Translational Clinical Research in the Department of Neurosurgery

Trial TypeTitlePrincipal InvestigatorEligibilty and Information
Advanced Parkinson's Disease with Motor Fluctuations (Interventional)RESTORESteven Ojemann, MDPamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu
Arteriovenous MalformationsApollo TM Onyx Delivery Micro Catheter Post Market Safety StudyJoshua Seinfeld, MD

Jen Maitlen, RN 303-724-1995

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Brain Injury Device (interventional)Physiological Effects of Intrathoracic Pressure Regulation in Patients With Decreased Cerebral Perfusion Due to Brain Injury or Intracranial PathologyRobert Neumann, MDJen Maitlen, RN 303-724-1995  jennifer.maitlen@ucdenver.edu
Brain Surgery BioBankingCentral Nervous System Biorepository ProtocolKevin O. Lillehei, MDJen Maitlen, RN 303-724-1995  jennifer.maitlen@ucdenver.edu
Brain TumorA Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects with Advanced Solid Tumors, Including Glioma, with an IDH1 MutationLia Gore, MD

Monica Robischon, RN 720-848-0663

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Brain TumorAn Expanded Access Protocol for the Treatement of Glioblastoma Multiforme in Patiens with Already Manufactured DCVax®-L, Autologous Dendritic Cells Pulsed with Tumor Lysate Antigen Who Have Screen-Failed Protocol 020221Kevin O. Lillehei, MD

Monica Robischon, RN 720-848-0661

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Brain Tumor Drug vs Radiation with Drug (interventional)Phase III Intergroup Study of Temozolomide Alone Versus Radiotherapy with Concomitant and Adjuvant Temozolomide Versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic GliomaBrian Kavanagh 
Brain Tumor Drug, Radiation (interventional)Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation versus Bevacizumab Alone as Treatment for Recurrent GlioblastomaLaurie Gaspar, MD

Monica Robischon, RN 720-848-0661 

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Brain Tumor ObservationalFrailty as a Predictor of Neurosurgical Outcomes in Brain Tumor PatientsD. Ryan Ormond, MDJen Maitlen, RN 303-724-1995  jennifer.maitlen@ucdenver.edu
Cerebral HemorrhageMinimally invasive Subcortical Parafascicular Access for   Clot Evacuation (MiSPACE) RegistrySamy Youssef, MD

Jen Maitlen, RN 303-724-1995

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Electrophysiology during Deep Brain Stimulation Surgery (Research)Using Parkinson’s disease to study the role of Substantia nigra pars reticulata in movement initiation and perception Aviva Abosch, MD, PhD

Pamela David Gerecht, PhD 303-724-4134   pamela.davidgerecht@ucdenver.edu

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Electrophysiology during Deep Brain Stimulation Surgery (Research)Local Field Potentials Recorded from Deep Brain Stimulating Electrodes Implanted for the Treatment of Parkinson’s Disease, Essential Tremor or DystoniaAviva Abosch, MD, PhD

Pamela David Gerecht, PhD 303-724-4134   pamela.davidgerecht@ucdenver.edu

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Electrophysiology during Deep Brain Stimulation Surgery (Research)Sensory Gating Measured with Microelectrode Recording During Deep Brain Stimulation SurgeryAviva Abosch, MD, PhDPamela David Gerecht, PhD 303-724-4134   pamela.davidgerecht@ucdenver.edu
Epilepsy (interventional)Stereotactic Laser Ablation for Temporal Lobe EpilepsySteven Ojemann, MDPamela David Gerecht, PhD 303-724-4134  pamela.davidgerecht@ucdenver.edu
Neuropsychology ObservationalUniversity of Colorado School of Medicine Neuropsychology DatabaseBrian Hoyt, PhDJen Maitlen, RN 303-724-1995   jennifer.maitlen@ucdenver.edu

 

Clinical Trials

TitleTrial TypePrincipal InvestigatorEligibility and Information
RESTOREAdvanced Parkinson's Disease with Motor Fluctuations (Interventional)Steven Ojemann, MDPamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu
Physiological Effects of Intrathoracic Pressure Regulation in Patients With Decreased Cerebral Perfusion Due to Brain Injury or Intracranial PathologyBrain Injury Device (interventional)Robert Neumann, MDJen Maitlen, RN 303-724-1995   jennifer.maitlen@ucdenver.edu
Phase III Intergroup Study of Temozolomide Alone Versus Radiotherapy with Concomitant and Adjuvant Temozolomide Versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic GliomaBrain Tumor Drug vs Radiation with Drug (interventional)Brian Kavanagh 
Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation versus Bevacizumab Alone as Treatment for Recurrent GlioblastomaBrain Tumor Drug, Radiation (interventional)Laurie Gaspar, MD

Monica Robischon, RN 720-848-0661

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Stereotactic Laser Ablation for Temporal Lobe EpilepsyEpilespy (interventional)Steven Ojemann, MDPamela David-Gerecht 303-724-4134 Pamela.DavidGerecht@ucdenver.edu

 

Clinical Research

TitleTrial TypePrincipal InvestigatorEligibility and Information
Frailty as a Predictor of Neurosurgical Outcomes in Brain Tumor PatientsBrain Tumor ObservationalD. Ryan Ormond, MD

Jen Maitlen, RN 303-724-1995 jennifer.maitlen@ucdenver.edu

Central Nervous System Biorepository ProtocolBrain Surgery BioBankingKevin O. Lillehei, MD

Jen Maitlen, RN 303-724-1995 jennifer.maitlen@ucdenver.edu

University of Colorado School of Medicine Neuropsychology DatabaseNeuropsychology ObservationalBrian Hoyt, PhD

Jen Maitlen, RN 303-724-1995 jennifer.maitlen@ucdenver.edu

Using Parkinson’s disease to study the role of Substantia nigra pars reticulata in movement initiation and perceptionElectrophysiology during Deep Brain Stimulation Surgery (Research)Aviva Abosch, MD, PhD

Pamela David Gerecht, PhD 303-724-4134 pamela.davidgerecht@ucdenver.edu

More Info

Local Field Potentials Recorded from Deep Brain Stimulating Electrodes Implanted for the Treatment of Parkinson’s Disease, Essential Tremor or DystoniaElectrophysiology during Deep Brain Stimulation Surgery (Research)Aviva Abosch, MD, PhD

Pamela David Gerecht, PhD 303-724-4134 pamela.davidgerecht@ucdenver.edu

More Info

Sensory Gating Measured with Microelectrode Recording During Deep Brain Stimulation SurgeryElectrophysiology during Deep Brain Stimulation Surgery (Research)Aviva Abosch, MD, PhD

Pamela David Gerecht, PhD 303-724-4134 pamela.davidgerecht@ucdenver.edu