Opioid Research Program

The vision of the University of Colorado Department of Emergency Medicine Opioid Research Program is to perform cutting edge research and programmatic implementation in the high priority and high impact areas of opioid use for pain and access to treatment for emergency department patients with an opioid use disorder (OUD).

We strive to be leaders in the field opioid research by examining how interventions for healthcare providers and patients can help advance clinical care and guide policymakers/administrators on systems-level reforms with the potential to achieve the triple aim of advancing population health, reducing health care costs, and improving the quality of care.

To date, we have developed and completed a variety of projects addressing the opioid crisis including: PDMP–EHR integration, clinical decision support to improve prescription opioid safety, improved decision-making for opioid prescribing, quantifying long-term consequences of opioid prescribing, evaluating the impact of legislative changes, and built a community collaboration to initiate treatment for opioid use disorder in the ED with a warm hand-off to community care.

All of our projects have the shared vision of providing accurate information and interventions that are: usable in a variety of settings, technologically feasible within provider workflows and sustainable beyond project funding. To accomplish these projects we have developed successful collaborations with multiple key stakeholders including: Colorado Department of Regulatory Agencies, the Bureau of Justice Assistance, Colorado Department of Public Health and Environment, Colorado Office of Behavioral Health, UCHealth Informatics, the Department of Defense, and the Office of the National Coordinator for Health Information Technology, amongst others.

Our Team

Current Grant Support

“Improving pain management and opioid safety through a systemwide, data driven evaluation of the CDC opioid prescribing guideline best practices and the use of Clinical Decision Support” R63/R33 NIH, NIDA, HEAL Data2Action 2022-2026 

“Project Bridge” Connecting the Emergency Department and Substance Use Treatment Services. ARTS SUID Treatment Center and SAMHSA. 2022-2027 

“A prospective evaluation of Colorado's new statutory PDMP mandates: compliance and patient outcomes” Bureau of Justice Assistance. Subcontract with Colorado Department of Regulatory Agencies. 2022-2025 

“Improving Emergency Department pain management through dissemination and implementation of best practices for alternatives to opioids” Substance Abuse and Mental Health Services (SAMHSA). 2020-2023 

“A Health System Wide Evaluation of Mandated Use and Clinical Decision Support Tools to Improve PDMP Utilization and Patient Outcomes” Bureau of Justice Assistance. Subcontract with Colorado Department of Regulatory Agencies. Action Researcher: 2020-2022 

Past Grant Support

“SB 18-22 Evaluation: Assess the implementation of Colorado Senate Bill 18-022 on patient outcomes and provider prescribing behavior” Colorado Department of Public Health and Environment. 2019-2022 

“Advancing PDMP and EHR integration Project: Integration Demonstration and Clinical Decision Support Proof of Concept (POC) test site” CDC/ONC. Site lead. 2019-2021 

“EMBED: Pragmatic trial of user-centered clinical decision support to implement Emergency department-initiated Buprenorphine for opioid use Disorder. NIH/NIDA UG3/UH3. PI Edward Melnick Yale. Site PI. $315K. 2019-2021 

“Development and Piloting of a Decision Tool for Emergency Department Opioid Initiation to Decrease Future Substance Abuse and Chronic use” Department of Defense: JPC 5 Substance Abuse Research Grant. Principle investigator. 2018-2021 

“Assess the Implementation of Colorado Senate Bill 18-0252 on Prescriber Behaviors” Comprehensive Opioid Abuse Program: Site Based Program Category 6 via subcontract with Colorado Department of Public Health and Environment. Action Researcher. 2018-2021 

“Colorado Opioid State Targeted Response: Expanding Access to Opioid Use Disorder Treatment Through Emergency Departments” SAMHSA State Targeted Response (STR) grant via Colorado Office of Behavioral Health. Principle investigator. 2018-2019 

“Pilot expansion of EHR-PDMP Integration” CDC via subcontract with Colorado Department of Public Health and Environment. Principle Investigator. 2017-19 

“The risk of long-term prescription opioid use and aberrant prescription behavior following an emergency department opioid prescription for acute back pain” Department of Defense; JPC 5 Substance Abuse Research Grant. Co-PI. 2016-18 

“A Stepwise Evaluation of Prescription Drug Monitoring Program Electronic health Record Integration, Decision Support and Mandated use.” Harold Rogers Prescription Drug Monitoring Program: PDMP Practitioner and Research Partnership Grant. Bureau of Justice Assistance. Principal Investigator. 2015-18 
Ryan White HIV/AIDS Treatment Extension Act Part A: early intervention services grant. US Department of Health and Human Services. Co-investigator. 5% cFTE. 2010-2015. 

“Prescription Opioid Safety in Emergency Departments.” University of Colorado Department of Emergency Medicine seed grant. Principal investigator. $3K. 2014 

“The Use of Prescription Drug Monitoring Programs and Geographic Information Systems to Identify Communities at Risk of Prescription Opioid Overdose Fatalities.” Emergency Medicine Foundation (EMF) Health Policy Research Grant. Principal Investigator. $50K. 2013 

“Long-term Opioid use after Discharge from the Emergency Department.” University of Colorado Department of Emergency Medicine seed grant. Principal investigator. $5K. 2013 

“Reducing Central Line-Associated Bloodstream Infections and Procedure Related Complications Through Simulation.” University of Colorado Department of Emergency Medicine Education Grant. Co-investigator. $7,147. 2012 

“The Efficacy and Safety of Epic Medication Alerts.” University of Colorado Hospital Clinical Efficacy and Patient Safety Grant. Co-Investigator. $20,000. 2012 

Peer-reviewed Journals 

Kelly T, Hoppe JA, et al. A Novel Social Work Approach to Emergency Department Buprenorphine Induction and Warm Hand-off to Community Providers. American J Emerg Med. 2020. Epub ahead of print. PMID: 31959523

Betz ME, Hyde H, DiGuiseppi C, Platts-Mills TF, Hoppe J, et al. Self-reported Opioid Use and Driving Outcomes among Older Adults:  Findings from the AAA LongROAD Study. J Am Board Fam Med. Accepted for publication.

Heard K, Bebarta VS, Hoppe JA, Monte AA. Does administration of haloperidol or ketorolac decrease opioid administration for abdominal pain patient? A retrospective study. Am J Emeg Med. 2019. Epub. PMID: 31138518

Weiner SG, Hoppe JA, Finkelman MD. Techniques to Shorten a Screening Tool for Emergency Department Patients. West J Emerg Med. 2019 Aug 20;20(5):804-809. PMID: 31539338

Wagner S, Hoppe JA, Zuckerman M, Schwarz K, McLaughlin J. Efficacy and safety of topical capsaicin for cannabinoid hyperemesis syndrome in the emergency department. Clin Tox. 2019. 2019 Sep 4:1-5. PMID: 31482758  

Kim,H, Hoppe JA, Emergency Department Provider Perspectives on Benzodiazepine-Opioid Co-Prescribing: A Qualitative Study. Academic Emerg Med.2018;25(1):15-24. PMID: 28791786

Wang GS, Hoppe JA, Brou L, Heard K. Medication Organizers (Pill Minders) Increase the Risk for Unintentional Pediatric Ingestions. Clin Toxicol (Phila). 2017;55(8):897-901. PMID: 28471310

Hoppe JA, McStay C, SunB, Capp R. Emergency Department Attending Physician Variation in Opioid Prescribing in Low Acuity Back Pain. West J Emerg Med. 2017;18(6): 135–1142. PMID: 29085548

Wang GS, Roosevelt G, Fagan K, Hoppe J. Pediatric Emergency Physician Knowledge and Utilization of Prescription Drug Monitoring Program. Clin Pediatr (Phila). 2017 Jan; 56(1):80-82. PMID: 26976807

Pomerleau AC, Nelson LS, Hoppe JA, Salzman M, Weiss PS, Perrone J. The Impact of Prescription Drug Monitoring Programs and Prescribing Guidelines on Emergency Department Opioid Prescribing: A Multi-Center Survey. Pain Med. 2017;18(5):889-897.PMID: 26995800

Burton JH, Hoppe JA, Echternach JM, Rodgers JM, Donato M. Quality Improvement Initiative to Decrease Variability of Emergency Physician Opioid Analgesic Prescribing. West J Emerg Med. 2016 May;17(3):258-63. PMID: 27330656

Pomerleau AC, Perrone J, Hoppe JA, Salzman M, Weiss PS, Nelson LS. Impact of Prior Therapeutic Opioid Use by Emergency Department Providers on Opioid Prescribing Decisions. West J Emerg Med. 2016 Nov;17(6):791-797. PMID: 27833690

Genco EK, Forster JE, Flaten H, Heard K, Goss F, Hoppe JA, Monte AA. Clinically Inconsequential Alerts: The Characteristics of Opioid Drug Alerts and Their Utility in Preventing Adverse Drug Events in the Emergency Department. Ann Emerg Med. 2016;67(2):240-48 

Frank JW, Levy C, Calcaterra SL, Hoppe JA, Binswanger IA. Naloxone Administration in US Emergency Departments, 2000-2011. J Med Toxicol. 2016 Jun;12(2):148-56. PMID: 26621354

Kim HS, Heard KJ, Heard S, Hoppe JA. Opioid prescription fill rates after emergency department discharge. Am J Health Syst Pharm. 2016 Jun 15;73(12):902-7. PMID: 27261241

Poon SJ, Nelson LS, Hoppe JA, Perrone J, Sande MK, Yealy DM, Beeson MS, Todd KH, Motov SM, Weiner SG. Consensus-Based Recommendations for an Emergency Medicine Pain Management Curriculum. J Emerg Med. 2016 Aug;51(2):147-54. PubMed PMID: 27369855

Hoppe JA, Kim H, Keard K. Association of emergency department opioid initiation with recurrent opioid use. Ann Emerg Med. 2015;65:493-499

Hoppe JA, Nelson L, Perrone JM, Weiner SG. Opioid prescribing in a Cross Section of US Emergency Departments. Ann Emerg Med. 2015;66:253-259

Monte AA, Heard KJ, Hoppe JA, et al. The accuracy of self-reported drug ingestion histories in emergency department patients. J Clin Pharmacol. 2015 Jan;55(1):33-8 

Monte AA, Bronstein AC, Heard KJ, Hoppe JA, et al. An outbreak of exposure to a novel synthetic cannabinoid. NEJM. 2014;370:389-90

Hoppe JA, Houghland J, Yaron M, Heard K. Recent Opioid Prescription History of Emergency Department Patients Prescribed Opioids. West J Emerg Med. 2013;14:247-252 

Alhelail MA, Hoppe JA, Rhyee SR, Heard KJ. Clinical Course of Repeated Supratherapeutic Ingestion of Acetaminophen. Clin Tox. 2011; 49:108-112

T Rhyee SH, Hoppe JA, Heard K. Multiple Aminotransferase Peaks Following Acute Acetaminophen Overdose. Pharmacotherapy 2010;30(10):1084-1088

Bebarta VS, Kao L, Froberg B, Hoppe JA, Et al. A Multicenter Comparison of the Safety of Oral Versus Intravenous Acetylcysteine for Treatment of Acetaminophen Overdose. Clin Toxicol. 2010; 48: 424-30

an HH, Hoppe JA, Heard K. A systematic review of the cardiovascular effects from overdose of atypical antipsychotic medications. Am J Emerg Med. 2009; 27(5):607-616.

Dart RC, Borron SW, Caravati EM, Hoppe JA, et al. Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care. Ann Emerg Med. 2009; 54(3):386-394

Hawk, K., Hoppe, JA, et al. Consensus recommendations on the treatment of opioid use disorder in the emergency department. Annals of emergency medicine. 2021; 78(3), 434-442 

Alishahi ML, Olson K, Brooks-Russel A, Hoppe JA, Runyan C. Provider Reactions to Opioid Prescribing Report Cards. J Pub Health Manag Practice. Epub May 2021. 28(2), E518-E524. 

Heard K, Ledbetter CM, Hoppe JA. Association of Emergency Department Opioid Administration with Ongoing Opioid Use: A Retrospective Cohort Study of Patients with Back Pain. Acad Emerg Med. 2020;27(11):1158-1165 

Melnick EP, Nath B, Ahmed OM, Hoppe J, et al. Progress Report on EMBED: A Pragmatic Trial of User-Centered Clinical Decision Support to Implement EMergency Department-Initiated BuprenorphinE for Opioid Use Disorder. J Psychiatr Brain Sci. Epub. 10.20900/jpbs.20200003 

Jeffery MM, D’Onofrio G, Paek H, Hoppe JA, et al. Trends in Emergency Department Visits and Hospital Admissions in Health Care Systems in 5 States in the First Months of the COVID-19 Pandemic in the US. JAMA Intern Med. 2020;180(10) 1328-1333 

Zuckerman M, Kelly T, Heard K, Zosel A, Marlin M, Hoppe J. Physician attitudes on buprenorphine induction in the emergency department: results from a multistate survey, Clinical Toxicology. 2020;Sep;1-7 

Kelly T, Hoppe JA, et al. A Novel Social Work Approach to Emergency Department Buprenorphine Induction and Warm Hand-off to Community Providers. American J Emerg Med. 2020;38(6):1286-1290 

Betz ME, Hyde H, DiGuiseppi C, Platts-Mills TF, Hoppe J, et al. Self-reported Opioid Use and Driving Outcomes among Older Adults: Findings from the AAA LongROAD Study. J Am Board Fam Med 2020;33:521–528 

Book Chapters

Hoppe JA, Monte AA. Anticholinergics. Rosen’s Emergency Medicine 2015, 2020. 

Holst J, Hoppe JA. Acid Base status in Markovchick: Emergency Medicine Secrets, 6e. Oct 2015.

Hoppe JA. Vision Loss. Chapter: Rosen and Barkin’s 5 minute Emergency Medicine Consult 2010-2012 revision

Buchanan J, Hoppe JA, Mendoza C, Rhyee SH. Toxicology. In Blok, B.K. et al eds. First Aid for the Emergency Medicine Boards. New York, NY: McGraw-Hill, 2008, updated 2011.

Hoppe JA. Phencyclidine. Chapter: Up to Date 2008-2020. Uptodate.com

Hoppe JA. Heat Exhaustion and Heat Stroke. Chapter: Emedicine 2006. Emedicine.com

Su M, Hoppe JA. Caustic Ingestion Protocol. Long Island Poison Control Center. 2005

In the News

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Emergency Medicine (SOM)

CU Anschutz

Leprino Building

12401 East 17th Avenue

7th Floor

Aurora, CO 80045


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