Selected High-Impact Publications

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Gaurav N, Qin W, Selvam K, Zhou Z, Liu J, Yin Y, Singh RK, O'Hara RA, Tavaf Z, Kumar A, Kono H, Narlikar GJ, Banaszynski LA, Leonhardt H, Kutateladze TG. HP1γ self-assembles and cooperates with KAP1 in repression of long noncoding RNA AI662270 in ESCs. Cell Rep. 2026 Feb 24;45(2):116874. doi: 10.1016/j.celrep.2025.116874. Epub 2026 Jan 21. PMID: 41575850.

Selvam K, Lu S, Messmer C, Pang Y, Biswas S, Khalil M, Zhang P, Tulaiha R, Zhou MM, Kitamura T, Lauberth SM, Blanco MA, Yang FC, Affar EB, Zhao Z, Zeng L, Wang L, Kutateladze TG. Recruitment of BRD4 to the ASXL1 genomic targets depends on the extra-terminal domain of BRD4. Nat Commun. 2026 Feb 17. doi: 10.1038/s41467-026-69565-z. Epub ahead of print. PMID: 41702923.

Adu-Ampratwum D, Annamalai AS, Dinh T, Lockwood JR, Bockbrader RH, Haney R, Kvaratskhelia M, Fuchs JR. Delineating Structural Functionalities of Lenacapavir Amenable to Modifications for Targeting Emerging Drug-Resistant HIV‑1 Capsid Variants. ACS Med Chem Lett. 2025 Sep 23;16(10):2007-2014. doi: 10.1021/acsmedchemlett.5c00405. PMID: 41089487; PMCID: PMC12516394.

Becht DC, Song J, Selvam K, Yin K, Bai W, Zhao Y, Wu R, Zheng YG, Kutateladze TG. The YEATS domain is a selective reader of histone methacrylation. Structure. 2025 Jul 3;33(7):1233-1239.e5. doi: 10.1016/j.str.2025.04.010. Epub 2025 May 7. PMID: 40339582; PMCID: PMC12227292.

Becht DC, Selvam K, Lachance C, Côté V, Li K, Nguyen MC, Pareek A, Shi X, Wen H, Blanco MA, Côté J, Kutateladze TG. A multivalent engagement of ENL with MOZ. Nat Struct Mol Biol. 2025 Apr;32(4):709-718. doi: 10.1038/s41594-024-01455-8. Epub 2025 Jan 10. PMID: 39794553.

Briganti L, Annamalai AS, Bester SM, Wei G, Andino-Moncada JR, Singh SP, Kleinpeter AB, Tripathi M, Nguyen B, Radhakrishnan R, Singh PK, Greenwood J, Schope LI, Haney R, Huang S-W, Freed EO, Engelman AN, Francis AC, Kvaratskhelia M. Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir. mBio. 2025 May 14;16(5):e0361324. doi: 10.1128/mbio.03613-24. Epub 2025 Apr 15. PMID: 40231850; PMCID: PMC12077090.

Gaurav N, O'Hara R, Hyder U, Qin W, Her C, Romero H, Kumar A, Marcaida MJ, Singh RK, Hovius R, Selvam K, Liu J, Martire S, Yao Y, Challa A, Dal Peraro M, Fierz B, Kono H, Cardoso MC, Debelouchina GT, Leonhardt H, D'Orso I, Banaszynski LA, Kutateladze TG. The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells. Nat Commun. 2025 May 31;16(1):5066. doi: 10.1038/s41467-025-60279-2. PMID: 40450002; PMCID: PMC12126490.

Huang SW, Briganti L, Annamalai AS, Greenwood J, Shkriabai N, Haney R, Armstrong ML, Wempe MF, Singh SP, Francis AC, Engelman AN, Kvaratskhelia M. The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir. PLoS Pathog. 2025 Jan 27;21(1):e1012862. doi: 10.1371/journal.ppat.1012862. PMID: 39869652; PMCID: PMC11892807.

Nguyen MC, Rostamian H, Raman A, Wei P, Becht DC, Erbse AH, Klein BJ, Gilbert TM, Zhang G, Blanco MA, Strahl BD, Taverna SD, Kutateladze TG. Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex. Nat Commun. 2024 Jun 24;15(1):5335. doi: 10.1038/s41467-024-49730-y. PMID: 38914563; PMCID: PMC11196586.

Vann KR, Sharma R, Hsu CC, Devoucoux M, Tencer AH, Zeng L, Lin K, Zhu L, Li Q, Lachance C, Ospina RR, Tong Q, Cheung KL, Yang S, Biswas S, Xuan H, Gatchalian J, Alamillo L, Wang J, Jang SM, Klein BJ, Lu Y, Ernst P, Strahl BD, Rothbart SB, Walsh MJ, Cleary ML, Côté J, Shi X, Zhou MM, Kutateladze TG. Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation. Nat Commun. 2025 Mar 6;16(1):2235. doi: 10.1038/s41467-025-57556-5. PMID: 40044670; PMCID: PMC11883000.

Dinh T, Tber Z, Rey JS, Mengshetti S, Annamalai AS, Haney R, Briganti L, Amblard F, Fuchs JR, Cherepanov P, Kim K, Schinazi RF, Perilla JR, Kim B, Kvaratskhelia M. The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir. bioRxiv [Preprint]. 2024 Jan 26:2024.01.26.577387. doi: 10.1101/2024.01.26.577387. PMID: 38328097; PMCID: PMC10849636.

Gaurav N, Kanai A, Lachance C, Cox KL, Liu J, Grzybowski AT, Saksouk N, Klein BJ, Komata Y, Asada S, Ruthenburg AJ, Poirier MG, Côté J, Yokoyama A, Kutateladze TG. Guiding the HBO1 complex function through the JADE subunit. Nat Struct Mol Biol. 2024 Jul;31(7):1039-1049. doi: 10.1038/s41594-024-01245-2. Epub 2024 Mar 6. PMID: 38448574; PMCID: PMC11320721.

Nguyen MC, Rostamian H, Raman A, Wei P, Becht DC, Erbse AH, Klein BJ, Gilbert TM, Zhang G, Blanco MA, Strahl BD, Taverna SD, Kutateladze TG. Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex. Nat Commun. 2024 Jun 24;15(1):5335. doi: 10.1038/s41467-024-49730-y. PMID: 38914563; PMCID: PMC11196586.

Liu J, Chaves-Arquero B, Wei P, Tencer AH, Ruiz-Albor A, Zhang G, Blanco FJ, Kutateladze TG. Molecular insight into the PCNA-binding mode of FBH1. Structure. 2023 May 4;31(5):511-517.e3. doi: 10.1016/j.str.2023.03.004. Epub 2023 Mar 28. PMID: 36990095.

Rosas R, Aguilar RR, Arslanovic N, Seck A, Smith DJ, Tyler JK, Churchill MEA. A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function. Elife. 2023 Jul 11;12:e83538. doi: 10.7554/eLife.83538. PMID: 37432722; PMCID: PMC10335832.

Tencer AH, Yu Y, Causse SZ, Campbell GR, Klein BJ, Xuan H, Cartier J, Miles MA, Gaurav N, Zadoroznyj A, Holt TA, Wen H, Hawkins CJ, Spector SA, Dubrez L, Shi X, Kutateladze TG. Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2. Nat Struct Mol Biol. 2023 Sep;30(9):1265-1274. doi: 10.1038/s41594-023-01044-1. Epub 2023 Jul 31. PMID: 37524969; PMCID: PMC10702411.

Bester SM, Adu-Ampratwum D, Annamalai AS, Wei G, Briganti L, Murphy BC, Haney R, Fuchs JR, Kvaratskhelia M. Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. mBio. 2022 Oct 26;13(5):e0180422. doi: 10.1128/mbio.01804-22. Epub 2022 Oct 3. PMID: 36190128; PMCID: PMC9600929. 

Davis CR, Backos D, Morais MC, Churchill MEA, Catalano CE. Characterization of a Primordial Major Capsid-Scaffolding Protein Complex in Icosahedral Virus Shell Assembly. J Mol Biol. 2022 Oct 15;434(19):167719. doi: 10.1016/j.jmb.2022.167719. Epub 2022 Jul 9. PMID: 35820453.

Vann KR, Acharya A, Jang SM, Lachance C, Zandian M, Holt TA, Smith AL, Pandey K, Durden DL, El-Gamal D, Côté J, Byrareddy SN, Kutateladze TG. Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection. Structure. 2022 Sep 1;30(9):1224-1232.e5. doi: 10.1016/j.str.2022.05.020. Epub 2022 Jun 17. PMID: 35716662; PMCID: PMC9212912.

Tencer AH, Liu J, Zhu J, Burkholder NT, Zhang Y, Wu W, Strahl BD, Ohta T, Kutateladze TG. The ZZ domain of HERC2 is a receptor of arginylated substrates. Sci Rep. 2022 Apr 11;12(1):6063. doi: 10.1038/s41598-022-10119-w. PMID: 35411094; PMCID: PMC9001736.

Klein BJ, Feigerle JT, Zhang J, Ebmeier CC, Fan L, Singh RK, Wang WW, Schmitt LR, Lee T, Hansen KC, Liu WR, Wang YX, Strahl BD, Anthony Weil P, Kutateladze TG. Taf2 mediates DNA binding of Taf14. Nat Commun. 2022 Jun 8;13(1):3177. doi: 10.1038/s41467-022-30937-w. PMID: 35676274; PMCID: PMC9177701

Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, Kewal Ramani VN, Voth GA, Engelman AN, Melikyan GB, Griffin PR, Asturias F, Kvaratskhelia M. Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection. Nat Commun. 2022 Oct 6;13(1):5879. doi: 10.1038/s41467-022-33662-6. PMID: 36202818; PMCID: PMC9537594.

Klein BJ, Cox KL, Jang SM, Singh RK, Côté J, Poirier MG, Kutateladze TG. Structural and biophysical characterization of the nucleosome-binding PZP domain. STAR Protoc. 2021 Apr 19;2(2):100479. doi: 10.1016/j.xpro.2021.100479. PMID: 33982013; PMCID: PMC8082262.

Klein BJ, Deshpande A, Cox KL, Xuan F, Zandian M, Barbosa K, Khanal S, Tong Q, Zhang Y, Zhang P, Sinha A, Bohlander SK, Shi X, Wen H, Poirier MG, Deshpande AJ, Kutateladze TG. The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations. Nat Commun. 2021 Jul 5;12(1):4130. doi: 10.1038/s41467-021-24418-9. PMID: 34226546; PMCID: PMC8257627.

Klein BJ, Cox KL, Jang SM, Singh RK, Côté J, Poirier MG, Kutateladze TG. Structural and biophysical characterization of the nucleosome-binding PZP domain. STAR Protoc. 2021 Apr 19;2(2):100479. doi: 10.1016/j.xpro.2021.100479. PMID: 33982013; PMCID: PMC8082262.

Engelberg IA, Liu J, Norris-Drouin JL, Cholensky SH, Ottavi SA, Frye SV, Kutateladze TG, James LI. Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1). J Med Chem. 2021 Jun 24;64(12):8510-8522. doi: 10.1021/acs.jmedchem.1c00430. Epub 2021 May 17. PMID: 33999620; PMCID: PMC8225578.

Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science. 2020 Oct 16;370(6514):360-364. doi: 10.1126/science.abb4808. PMID: 33060363.

Burgoyne AM, Vann KR, Joshi S, Morales GA, Vega FM, Singh A, Pal D, Merati AB, Kutateladze TG, Durden DL. A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov. 2020 Jul 28;6(1):49. doi: 10.1038/s41421-020-0181-z. PMID: 32793389; PMCID: PMC7385619.

Duff MR, Redzic JS, Ryan LP, Paukovich N, Zhao R, Nix JC, Pitts TM, Agarwal P, Eisenmesser EZ. Structure, dynamics, and function of the evolutionarily changing biliverdin reductase B family. J Biochem. 2020 Apr 4:mvaa039. doi: 10.1093/jb/mvaa039. Online ahead of print. PMID: 32246827

Klein BJ, Cox KL, Jang SM, Côté J, Poirier MG, Kutateladze TG. Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin. Structure. 2020 Jan 7;28(1):105-110.e3. doi: 10.1016/j.str.2019.10.014. Epub 2019 Nov 8. PubMed PMID:31711755; PubMed Central PMCID: PMC6949404

Liu J, Xue Z, Zhang Y, Vann KR, Shi X, Kutateladze TG. Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1. Structure. 2020 Nov 3;28(11):1225-1230.e3. doi: 10.1016/j.str.2020.07.003. Epub 2020 Jul 28. PMID: 32726574.

Liu J, Xue Z, Vann KR, Shi X, Kutateladze TG. Protocol for Biochemical Analysis and Structure Determination of the ZZ Domain of the E3 Ubiquitin Ligase HERC2. STAR Protoc. 2020 Oct 28;1(3):100155. doi: 10.1016/j.xpro.2020.100155. PMID: 33377049; PMCID: PMC7757301.

Tencer AH, Cox KL, Wright GM, Zhang Y, Petell CJ, Klein BJ, Strahl BD, Black JC, Poirier MG, Kutateladze TG. Molecular mechanism of the MORC4 ATPase activation. Nat Commun. 2020 Oct 29;11(1):5466. doi: 10.1038/s41467-020-19278-8. PMID: 33122719; PMCID: PMC7596504.

Vann KR, Pal D, Morales GA, Burgoyne AM, Durden DL, Kutateladze TG. Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep. 2020 Jul 21;10(1):12027. doi: 10.1038/s41598-020-68964-6. PMID: 32694708; PMCID: PMC7374098.

Wang J, Murphy EJ, Nix JC, Jones DNM. Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail. Sci Rep. 2020 Feb 24;10(1):3300. doi: 10.1038/s41598-020-60242-9. PubMed PMID: 32094450.

Zhang Y, Guo Y, Gough SM, Zhang J, Vann KR, Li K, Cai L, Shi X, Aplan PD, Wang GG, Kutateladze TG. Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun. 2020 Jul 3;11(1):3339. doi: 10.1038/s41467-020-17098-4. PMID: 32620764; PMCID: PMC7335091.

Zhang Y, Kutateladze TG. Molecular structure analyses suggest strategies to therapeutically target SARS-CoV-2. Nat Commun. 2020 Jun 10;11(1):2920. doi: 10.1038/s41467-020-16779-4.PMID: 32523109

Anantharajan J, Zhou H, Zhang L, Hotz T, Vincent MY, Blevins MA, Jansson AE, Kuan JWL, Ng EY, Yeo YK, Baburajendran N, Lin G, Hung AW, Joy J, Patnaik S, Marugan J, Rudra P, Ghosh D, Hill J, Keller TH, Zhao R, Ford HL, Kang C. Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells. Mol Cancer Ther. 2019 Sep;18(9):1484-1496. doi: 10.1158/1535-7163.MCT-18-1239. Epub 2019 Jul 8. PubMed PMID: 31285279; PubMed Central PMCID: PMC6726557.

Dostal V, Churchill MEA. Cytosine methylation of mitochondrial DNA at CpG sequences impacts transcription factor A DNA binding and transcription. Biochim Biophys Acta Gene Regul Mech 1862(5):598-607, 2019. PMID:30807854 /

Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Nix JC, Azam T, Zhang L, Zhao R, Kieft JS, The E, Meng X, Dinarello CA. Interleukin-37 monomer is the active form for reducing innate immunity. Proc Natl Acad Sci U S A 116(12):5514-5522, 2019. PMID:30819901 / PMC6431183

Klein BJ, Cox KL, Jang SM, Côté J, Poirier MG, Kutateladze TG. Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin. Structure. 2020 Jan 7;28(1):105-110.e3. doi: 10.1016/j.str.2019.10.014. Epub 2019 Nov 8. PubMed PMID: 31711755; PubMed Central PMCID: PMC6949404.

Klein BJ, Jang SM, Lachance C, Mi W, Lyu J, Sakuraba S, Krajewski K, Wang WW, Sidoli S, Liu J, Zhang Y, Wang X, Warfield BM, Kueh AJ, Voss AK, Thomas T, Garcia BA, Liu WR, Strahl BD, Kono H, Li W, Shi X, Côté J, Kutateladze TG. Histone H3K23- specific acetylation by MORF is coupled to H3K14 acylation. Nat Commun. 2019 Oct 17;10(1):4724. doi: 10.1038/s41467-019-12551-5. PubMed PMID: 31624313; PubMed Central PMCID: PMC6797804.

Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu- Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife. 2019 May 23;8. pii: e46344. doi:

10.7554/eLife.46344. PubMed PMID: 31120420; PubMed Central PMCID: PMC6581505.

Wilson TA, Koneru PC, Rebensburg SV, Lindenberger JJ, Kobe MJ, Cockroft NT, Adu- Ampratwum D, Larue RC, Kvaratskhelia M, Fuchs JR. An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors. ACS Med Chem Lett. 2019 Jan 30;10(2):215-220. doi: 10.1021/acsmedchemlett.8b00633. eCollection 2019 Feb 14. PubMed PMID: 30783506; PubMed Central PMCID: PMC6378678.

Yesselman JD, Eiler D, Carlson ED, Gotrik MR, d'Aquino AE, Ooms AN, Kladwang W, Carlson PD, Shi X, Costantino DA, Herschlag D, Lucks JB, Jewett MC, Kieft JS, Das R. Computational design of three-dimensional RNA structure and function. Nat Nanotechnol. 2019 Sep;14(9):866-873. doi: 10.1038/s41565-019-0517-8. Epub 2019 Aug 19. PubMed PMID: 31427748.

Zhang Y, Ahn J, Green KJ, Vann KR, Black J, Brooke CB, Kutateladze TG. MORC3 Is a Target of the Influenza A Viral Protein NS1. Structure. 2019 Jun 4;27(6):1029- 1033.e3. doi: 10.1016/j.str.2019.03.015. Epub 2019 Apr 18. PubMed PMID: 31006586.

Zhang Y, Klein BJ, Cox KL, Bertulat B, Tencer AH, Holden MR, Wright GM, Black J, Cardoso MC, Poirier MG, Kutateladze TG. Mechanism for autoinhibition and activation of the MORC3 ATPase. Proc Natl Acad Sci U S A 116(13):6111-6119, 2019. PMID:30850548 / PMC6442546

Zhang Y, Mun SR, Linares JF, Towers CG, Thorburn A, Diaz-Meco MT, Kwon YT, Kutateladze TG. Mechanistic insight into the regulation of SQSTM1/p62. Autophagy 15(4):735-737, 2019. PMID:30653391 / PMC6526835

Zhang Y, Jang Y, Lee JE, Ahn J, Xu L, Holden MR, Cornett EM, Krajewski K, Klein BJ, Wang SP, Dou Y, Roeder RG, Strahl BD, Rothbart SB, Shi X, Ge K, Kutateladze TG. Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF. Nat Commun 10(1):2314, 2019. PMID:31127101 / PMC6534582

Klein BJ, Vann KR, Andrews FH, Wang WW, Zhang J, Zhang Y, Beloglazkina AA, Mi W, Li Y, Li H, Shi X, Kutateladze AG, Strahl BD, Liu WR, Kutateladze TG. Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain. Nat Commun 9(1):4574, 2018. PMID:30385749 / PMC6212594

Klein BJ, Krajewski K, Restrepo S, Lewis PW, Strahl BD, Kutateladze TG. Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers. Epigenetics

13(7):683-692, 2018. PMID:30045670 / PMC6224213

Klein BJ, Ahmad S, Vann KR, Andrews FH, Mayo ZA, Bourriquen G, Bridgers JB, Zhang J, Strahl BD, Cote J, Kutateladze TG. Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain. Nucleic Acids Res 46: 421-430, 2018. PMID: 29145630 / PMC5758897

Liu H, Wang C, Lee S, Ning F, Wang Y, Zhang Q, Chen Z, Zang J, Nix J, Dai S, Marrack P, Hagman J, Kappler J, Zhang G. Specific recognition of arginine methylated histone tails by JMJD5 and JMJD7. Sci Rep 8: 3275, 2018. PMID: 29459673 / PMC5818494

MacFadden A, O'Donoghue Z, Silva P, Chapman EG, Olsthoorn RC, Sterken MG, Pijlman GP, Bredenbeek PJ, Kieft JS. Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs. Nat Commun 9: 119, 2018. PMID: 29317714 / PMC5760640

Mi W, Zhang Y, Lyu J, Wang X, Tong Q, Peng D, Xue Y, Tencer AH, Wen H, Li W, Kutateladze TG, Shi X. The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex- mediated histone acetylation and gene activation. Nat Commun 9(1):3759, 2018. PMID:30217978 / PMC6138639

Nichols PJ, Henen MA, Born A, Strotz D, Guntert P, Vogeli B. High-resolution small RNA structures from exact nuclear Overhauser enhancement measurements without additional restraints. Commun Biol 1: 61, 2018. PMID: 30271943 / PMC6123705

Salmon L, Stull F, Sayle S, Cato C, Akgul S, Foit L, Ahlstrom LS, Eisenmesser EZ, Al- Hashimi HM, Bardwell JCA, Horowitz S. The mechanism of HdeA unfolding and chaperone activation. J Mol Biol 430: 33-40, 2018. PMID: 29138002 / PMC5738273

Steckelberg AL, Akiyama BM, Costantino DA, Sit TL, Nix JC, Kieft JS. A folded viral noncoding RNA blocks host cell exoribonucleases through a conformationally dynamic RNA structure. Proc Natl Acad Sci U S A 115: 6404-6409, 2018. PMID: 29866852 / PMC6016793

Zhang Y, Mun SR, Linares JF, Ahn J, Towers CG, Ji CH, Fitzwalter BE, Holden MR, Mi W, Shi X, Moscat J, Thorburn A, Diaz-Meco MT, Kwon YT, Kutateladze TG. ZZ- dependent regulation of p62/SQSTM1 in autophagy. Nat Commun. 2018 Oct 22;9(1):4373. doi: 10.1038/s41467-018-06878-8. PubMed PMID: 30349045; PubMed Central PMCID: PMC6197226.

Zhang Y, Xue Y, Shi J, Ahn J, Mi W, Ali M, Wang X, Klein BJ, Wen H, Li W, Shi X, Kutateladze TG. The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3. Nat Struct Mol Biol 25(9):841-849, 2018. PMID:30150647 / PMC6482957

Andrews FH, Singh AR, Joshi S, Smith CA, Morales GA, Garlich JR, Durden DL, Kutateladze TG. Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. Proc Natl Acad Sci U S A 114: E1072-E1080, 2017. PMID: 28137841 / PMC5320964

Blevins MA, Huang M, Zhao R. The role of CtBP1 in oncogenic processes and its potential as a therapeutic target. Mol Cancer Ther 16: 981-990, 2017. PMID: 28576945 / PMC5458631

Brown DA, Di Cerbo V, Feldmann A, Ahn J, Ito S, Blackledge NP, Nakayama M, McClellan M, Dimitrova E, Turberfield AH, Long HK, King HW, Kriaucionis S, Schermelleh L, Kutateladze TG, Koseki H, Klose RJ. The SET1 complex selects actively transcribed target genes via multivalent interaction with CpG island chromatin. Cell Rep 20: 2313-2327, 2017. PMID: 28877467 / PMC5603731

Espinosa S, Zhang L, Li X, Zhao R. Understanding pre-mRNA splicing through crystallography. Methods Epub ahead of print, 2017. PMID: 28506657

Gatchalian J, Ali M, Andrews FH, Zhang Y, Barrett AS, Kutateladze TG. Structural insight into recognition of methylated histone H3K4 by Set3. J Mol Biol 429: 2066-2074, 2017. PMID: 27697561 / PMC5374059

Gibson MD, Gatchalian J, Slater A, Kutateladze TG, Poirier MG. PHF1 Tudor and N- terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibility. Nucleic Acids Res 45: 3767-3776, 2017. PMID: 28082396 / PMC5397176

Holliday MJ, Camilloni C, Armstrong GS, Vendruscolo M, Eisenmesser EZ. Networks of dynamic allostery regulate enzyme function. Structure 25: 276-286, 2017. PMID: 28089447 / PMC5336394

Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M. Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing. J Biol Chem 292: 19814-19825, 2017. PMID: 28972144 / PMC5712621

Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: A small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget 8: 6742-6762, 2017. PMID: 28039486 / PMC5341751

Klein BJ, Simithy J, Wang X, Ahn J, Andrews FH, Zhang Y, Cote J, Shi X, Garcia BA, Kutateladze TG. Recognition of histone H3K14 acylation by MORF. Structure 25: 650-

654 e2, 2017. PMID: 28286003 / PMC5415407

Liu H, Wang C, Lee S, Deng Y, Wither M, Oh S, Ning F, Dege C, Zhang Q, Liu X, Johnson AM, Zang J, Chen Z, Janknecht R, Hansen K, Marrack P, Li CY, Kappler JW, Hagman J, Zhang G. Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. Proc Natl Acad Sci U S A 114: Epub ahead of print, 2017. PMID: 28847961 / PMC5604019

Liu S, Li X, Zhang L, Jiang J, Hill RC, Cui Y, Hansen KC, Zhou ZH, Zhao R. Structure of the yeast spliceosomal postcatalytic P complex. Science 358: 1278-1283, 2017. PMID: 29146870 / Required

Mi W, Guan H, Lyu J, Zhao D, Xi Y, Jiang S, Andrews FH, Wang X, Gagea M, Wen H, Tora L, Dent SYR, Kutateladze TG, Li W, Li H, Shi X. YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nat Commun. 2017 Oct 20;8(1):1088. doi: 10.1038/s41467-017-01173-4. PubMed PMID: 29057918; PubMed Central PMCID: PMC5651844.

Tencer AH, Gatchalian J, Klein BJ, Khan A, Zhang Y, Strahl BD, van Wely KHM, Kutateladze TG. A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO. Structure. 2017 Oct 3;25(10):1530-1539.e3. doi: 10.1016/j.str.2017.08.009. Epub 2017 Sep 14. PubMed PMID: 28919441; PubMed Central PMCID: PMC5679713.

Zhou H, Zhang L, Vartuli RL, Ford HL, Zhao R. The Eya phosphatase: Its unique role in cancer. Int J Biochem Cell Biol, Epub ahead of print, 2017. PMID: 28887153

Akiyama BM, Laurence HM, Massey AR, Costantino DA, Xie X, Yang Y, Shi PY, Nix JC, Beckham JD, Kieft JS. Zika virus produces noncoding RNAs using a multi- pseudoknot structure that confounds a cellular exonuclease. Science. 2016 Dec 2;354(6316):1148-1152. Epub 2016 Nov 10. PubMed PMID: 27934765; PubMed Central PMCID: PMC5476369.

Andrews FH, Shinsky SA, Shanle EK, Bridgers JB, Gest A, Tsun IK, Krajewski K, Shi X, Strahl BD, Kutateladze TG. The Taf14 YEATS domain is a reader of histone crotonylation. Nat Chem Biol 12: 396-8, 2016. PMID: 27089029 / PMC4871749

Andrews FH, Tong Q, Sullivan KD, Cornett EM, Zhang Y, Ali M, Ahn J, Pandey A, Guo AH, Strahl BD, Costello JC, Espinosa JM, Rothbart SB, Kutateladze TG. Multivalent chromatin engagement and inter-domain crosstalk regulate MORC3 ATPase. Cell Rep 16: 3195-3207, 2016. PMID: 27653685 / PMC5074691

Gatchalian J, Ali M, Andrews FH, Zhang Y, Barrett AS, Kutateladze TG. Structural Insight into Recognition of Methylated Histone H3K4 by Set3. J Mol Biol. 2017 Jun

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Gatchalian J, Gallardo CM, Shinsky SA, Ospina RR, Liendo AM, Krajewski K, Klein BJ, Andrews FH, Strahl BD, KH MvW, Kutateladze TG. Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive. Nucleic Acids Res 44: 6102-12, 2016. PMID: 27016734 / PMC5291243

Jaafar ZA, Oguro A, Nakamura Y, Kieft JS. Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling. Elife 5: e21198, 2016. PMID: 28009256 / PMC5238962

Klein BJ, Muthurajan UM, Lalonde ME, Gibson MD, Andrews FH, Hepler M, Machida S, Yan K, Kurumizaka H, Poirier MG, Cote J, Luger K, Kutateladze TG. Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation. Nucleic Acids Res 44: 472-84, 2016. PMID: 26626149 / PMC4705663

Klein BJ, Wang X, Cui G, Yuan C, Botuyan MV, Lin K, Lu Y, Wang X, Zhao Y, Bruns CJ, Mer G, Shi X, Kutateladze TG. PHF20 Readers link methylation of histone H3K4 and p53 with H4K16 acetylation. Cell Rep 17: 1158-1170, 2016. PMID: 27760318 / PMC5125728

Liu WH, Roemer SC, Zhou Y, Shen ZJ, Dennehey BK, Balsbaugh JL, Liddle JC, Nemkov T, Ahn NG, Hansen KC, Tyler JK, Churchill ME. The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones. Elife 5: e18023, 2016. PMID: 27690308 / PMC5045291

Malarkey CS, Gustafson CE, Saifee JF, Torres RM, Churchill ME, Janoff EN. Mechanism of mitochondrial transcription factor a attenuation of CpG-induced antibody production. PLoS One 11: e0157157, 2016. PMID: 27280778 / PMC4900672

Zhang X, Peng D, Xi Y, Yuan C, Sagum CA, Klein BJ, Tanaka K, Wen H, Kutateladze TG , Li W, Bedford MT, Shi X. G9a-mediated methylation of ERalpha links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression. Nat Commun 7: 10810, 2016. PMID: 26960573 / PMC4792926

Zhu L, Li Q, Wong SH, Huang M, Klein BJ, Shen J, Ikenouye L, Onishi M, Schneidawind D, Buechele C, Hansen L, Duque-Afonso J, Zhu F, Martin GM, Gozani O, Majeti R, Kutateladze TG, Cleary ML. ASH1L Links histone H3 Lysine 36 dimethylation to MLL leukemia. Cancer Discov 6: 770-83, 2016. PMID: 27154821 / PMC4930721

Hartwick EW, Costantino DA, MacFadden A, Nix JC, Tian S, Das R, Kieft JS. Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels. Nat Commun 9(1):5074, 2018. PMID:30498211 / PMC6265322