Projects

Airways
DEVICE
Phase III trial comparing the effect of video vs direct laryngoscope on first pass success of emergency tracheal intubation of critically ill adults in the acute care setting.

PREOXI
Phase III trial comparing the effect of preoxygenation with non-invasive positive pressure ventilation to preoxygenation with a facemask on the incidence of hypoxemia, among critically ill adults undergoing emergency tracheal intubation.
COVID-19
ACTIV-3
Phase III trial platform to evaluate the efficacy and safety of antiviral treatments for hospitalized COVID-19 patients
https://petalnet.org/public/covid19

ACTIV-4 Host Tissue
Phase III platform trial evaluating the efficacy and safety of host-directed interventions to improve outcomes for hospitalized COVID-19 patients.
https://petalnet.org/public/covid19 

IVY
National network using real-world data to evaluate vaccine effectiveness of COVID-19 and influenza vaccination in preventing hospitalizations and deaths.

mAb Colorado
Multicenter study of the dissemination, implementation, and real-world effectiveness of neutralizing monoclonal antibody and other antiviral treatments for high-risk outpatients with COVID-19
https://medschool.cuanschutz.edu/mab-colorado 

RECOVER
National longitudinal observational cohort study to understand, prevent, and treat long-term health effects related to post-acute sequelae of SARS-CoV-2 (PASC).

STRIVE – coming soon

TREAT NOW
Phase III, out-patient clinical trial to test the efficacy and safety of the antiviral agent lopinavir/ritonavir to prevent disease progression and improve recovery in outpatients with COVID-19.
PETAL

PETAL logohttps://petalnet.org/

CLOVERS
Phase III trial of liberal fluids vs restrictive fluids and early vasopressors in sepsis-induced hypotension.

ASTER
Phase IIb trial of IV acetaminophen or high dose vitamin C for patients with sepsis and shock or acute respiratory failure.

  
SAVE-O2

Save O2 logoTrauma Trial
Multicenter pragmatic trial assessing, feasibility, safety, and effectiveness of a targeted normoxia approach to conserve oxygen and improve clinical outcomes in critically injured patients at 8 U.S. level 1 trauma centers.

Burn Trial
Multicenter pragmatic trial assessing, feasibility, safety, and effectiveness of the targeted normoxia approach to conserve oxygen and improve clinical outcomes in major burn patients at 6 U.S. burn centers.

SIREN

Siren logohttps://siren.network/clinical-trials

BOOST-3
Phase III trial to determine efficacy of a treatment protocol based on brain tissue oxygenation (PbtO2) monitoring compared to treatment based on intracranial pressure (ICP) monitoring alone.

ICECAP
Phase III trial to determine the optimal duration of cooling in survivors of out of hospital cardiac arrest.


Emergency Medicine (SOM)

CU Anschutz

Leprino Building

12401 East 17th Avenue

7th Floor

Aurora, CO 80045


720-848-6777

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