How does the structure of a genome evolve over time? My research program investigates the molecular causes and phenotypic consequences of the broadly defined family of genomic features known as structural variations (SVs). SVs like aneuploidy, loss-of-heterozygosity, and copy number alteration are pervasive, yet poorly understood genomic elements which contribute significantly to the genotypic and phenotypic diversity of eukaryotic populations. My current work is addressing many fascinating and important biological questions focused on understanding how SVs arise in the genome, and how these variations contribute to genome stability and evolution, phenotypic diversity, and cellular and organismal fitness. This research will continue to advance our current understanding of the genomic evolution that occurs across all forms of life, ranging from the somatic genomic evolution which occurs in microbial populations and during the progression of cancer, to large-scale evolutionary events, such as speciation.