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Professor and Vice Chair
Director, School of Medicine Structural Biology and Biophysics Core Facilities
Ph: (303) 724-3257
E: jeffrey.kieft@cuanschutz.edu
The latest news
Updated June 3, 2021
- Steve Bonilla has been named an HHMI Hannah Gray Fellow. Congratulations!
- Quentin Vicens is co-PI on an awarded NIH R21 grant. Congratulations!
- Matt Szucs was named an RNA BioScience Initiative Scholar and has been awarded an NIH F31 fellowship. Congratulations!
- Anna-Lena Steckelberg has departed and is starting her own lab at Columbia University as an Asst. Professor. Good luck!
- Zoe O'Donoghue will be an AAAS Science and Technology Policy Fellow, starting this fall. She will be working in USAID's Global Health Security Program, Office of Infectious Disease, Division of Emerging Threats. Congratulations!
- Ben Akiyama has accepted a position at Meso Scale Discovery in Rockville, MD and will start there in a few months. Congratulations!
- Conner Langeberg won the Best Poster Award at the 2021 Structural Biology and Biochemistry minisymposium. Congratulations!
- Jeff has been named Chair of the NIH Molecular Structure and Function A (MSFA) study section, and was elected a Director of the RNA Society, to serve 2022-2023.
​Coming up
Updated June 3, 2021
- May 25 - June 5: RNA Society - several Kieft Lab posters and presentations!
- June 22, 3 pm: RNA BioScience Initiative Chalk Talk (Matt Szucs will be presenting)
- June 23-24: Jeff will be speaking at The RNA Structure Conference, online.
Hot off the press (or soon to be)
Updated Jun 3, 2021
Peer Reviewed:
*Steckelberg, A.-L., *Vicens, Q., Costantino, D.A., Nix, J.C., Kieft, J.S. (2020) The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold. RNA 26, 1767-1776. *These authors contributed equally
Szucs, M.J., Jones, R.A., Vicens, Q., Kieft, J.S. (2020) A new subclass of exoribonuclease resistant RNA found in multiple Flaviviridae genera. mBio, 11(5):e02352-20. doi: 10.1128/mBio.02352-20.
Sherlock, M.E., Hartwick, E.W., Kieft, J.S. (2021) Structural diversity and phylogenetic distribution of valyl tRNA-like structures in viruses. RNA 27, 27-39.
Jones, R.A., Steckelberg, A.-L., Szucs, M.J., Akiyama, B.M., Vicens, Q., & Kieft, J.S. (2021) Different tertiary interactions create the same important 3-D features in divergent flavivirus xrRNAs. RNA 27, 54-65.
Nichols, P.J., Bevers, S., Henen, M., Kieft, J.S., *Vicens, Q., *Vogeli, B. (2021) Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces AZ junctions. Nature Communications 12, 793- *Joint corresponding authors
Langeberg, C.J., Sherlock, M.E., MacFadden, A., Kieft, J.S. An expanded class of histidine-accepting viral rRNA-like structures. RNA 27, 653-664.
Akiyama, B.M., Graham, M.E. O'Donoghue, Z., Beckham, J.D., Kieft, J.S. Three-dimensional structure of a flavivirus dumbbell RNA revelas molecular details of an RNA regulator of replication. (in press) https://doi.org/10.1101/2020.09.17.300806
Preprints (in review/revision):
Eiler, D.R., Wimberly, B.T., Bilodeau, D.Y., Rissland, O.R., Kieft, J.S. The Giardia lamblia ribosome structure reveals divergences in translation and quality control pathways. bioRxiv 2020.09.30.321331; doi: https://doi.org/10.1101/2020.09.30.321331
Bonilla, S., Sherlock, M.E., MacFadden, A. Kieft, J.S. A structured viral RNA uses molecular mimicry and conformational dynamics to coordinate multiple functions. bioRxiv 2020.09.18.302638; doi: https://doi.org/10.1101/2020.09.18.302638