |
Yael Aschner | Pulmonary Sciences and Critical Care Medicine | scRNA-seq | Analysis of ARDS BAL |
Matthew Burchill | Gastroenterology and Hepatology | scRNA-seq | Dissection of the T lymphocyte activation landscape in NASH |
David Clouthier | Craniofacial Biology | scRNA-seq | A transcriptional code coordinates jaw development |
Howard Davidson | Barbara Davis Center | scRNA-seq | Profiling T cell responses to low affinity polyclonal stimuli |
Jonathan Kurche & David Schwartz | Pulmonary and Critical Care | scRNA-seq | Single nuclei RNA sequencing in idiopathic pulmonary fibrosis (IPF) |
Hong Li and Eriv Van Otterloo | Craniofacial Biology | scRNA-seq | Redefining the ameloblast lineage |
Martin McCarter | Surgical Oncology | scRNA-seq | Analysis of tumor infiltrating MDSCs in human melanoma |
Joanna Poczobutt & Oliver Eickelberg | Pulmonary and Critical Care | scRNA-seq | The role of MZB1-positive plasma B cells in idiopathic pulmonary fibrosis |
Beth Tamburini | Immunology | scRNA-seq | Transcriptional profiling of lymphatic endothelial cells and dedritic cells during antigen archiving exchange |
Ivana Yang | Pulmonary and Critical Care | scRNA-seq | Characterization of bronchoalveolar lavage cell populations from patients with sarcoidosis |
RECIPIENT | DEPARTMENT | AWARD | PROJECT |
Steve Anderson | Pathology | Bioinformatics Support | Analysis of the role of glucose metabolism upon tumor-initiating cells |
David Bentley | BMG | Bioinformatics Support | The development of a bioinformatics pipeline to characterize nascent RNA structure |
Nicholas Foreman | Hematology | Bioinformatics Support | Single-cell mRNA seq analysis of pedatric brain tumors |
Bernice Gitomer | Renal Medicine | Bioinformatics Support | Identification of the etiology of the bone defect in patients with autosomal dominant polycystic kidney disease (ADPKD) |
Eva Grayck | Cardiovascular and Pulmonary | Bioinformatics Support | Bioinformatic analysis of RNA sequencing data to interrogate the redox regulation of alveolar macrophage populations in acute lung injury |
Craig Jordan | Hematology | Bioinformatics Support | Identification and characterization of drug-resistant subpopulations in AML |
Elizabeth Wellberg | Pathology | Bioinformatics Support | Using gene expression profiles to predict obesity-associated breast cancer progression |
Bruce Appel | Pediatrics, Stem Cell Biology | scRNA-seq | Single cell RNA-seq investigation of glial cell heterogeneity |
Kristin Artinger | Craniofacial Biology | scRNA-seq | Single cell profiling of neural crest derived cancers |
Linda Barlow | CDB | scRNA-seq | Single cell RNA-seq of Sox2-GFP lingual epithelial cells |
Dick Davis | BMG | scRNA-seq | Single cell RNA-seq analysis of ascarsis development |
Peter Dempsey | Gastroenterology, Hepatology, and Nutrition | scRNA-seq | Reversion of Defa4Cre-expressing Paneth cells to a stem cell state in response to intestinal injury |
Robert Doebele | Oncology | scRNA-seq | Single cell analysis of oncogene-driven lung adenocarcinoma to determine mechanisms of residual disease following oncogene-targeted therapy |
Patricia Ernst | Pharmacology | scRNA-seq | Enhancing hematopoietic stem cell emergence from pluripotent embryonic stem cells using MLL1 induction |
James Nichols | Craniofacial Biology | scRNA-seq | Understanding jaw evolution by comparing craniofacial progenitor cells in lamprey and zebrafish |
Holger Russ | Barbara Davis Center | scRNA-seq | Elucidating human beta cell subtype regulation and interconversion in health and disease |
Howard Davidson | Barbara Davis Center | scRNA-seq | Single cell profiling in type 1 diabetes |
Joan Hooper | CDB | scRNA-seq | Analysis of craniofacial development |
Lori Sussel | Barbara Davis Center | scRNA-seq | Analysis of pancreatic progenitors |
RECIPIENT | DEPARTMENT | AWARD | PROJECT |
Erin Baschal | Orthopedics | Clinical | Comparison of facet joint cartilage RNA from adolescent idiopathic scoliosis patients and control individuals |
Kathleen Connell | Urogynecology and Reconstructive Surgery | Clinical | Epigenetic and RNA expression profiles in women with pelvic organ prolapse |
James Costello | Pharmacology | Clinical | RNA sequencing analysis of bladder cancer cell lines that localize to the lung and liver |
Tom Evans | CDB | Seed Grant | Identification of novel RNA targets of sm-rings |
Bernice Gitomer | Renal Diseases and Hypertension | Seed Grant | Prediction of the rate of autosomal dominant polycystic kidney disease progression based on circulating miRNA levels |
Aaron Johnson | BMG | Seed Grant | m6A RNA modification in long noncoding RNA matchmaking and heterochromatin formation |
Sandy Martin | CDB | Seed Grant | Investigating RNA editing in the brain of mammalian hibernator and Investigating transcript isoform dynamics in a hibernator |
Lee Niswander | Molecular, Cellular & Developmental Biology | Seed Grant | An alternative splicing mechanism in the lincRNA-1354 locus commits embryonic stem cells to neural differentiation |
Eric Pietras | Hematology | Seed Grant | Role of RNA splicing factor U2AF1 mutations in regulating hematopoietic stem cell inflammation response and myelodysplastic syndrome |
Jennifer Richer | Pathology | Seed Grant | Targeting the long non-coding RNA MALAT1 in ovarian cancer |
Mario Santiago | Infectious Diseases | Seed Grant | Noncoding RNAs in mucosal HIV-1 persistence and pathogenesis |
Carol Sartorius & Peter Kabos | Pathology & Oncology | Seed Grant | Single cell analysis of organ specific metastasizing cells in estrogen receptor positive breast cancer |
Lori Sussel | Barbara Davis Center | Seed Grant | lncRNA discovery in motor neurons |
Trevor Williams | Craniofacial Biology | Seed Grant | Probing the consequences of the disruption of epigenetic bookmarking in human Branchio-oculo-facial Syndrome using single-cell sequencing |