HEALTHY VOLUNTEERS

DREAMS (19-0393)   

• Investigator: Teri Schreiner, MD, MPH  
• Purpose: to learn more about the risk factors for and causes of MS by studying children who are first degree relatives of people with MS.
• Timeline: a single 3-4 hour study visit (includes MRI and blood draw).
• Key Eligibility Criteria:
  • Age 10-17 years old
  • Have parent or sibling with MS
  • No diagnosis of MS or early symptoms of MS.

RISE-MS (17-1884)   

• Investigator: Enrique Alvarez, MD, PhD and John Corboy, MD 
• Purpose: to learn more about the risk factors for and causes of MS by studying first degree relatives of people with MS.
• Timeline: a single 2-3 hour study visit (includes MRI and blood draw).
• ClinicalTrials.gov Identifier: NCT03586986 
• Key Eligibility Criteria:
  • Age 10-17 years old
  • Have parent or sibling with MS
  • No diagnosis of MS or early symptoms of MS.
    

Cytokine Observational Study (18-1356)  

• Investigator: Amy Amara, MD, PhD
• Purpose: to test the blood levels of cytokines in patients with Parkinson’s Disease or Essential Tremor, compared with healthy controls to explore potential biomarkers of Parkinson’s Disease and Essential Tremor.
• Timeline: one time blood draw.
• Key Eligibility Criteria:
  • 60-75 years of age
  • Does not have any form of parkinsonism or Essential Tremor
  • Does not have any inflammatory disease

Michael J. Fox Foundation PPMI 2.0 (20-1204) 

• Investigator: Michelle Fullard, MD, MSCE  
• Purpose: to continue to obtain information from people with and without Parkinson’s disease (PD) so that researchers may better understand how PD progresses, in order to inform better treatments.
• Timeline: 2 visits annually for up to 7 years.
• ClinicalTrials.gov Identifier: NCT04477785
• Key Eligibility Criteria:
  • Have NOT been diagnosed with PD
  • Do NOT have a first degree relative with PD
  • Age: 30+ years old OR have NOT been diagnosed with PD
  • Have a first degree relative with PD, age: 60+ years old

Facial Expressions Study (17-0599)

• Investigator: Peter Pressman, MD
• Purpose: to understand how the brain makes different facial expressions using high speed videography, learn more about how neurological disorders may impact a person’s facial movements and expressions, and develop the groundwork for a diagnostic tool that would detect differences between a person’s facial movements/expressions and their emotions.
• Timeline: one study visit that will last approximately one hour.
• CUACC Website: click here
• Key Eligibility Criteria:
  • Age: 18-75 years old
  • Diagnosis: Mild Cognitive Impairment (MCI) or dementia OR have NOT been diagnosed with a memory disorder
  • Are right handed

DN (19-3004)

•  Study Title: Participants Needed for Research Study About Diabetes and Neuropathy.
• Investigator: Vera Fridman, MD
• Purpose: to learn more about the underlying causes of diabetic neuropathy by looking for the presence of abnormal molecules in the blood and skin and comparing them in people with and without Type 2 Diabetes.
• Procedures: blood draw, skin biopsy, neurological and physical exam.
• Timeline: 2 study visits which will occur within 30 days of each other.
• Key Eligibility Criteria:
  • Age: 45-65 years old
  • Have NOT been diagnosed with Type 2 Diabetes (T2D)
    

DOMYA (23-1307)

• Investigator: Thomas Ragole, MD
• Purpose: to assess the effectiveness and safety of an investigational digital tool called ME&MG, which allows patients with generalized Myasthenia Gravis (gMG) to self-monitor their symptoms.
• Device: ME&MG smartphone application (investigational software as a medical device).
• Timeline:Screening/Inclusion visit (Day 0) and an At Home Digital Test (Day 1).
• ClinicalTrials.gov Identifier: NCT05564936
• Key Eligibility Criteria:
  • Age: 18 years to 60 years
  • Owning and able to use a personal smartphone which software version is above 14 for IOS and 8 for Android