The Schmidt laboratory investigates the mechanisms responsible for the development and resolution of organ injury during sepsis. Our interests include the structure and function of the endothelial glycocalyx, a ubiquitous layer of glycosaminoglycans lining the vascular lumen. Our studies provide new insights into septic acute lung and kidney injury, as well as the persistent neurocognitive dysfunction faced by sepsis survivors. Our laboratory is similarly interested in alveolar epithelial glycosaminoglycan fragmentation during direct lung injury, and the impact of fragmentation on host-pathogen interaction and lung repair/fibrosis. Emerging interests of our laboratory include the effects of aging on sepsis outcomes, as well as the isolation of glycosaminoglycans from biological tissues and their structural analysis.