Opioid, Alcohol, and Substance Use Disorder Implementation Science (OASIS) Program

The vision of the University of Colorado Department of Emergency Medicine Opioid, Alcohol, and Substance use Implementation Science (OASIS) program is to perform cutting edge translational research, implementation science, and evaluation in the high impact areas of opioid safety, Prescription Drug Monitoring Program (PDMP) use, screening and treatment initiation. Our focus is on patients with substance use disorder (SUD) including opioid use disorder (OUD) and alcohol use disorder (AUD). We employ a data driven approach using established implementation science methods to complete pragmatic research evaluating both implementation strategies and the effectiveness of the interventions.

We strive to be leaders in the field of SUD research by developing and evaluating interventions to improve care for people with a SUD and guide policymakers/administrators on systems-level reforms. Together we aim to advance population health and improve the quality of care.

To date, we have developed and completed a variety of projects addressing the opioid crisis including: PDMP–EHR integration, clinical decision support to improve prescription opioid safety, improved decision-making for opioid prescribing, quantifying long-term consequences of opioid prescribing, evaluating the impact of legislative changes, and building a community collaboration to initiate treatment for opioid use disorder in the ED with a warm hand-off to community care.

All our projects have a shared vision of providing accurate information and interventions that are: usable in a variety of settings, technologically feasible within provider workflows, and sustainable beyond project funding. To accomplish these projects, we have developed successful collaborations with multiple key stakeholders including: NIH/NIDA, SAMHSA, Colorado Department of Regulatory Agencies, the Bureau of Justice Assistance, Colorado Department of Public Health and Environment, Colorado Behavioral Health Administration, UCHealth Informatics, the Department of Defense, and the Office of the National Coordinator for Health Information Technology, amongst others.

Our Team

Jason Hoppe, DO is a clinician-researcher, medical toxicologist and Associate Professor in the Department of Emergency Medicine at the University of Colorado School of Medicine. He is also a consultant in medical toxicology at Denver Health, Children’s Hospital Colorado and the Rocky Mountain Poison and Drug Center. His clinical work, research, and public health efforts are aimed at addressing the complicated decision-making process regarding the opioid prescribing and effectively initiating treatment for patients with an opioid use disorder. He recently developed and piloted a program to initiate buprenorphine treatment in the Emergency Department with a warm hand-off to community partners. He is a national expert in prescription opioid safety, prescription drug monitoring programs (PDMP), and provider decision-making. Dr. Hoppe is a founding member of the Colorado Consortium for Prescription Drug Abuse Prevention and has assisted with multiple public health efforts, education programs and successful legislative changes in Colorado regarding PDMP access, opioid prescribing and medications for opioid use disorder.

Aaron Barbour, B.S. is a data analytics & business intelligence developer. His first introduction to clinical research was at the Barbara Davis Center working for multiple clinical research studies related to type one diabetes. At the Barbara Davis Center, he worked as the clinical database manager for four research studies where he was responsible for database development, creating web applications and REDCap development. Within the OASIS program, he brings his experience to assist the team with their data and technical needs. The team leverages these resources to make data driven decisions about treatment and to improve patient care.

Izzie (Margaret) Clinton has served as a clinical informaticist in the Department of Emergency Medicine at the University of Colorado Anschutz Medical Campus since fall 2023. She has decades of experience in healthcare and has been working with Epic Electronic Health Record (EHR) data since 2018. Izzie takes an understanding of how end users use and builders design Epic applications and uses that understanding to develop data extracts optimized for interpretability and streamlined for statistical analysis. Izzie also builds dashboards and leverages CU Anschutz’ Health Data Compass Data Warehouse, to securely manage and broker Protected Health Information (PHI) from multiple sources.

Kennon Heard, MD is Section Chief of Medical Toxicology at the University of Colorado School of Medicine where he is a Professor of Emergency Medicine. He is also an attending physician for the Rocky Mountain Posion and Drug Center. He works and teaches at the University of Colorado Hospital Emergency Department. His research interests include improving opioid use, medical conditions associated with cannabis use, acetaminophen poisoning and research design. He has authored over 100 papers and 20 book chapters in various areas of Emergency Medicine and Toxicology.

Jared Heinze, MPH, joined the Opioid, Alcohol, and Substance use Implementation Science (OASIS) program as the Research Services Program Manager in April 2025. Jared has interdisciplinary training in behavioral neuroscience and public health. Along with his training he brings over 10 years of research administrative experience to the program. Jared started his career as a research professional at the University of Colorado Boulder where he helped to develop and translate therapeutic interventions for patients with behavioral affective disorders. Jared’s focus within the Substance Use Research Program is to develop and expand research projects and community partnerships aimed at improving access to and reducing unwarranted variation in the use of evidence-based, effective care for treatment of substance use disorders

Colin Hensen, MS is a Research Scientist with the Center for Innovative Design and Analysis, in the Department of Biostatistics & Informatics at the Colorado School of Public Health. Colin’s expertise lies in statistical analysis and methodology, study design, and data management. Since joining the OASIS research team in 2022, Colin has worked on studies involving provider workflow interventions to reduce high-risk prescribing and has focused on evaluating the impacts of these interventions both to the provider workflow as well as on longer-term health outcomes for patients.

Lauren Kargul, B.S. is a Research Services Senior Professional with the University of Colorado Department of Emergency Medicine’s Opioid, Alcohol, and Substance use Implementation Science (OASIS) program. She brings a strong background in healthcare coordination, wellness education, and substance use treatment, with expertise at the intersection of clinical practice and data-driven quality improvement. Lauren supports research focused on opioid safety and treatment access through her work in protocol development, data management, and patient-centered interventions. She has led community wellness initiatives and education programs, contributing to the implementation of sustainable, evidence-based strategies that improve outcomes for individuals with opioid use disorder.

Jacob Lebin, MD is an Assistant Professor at the University of Colorado and a consultant in medical toxicology at Denver Health, Children’s Hospital Colorado, and the Rocky Mountain Poison and Drug Center. His research interests include implementation of best practices for the management of alcohol withdrawal and the use of clinical decision support for ED-based treatment of alcohol and opioid use disorder. He is a scholar of the National Foundation of Emergency Medicine and member of the NIH/NIDA ANTIDOTE Institute through the American College of Medical Toxicology.

Zhixin Lun, PhD, is a Research Associate biostatistician at the Center for Innovative Design and Analysis (CIDA) in the Department of Biostatistics and Informatics at the University of Colorado Anschutz Medical Campus. She specializes in observational studies, missing data analysis, causal inference, and open-source software development. Her research interests include developing and applying mathematical models and statistical methods in pharmaceutical economics and health outcomes evaluation using large-scale electronic health records (EHR) and administrative claims datasets (APCD, Medicare, etc.), creating imputation methods for missing data from multivariate non-normal distributions, and conducting sensitivity analyses for unmeasured covariates in causal inference, with applications in observational epidemiology. For over four years, she has focused on observational research related to opioid usage and patient safety. With more than a decade of experience in statistical programming using R, SAS, and Python, she has co-authored two R packages. Additionally, she collaborates with Children’s Hospital to develop AI tools for a comprehensive understanding of health and disease. She is a member of the American Statistical Association and the Society for Industrial and Applied Mathematics.

Consulting Subject Matter Expert Sean Michael, MD (Informatics) is currently the Emergency Department Medical Director at the University of Colorado Hospital and the Fellowship Director of the Emergency Medicine Administration, Operations, and Quality Fellowship at the University of Colorado School of Medicine. Raised in Denver, CO, he attended medical school at the University of Colorado and completed emergency medicine residency at Detroit Receiving Hospital. He attended fellowship training in administration, operations, and leadership at the University of Massachusetts, where he also earned an MBA. His research interests focus on ED and hospital crowding, patient flow, and provider behavior change, particularly around high-variation resource utilization and opioid prescribing. He is also board-certified in Clinical Informatics and holds a number of Epic builder and analyst certifications that support his work on clinical decision support systems, data analytics, and workflow design.

Heather Tolle, PhD joined UCDenver in October 2021 as Project Manager for Dr Jason Hoppe with a long history in research. Heather started her research career at the University of Louisville translating interventions for patients with traumatic spinal cord injuries from the lab to the clinic. Heather has also monitored trends of substance use treatment across the state of Colorado. She brings her background of criminal justice, substance use disorder, and medical research to the opioid research program focusing on the larger community aspects of the opioid crisis.

Grants
Publications

Current Grant Support

“Project Bridge: Medication-Assisted Treatment for Prescription Drug and Opioid Addiction” SAMHSA

“Expanding Emergency Department Care Coordination to Improve Access to Medications for Opioid Use Disorder (MOUD) and Linkage to Care for People with Opioid Use Disorder (OUD) in Adam’s CountyAdams County” Adams County Opioid Abatement. 2023-2025

“A prospective evaluation of Colorado’s new statutory PDMP mandates: compliance and patient outcomes” Colorado Department of Regulatory Agencies 2023-2025

“Improving pain management and opioid safety through a systemwide, data driven evaluation of the CDC opioid prescribing guidelines best practices and the use of Clinical Decision Support” R33 NIH, NIDA 2022-2027

“Navigating Data Solutions for Chronic Pain and Opioid Use Disorder” NIH, NIDA 2022-2028

Past Grant Support

“Improving Emergency Department pain management through dissemination and implementation of best practices for alternatives to opioids” Substance Abuse and Mental Health Services (SAMHSA). 2020-2023

“A Health System Wide Evaluation of Mandated Use and Clinical Decision Support Tools to Improve PDMP Utilization and Patient Outcomes” Bureau of Justice Assistance. Subcontract with Colorado Department of Regulatory Agencies. Action Researcher: 2020-2022

“SB 18-22 Evaluation: Assess the implementation of Colorado Senate Bill 18-022 on patient outcomes and provider prescribing behavior” Colorado Department of Public Health and Environment. 2019-2022

“Advancing PDMP and EHR integration Project: Integration Demonstration and Clinical Decision Support Proof of Concept (POC) test site” CDC/ONC. Site lead. 2019-2021

“EMBED: Pragmatic trial of user-centered clinical decision support to implement Emergency department-initiated Buprenorphine for opioid use Disorder. NIH/NIDA UG3/UH3. PI Edward Melnick Yale. Site PI. $315K. 2019-2021

“Development and Piloting of a Decision Tool for Emergency Department Opioid Initiation to Decrease Future Substance Abuse and Chronic use” Department of Defense: JPC 5 Substance Abuse Research Grant. Principle investigator. 2018-2021

“Assess the Implementation of Colorado Senate Bill 18-0252 on Prescriber Behaviors” Comprehensive Opioid Abuse Program: Site Based Program Category 6 via subcontract with Colorado Department of Public Health and Environment. Action Researcher. 2018-2021

“Colorado Opioid State Targeted Response: Expanding Access to Opioid Use Disorder Treatment Through Emergency Departments” SAMHSA State Targeted Response (STR) grant via Colorado Office of Behavioral Health. Principle investigator. 2018-2019

“Pilot expansion of EHR-PDMP Integration” CDC via subcontract with Colorado Department of Public Health and Environment. Principle Investigator. 2017-19

“The risk of long-term prescription opioid use and aberrant prescription behavior following an emergency department opioid prescription for acute back pain” Department of Defense; JPC 5 Substance Abuse Research Grant. Co-PI. 2016-18

“A Stepwise Evaluation of Prescription Drug Monitoring Program Electronic health Record Integration, Decision Support and Mandated use.” Harold Rogers Prescription Drug Monitoring Program: PDMP Practitioner and Research Partnership Grant. Bureau of Justice Assistance. Principal Investigator. 2015-18

"Ryan White HIV/AIDS Treatment Extension Act Part A: early intervention services grant." US Department of Health and Human Services. Co-investigator. 5% cFTE. 2010-2015.

“Prescription Opioid Safety in Emergency Departments.” University of Colorado Department of Emergency Medicine seed grant. Principal investigator. $3K. 2014

“The Use of Prescription Drug Monitoring Programs and Geographic Information Systems to Identify Communities at Risk of Prescription Opioid Overdose Fatalities.” Emergency Medicine Foundation (EMF) Health Policy Research Grant. Principal Investigator. $50K. 2013

“Long-term Opioid use after Discharge from the Emergency Department.” University of Colorado Department of Emergency Medicine seed grant. Principal investigator. $5K. 2013

“Reducing Central Line-Associated Bloodstream Infections and Procedure Related Complications Through Simulation.” University of Colorado Department of Emergency Medicine Education Grant. Co-investigator. $7,147. 2012

“The Efficacy and Safety of Epic Medication Alerts.” University of Colorado Hospital Clinical Efficacy and Patient Safety Grant. Co-Investigator. $20,000. 2012

Lebin JA, Sommers S, Lun Z, Hensen C, Hoppe JA. Clinical decision support as an implementation strategy to expand identification and administration of treatment of opioid use disorder in the emergency department. J Subst Use Addict Treat. 2025 May;172:209653. doi: 10.1016/j.josat.2025.209653. Epub 2025 Feb 22. PubMed PMID: 39993715.

Iscoe MS, Diniz Hooper C, Levy DR, Buchanan L, Dziura J, Meeker D, Taylor RA, D'Onofrio G, Oladele C, Sarpong DF, Paek H, Wilson FP, Heagerty PJ, Delgado MK, Hoppe J, Melnick ER. Adaptive decision support for addiction treatment to implement initiation of buprenorphine for opioid use disorder in the emergency department: protocol for the ADAPT Multiphase Optimization Strategy trial. BMJ Open. 2025 Feb 20;15(2):e098072. doi: 10.1136/bmjopen-2024-098072. PubMed PMID: 39979056; PubMed Central PMCID: PMC11842997.

Lebin JA, Sommers S, Lun Z, Hensen C, Hoppe JA. Clinical decision support as an implementation strategy to expand identification and administration of treatment of opioid use disorder in the emergency department. Journal of Substance Use and Addiction Treatment. 2025 May 1;172:209653.

Sommers SW, Tolle HJ, Trinkley KE, Johnston CG, Dietsche CL, Eldred SV, Wick AT, Hoppe JA. Clinical Decision Support to Increase Emergency Department Naloxone Coprescribing: Implementation Report. JMIR Med Inform. 2024 Nov 6;12:e58276. doi: 10.2196/58276. PubMed PMID: 39504560; PubMed Central PMCID: PMC11560079.

Sommers S, Wendel S, Greig A, Barbour A, Griffith R, Magdaleno M, Skaggs M, Michael S, Bookman K, Tolle H, Hoppe J. Improved outpatient follow-up after implementation of emergency department-based physical therapy. Acad Emerg Med. 2024 Oct;31(10):1062-1064. doi: 10.1111/acem.14944. Epub 2024 Jun 17. PubMed PMID: 38881276.

Comstock G, Truszczynski N, Michael SS, Hoppe J. Variability in Practice of Buprenorphine Treatment by Emergency Department Operational Characteristics. West J Emerg Med. 2024 Jul;25(4):483-489. doi: 10.5811/westjem.18019. PubMed PMID: 39028234; PubMed Central PMCID: PMC11254146.

Heil JM, Lassiter JM, Salzman MS, Herring A, Hoppe J, Lynch M, Weiner SG, Roberts B, Haroz R. A qualitative assessment of emergency physicians' experiences with robust emergency department buprenorphine bridge programs. Acad Emerg Med. 2024 Jun;31(6):576-583. doi: 10.1111/acem.14880. Epub 2024 Feb 15. PubMed PMID: 38357749.

Lebin JA, Bass ME, Heard K, Hoppe J, Jacknin G. A Retrospective Evaluation of Adjunctive Phenobarbital vs. Benzodiazepine Alone for the Treatment of Moderate Alcohol Withdrawal in the Emergency Department. J Emerg Med. 2024 Apr;66(4):e516-e522. doi: 10.1016/j.jemermed.2023.12.007. Epub 2023 Dec 14. PubMed PMID: 38485572.

Lebin JA, Bass ME, Heard K, Hoppe J, Jacknin G. A Retrospective Evaluation of Adjunctive Phenobarbital vs. Benzodiazepine Alone for the Treatment of Moderate Alcohol Withdrawal in the Emergency Department. The Journal of Emergency Medicine. 2024 Apr 1;66(4):e516-22.

Hawk KF, Weiner SG, Rothenberg C, Bernstein E, D'Onofrio G, Herring A, Hoppe J, Ketcham E, LaPietra A, Nelson L, Perrone J, Ranney M, Samuels EA, Strayer R, Sharma D, Goyal P, Schuur J, Venkatesh AK. Leveraging a Learning Collaborative Model to Develop and Pilot Quality Measures to Improve Opioid Prescribing in the Emergency Department. Ann Emerg Med. 2024 Mar;83(3):225-234. doi: 10.1016/j.annemergmed.2023.08.490. Epub 2023 Oct 11. PubMed PMID: 37831040.

Hoppe JA, Ledbetter C, Tolle H, Heard K. Implementation of Electronic Health Record Integration and Clinical Decision Support to Improve Emergency Department Prescription Drug Monitoring Program Use. Ann Emerg Med. 2024 Jan;83(1):3-13. doi: 10.1016/j.annemergmed.2023.07.002. Epub 2023 Aug 25. PubMed PMID: 37632496.

Sullivan KJ, Gabella B, Ziegler K, Tolle H, Giano Z, Hoppe J. Impact of Statewide Statute Limiting Days' Supply to Opioid-Naive Patients. Am J Prev Med. 2024 Jan;66(1):112-118. doi: 10.1016/j.amepre.2023.08.015. Epub 2023 Aug 20. PubMed PMID: 37604303.

Hughes A, Amaducci A, Campleman SL, Li S, Costantini M, Spyres MB, Spungen H, Kent J, Falise A, Culbreth R, Wax PM, Brent J, Aldy K. The Toxicology Investigators Consortium 2023 Annual Report. J Med Toxicol. 2024 Oct;20(4):350-380. doi: 10.1007/s13181-024-01033-w. Epub 2024 Sep 10. PubMed PMID: 39256327; PubMed Central PMCID: PMC11436580.

Weiner SG, Hoppe JA. Contextualising opioid-related risk factors before an initial opioid prescription. BMJ Qual Saf. 2023 Dec 14;33(1):1-3. doi: 10.1136/bmjqs-2023-016336. PubMed PMID: 37500564; PubMed Central PMCID: PMC10817995.

Sommers S, Tolle H, Napier C, Hoppe J. Targeted messaging to improve the adoption of clinical decision support for prescription drug monitoring program use. J Am Med Inform Assoc. 2023 Sep 25;30(10):1711-1716. doi: 10.1093/jamia/ocad127. PubMed PMID: 37433582; PubMed Central PMCID: PMC10531197.

Simpson MJ, Ritger C, Hoppe JA, Holland WC, Morris MA, Nath B, Melnick ER, Tietbohl C. Implementation strategies to address the determinants of adoption, implementation, and maintenance of a clinical decision support tool for emergency department buprenorphine initiation: a qualitative study. Implement Sci Commun. 2023 Apr 20;4(1):41. doi: 10.1186/s43058-023-00421-7. PubMed PMID: 37081581; PubMed Central PMCID: PMC10117277.

Weiner SG, Hoppe JA. Accelerating Practice Change in the Emergency Department. JAMA Netw Open. 2023 Apr 3;6(4):e235453. doi: 10.1001/jamanetworkopen.2023.5453. PubMed PMID: 37017976.

Amaducci AM, Campleman SL, Li S, Karshenas DL, Spyres MB, Farrugia LA, Kang AM, Culbreth RE, Wax PM, Brent J, Aldy K. The Toxicology Investigators Consortium 2022 Annual Report. J Med Toxicol. 2023 Oct;19(4):313-340. doi: 10.1007/s13181-023-00962-2. Epub 2023 Aug 29. PubMed PMID: 37644342; PubMed Central PMCID: PMC10522558.

Kelly TD, Hawk KF, Samuels EA, Strayer RJ, Hoppe JA. Improving Uptake of Emergency Department-initiated Buprenorphine: Barriers and Solutions. West J Emerg Med. 2022 Jul 11;23(4):461-467. doi: 10.5811/westjem.2022.2.52978. PubMed PMID: 35980414; PubMed Central PMCID: PMC9391022.

Melnick ER, Nath B, Dziura JD, Casey MF, Jeffery MM, Paek H, Soares WE 3rd, Hoppe JA, Rajeevan H, Li F, Skains RM, Walter LA, Patel MD, Chari SV, Platts-Mills TF, Hess EP, D'Onofrio G. User centered clinical decision support to implement initiation of buprenorphine for opioid use disorder in the emergency department: EMBED pragmatic cluster randomized controlled trial. BMJ. 2022 Jun 27;377:e069271. doi: 10.1136/bmj-2021-069271. PubMed PMID: 35760423; PubMed Central PMCID: PMC9231533.

Alishahi ML, Olson K, Brooks-Russell A, Hoppe J, Runyan C. Provider Reactions to Opioid-Prescribing Report Cards. J Public Health Manag Pract. 2022 Mar-Apr 01;28(2):E518-E524. doi: 10.1097/PHH.0000000000001382. PubMed PMID: 34016911.

Soares WE 3rd, Melnick ER, Nath B, D'Onofrio G, Paek H, Skains RM, Walter LA, Casey MF, Napoli A, Hoppe JA, Jeffery MM. Emergency Department Visits for Nonfatal Opioid Overdose During the COVID-19 Pandemic Across Six US Health Care Systems. Ann Emerg Med. 2022 Feb;79(2):158-167. doi: 10.1016/j.annemergmed.2021.03.013. Epub 2021 Mar 19. PubMed PMID: 34119326; PubMed Central PMCID: PMC8449788.

Love JS, Karshenas DL, Spyres MB, Farrugia LA, Kang AM, Nguyen H, Campleman SL, Li S, Wax PM, Brent J, Aldy K. The Toxicology Investigators Consortium Case Registry-the 2021 Annual Report. J Med Toxicol. 2022 Oct;18(4):267-296. doi: 10.1007/s13181-022-00910-6. Epub 2022 Sep 7. PubMed PMID: 36070069; PubMed Central PMCID: PMC9450833.

Hawk K, Hoppe J, Ketcham E, LaPietra A, Moulin A, Nelson L, Schwarz E, Shahid S, Stader D, Wilson MP, D'Onofrio G. Consensus Recommendations on the Treatment of Opioid Use Disorder in the Emergency Department. Ann Emerg Med. 2021 Sep;78(3):434-442. doi: 10.1016/j.annemergmed.2021.04.023. Epub 2021 Jun 23. PubMed PMID: 34172303.

Weiner SG, Hoppe JA. Prescribing Naloxone to High-Risk Patients in the Emergency Department: Is it Enough?. Jt Comm J Qual Patient Saf. 2021 Jun;47(6):340-342. doi: 10.1016/j.jcjq.2021.03.012. Epub 2021 Apr 4. PubMed PMID: 33958290; PubMed Central PMCID: PMC8165019.

Zuckerman M, Kelly T, Heard K, Zosel A, Marlin M, Hoppe J. Physician attitudes on buprenorphine induction in the emergency department: results from a multistate survey. Clin Toxicol (Phila). 2021 Apr;59(4):279-285. doi: 10.1080/15563650.2020.1805461. Epub 2020 Sep 1. PubMed PMID: 32870039.

Lebin JA, Mudan A, Murphy CE, Wang RC, Smollin CG. Return Encounters in Emergency Department Patients Treated with Phenobarbital Versus Benzodiazepines for Alcohol Withdrawal. Journal of Medical Toxicology. 2021 Oct 25:1-7.

Heard K, Ledbetter CM, Hoppe JA. Association of Emergency Department Opioid Administration With Ongoing Opioid Use: A Retrospective Cohort Study of Patients With Back Pain. Acad Emerg Med. 2020 Nov;27(11):1158-1165. doi: 10.1111/acem.14071. Epub 2020 Jul 30. PubMed PMID: 32609923; PubMed Central PMCID: PMC8079173.

Jeffery MM, D'Onofrio G, Paek H, Platts-Mills TF, Soares WE 3rd, Hoppe JA, Genes N, Nath B, Melnick ER. Trends in Emergency Department Visits and Hospital Admissions in Health Care Systems in 5 States in the First Months of the COVID-19 Pandemic in the US. JAMA Intern Med. 2020 Oct 1;180(10):1328-1333. doi: 10.1001/jamainternmed.2020.3288. PubMed PMID: 32744612; PubMed Central PMCID: PMC7400214.

Wagner S, Hoppe J, Zuckerman M, Schwarz K, McLaughlin J. Authors' response to "Efficacy and safety of topical capsaicin for cannabinoid hyperemesis syndrome in the emergency department". Clin Toxicol (Phila). 2020 Sep;58(9):939. doi: 10.1080/15563650.2020.1716982. Epub 2020 Feb 18. PubMed PMID: 32067516.

Betz ME, Hyde H, DiGuiseppi C, Platts-Mills TF, Hoppe J, Strogatz D, Andrews HF, Mielenz TJ, Hill LL, Jones V, Molnar LJ, Eby DW, Li G. Self-Reported Opioid Use and Driving Outcomes among Older Adults: The AAA LongROAD Study. J Am Board Fam Med. 2020 Jul-Aug;33(4):521-528. doi: 10.3122/jabfm.2020.04.190429. PubMed PMID: 32675263; PubMed Central PMCID: PMC9478563.

Wagner S, Hoppe J, Zuckerman M, Schwarz K, McLaughlin J. Efficacy and safety of topical capsaicin for cannabinoid hyperemesis syndrome in the emergency department. Clin Toxicol (Phila). 2020 Jun;58(6):471-475. doi: 10.1080/15563650.2019.1660783. Epub 2019 Sep 4. PubMed PMID: 31482758.

Kelly T, Hoppe JA, Zuckerman M, Khoshnoud A, Sholl B, Heard K. A novel social work approach to emergency department buprenorphine induction and warm hand-off to community providers. Am J Emerg Med. 2020 Jun;38(6):1286-1290. doi: 10.1016/j.ajem.2019.12.038. Epub 2020 Jan 7. PubMed PMID: 31959523.

Heard K, Bebarta VS, Hoppe JA, Monte AA. Does administration of haloperidol or ketorolac decrease opioid administration for abdominal pain patients? A retrospective study. Am J Emerg Med. 2020 Mar;38(3):517-520. doi: 10.1016/j.ajem.2019.05.038. Epub 2019 May 22. PubMed PMID: 31138518; PubMed Central PMCID: PMC6937392.

Melnick ER, Nath B, Ahmed OM, Brandt C, Chartash D, Dziura JD, Hess EP, Holland WC, Hoppe JA, Jeffery MM, Katsovich L, Li F, Lu CC, Maciejewski K, Maleska M, Mao JA, Martel S, Michael S, Paek H, Patel MD, Platts-Mills TF, Rajeevan H, Ray JM, Skains RM, Soares WE 3rd, Deutsch A, Solad Y, D'Onofrio G. Progress Report on EMBED: A Pragmatic Trial of User-Centered Clinical Decision Support to Implement EMergency Department-Initiated BuprenorphinE for Opioid Use Disorder. J Psychiatr Brain Sci. 2020;5. doi: 10.20900/jpbs.20200003. Epub 2020 Feb 21. PubMed PMID: 32309637; PubMed Central PMCID: PMC7164817.

Lebin JA, Huynh L, Morse SC, Jablonowksi K, Hall J, Whiteside LK. Predictors of receiving an emergency department naloxone prescription following an opioid overdose. The American Journal of Emergency Medicine. 2020 Sep 14.

Weiner SG, Hoppe JA, Finkelman MD. Techniques to Shorten a Screening Tool for Emergency Department Patients. West J Emerg Med. 2019 Aug 20;20(5):804-809. doi: 10.5811/westjem.2019.7.42938. PubMed PMID: 31539338; PubMed Central PMCID: PMC6754189.

Wang GS, Hoppe J, Brou L, Heard K. In response to "Balancing the risks and benefits of medication organizers". Clin Toxicol (Phila). 2018 Feb;56(2):156. doi: 10.1080/15563650.2017.1348511. Epub 2017 Jul 27. PubMed PMID: 28748717.

Kim HS, McCarthy DM, Hoppe JA, Mark Courtney D, Lambert BL. Emergency Department Provider Perspectives on Benzodiazepine-Opioid Coprescribing: A Qualitative Study. Acad Emerg Med. 2018 Jan;25(1):15-24. doi: 10.1111/acem.13273. Epub 2017 Sep 19. PubMed PMID: 28791786; PubMed Central PMCID: PMC5764790.

Murphy DL, Lebin JA, Severtson SG, Olsen HA, Dasgupta N, Dart RC. Comparative Rates of Mortality and Serious Adverse Effects Among Commonly Prescribed Opioid Analgesics. Drug Saf. 2018:1-9.

Lebin JA, Murphy DL, Severtson SG, Bau GE, Dasgupta N, Dart RC. Scoring the Best Deal: Quantity Discounts and Street Price Variation of Diverted Oxycodone and Oxymorphone. Pharmacoepidemiol Drug Saf. 2018;1–6.

Hoppe JA, McStay C, Sun BC, Capp R. Emergency Department Attending Physician Variation in Opioid Prescribing in Low Acuity Back Pain. West J Emerg Med. 2017 Oct;18(6):1135-1142. doi: 10.5811/westjem.2017.7.33306. Epub 2017 Sep 18. PubMed PMID: 29085548; PubMed Central PMCID: PMC5654885.

Wang GS, Hoppe JA, Brou L, Heard KJ. Medication organizers (pill minders) increase the risk for unintentional pediatric ingestions. Clin Toxicol (Phila). 2017 Sep;55(8):897-901. doi: 10.1080/15563650.2017.1321117. Epub 2017 May 4. PubMed PMID: 28471310.

Pomerleau AC, Nelson LS, Hoppe JA, Salzman M, Weiss PS, Perrone J. The Impact of Prescription Drug Monitoring Programs and Prescribing Guidelines on Emergency Department Opioid Prescribing: A Multi-Center Survey. Pain Med. 2017 May 1;18(5):889-897. doi: 10.1093/pm/pnw032. PubMed PMID: 26995800.

Wang GS, Roosevelt G, Fagan K, Hoppe J. Pediatric Emergency Physician Knowledge and Utilization of Prescription Drug Monitoring Program. Clin Pediatr (Phila). 2017 Jan;56(1):80-82. doi: 10.1177/0009922816638508. Epub 2016 Jul 20. PubMed PMID: 26976807.

Pomerleau AC, Perrone J, Hoppe JA, Salzman M, Weiss PS, Nelson LS. Impact of Prior Therapeutic Opioid Use by Emergency Department Providers on Opioid Prescribing Decisions. West J Emerg Med. 2016 Nov;17(6):791-797. doi: 10.5811/westjem.2016.8.30965. Epub 2016 Sep 29. PubMed PMID: 27833690; PubMed Central PMCID: PMC5102609.

Poon SJ, Nelson LS, Hoppe JA, Perrone J, Sande MK, Yealy DM, Beeson MS, Todd KH, Motov SM, Weiner SG. Consensus-Based Recommendations for an Emergency Medicine Pain Management Curriculum. J Emerg Med. 2016 Aug;51(2):147-54. doi: 10.1016/j.jemermed.2016.05.009. Epub 2016 Jun 29. PubMed PMID: 27369855.

Kim HS, Heard KJ, Heard S, Hoppe JA. Opioid prescription fill rates after emergency department discharge. Am J Health Syst Pharm. 2016 Jun 15;73(12):902-7. doi: 10.2146/ajhp150528. PubMed PMID: 27261241.

Burton JH, Hoppe JA, Echternach JM, Rodgers JM, Donato M. Quality Improvement Initiative to Decrease Variability of Emergency Physician Opioid Analgesic Prescribing. West J Emerg Med. 2016 May;17(3):258-63. doi: 10.5811/westjem.2016.3.29692. Epub 2016 May 2. PubMed PMID: 27330656; PubMed Central PMCID: PMC4899055.

Genco EK, Forster JE, Flaten H, Goss F, Heard KJ, Hoppe J, Monte AA. Clinically Inconsequential Alerts: The Characteristics of Opioid Drug Alerts and Their Utility in Preventing Adverse Drug Events in the Emergency Department. Ann Emerg Med. 2016 Feb;67(2):240-248.e3. doi: 10.1016/j.annemergmed.2015.09.020. Epub 2015 Nov 6. PubMed PMID: 26553282; PubMed Central PMCID: PMC4955849.

Hoppe JA, Nelson LS, Perrone J, Weiner SG. Opioid Prescribing in a Cross Section of US Emergency Departments. Ann Emerg Med. 2015 Sep;66(3):253-259.e1. doi: 10.1016/j.annemergmed.2015.03.026. Epub 2015 May 4. PubMed PMID: 25952503; PubMed Central PMCID: PMC4550521.

Monte AA, Anderson P, Hoppe JA, Weinshilboum RM, Vasiliou V, Heard KJ. Accuracy of Electronic Medical Record Medication Reconciliation in Emergency Department Patients. J Emerg Med. 2015 Jul;49(1):78-84. doi: 10.1016/j.jemermed.2014.12.052. Epub 2015 Mar 19. PubMed PMID: 25797942; PubMed Central PMCID: PMC4476907.

Hoppe JA, Kim H, Heard K. Association of emergency department opioid initiation with recurrent opioid use. Ann Emerg Med. 2015 May;65(5):493-499.e4. doi: 10.1016/j.annemergmed.2014.11.015. Epub 2014 Dec 18. PubMed PMID: 25534654.

Monte AA, Heard KJ, Hoppe JA, Vasiliou V, Gonzalez FJ. The accuracy of self-reported drug ingestion histories in emergency department patients. J Clin Pharmacol. 2015 Jan;55(1):33-8. doi: 10.1002/jcph.368. Epub 2014 Jul 28. PubMed PMID: 25052325; PubMed Central PMCID: PMC4276443.

Hoppe J, Howland MA, Nelson L. The role of pharmacies and pharmacists in managing controlled substance dispensing. Pain Med. 2014 Dec;15(12):1996-8. doi: 10.1111/pme.12531. Epub 2014 Aug 19. PubMed PMID: 25138390.

Frank JW, Levy C, Calcaterra SL, Hoppe JA, Binswanger IA. Naloxone Administration in US Emergency Departments, 2000-2011. J Med Toxicol. 2016 Jun;12(2):148-56. doi: 10.1007/s13181-015-0525-5. PubMed PMID: 26621354; PubMed Central PMCID: PMC4880605.

Lebin JA, Mitchell K, Lun Z, Hensen C, Calcaterra SL, Trinkley K, Hoppe JA. Clinical Decision Support to Increase Naloxone Co-Prescribing from the Inpatient Setting. Journal of General Internal Medicine. Accepted.

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Opioid, Alcohol, and Substance Use Disorder Implementation Science (OASIS) Program

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