Chromosome and FISH analysis of oncology blood is performed to detect acquired clonal chromosome abnormalities associated with hematologic neoplasms including acute leukemias, myeloproliferative and lymphoproliferative neoplasms, and myelodysplastic syndromes. This test should not be requested unless 5% circulating blasts are present in peripheral blood.

Chromosome and FISH analysis of bone marrow is performed to detect acquired clonal chromosome abnormalities associated with hematologic neoplasms, such as acute leukemias, myeloproliferative and lymphoproliferative neoplasms, and myelodysplastic syndromes. Bone marrow core is indicated in cases of packed marrow.

Chromosome and FISH of solid tumor or lymph node biopsies are performed to detect acquired chromosome abnormalities associated with tumors or lymphomas.

Note:  Peripheral blood usually is not the ideal sample type of choice for hematologic neoplasms.  It should only be submitted if a bone marrow cannot be aspirated or as a backup if only a bone marrow core biopsy can be submitted.

Molecular cytogenetic studies using fluorescence in situ hybridization (FISH) are often performed in addition to the chromosome analysis. 

Please see Fish Test List for a comprehensive view of all the probes and tests we provide.