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Johannes Menzel, Ph.D.

Postdoctoral fellow, Department of Biochemistry and Molecular Genetics


Whitehorse, Yukon Territory, Canada


University of Victoria

Bachelor of Science Biochemistry


University of Saskatchewan

Master of Science, Anatomy and Cell Biology


University of Colorado Anschutz Medical School

Ph.D. Molecular Biology


I am interested in adaptive oncogenesis, particularly in factors associated with aging that influence initiation, progression, and relapse of cancer. I plan to leverage mouse models to investigate how age and chemotherapy-induced alterations within the bone marrow microenvironment impinge on the evolution of therapeutic resistance and self-renewal of leukemic stem cells. Currently, I am investigating how the loss or reduction of C/EBP (CCAAT-enhancer-binding proteins), a family of proteins associated with normal and malignant hematopoietic myeloid differentiation that often have reduced expression at relapse, increased self-renewal of leukemic stem cells under therapy-induced selective pressure. My hope is that a better understanding of clonal evolution will lead to therapies that prevent selection for phenotypes that mediate disease progression and drug resistance. 

Publications: Link to Johannes's publications 
Catherine Danis, PhD

Biochemistry and Molecular Genetics

CU Anschutz

Research I South

12801 East 17th Avenue

Mail Stop 8101

Aurora, CO 80045


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