COVID-19 Monoclonal Antibody (mAb) Implementation Blueprint

This guide aims to provide practical guidance to help clinicians and other key stakeholders increase awareness and access to COVID-19 mAbs for outpatients with mild to moderate SARS-CoV-2 infection.

In different modules, we provide resources and examples of clinical workflows to increase:

  • Referral to health care settings offering mAbs
  • Intravenous treatment with mAb cocktails
  • Subcutaneous treatment (e.g. REGEN-CoV)
  • Local public health agency processes for increasing referrals
    to mAbs
  • This guide also includes patient and clinician handouts


This implementation blueprint, including its component patient and clinician handouts, were developed between June 2021-December 2021. Information provided reflects information gathered prior to the rapid spread of the Omicron variant of the SARS-CoV-2 virus. This implementation blueprint is provided for reference if/when other mAb treatments are again shown to be effective.


mAb Colorado Graphic Novel


The mAb graphic novel walks viewers through the process of getting monoclonal antibodies (mAb) for COVID-19 and covers:

  • What to expect
  • How treatment works in the body
  • How long it takes
  • Benefits of treatment 

All in a brief and easy-to-understand 2-minute animated video.


For more information on how you can get treated with monoclonal antibodies please visit the CDPHE treatment webpage. 

Click here to visit CDPHE treatment webpage


This project was funded by a grant from the National Institutes of Health (NIH) and National Center for Advancing Translational Sciences (NCATS) (award number UL1-TR002535-03S3).