News from the RNA Bioscience Initiative
RNA polymerase travels along each gene from beginning to end and makes an RNA copy of the genetic code. New research from the Bentley lab shows that the RNA polymerase likes to “take a break” or “pause” in a zone at the beginning of genes. Control of this pausing likely impacts how genetic information is accessed and used to control living cells.
We encourage you to watch the latest video from the RNA Bioscience Initiative. In this video RBI co-founder and co-director, Dr. David Bentley, deftly explains the nature of RNA in simple, accessible terms. Please share this video with friends and family
and help us expand understanding of RNA and RNA research to a broader audience.
CONGRATULATIONS Dr. Ramos! This award acknowledges exceptional contributions to RNA science by a trainee who is underrepresented in biomedical research. Jillian was recognized for her "contributions to understanding tRNA structure and function, combined with her outreach, mentoring and education activities."Read More
December 15, 2021
The RBI Summer Internship Program is a PAID, 10-week hands-on, mentored research opportunity for undergraduates who want to gain real-world laboratory experience in RNA biology, chemistry, biochemistry, genomics, and bioinformatics.Apply Now
CONGRATULATIONS Dr. Swain! This grant from NIH-NIDCR, titled N6-methyladenosine in Candida white-opaque switching and oral infection, will provide an additional 2 years of postdoctoral support ($90,000 per year) AND $249,000/year for 3 years upon starting an independent lab as a faculty member.Read More
This study reveals how viral RNAs can use a combination of static and dynamic RNA structures to bind host machinery through highly noncanonical interactions, and highlights the utility of cryo-EM for visualizing small, conformationally dynamic structured RNAs.
Congratulations to Steve and his co-authors Maddie Sherlock, Andrea MacFadden, and Jeff Kieft!
A comprehensive evaluation of the RBI Pilot Grant Program recently revealed a success story beyond our wildest dreams. Investigators were able to leverage data from their RBI pilot grant awards into $56,540,451 worth of additional grant funding. This represents a return on investment (ROI) of 2172%!!! Special thanks to the RBI Informatics Fellows and the entire RBI team for their hard work!Read More
CONGRATULATIONS Dr. Dennison! Brenna completed her graduate work "Srsf3 mediates alternative RNA splicing downstream of PDGFRa signaling in the facial mesenchyme" in the Fantauzzo Lab- Department of Craniofacial Biology, School of Dental Medicine.Read More
The latest round of RBI Pilot Grants netted 59 applications and 20 awards. These awards will enable investigators from two different schools (School of Medicine and School of Pharmaceutical Sciences), representing seven unique departments and 6
divisions, to add RNA-based technologies to their research programs. Congratulations to all!
Congratulations to Lorraine Davis, Arely Diaz, Hei-Yong Grant Lo, and Cormac Lucas the RBI 2021-2022 RNA Scholars. These four graduate students were selected from a pool of 7 accomplished applicants. Each displays outstanding promise toward advancing
RBI's Evan Morrison and his mentor, Olivia Rissland, have been selected as one of 50 new HHMI Gilliam student-advisor pairs. Gilliam fellowships are awarded to outstanding graduate students and their PhD mentors as part of a program to foster diversity and inclusion in biomedical or life science disciplines.
The NSF has awarded RBI's Dr. Olivia Rissand a prestigious Early Career Development award to study the maternal-to-zygotic transition in animal embryogenesis. The award will provide $1.3 million dollars of funding over five years.
RBI faculty members Matt Taliaferro, PhD and Chad Pearson, PhD, have been awarded a $1 million grant from the W.M. Keck Foundation for their project Control of cell division through centrosomal RNA localization. The goal of this study is to uncover the identity of centrosomal RNAs essential to the proper regulation of cell division. Given the links between centrosome dysfunction and cancer, it may reveal previously unidentified mechanisms that contribute to tumorigenesis.
Dr. Sujatha Jagannathan was recently awarded an investigator-initiated research grant by the FSHD Society. This grant will support her lab's work on identifying the mechanism by which the DUX4 inhibits nonsense-mediated RNA deco (NMD) in the human muscle disease facioscapulohumeral muscular dystrophy (FSHD). Congratulations Suja!
Congratulations to former RBI Scholar Brenna Dennison, whose manuscript has been featured in Development. Brenna was an RBI Scholar for the 2019-2020 year, and is currently a PhD student in Dr. Katherine Fantauzzo's lab.
Congratulations to Divya Kolakada, current RBI Scholar, for being awarded a Predoctoral Fellowship by the American Heart Society. Currently a PhD student in Dr. Sujatha Jagannathan's lab, Divya's project will be focused on investigating the fate of NMD substrates and their protein products.
Find out how Dr. Saldi leveraged her CU Anschutz-RBI training to advance her career. Currently she serves as the laboratory director of the COVID-19 Surveillance Lab at the BioFrontiers Institute and Chief Scientific Officer of TUMI Genomics, a diagnostics company she co-founded in 2020.
The RNA Bioscience Initiative financially supports graduate students as part of its education and training program. Eligible applicants are graduate students whose research focuses primarily on RNA, and who have completed two research years in their thesis lab and passed their comprehensive exam (as of August). The RNA Scholar Awards are for 1 year and are not renewable. RBI RNA Scholars will receive $35,000 (towards their stipend) and an additional $2,000 for educational expenses (such as computer, research-relevant software, or travel to a conference).
May 18, 2021
Learn about RBI faculty, Rui Zhao, Neel Mukherjee, and Aaron Johnson, and their collective determination to conquer cancer. Their studies of RNA biology demonstrate the paradoxical role of RNA in cancer, as both driver of disease and potential therapy.
February 18, 2021
February 8, 2021
Congratulations to former RBI Scholar, Katie Yergert, whose manuscript is featured as the cover piece for the current issue of Plos Biology. Katie was an RBI Scholar for the 2018-2019 year, and is currently working as a Postdoctoral Fellow in Dr. Gary
Bassell's laboratory at Emory University.
January 1, 2021
Congratulations to Roberto Castro-Gutierrez, Raeann Goering, Divya Kolakada, Nicole Moss, and Matthew Szucs the RBI 2020-2021 RNA Scholars. These five graduate students were selected from a pool of 9 accomplished applicants. Each displays outstanding
promise toward advancing RNA biology.
November 17, 2020
Congratulations to Dr. Randall Cohrs who was awarded an R01 through NIAID. The goal of Dr. Cohr's project is to study transcription of VLT and ORF 63 to provide insight into molecular mechanisms that regulate VZV latency and reactivation, which will allow his lab to develop novel intervention strategies that effectively target latent VZV and consequently the burden of herpes zoster disease.
Hesselberth Awarded NIH Director’s Transformative Research Grant
October 6, 2020
The RBI co-director was one of nine winners selected to pursue a high-risk high-reward project. Dr. Hesselberth will work to develop new approaches to measure biochemical heterogeneity at single-cell resolution.
Read More (click and scroll down)
August 17, 2020
This RBI faculty member, one of three highly accomplished awardees, was recognized for her groundbreaking work on RNA surveillance and how dysregulation of this process contributes to disease.
June 15, 2020
This RBI faculty member, one of five impressive awardees, is tasked with improving methods for early cancer detection using cell-free DNA.