NEUROHOSPITALIST/STROKE RESEARCH

CADASIL (22-0235)

• Investigator: Karen Orjuela, MD
• Purpose: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common heritable cause of vascular dementia, but many of the early symptoms of the disease remain poorly understood. This study is designed to look at how a person's body, brain, and behavior change throughout the stages of this disease, and what factors might serve as additional risks or protective factors.
• Timeline: 3 in-person study visits over 5 years.
• ClinicalTrials.gov Identifier: NCT05677880 
•  Key Eligibility Criteria:
  • CADASIL Participants:
    • Age: 18+ years old
    • positive NOTCH3* genetic testing; or a positive skin biopsy; or willingness to have a NOTCH3 genetic test prior to enrolling and are a -risk for, or diagnosed clinically, with CADASIL
  • CADASIL Participant Chosen Companion:
    • Same criteria as CADASIL participants except are or were at risk for CADASIL but have Negative NOTCH3* genetic testing