Lynelle Smith MD

Publications and Presentations

Peer-Reviewed Publications

1. Meredith AA, Meredith NR, Smith L, Rosser J. Circulating Nucleated Red Blood Cells: An Updated Reference Interval. Arch Pathol Lab Med. Published online March 4, 2024. doi:10.5858/arpa.2023-0328-OA  
2. Davies KD, Smith LP*, Guimaraes-Young A, et al. Prospective Clinical Prognostication of Endometrial Carcinomas Based on Next-Generation Sequencing and Immunohistochemistry-Real-World Implementation and Results at a Tertiary Care Center. Int J Gynecol Pathol. Published online October 4, 2023. doi:10.1097/PGP.0000000000000994  *Significant contribution  
3. Smith LP, Brubaker LW, Wolsky RJ. It Does Exist! Diagnosis and Management of Thyroid Carcinomas Originating in Struma Ovarii. Surg Pathol Clin. 2023;16(1):75-86. doi:10.1016/j.path.2022.09.008  
4. Kerwin CM, Markese M, Moroney MR, Smith LP, Patel NU. Adenocarcinoma of the uterine cervix, gastric-type (GAS): a review of the literature focused on pathology and multimodality imaging. Abdom Radiol (NY). 2023;48(2):713-723. doi:10.1007/s00261-022-03724-w  
5. Author of HSV Pneumonia, 2022 FNA-B: Infectious and Granulomatous FNA - Digital Slide Program in Fine-Needle Aspiration, ©2022 College of American Pathologists. Online CME/CE education activity released October 17, 2022.  
6. Reviewing editor of Spindle Cell Melanoma, 2022 FNA-A: Head and Neck FNA - Digital Slide Program in Fine-Needle Aspiration, ©2022 College of American Pathologists. Online CME/CE education activity released April 18, 2022.  
7.  Smith LP, Bitler BG, Richer JK, Christenson JL. Tryptophan catabolism in epithelial ovarian carcinoma. Trends Cancer Res. 2019;14:1-9.  
8. Hernández-Saavedra D, Sanders L, Perez MJ, Kosmider, B, Smith LP, Mitchell JD, Yoshida T, Tuder RM. RTP801 Amplifies Nicotinamide Adenine Dinucleotide Phosphate Oxidase-4-Dependent Oxidative Stress Induced by Cigarette Smoke. Am J Respir Cell Mol Biol. 2017;56(1):62-73. doi:10.1165/rcmb.2016-0144OC  
9. Rutebemberwa A, Stevens MJ, Perez MJ, Smith LP, Sanders L, Cosgrove G, Robertson CE, Tuder RM, Harris JK. Novosphingobium and its potential role in chronic obstructive pulmonary diseases: insights from microbiome studies. PLoS One. 2014;9(10):e111150. Published 2014 Oct 23. doi:10.1371/journal.pone.0111150 
10. Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014;184(9):2382-2389. doi:10.1016/j.ajpath.2014.06.002 
11. Dahlman JE, Barnes C, Khan O, et al. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat Nanotechnol. 2014;9(8):648-655. doi:10.1038/nnano.2014.84. 
12.  Rutebemberwa A, Stevens MJ, Perez MJ, Smith LP, Sanders L, Cosgrove G, Robertson CE, Tuder RM, Harris JK. Novosphingobium and its potential role in chronic obstructive pulmonary diseases: insights from microbiome studies. PLoS One. 2014;9(10):e111150. Published 2014 Oct 23. doi:10.1371/journal.pone.0111150 
13. Lygizos MI, Yang Y, Altmann CJ, Okamura K., Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013;1(6):e00153. doi:10.1002/phy2.153 
14. Hunt JM, Bethea B, Liu X, Gandjeva A, Mammen PP, Stacher E, Gandjeva MR, Parish E, Perez MJ, Smith LP, Graham BB, Kuebler WM, Tuder RM. Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease. Am J Physiol Lung Cell Mol Physiol. 2013;305(10):L725-L736. doi:10.1152/ajplung.00186.2013  
15. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012;18(8):1217-1223. doi:10.1038/nm.2843 
16. Hellier JL, Arevalo NL, Smith L, Xiong KN, Restrepo D. α7-Nicotinic acetylcholine receptor: role in early odor learning preference in mice. PLoS One. 2012;7(4):e35251. doi:10.1371/journal.pone.0035251 
17. Zhang Y, Morisetti P, Kim J, Smith L, Lin H. Regioselectivity preference of testosterone hydroxylation by cytochrome P450 3A4. Theoretical Chemistry Accounts. 2008, Dec; 121(5): 313-319. 

Poster & Platform Presentations

1. Smith LP, Wolsky RJ. Retrospective Reclassification of 188 Consecutive Endometrial Carcinomas by FIGO 2023 Staging, Including Molecular Classification. Platform Presentation, March 2024 at the United States & Canadian Academy of Pathology Annual Meeting. Baltimore, MD 
2. Smith LP, Knoeckel C, Black M, Sheren J, Corr BR, Wolsky RJ. Morphological Compartmentalization of CTNNB1 Mutation to Glands and/or Squamous Morules in Endometrial Endometrioid Carcinoma: Practical Implications for Using β-catenin IHC to Guide Localization of DNA Sampling for Mutational Analysis. Stowell-Orbison Award Poster Presentation, March 2024 at the United States & Canadian Academy of Pathology Annual Meeting. Baltimore, MD.  
3. Xiong J*, Smith LP*, Black M, Wolsky RJ, Post MD. Histopathologic Correlation with ARID1A Immunohistochemistry in Endometrial Carcinomas, Including Description of Subclonal ARID1A Loss. Stowell-Orbison Award Poster Presentation, March 2024 at the United States & Canadian Academy of Pathology Annual Meeting. Baltimore, MD.  *Co-first author 
4. Gadara E, Smith LP, Guimaraes-Young A. Aisner DL. Think Quik: Successful, Routine Use of Cytology Specimens in a Solid Tumor Molecular Laboratory. Platform presentation, November 2023 at the American Society of Cytopathology 71st Annual Scientific Meeting. Austin, TX.  
5. Corr BR, Hu J, Walsh C, Alldredge J, Brubaker L, Guntupalli S, Behbakht K, Lefkowits C, Fisher CM, Spinosa S, Porragas-Paseiro H, Pino D, Smith LP, Guimaraes-Young A, Davies K, Aisner DL, Wolsky RJ. Uniform prospective molecular analysis of endometrial carcinoma: feasibility, outcomes, and effect on management. Poster presentation, October 2023 at the European Society for Medical Oncology Congress 2023. Madrid, Spain.  
6.  Guimaraes-Young A, Smith LP, Aisner DL, Wolsky RJ, Corr BR, Davies K. Targeted Next-Generation Sequencing Panel Reveals Differences in Mutational Patterns between Endometrial Cancer Molecular Classifier Subgroups. Poster presentation, November 2022 at the Association for Molecular Pathology Annual Meeting. Phoenix, AZ.  
7.  Smith LP, Pino D, Davies K, Berning A, Post MD, Corr BR, Guntupalli S, Fisher CM, Aisner D, Wolsky RJ. Implementation of Endometrial Cancer TCGA Classification Using ProMisE: Experience at a Tertiary Care Center. Poster presentation March 2022 at the United States & Canadian Academy of Pathology Annual Meeting. Los Angeles, CA.
8.  Smith LP, Ahrendt GM, Sams SB. Standardization of Breast Sentinel Lymph Node Evaluation at Intraoperative Consultation Decreases Discrepancies Between Frozen and Final Diagnosis. Poster presentation, March 2021 at the United States & Canadian Academy of Pathology Annual Meeting, Virtual. 
9.  Smith LP, Jian J. Recurrent Metastatic Giant Cell Tumor in the Lung with Denosumab-Treatment Effect. Published in: Archives of Pathology & Laboratory Medicine. Poster presentation at the College of American Pathologist Annual Meeting 2020, Virtual.  Volume 144, Issue 9s1 September 2020 
10. Vaughan VC, O’Donnell E, Xu CY, Ho L, Narayan S, Smith LP, et. Al. Improving Communication among Autopsy Residents & Care Providers. Presented February 2020 at the University of Colorado GME (Graduate Medical Education) Bonus Project Annual Poster Session. Aurora, CO.  
11.  Smith LP, Harrell LM, Christenson JL, et al. Tryptophan Catabolism in Ovarian Cancer. Presented April 2018 at the American Association for Cancer Research Annual Meeting, Chicago, IL.  
12.  Smith, LP, Rodman, B., Merboth, E. Time to Pathological Diagnosis of Breast Biopsies, Quality Improvement. Presented March 2017 at the University of Colorado School of Medicine-Colorado Springs Branch Awards Ceremony, Colorado Springs, CO. 
13.  Smith, LP, Gordon, M.A., Betker, J.L., Anchordoquy, T.J., Richer, J.K. Lipoplex delivery of micro-RNA 200C to ovarian cancer cells. Presented February 2016 at the University of Colorado - AMC Student Research Forum, Aurora, CO. 
14.  Smith, LP, Gordon, M.A., Betker, J.L., Anchordoquy, T.J., Richer, J.K. Lipoplex delivery of micro-RNA 200c to ovarian cancer cells. Platform Presentation, February 2016 at the American Federation for Medical Research; Western Regional Meeting; Carmel, CA 

Published Artwork