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Johannes Menzel, Ph.D.

Postdoctoral fellow, Department of Biochemistry and Molecular Genetics


Hometown:

Whitehorse, Yukon Territory, Canada

Education:

University of Victoria

Bachelor of Science Biochemistry

 

University of Saskatchewan

Master of Science, Anatomy and Cell Biology

 

University of Colorado Anschutz Medical School

Ph.D. Molecular Biology

Research:

I am interested in adaptive oncogenesis, particularly in factors associated with aging that influence initiation, progression, and relapse of cancer. I plan to leverage mouse models to investigate how age and chemotherapy-induced alterations within the bone marrow microenvironment impinge on the evolution of therapeutic resistance and self-renewal of leukemic stem cells. Currently, I am investigating how the loss or reduction of C/EBP (CCAAT-enhancer-binding proteins), a family of proteins associated with normal and malignant hematopoietic myeloid differentiation that often have reduced expression at relapse, increased self-renewal of leukemic stem cells under therapy-induced selective pressure. My hope is that a better understanding of clonal evolution will lead to therapies that prevent selection for phenotypes that mediate disease progression and drug resistance. 

Contact:‚Äčjohannes.menzel@cuanschutz.edu
Catherine Danis, PhD