PET/SPECT/CT
The Animal Imaging Shared Resource (AISR) performs microPET/CT and microSPECT/CT protocol development, image acquisition and image analysis for small animal models and imaging phantoms.
Nuclear medicine images are produced by giving the animal short-lived radioactive isotopes and detecting their decay using a gamma camera (SPECT) or positron emission (PET) scanner, revealing the spatial and temporal distribution of target-specific radiotracers and pharmaceuticals. An extensive array of radiopharmaceuticals, or molecular probes exist (based on 11C, 13N, 15O, 18F, 124I, 64Cu, 68Ga, 89Zr for PET and 123I, 99mTc, 201Ti, 111In for SPECT) to image diverse aspects of tumor physiology and biology. Data can reveal properties such as glucose metabolism, blood volume and flow, tissue uptake, receptor binding, and oxygen utilization. Since both modalities have a relatively low spatial resolution, CT is usually added for an anatomical overlay of the biodistribution of the radiolabeled probe.
Facility:
The Siemens Inveon microPET and microCT scanners were installed in 2008.
The Mediso SPECT/CT was installed in 2016 (please contact Yubin Miao, PhD, Yubin.Miao@CUAnschutz.edu for more information on SPECT radiotracers).
Protocols:
- Glucose uptake and metabolism using 18FDG-PET/CT
- Dynamic and static PET/CT using novel 18F-amino acid and 11C-acetate metabolic tracers
- Peptide SPECT/CT imaging and tracer development – Yubin Miao, PhD, Yubin.Miao@CUAnschutz.edu
To Schedule a Service:
Small Animal Imaging PET/SPECT/CT
- To schedule a consultation for small animal PET-based studies and study design please contact Natalie Serkova, PhD, Natalie.Serkova@CUAnschutz.edu, (303)359-0870.
- To schedule a PET imaging appointment follow these instructions for new iLab users, service requests, and equipment reservations.
- You must have an approved IACUC protocol. Please contact or Jenna Steiner, AAS, CVT, Jenna.Steiner@CUAnschutz.edu for the instructions, SOPs, and pre-approval of PET studies to your IACUC protocol. Please visit the Institutional Animal Care and Use Committee for more information.
- If you are interested in a SPECT/CT imaging consultation or appointment, please go to this website and contact Yubin Miao, PhD, Yubin.Miao@CUAnschutz.edu for further information.
PET/CT Scientific Highlights:
The University of Colorado Anschutz Medical Campus has an onsite Radiochemistry lab that currently has the capability to produce 18F, 11C, and 13N. More information about our onsite radiochemistry lab can be found on the Radiochemistry webpage.
FDG-PET/CT on leukemic mice, PI: Craig Jordan, PhD (available at Cancer Cell 2018, PMID: 30270124)
FES-PET/CT on Lung Metastases from ER+ breast cancer, PI: Carol Sartorius, PhD and Natalie Serkova, PhD
Contact Us
Natalie Serkova, PhD
Core Director
Office: (303) 724-1086
Natalie.Serkova@CUAnschutz.edu
Jenna Steiner, AAS, CVT
Core Manager
Office: (303) 724-2942
Jenna.Steiner@CUAnschutz.edu
Soudabeh Kargar, PhD
Image Analyst
soudabeh.kargar@CUAnschutz.edu
Francis G. Garay
Senior Research Professional
Office: (303) 724-2499
Francis.GarayTriminio@CUAnschutz.edu
Location: RC1N Vivarium, Suite 1, Rm 0434