ALZHEIMER'S DISEASE/MEMORY DISORDERS RESEARCH

Conversational Speech Analysis (CSA) Study (18-0456)

• Investigator: Peter Pressman, MD
• Purpose: to learn more about how speech changes over time in adult populations, understand how those changes reflect changes in cognition, and develop new ways of detecting MCI and dementia using everyday speech.
• Timeline: two study visits, one year apart.
• Study flyer: click here
• Key Eligibility Criteria: diagnosis: mild cognitive impairment (MCI) or dementia OR have NOT been diagnosed with a memory disorder, age: 40-95 years old.

Facial Expressions Study (17-0599)

• Investigator: Peter Pressman, MD
• Purpose: to understand how the brain makes different facial expressions using high speed videography, learn more about how neurological disorders may impact a person’s facial movements and expressions, and develop the groundwork for a diagnostic tool that would detect differences between a person’s facial movements/expressions and their emotions.
• Timeline: one study visit that will last approximately one hour.
• CUACC Website: click here
• Key Eligibility Criteria: diagnosis: mild cognitive impairment (MCI) or dementia OR have NOT been diagnosed with a memory disorder, age: 18-75 years old, are right handed.

Bio-AD

Linda Crnic Institute for Down Syndrome Research Studies

Facial Expressions Study (17-0599)

• Investigator: Peter Pressman, MD
• Purpose: to understand how the brain makes different facial expressions using high speed videography, learn more about how neurological disorders may impact a person’s facial movements and expressions, and develop the groundwork for a diagnostic tool that would detect differences between a person’s facial movements/expressions and their emotions.
• Timeline: one study visit that will last approximately one hour.
• CUACC Website:click here
• Key Eligibility Criteria: diagnosis: mild cognitive impairment (MCI) or dementia OR have NOT been diagnosed with a memory disorder, age: 18-75 years old, are right handed.

ALLFTD (21-2833)

• Investigator:  Peter Pressman, MD
• Purpose: the ARTFL LEFFTDS Longitudinal Frontotemporal Dementia (ALLFTD) study aims to evaluate sporadic (s-) and familial (f-) frontotemporal lobar degeneration (FTLD) patients and asymptomatic family members of f-FTLD patients, characterizing the cohorts longitudinally and informing clinical trial design (Biofluid-Focused and Longitudinal arms available).
• ClinicalTrials.gov Identifier: NCT04363684

• ALLFTD Biofluid Timeline: one-time visit with questionnaires, neurological exam, blood drawn, and optional lumbar puncture.
• Biofluid Key Eligibility Criteria: diagnosis: FTLD syndrome like bvFTD, bvFTD with ALS, PPA, PSP, or CBD, age: 18+ years old.

• ALLFTD Longitudinal Timeline: annual visit to the clinic, each lasting 2–3 days, with questionnaires, thinking and memory questions, neurological exam, blood drawn, and an MRI.
  
• Longitudinal Key Eligibility Criteria: age: 18+ years old, diagnosis: FTLD syndrome like bvFTD, bvFTD with ALS, PPA, PSP, or CBD, OR are from a family with a mutation in a gene known tocause FTLD (such as C9orf72, MAPT, and GRN) OR have a significant family history of FTLD suggesting a familial genetic mutation.
  

Conversational Speech Analysis (CSA) Study (18-0456)

• Investigator: Peter Pressman, MD
• Purpose: to learn more about how speech changes over time in adult populations, understand how those changes reflect changes in cognition, and develop new ways of detecting MCI and dementia using everyday speech.
• Timeline: two study visits, one year apart.
• Study flyer: click here
• Key Eligibility Criteria: diagnosis: mild cognitive impairment (MCI) or dementia OR have NOT been diagnosed with a memory disorder, age: 40-95 years old.

LIIA (18-2607)

• Investigator: Brianne Bettcher, PhD, ABPP-CN 
• Purpose: to examine how inflammation and COVID-19 exposure influences brain health. Data gathered from this study will be used to better understand how inflammation may or may not disrupt thinking and memory. 
• Timeline: two study visits over the course of two years.
• Colorado Aging Brain Lab Website: click here
• ClinicalTrials.gov Identifier: NCT03944603 
• Key Eligibility Criteria: age: 60+ years old, in good general health, have NOT been diagnosed with a memory disorder, willing to undergo 2 lumbar punctures over the course of the study.
  

ImTAB (19-1423)

• Investigator: Brianne Bettcher, PhD, ABPP-CN 
• Purpose: to better understand how a mild traumatic brain injury in late life relates to inflammation, markers of Alzheimer’s disease related proteins, and clinical functioning over time.
• Timeline: two study visits over the course of one year (a baseline and a one year follow-up visit).
• Colorado Aging Brain Lab Website: click here
• Key Eligibility Criteria: age: 65+ years old, in good general health, have NOT been diagnosed with a memory disorder, have had a concussion within the past 5 years.
  

Facial Expressions Study (17-0599)

• Investigator: Peter Pressman, MD
• Purpose: to understand how the brain makes different facial expressions using high speed videography, learn more about how neurological disorders may impact a person’s facial movements and expressions, and develop the groundwork for a diagnostic tool that would detect differences between a person’s facial movements/expressions and their emotions.
• Timeline: one study visit that will last approximately one hour.
• CUACC Website: click here
• Key Eligibility Criteria: diagnosis: mild cognitive impairment (MCI) or dementia OR have NOT been diagnosed with a memory disorder, age: 18-75 years old, are right handed.

Conversational Speech Analysis (CSA) Study (18-0456)

• Investigator: Peter Pressman, MD
• Purpose: to learn more about how speech changes over time in adult populations, understand how those changes reflect changes in cognition, and develop new ways of detecting MCI and dementia using everyday speech.
• Timeline: two study visits, one year apart.
• Study flyer: click here
• Key Eligibility Criteria: diagnosis: mild cognitive impairment (MCI) or dementia OR have NOT been diagnosed with a memory disorder, age: 40-95 years old.
  

Facial Expressions Study (17-0599)

• Investigator: Peter Pressman, MD
• Purpose: to understand how the brain makes different facial expressions using high speed videography, learn more about how neurological disorders may impact a person’s facial movements and expressions, and develop the groundwork for a diagnostic tool that would detect differences between a person’s facial movements/expressions and their emotions.
• Timeline: one study visit that will last approximately one hour.
• CUACC Website: click here
• Key Eligibility Criteria: diagnosis: mild cognitive impairment (MCI) or dementia OR have NOT been diagnosed with a memory disorder, age: 18-75 years old, are right handed.

Conversational Speech Analysis (CSA) Study (18-0456)

• Investigator: Peter Pressman, MD
• Purpose: to learn more about how speech changes over time in adult populations, understand how those changes reflect changes in cognition, and develop new ways of detecting MCI and dementia using everyday speech.
• Timeline: two study visits, one year apart.
• Study flyer: click here
• Key Eligibility Criteria: diagnosis: mild cognitive impairment (MCI) or dementia OR have NOT been diagnosed with a memory disorder, age: 40-95 years old.
  

Facial Expressions Study (17-0599)

• Investigator: Peter Pressman, MD
• Purpose: to understand how the brain makes different facial expressions using high speed videography, learn more about how neurological disorders may impact a person’s facial movements and expressions, and develop the groundwork for a diagnostic tool that would detect differences between a person’s facial movements/expressions and their emotions.
• Timeline: one study visit that will last approximately one hour.
• CUACC Website: click here
• Key Eligibility Criteria: diagnosis: mild cognitive impairment (MCI) or dementia OR have NOT been diagnosed with a memory disorder, age: 18-75 years old, are right handed.