Dr. Suet Nee Chen's lab is located within University of Colorado-Anschutz Medical Campus and the Department of Medicine-Division of Cardiology.

Her cutting edge laboratory focus on translational genomics research to define disease-causing gene mutations and to develop mechanism based treatment for inherited cardiomyopathy.   Dr. Chen's laboratory also develops and interrogates genetically engineered mouse models and CRISPR/Cas9 genome-edited human induced pluripotent stem cells to elucidate molecular mechanisms that cause the disease.

Major research projects focus on genetic contributions on intracellular signaling pathways, cell fate lineage tracing and identification of paracrine factors that mediate cross-talk between cardiac cells (cardiac myocytes, epicardial cells and fibroblasts) in the pathogenesis of dilated and arrhythmogenic cardiomyopathy.

Her highly motivated lab translates basic research discoveries into clinical treatment and diagnostics for genetic heart disease through collaborative interactions with the Mestroni and Taylor laboratories.   

Disease-Oriented Research Approach


Diesease oriented

Research


Molecular Mechanism Studies

Hippo_Model

 

Cell fate lineage tracing

Disease-Oriented Research Approach

Cross-talk between cardiac myocytes and non-cardiac myocytes

Crosstalk_cell typesv2