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Radiology Styles

Miao Lab

Yubin Miao, PhD (250 x 333)

The research interests in my laboratory focus on developing novel radiolabeled peptides for cancer (melanoma, breast and prostate cancers) diagnosis and treatment. Specifically, we are using radiolabeled peptides to target G protein-coupled receptors (GPCRs) that are over-expressed on cancer cells for cancer detection and therapy. Radiolabeled peptides are attractive probes for cancer imaging and therapy due to their specific nanomolar binding with the GPCRs on cancer cells. Radiolabeled peptides can selectively deliver diagnostic and therapeutic radionuclides to cancer cells through peptide-receptor interactions for imaging and therapy. Hence, malignant tumors can be detected non-invasively by imaging modalities (SPECT or PET) through the collection of photons generated from diagnostic radionuclides. Moreover, malignant tumors can be effectively treated by targeted radiation yielded from therapeutic radionuclides delivered by peptides.​

—Yubin Miao, PhD

Selected Publications (Chronological)

  1. Haixun Guo, Nalini Shenoy, Benjamin M. Gershman, Jianquan Yang, Larry A. Sklar, Yubin Miao. Metastatic melanoma imaging with an 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide. Nuclear Medicine and Biology 2009;36:267-276.
  2. Jianquan Yang, Haixun Guo, Fabio Gallazzi, R. Steven Padilla, Marianne Berwick, Yubin Miao. Evaluation of a novel RGD-conjugated alpha-melanocyte stimulating hormone hybrid peptide for potential melanoma therapy. Bioconjugate Chemistry 2009;20:1634-1642.
  3. Haixun Guo, Jianquan Yang, Fabio Gallazzi, Eric R. Prossnitz, Larry A. Sklar, Yubin Miao. Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide. Bioconjugate Chemistry 2009;20:2162-2168.
  4. Haixun Guo, Jianquan Yang, Nalini Shenoy, Yubin Miao. Gallium-67-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide for primary and metastatic melanoma imaging. Bioconjugate Chemistry 2009;20:2356-2363.
  5. Haixun Guo, Jianquan Yang, Fabio Gallazzi, Yubin Miao. Reduction of the ring size of radiolabeled lactam bridge-cyclized alpha-MSH peptide resulting in enhanced melanoma uptake. Journal of Nuclear Medicine 2010;51:418-426.
  6. Thomas P. Quinn, Xiuli Zhang, Yubin Miao. Targeted melanoma imaging and therapy with radiolabeled alpha-melanocyte stimulating hormone peptide analogues. The Italian Journal of Dermatology 2010;145:245-258.
  7. Jianquan Yang, Haixun Guo, Yubin Miao. Technetium-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptides for human melanoma imaging. Nuclear Medicine and Biology 2010;37:873-883.
  8. Jianquan Yang, Haixun Guo, R. Steven Padilla, Marianne Berwick, Yubin Miao. Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide. Bioorganic & Medicinal Chemistry 2010;18:6695-6700.
  9. Haixun Guo, Jianquan Yang, Fabio Gallazzi, Yubin Miao. Effects of the amino acid linkers on melanoma-targeting and pharmacokinetic properties of indium-111-labeled lactam bridge-cyclized α-MSH peptides. Journal of Nuclear Medicine 2011;52:608-616.
  10. Haixun Guo, Fabio Gallazzi, Larry A. Sklar, Yubin Miao. A novel Indium-111-labeled gonadotropin-releasing hormone peptide for human prostate cancer imaging. Bioorganic & Medicinal Chemistry Letters 2011;21:5183-5186.
  11. Haixun Guo, Jie Lu, Helen J. Hathaway, Melanie E. Royce, Eric R. Prossnitz, Yubin Miao. Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides. Bioconjugate Chemistry 2011;22:1682-1689.
  12. Haixun Guo, Yubin Miao. Cu-64-labeled lactam bridge-cyclized alpha-MSH peptides for PET imaging of melanoma. Molecular Pharmaceutics 2012;9:2322-2330.
  13. Haixun Guo, Fabio Gallazzi, Yubin Miao. Ga-67-labeled lactam bridge-cyclized alpha-MSH peptides with enhanced melanoma uptake and reduced renal uptake. Bioconjugate Chemistry 2012;23:1341-1348.
  14. Jianquan Yang, Jie Lu, Yubin Miao. Structural modification on the Lys linker enhanced tumor to kidney uptake ratios of Tc-99m-labeled RGD-conjugated alpha-MSH hybrid peptides. Molecular Pharmaceutics 2012;9:1418-1424.
  15. Jianquan Yang, Yubin Miao. Substitution of Gly with Ala enhanced the melanoma uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorganic & Medicinal Chemistry Letters 2012;22:1541-1545.
  16. Haixun Guo, Fabio Gallazzi, Yubin Miao. Design and evaluation of Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptides for melanoma imaging. Molecular Pharmaceutics 2013;10:1400-1408.
  17. Haixun Guo, Yubin Miao. Melanoma targeting property of a Lu-177-labeled lactam bridge-cyclized alpha-MSH peptide. Bioorganic & Medicinal Chemistry Letters 2013;23:2319-2323.
  18. Jianquan Yang, Liqin Liu, Yubin Miao. Effects of the Arg-Pro and Gly-Gly-Nle moieties on melanocortin-1 receptor binding affinities of alpha-melanocyte stimulating hormone peptides. ACS Medicinal Chemistry Letters 2013;4:1000-1004.
  19. Haixun Guo, Helen J. Hathaway, Melanie E. Royce, Eric R. Prossnitz, Yubin Miao. The influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorganic & Medicinal Chemistry Letters 2013;23:5484-5487.
  20. Adam M. Flook, Jianquan Yang, Yubin Miao. Evaluation of new Tc-99m-labeled Arg-X-Asp-conjugated alpha-melanocyte stimulating hormone peptides for melanoma imaging. Molecular Pharmaceutics 2013;10:3417-3424.
  21. Adam M. Flook, Jianquan Yang, Yubin Miao. Effects of amino acids on melanoma targeting and clearance properties of Tc-99m-labeled Arg-X-Asp-conjugated alpha-melanocyte stimulating hormone peptides. Journal of Medicinal Chemistry 2013;56:8793-8802.
  22. Jianquan Yang, Adam M. Flook, Changjian Feng, Yubin Miao. Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorganic & Medicinal Chemistry Letters 2014;24:195-198.
  23. Kubra Durkan, Zongrun Jiang, Tammy L. Rold, Gary L. Sieckman, Timothy J. Hoffman Rajendra Prasad Bandari, Liqin Liu, Yubin Miao, Tamila Stott Reynolds, Charles J. Smith. A heterodimeric 64Cu-NO2A-RGD-Glu-6-Ahx-RM2 αvβ3/GRPr-targeting antagonist radiotracer for PET imaging of prostate cancer. Nuclear Medicine and Biology 2014;41:133-139.
  24. Jie Lu, Helen J. Hathaway, Melanie E. Royce, Eric R. Prossnitz, Yubin Miao. Introduction of D-Phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorganic & Medicinal Chemistry Letters 2014;24:725-730.
  25. Adam M. Flook, Jianquan Yang, Yubin Miao. Substitution of the Lys linker with the β-Ala linker dramatically decreased the renal uptake of Tc-99m-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated α-MSH peptides. Journal of Medicinal Chemistry 2014;57:9010-9018.
  26. Haixun Guo, Yubin Miao. Introduction of an aminooctanoic acid linker enhances uptake of Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptide in melanoma. Journal of Nuclear Medicine 2014;55:2057-2063.
  27. Tamila J. Stott Reynolds, Rebecca Schehr, Dijie Liu, Jingli Xu, Yubin Miao, Tammy L. Rold, Michael Lewis, Charles J. Smith. Characterization and evaluation of DOTA-conjugated bombesin/RGD-antagonists for prostate cancer tumor imaging and therapy. Nuclear Medicine and Biology 2015;42:99-108.
  28. Jingli Xu, Jianquan Yang, Yubin Miao. Dual receptor-targeting Technetium-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptides for human melanoma imaging. Nuclear Medicine and Biology 2015;42:369-374.
  29. Jianquan Yang, Chien-An A. Hu, Yubin Miao. Tc-99m-labeled RGD-conjugated alpha-MSH hybrid peptides with reduced renal uptake. Amino Acids 2015;47:813-823.​
  30. Zhenlong Wu, Chien-An A. Hu, Guoyao Wu, Siqin Zhaorigetu, Hitendra Chand, Kaiji Sun, Yun Ji, Bing Wang, Zhaolai Dai, Brian Walton, Yubin Miao, Yongqing Hou. Intimacy and a deadly feud: The interplay of autophagy and apoptosis mediated by amino acid. Amino Acids 2015;47:2089-2099.​
  31. Andrei V. Astashkin, Li Chen, Bradley O. Elmore, Deepak Kunwar, Yubin Miao, Huiying Li, Thomas L. Poulos, Linda J. Roman, Changjian Feng. Probing the hydrogen bonding of the Ferrous-NO heme center of nNOS by pulsed EPR. Journal of Physical Chemistry A 2015;119:6641-6649.
  32. Li Chen, Huayu Zheng, Wenbing Li, Wei Li, Yubin Miao, Changjian Feng. Role of a conserved tyrosine residue in the FMN-Heme interdomain electron transfer in inducible nitric oxide synthase. Journal of Physical Chemistry A 2016;120:7610-7616.​
  33. Liqin Liu, Jingli Xu, Jianquan Yang, Changjian Feng, Yubin Miao. Imaging human melanoma using a novel Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptide. Bioorganic & Medicinal Chemistry Letters 2016;26:4724-4728.​
  34. Zongrui Jiang, Rajendra P. Bandari, Tamila J. Stott Reynolds, Jingli Xu, Yubin Miao, Tammy L. Rold, Ashley F. Szczodroski, Silvia S. Jurisson, Charles J. Smith. Molecular imaging investigations of a 67Ga/64Cu labeled bivalent ligand, [RGD-Glu-(DO3A)-6-Ahx-RM2], targeting GRPR/αvβ3 biomarkers: a comparative study. Radiochimica Acta 2016;104:499-512.​
  35. Liqin Liu, Jingli Xu, Jianquan Yang, Changjian Feng, Yubin Miao. Metastatic melanoma imaging using a novel Tc-99m-labeled lactam-cyclized alpha-MSH peptide. Bioorganic & Medicinal Chemistry Letters 2017;27:4952-4955.​
  36. Jingli Xu, Changjian Feng, Yubin Miao. Evaluation of novel 111In-labeled gonadotropin-releasing hormone peptides for human prostate cancer imaging. Bioorganic & Medicinal Chemistry Letters 2017;27:4647-4651.​
  37. Nilantha Bandara, Tamila J. Stott Reynolds, Rebecca Schehr, Rajendra P. Bandari, Philipp J. Diebolder, Stephanie Krieger, Jingli Xu, Yubin Miao, Buck E. Rogers, Charles J. Smith. Matched-pair, 86Y/90Y-labeled, bivalent RGD/bombesin antagonist, [RGD-Glu-(DO3A)-6-Ahx-RM2], as a potential theranostic agent for prostate cancer. Nuclear Medicine Biology 2018;62-63:71-77.
  38. Jinghui Li, Huayu Zheng, Wei Wang, Yubin Miao, Changjian Feng. Role of an isoform-specific residue at the calmodulin-heme (NOS) interface in the FMN-heme electron transfer. FEBS Letters 2018;592:2425-2431.
  39. Andrei Astashkin, Jinghui Li, Huayu Zheng, Yubin Miao, Changjian Feng. A docked state conformational dynamics model to explain the ionic strength dependence of FMN-heme electron transfer in nitric oxide synthase. Journal of Inorganic Biochemistry 2018;184:146-155.
  40. Brian D. Berman, Rebecca T. Pollard, Erika Shelton, Ramesh Karki, Peter Smith-Jones, Yubin Miao. GABAA receptor availability changes underlie symptoms in isolated cervical dystonia. Frontiers in Neurology 2018;9:188.
  41. Jianquan Yang, Jingli Xu, Rene Gonzalez, Thomas Lindner, Clemens Kratochwil, Yubin Miao. 68Ga-DOTA-GGNle-CycMSHhex targets the melanocortin-1 receptor for melanoma imaging. Science Translational Medicine 2018;10:eaau4445.
  42. Jingli Xu, Jianquan Yang, Rene Gonzalez, Darrell R. Fisher, Yubin Miao. Melanoma targeting property of Y-90-labeled lactam-cyclized alpha-melanocyte-stimulating hormone peptide. Cancer Biotherapy and Radiopharmaceuticals 2019;34:597-603.
  43. Jianquan Yang, Jingli Xu, Lina Cheuy, Rene Gonzalez, Darrell R. Fisher, Yubin Miao. Novel Pb-203-labeled lactam-cyclized alpha-melanocyte-stimulating hormone peptide for melanoma targeting. Molecular Pharmaceutics 2019;16:1694-1702.
  44. Jingli Xu, Zheng Qiao, Rene Gonzalez, Yubin Miao. Facile preparation of a novel Ga-67-labeled NODAGA-conjugated lactam-cyclized alpha-MSH peptide at room temperature for melanoma targeting. Bioorganic & Medicinal Chemistry Letters 2020;30:127627.
  45. Zheng Qiao, Jingli Xu, Rene Gonzalez, Yubin Miao. Novel [99mTc]-Tricarbonyl-NOTA-conjugated lactam-cyclized alpha-MSH peptide with enhanced melanoma uptake and reduced renal uptake. Molecular Pharmaceutics 2020;17:3581-3588.
  46. Yubin Miao and Thomas P. Quinn. Advances in receptor-targeted radiolabeled peptides for melanoma imaging and therapy. Journal of Nuclear Medicine 2021;62:313-318.
  47. Emerson Bernardes, Peter Caravan, R Michael van Dam, Winnie Deuther-Conrad, Beverley Ellis, Shozo Furumoto, Benjamin Guillet, Ya-Yao Huang, Hongmei Jia, Peter Laverman, Zijing Li, Zhaofei Liu, Filippo Lodi, Yubin Miao, Lars Perk, Ralf Schirrmacher, Johnny Vercoullie, Hua Yang, Min Yang, Xing Yang, Junbo Zhang, Ming-Rong Zhang, Hua Zhu. Highlight selection of radiochemistry and radiopharmacy developments by editorial board. EJNMMI Radiopharmacy and Chemistry 2022;7:9.
  48. Jingli Xu, Fabio Gallazzi, Darrell R. Fisher, Rene Gonzalez, Yubin Miao. The effect of albumin binding moiety on tumor targeting properties of 67Ga-labeled albumin binder-conjugated alpha-melanocyte-stimulating hormone peptides. Cancer Biotherapy and Radiopharmaceuticals 2022;37:47-55.
  49. Zheng Qiao, Jingli Xu, Rene Gonzalez, Yubin Miao. Novel 64Cu-labeled NOTA-conjugated lactam-cyclized alpha-melanocyte-stimulating hormone peptides with enhanced tumor to kidney uptake ratios. Molecular Pharmaceutics 2022;19:2535-2541.
  50. Zheng Qiao, Jingli Xu, Rene Gonzalez, Yubin Miao. Novel Al18F-NOTA-conjugated lactam-cyclized alpha-melanocyte-stimulating hormone peptides with enhanced melanoma uptake Bioconjugate Chemistry 2022;33:982-990.
  51. Zheng Qiao, Jingli Xu, Darrell R. Fisher, Rene Gonzalez, Yubin Miao. Introduction of a polyethylene glycol linker improves uptake of 67Cu-NOTA-conjugated lactam-cyclized alpha-melanocyte-stimulating hormone peptide in melanoma. Cancers 2023;15:2755.
  52. Zheng Qiao, Jingli Xu, Rene Gonzalez, Yubin Miao. Effects of polyethylene glycol and 8-aminooctanoic acid linkers on melanoma uptake of [99mTc]Tc-tricarbonyl-NOTA-conjugated lactam-cyclized alpha-MSH peptides. Bioconjugate Chemistry 2023;34:934-940.
Yubin Miao, PhD

Yubin Miao, PhD

Principal Investigator

Phone: (303) 724-3763

E-mail: yubin.miao@cuanschutz.edu

Zheng Qiao, PhD

Zheng Qiao, PhD

Research Associate

Phone: (303) 724-8796

E-mail: zheng.qiao@cuanschutz.edu

Department of Radiology

CU Anschutz

Leprino Building

12401 East 17th Avenue

Aurora, CO 80045

720-848-0000

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