HEALTHY VOLUNTEERS

ImTAB (19-1423)

• Investigator: Brianne Bettcher, PhD, ABPP-CN 
• Purpose: to better understand how a mild traumatic brain injury in late life relates to inflammation, markers of Alzheimer’s disease related proteins, and clinical functioning over time.
• Timeline: two study visits over the course of one year (a baseline and a one year follow-up visit).
• Colorado Aging Brain Lab Website: click here
• Key Eligibility Criteria: age 65+ years old, in good general health, have NOT been diagnosed with a memory disorder, have had a concussion within the past 5 years.
  

LIIA (18-2607) 

• Investigator: Brianne Bettcher, PhD, ABPP-CN 
• Purpose: to examine how inflammation and COVID-19 exposure influences brain health. Data gathered from this study will be used to better understand how inflammation may or may not disrupt thinking and memory. 
• Timeline: two study visits over the course of two years.
• Colorado Aging Brain Lab Website: click here
• ClinicalTrials.gov Identifier: NCT03944603 
• Key Eligibility Criteria: age 60+ years old, in good general health, have NOT been diagnosed with a memory disorder, willing to undergo 2 lumbar punctures over the course of the study.
  

Cytokine Observational Study (18-1356)  

• Investigator:  Maureen Leehey, MD, FAAN  
• Purpose: to learn more about the level of inflammatory and other markers in the blood of patients with Parkinson’s disease (PD), essential tremor (ET), and healthy volunteers.
• Timeline: one time blood draw.
• Key Eligibility Criteria: have NOT been diagnosed with PD or ET, age: 60-75 years old.

Michael J. Fox Foundation PPMI 2.0 (20-1204) 

• Investigator: Michelle Fullard, MD, MSCE  
• Purpose: to continue to obtain information from people with and without Parkinson’s disease (PD) so that researchers may better understand how PD progresses, in order to inform better treatments.
• Timeline: 2 visits annually for up to 7 years.
• ClinicalTrials.gov Identifier: NCT04477785
• Key Eligibility Criteria: have NOT been diagnosed with PD, do NOT have a first degree relative with PD, age: 30+ years old OR have NOT been diagnosed with PD, have a first degree relative with PD, age: 60+ years old.
  

DREAMS (19-0393)   

• Investigator: Teri Schreiner, MD, MPH  
• Purpose: to learn more about the risk factors for and causes of MS by studying children who are first degree relatives of people with MS.
• Timeline: a single 3-4 hour study visit (includes MRI and blood draw).
• Key Eligibility Criteria: age 10-17 years old, have parent or sibling with MS, no diagnosis of MS or early symptoms of MS.

RISE-MS (17-1884)   

• Investigator: Enrique Alvarez, MD, PhD and John Corboy, MD 
• Purpose: to learn more about the risk factors for and causes of MS by studying first degree relatives of people with MS.
• Timeline: a single 2-3 hour study visit (includes MRI and blood draw).
• ClinicalTrials.gov Identifier: NCT03586986 
• Key Eligibility Criteria: age 10-17 years old, have parent or sibling with MS, no diagnosis of MS or early symptoms of MS.
  

DN (19-3004)

•  Study Title: Participants Needed for Research Study About Diabetes and Neuropathy.
• Investigator: Vera Fridman, MD
• Purpose: to learn more about the underlying causes of diabetic neuropathy by looking for the presence of abnormal molecules in the blood and skin and comparing them in people with and without Type 2 Diabetes.
• Procedures: blood draw, skin biopsy, neurological and physical exam.
• Timeline: 2 study visits which will occur within 30 days of each other.
• Key Eligibility Criteria: age: 45-65 years old, have NOT been diagnosed with Type 2 Diabetes (T2D).
  

• Title: Investigating Cortial Networks Disruption and Rehabilitation After Traumatic Brain Injury (19-0049)
• Investigator: Isabelle Buard, PhD
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