Acute Ischemic Stroke Research

We aim to combat the sex and gender disparities in acute ischemic stroke through translational research. Our team focus on all aspects of ischemic stroke care in the prehospital and emergency department settings. In addition to our focus on the quality of care, we are also interested in identifying sex-based differences in the metabolic response to stroke that are amenable to manipulation for neuroprotection.

Our Team

Picture of Layne Dylla

Layne Dylla, MD, PhD
Assistant Professor, Department of Emergency Medicine University of Colorado School of Medicine 

Picture of Hannah Higgins

Hannah M. Higgins, MSc 
Professional Research Assistant Department of Emergency Medicine

Active Research

Sex-based Differences in the Ischemic-Reperfusion Response to Hyperoxia for the Treatment of Acute Ischemic Stroke 
Supported by  Building Interdisciplinary Research Careers in Women's Health - K12-HD057022; Ludeman Family Center for Women’s Health Research Covid-19 Supplement.  
Description / Aims  The study assesses for sex differences in the cell death, immune, and clinical response to hyperoxia for the emergency department treatment of acute ischemic stroke. 
Sex-based Differences in the Metabolic Response to Stroke 
Supported by  Colorado Clinical and Translational Sciences Institute CO-J-22-13; The study assesses for sex differences in tryptophan metabolism via the kynurenine pathway in acute ischemic stroke and conducts a preliminary untargeted metabolomic survey of sex differences in stroke.  

Closed Research

The Role of Hyperoxia in the Emergency Department Treatment of Acute Ischemic Stroke. 
Supported by  American Heart Association Early Scientist Career Development Award - 19CDA34660039. Pilot study of the feasibility, safety, and early efficacy of brief early hyperoxia therapy for the emergency department treatment of acute ischemic stroke. 

Stroke

Analysis of gender disparities in prehospital and emergency department care for acute ischemic stroke 

Analysis of differences in patient presentation accounting for infarct location in males and females with acute ischemic stroke 

  • Dylla L., Higgins H.M., Piper C., Poisson S.N., Herson P.S., Monte A.A., Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes – where is the data: A Systematic Review. Frontiers in Neurology. In press 
  • Arnold C.G., Dylla L., Monte A.A., Heard K., Heard S., D’Alessandro A., Reynolds K., Dart R., Rumack B., Sonn B.(2022) Metabolomic evaluation of N-acetyl-p-benzoquinone imine protein adduct formation with therapeutic acetaminophen administration: sex-based physiologic differences. Journal of Medical Toxicology. Published online 24 Jun 2022. PMID: 35751009  
  • Dylla L., Rice J.D., Poisson S.N., Monte A., Higgins H.M., Ginde, A.A. Herson P.S. (2021) Analysis of Stroke Care Among 2019-2020 National Emergency Medical Services Information System Encounters. Journal of Stroke and Cerebrovascular Diseases. 31(3) online ahead of print. PMID 34998044.  
  • Dylla L., Herson, P.S., Poisson, S.N., Rice, J.D., Ginde, A.A. (2021) Association Between Chronic Inflammatory Diseases and Stroke-Associated Pneumonia – an Epidemiological Study. Journal of Stroke and Cerebrovascular Diseases. 30(4):105605. PMID 33482567.  
  • Dylla L., Cushman, J.T., Abar, B., Benesch, C., Jones, C., O’Banion, K., Adler, D. (2020) Retrospective Analysis of the Hemodynamic Consequences of Prehospital Supplemental Oxygen in Acute Stroke. American Journal of Emergency Medicine. 38(10):2125-2129. PMID 33069547.  
  • Dylla L., Adler, D., Abar, B., Benesch, C., Jones, C., O’Banion, K., Cushman, J.T. (2020) The authors respond: Studying prehospital supplemental oxygen in stroke. American Journal of Emergency Medicine. 38(11):2473. PMID 32173233   
  • Dylla L., Adler, D., Abar, B., Benesch, C., Jones, C., O’Banion, K., Cushman, J.T. (2019) Prehospital Supplemental Oxygen for Acute Stroke – a Retrospective Analysis. American Journal of Emergency Medicine. S0735-6757(19):30741-7. PMID 31787444  
  • Dylla L., Klawitter J., Clendenen N.J., Rice J.D., Poisson S.N., Herson P.S., Ginde A.A., Monte A.A. (2022) Sex Differences in Tryptophan Metabolism in Acute Ischemic Stroke. 2022 Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Annual Meeting, Virtual Meeting.