|Why Disease-Modifying Therapy Efficacy Varies With Age|
Immunopathology changes with age, so older individuals with multiple sclerosis need medications that focus on effects inside the nervous system, explained Dr. John Corboy, Professor of Neurology and Co-director of the Rocky Mountain MS Center.
American Journal of Managed Care, Oct. 9, 2020
“We proposed in a paper published in F1000 that GM-CSF Leukine would be a treatment for COVID-19. The idea was based on some preliminary work with Dr. Ken Tyler's lab showing that GM-CSF prevented the death of mice infected with West Nile Virus,” reported Dr. Huntington Potter. “We made a leap to suggest…that this natural protein might be a treatment for COVID-19. And there are now at least two clinical trials being carried out with GM-CSF treatment for COVID-19, one in Belgium and one in Singapore. One would never necessarily have thought that all of our work on Alzheimer's disease would give us an insight into how to treat COVID-19, but it did. That's one of the reasons it's so great to be in a university setting where ideas can be tested by essentially moving to the fifth floor from the fourth floor of our research building.”
|Young Women May Face Greater Stroke Risk Than Young Men|
“We have this sense of security that women don’t have as many strokes because estrogen in premenopausal women can be protective for cardiovascular events, but that’s a false assumption,” said the study’s lead author, Dr. Michelle Leppert, assistant professor of neurology at University of Colorado School of Medicine.
Herald Review (Big Rapids, Mich.), Sept. 18, 2020
|The New Coronavirus Can Infect Brain Cells, Study Finds|
“This study is the first to do an extensive analysis of SARS-CoV-2 [brain] infection using three models,” said Dr. Maria Nagel, professor of neurology and ophthalmology at the University of Colorado School of Medicine, who was not involved in the study.
LiveScience, Sept. 13, 2020
|Research About Stopping Disease-Modifying Therapies for MS|
Do patients with multiple sclerosis who have been on disease-modifying therapies (DMTs) for decades need to keep taking them? Dr. John Corboy, professor of neurology, University of Colorado Denver, School of Medicine, and co-director of the Rocky Mountain MS Center at Anschutz Medical Campus, explains what is known about this area.
AJMC, Sept. 12, 2020
|The Aging Brain: Exploring the Connection Between Neurology and Elevation|
When it comes to looking at the potential correlation between living at high elevation and the risk for dementia-inducing diseases, Drs. Huntington Potter and Peter Pressman of the Alzheimer’s and Cognition Center said it would take great effort, time and funding to research.
Summit Daily News, Sept. 10, 2020
|Long After the Fire of a Covid-19 Infection, Mental and Neurological Effects Can Still Smolder|
“It’s sort of like you’re trying to put out the fire and then a little bit later, you go look at the nervous system as the embers,” said Dr. Victoria Pelak, Professor of Neurology and Ophthalmology. “Because you are so concerned with the raging fire, you haven’t really been able to pay attention to the nervous system as much as you normally would.”
STAT, Aug. 12, 2020
|CU Anschutz Researchers Win NIH Grant to Study COVID-19 Impact on Sense of Smell|
“The virus often starts in the nose before making its way to the lungs,” said Diego Restrepo, PhD, Professor of cell and developmental biology, who will co-investigate with Maria Nagel, MD, Professor of Neurology and Ophthalmology. “We think this may spark an inflammatory response that releases cytokines which in turn silence olfactory sensory neurons in the nose.”
CU Anschutz Today, July 21, 2020
|Three Stages to COVID-19 Brain Damage, New Review Suggests|
Dr. Kenneth Tyler, Chair of the Department of Neurology at the University of Colorado School of Medicine, disagreed that all hospitalized patients with COVID-19 should routinely receive an MRI. “Whenever you are using a piece of equipment on patients who are COVID-19 infected, you risk introducing the infection to uninfected patients."
Medscape, June 29, 2020
|Does the Immune System Play a Role in Parkinson's Disease?|
“It has long been suspected that immune alterations are an important part of the development of PD,” says Dr. Maureen Leehey, Professor of Neurology at the University of Colorado School of Medicine.
Health Central, June 8, 2020
|What to Know Before Heading to an Open Beach This Summer|
“It’s really the close contact with people – whether in the water or on land – that’s the concern,” Dr. Daniel Pastula, neuro-infectious disease expert and Associate Professor of Neurology, said in a recent report by UCHealth.
Newsweek, May 22, 2020
|COVID 19: What Other Respiratory Viruses Can Reveal About Neurologic Symptoms|
Kenneth L. Tyler, Louise Baum Endowed Professor and Chair of Neurology at University of Colorado School of Medicine, said he tends to think of the potential neurologic impacts of CoV-2 as falling into one of three broad categories.
Neurology Today, May 21, 2020
Inflamed brains, toe rashes, strokes: Why COVID-19’s weirdest symptoms are only emerging now
“Almost all the [neurological] things we’re seeing now with COVID-19 are things you might have predicted would have happened,” says Kenneth Tyler, chairman of the department of neurology at the University of Colorado School of Medicine and a fellow of the American Academy of Neurology.
National Geographic, May 21, 2020
|Neuropalliative Care During COVID-19 – How Clinicians Help Patients and Families Cope with Isolation, Fear, and Life-Limiting Illness|
“It’s like a modern version of an old-fashioned home visit,” said Christina L. Vaughan, associate professor and chief of the division of neuropalliative care in the department of neurology at the University of Colorado, Anschutz Medical Campus. “This has really sparked a lot of conversation. So much of palliative care is understanding someone’s story and what is important to them.”
Neurology Today, May 18, 2020
Amanda L. Piquet, assistant professor of neurology at the University of Colorado School of Medicine, said it was after the first day that the five weeks of “stay-at-home” restrictions had been lifted that she realized she really needed a vacation. Dr. Piquet, who has a 4-year-old and an 8-month-old child, is a neurohospitalist and works part-time in the hospital where she has inpatient duties.
Samantha K. Holden, assistant professor of neurology at the University of Colorado School of Medicine, encountered her first work-family challenge during her first week of full-time telemedicine at home. Dr. Holden had asked an older patient to walk around his room so she could examine his gait—when all of a sudden, a little 4-year-old face appeared behind her on the screen.
Neurology Today, May 5, 2020
Coronavirus in Context Video Series, with WebMD’s Chief Medical Officer, John Whyte, MD, MPH, who discusses neurological effects of COVID-19 with Kenneth Tyler, department chair of neurology at University of Colorado School of Medicine.
WebMD, May 5, 2020
The brain and nerves may also fall prey to direct attack. Dr. Kenmeth Tyler, Chair of the Department of Neurology, cautions that direct central nervous system (CNS) attack is still being worked out at this time. There are many routes a virus could take to invade the CNS.
Medscape, April 23, 2020
Other coronaviruses that affect humans can invade the central nervous system, so it makes sense COVID-19 may have neurologic manifestations, Dr. Kenneth Tyler, chair of Neurology at University of Colorado School of Medicine, told Neurology Today, a publication of the American Academy of Neurology.
Neurology Today, April 13, 2020
“Time is really of the essence,” said Dr. Michelle Leppert, Assistant Professor of Neurology, who treated a stroke patient. “This was true before COVID. And the faster we can get a patient seen and get care to them, the
better the outcome is.”
Channel 7, April 14, 2020
Infectious disease expert Dr. Daniel Pastula says viral dose could matter — a
lot. “The lower the viral dose that you may get, we do think that there’s a better chance for your immune system to recognize what’s going on and fight it off before it causes problems,” he told CBS4’s
CBS4, April 7, 2020
Kenneth L. Tyler, Louis Baum Endowed Professor and Chair of Neurology at University of
Colorado School of Medicine, noted that earlier this year a report from three COVID-19-designated hospitals in Wuhan, China, indicated that more than one-third of coronavirus patients had some type of neurologic symptom, including
altered consciousness, evidence of skeletal muscle damage, and acute cerebrovascular disease.
Neurology Today, April 2, 2020
Good, old-fashioned soap, even if it’s the cheap, generic kind, works better than hand sanitizer to remove the coronavirus. It’s all about chemistry, says Dr. Daniel Pastula.
UCHealth Today, March 30, 2020
Medscape recently spoke with central nervous system infection specialist and chair of University of Colorado's neurology department, Dr. Kenneth Tyler,
about what implications the new coronavirus could have on patients and practice.
Medscape, March 26, 2020
Dr. Daniel Pastula, UCHealth University of Colorado Hospital and CU School of Medicine,
explained how the virus could easily infect the human body, as we have no pre-existing defences against it, adding: “Our bodies don’t immediately recognise it as a dangerous intruder.”
Express (London), March 20, 2020
“I get about 90-95 percent of my diagnosis from talking to them, getting to know them,” Dr. Samantha Holden,
a behavioral neurologist with University of Colorado Health and Assistant Professor of neurology at CU School of Medicine, said. “Even though we can’t cure these things, we can definitely manage them and make sure we’re
improving people’s quality of life.”
Channel 7, March 20, 2020
Hospitals in mountain communities, where the virus is spreading more widely, already are running short of protective gear and other resources to care for a higher volume of patients, said Dr. Daniel Pastula,
a University of Colorado School of Medicine infectious disease specialist who visited some of the harder-hit communities.
Denver Post, March 16, 2020
Typically, MS follows a classic relapse/remission pattern. “You get this burst of inflammation in a spot in the brain, and the inflammation runs its course,” Dr. Timothy Vollmer,
a neurologist at the University of Colorado who specializes in multiple sclerosis, tells SELF. After this “attack,” you then “recover,” and the symptoms retreat for a time period until the next attack.
Self, March 1, 2020
The study “raises the question of whether there is such a thing as HE,” commented Kenneth L. Tyler,
Louise Baum Endowed Professor and Chair of Neurology at the University of Colorado School of Medicine. “There aren't any validated diagnostic criteria, and the breadth of clinical presentations and lab criteria across patients
labeled with it is pretty broad.”
Neurology Today, Feb 20, 2020
As reported in the February 10, 2020 issue of JAMA Neurology, Dr. Benzi Kluger and School of Medicine colleagues evaluated whether
outpatient palliative care is associated with improvements in patient-centered outcomes compared with standard care among 210 patients with Parkinson disease and related disorders and 175 caregivers.
Physician’s Weekly, Feb 10, 2020
Kyle Parker convulsed so violently he broke his back in four places. Then he opted for an innovative brain surgery and he’s 100% seizure free. Cornelia Drees, MD,
Associate Professor of Neurology, describes the laser ablation surgery that ended Kyle's unpredictable seizures.
UCHealth Today, Jan. 22, 2020
Because there was variability between individuals, “looking at a population enables one to see overall trends,” says neurologist Ken Tyler, MD,
Professor and Chair of Neurology of the CU School of Medicine, who was not involved in the research. “We need to aggressively follow all children whose mothers were exposed to Zika during pregnancy to understand the nature of
their neurological delays.”
Science News, Jan. 6, 2020