Chike Nwabuo MD

Publications and Presentations

1.         Nwabuo CC, Vasan RS. Pathophysiology of Hypertensive Heart Disease: Beyond Left Ventricular Hypertrophy. Curr Hypertens Rep. 2020 Feb 3;22(2):11. doi: 10.1007/s11906-020-1017-9. PMID: 32016791.

2.         Nwabuo CC, Duncan M, Xanthakis V, Peterson LR, Mitchell GF, McManus D, Cheng S, Vasan RS. Association of Circulating Ceramides With Cardiac Structure and Function in the Community: The Framingham Heart Study. J Am Heart Assoc. 2019 Oct;8(19):e013050. doi: 10.1161/JAHA.119.013050. Epub 2019 Sep 24. PubMed PMID:31549564;

3.         Nwabuo CC, Yano Y, Moreira HT, Appiah D, Vasconcellos HD, Aghaji QN, Viera A, Rana JS, Shah RV, Murthy VL, Allen NB, Schreiner PJ, Lloyd-Jones DM, Lima JAC. Association Between Visit-to-Visit Blood Pressure Variability in Early Adulthood and Myocardial Structure and Function in Later Life. JAMA Cardiol. 2020 Jul 1;5(7):795-801. doi: 10.1001/jamacardio.2020.0799.

4.         Nwabuo CC, Betoko AS, Reis JP, Moreira HT, Vasconcellos HD, Guallar E, Cox C, Sidney S, Ambale-Venkatesh B, Lewis CE, Schreiner PJ, Lloyd-Jones D, Kiefe CI, Gidding SS, Lima JAC. Coffee and tea consumption in the early adult lifespan and left ventricular function in middle age: the CARDIA study. ESC Heart Fail. 2020 Aug;7(4):1510-1519. doi: 10.1002/ehf2.12684. Epub 2020 May 25. PMID: 32449612; PMCID: PMC7373924.

5.         Appiah D, Farias RM, Olokede OA, Nwabuo CC, Bhende KM, Ebong IA, Byrd TL, Nair N. The influence of individual and neighborhood-level characteristics on rural-urban disparities in cardiovascular disease mortality among U.S. women diagnosed with breast and gynecologic cancers. Gynecol Oncol. 2021 May;161(2):483-490. doi: 10.1016/j.ygyno.2020.11.023. Epub 2021 Mar 6. PMID: 33750605.

6.         Nwabuo CC, Appiah D, Moreira HT, Vasconcellos HD, Yano Y, Reis JP, Shah RV, Murthy VL, Allen NB, Sidney S, Muntner P, Lewis CE, Lloyd-Jones DM, Schreiner PJ, Gidding SS, Lima JA. Long-term cumulative blood pressure in young adults and incident heart failure, coronary heart disease, stroke, and cardiovascular disease: The CARDIA study. Eur J Prev Cardiol. 2020 Apr 10:2047487320915342. doi: 10.1177/2047487320915342. Epub ahead of print. PMID: 32276575.

7.         Moreira HT, Vasconcellos HD, Ambale-Venkatesh B, Brittain EL, Nwabuo CC, Schmidt A, Lloyd-Jones DM, Carr JJ, Lewis CE, Jacobs DR Jr, Gidding SS, Lima JAC. Pulmonary Artery Acceleration Time in Young Adulthood and Cardiovascular Outcomes Later in Life: The Coronary Artery Risk Development in Young Adults Study. J Am Soc Echocardiogr. 2019 Oct 21. pii: S0894-7317(19)30945-9. doi: 10.1016/j.echo.2019.07.025.

8.         Nwabuo CC, Moreira HT, Vasconcellos HD, Mewton N, Opdahl A, Ogunyankin KO, Ambale-Venkatesh B, Schreiner PJ, Armstrong AAC, Lewis CE, Jacobs DR Jr, Lloyd-Jones D, Gidding SS, Lima JAC. Left ventricular global function index predicts incident heart failure and cardiovascular disease in young adults: the coronary artery risk development in young adults (CARDIA) study. Eur Heart J Cardiovasc Imaging. 2018 Sep 20. doi: 10.1093/ehjci/jey123.

9.         Vasconcellos HD, Moreira HT, Ciuffo L, Nwabuo CC, Yared GS, Ambale-Venkatesh B, Armstrong AC, Kishi S, Reis JP, Liu K, Lloyd-Jones DM, Colangelo LA, Schreiner PJ, Sidney S, Gidding SS, Lima JAC. Cumulative blood pressure from early adulthood to middle age is associated with left atrial remodelling and subclinical dysfunction assessed by three-dimensional echocardiography: a prospective post hoc analysis from the coronary artery risk development in young adults study. Eur Heart J Cardiovasc Imaging. 2018 Sep 1;19(9):977-984. doi: 10.1093/ehjci/jey086.

10.       Nwabuo CC, Moreira HT, Vasconcellos HD, Ambale-Venkatesh B, Yoneyama K, Ohyama Y, Sharma RK, Armstrong A, Ostovaneh M, Lewis CE, Liu K, Schreiner PJ, Ogunyankin KO, Gidding SS, Lima JAC. Association of Aortic Root Dilation from Early Adulthood to Middle Age with Cardiac Structure and Function: The CARDIA Study.        J Am Soc Echocardiogr. 2017 Dec;30 (12):1172-1179. doi: 10.1016/j.echo.2017.08.001. Epub 2017 Sep 15

11.       Appiah D, Schreiner PJ, Gunderson EP, Konety SH, Jacobs DR Jr, Nwabuo CC, Ebong IA, Whitham HK, Goff DC Jr, Lima JA, Ku IA, Gidding SS. Association of Gestational Diabetes Mellitus With Left Ventricular Structure and Function: The CARDIA Study. Diabetes Care. 2016 Mar;39(3):400-7.

12.       Brittain EL, Nwabuo C, Xu M, Gupta DK, Hemnes AR, Moreira HT, De Vasconcellos  HD, Terry JG, Carr JJ, Lima JA. Echocardiographic Pulmonary Artery Systolic Pressure in the Coronary Artery Risk Development in Young Adults (CARDIA) Study:  Associations With Race and Metabolic Dysregulation. J Am Heart Assoc. 2017 Mar 30;6(4). pii: e005111. doi: 10.1161/JAHA.116.005111.

13.       Moreira HT, Nwabuo CC, Armstrong AC, Kishi S, Gjesdal O, Reis JP, Schreiner PJ, Liu K, Lewis CE, Sidney S, Gidding SS, Lima JAC, Ambale-Venkatesh B. Reference Ranges and Regional Patterns of Left Ventricular Strain and Strain Rate Using Two-Dimensional Speckle-Tracking Echocardiography in a Healthy Middle-Aged Black and White Population: The CARDIA Study. J Am Soc Echocardiogr. 2017 Jul;30(7):647-658.e2. doi: 10.1016/j.echo.2017.03.010. Epub 2017 May 13.

14.       Nwabuo CC, Dy SM, Weeks K, Young JH. Factors associated with appointment non-adherence among African-Americans with severe, poorly controlled hypertension. PLoS One. 2014 Aug 14;9(8):e103090. doi: 10.1371/journal.pone.0103090

15.       Appiah D, Schreiner PJ, Nwabuo CC, Wellons MF, Lewis CE, Lima JA. The association of surgical versus natural menopause with future left ventricular structure and function: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Menopause. 2017 Jul 10. doi: 10.1097/GME.0000000000000919.

16.       Doria de Vasconcellos H, Betoko A, Ciuffo LA, Moreira HT, Nwabuo CC, Ambale-Venkatesh B, Reis JP, Allen N, Lloyd-Jones DM, Colangelo LA, Schreiner PJ, Lewis CE, Shikany JM, Sidney S, Cox C, Gidding SS, Lima JAC. Sex Differences in the Association of Cumulative Body Mass Index from Early Adulthood to Middle Age and Left Atrial Remodeling Evaluated by Three-Dimensional Echocardiography: The Coronary Artery Risk Development in Young Adults Study. J Am Soc Echocardiogr. 2020 Jul;33(7):878-887.e3. doi: 10.1016/j.echo.2020.02.013. Epub 2020 Apr 24. PMID: 32336609; PMCID: PMC7388576.
17.       Moreira HT, Volpe GJ, Marin-Neto JA, Ambale-Venkatesh B, Nwabuo CC, Trad HS, Romano MM, Pazin-Filho A, Maciel BC, Lima JA, Schmidt A. Evaluation of Right Ventricular Systolic Function in Chagas Disease Using Cardiac Magnetic Resonance Imaging. Circ Cardiovasc Imaging. 2017 Mar;10(3). pii: e005571. doi: 10.1161/CIRCIMAGING.116.005571.

18.       Moreira HT, Volpe GJ, Marin-Neto JA, Nwabuo CC, Ambale-Venkatesh B, Gali LG, Almeida-Filho OC, Romano MMD, Pazin-Filho A, Maciel BC, Lima JAC, Schmidt A. Right Ventricular Systolic Dysfunction in Chagas Disease Defined by Speckle-Tracking Echocardiography: A Comparative Study with Cardiac Magnetic Resonance Imaging. J Am Soc Echocardiogr. 2017 May;30(5):493-502. doi: 10.1016/j.echo.2017.01.010.

19.       Chibungu A, Gundareddy V, Wright SM, Nwabuo CC, Bollampally P, Landis R, Eid SM. Management of Cocaine-Induced Myocardial Infarction: 4-Year Experience at an Urban Medical Center. South Med J. 2016 Mar;109(3):185-90.

20.       Subramanya V, Ambale-Venkatesh B, Ohyama Y, Zhao D, Nwabuo CC, Post WS, Guallar E, Ouyang P, Shah SJ, Allison MA, Ndumele CE, Vaidya D, Bluemke DA, Lima  JA, Michos ED. Relation of Sex Hormone Levels with Prevalent and 10-year Change in Aortic Distensibility Assessed by MRI: The Multi-Ethnic Study of Atherosclerosis. Am J Hypertens. 2018 Feb 19. doi: 10.1093/ajh/hpy024

21.       Subramanya V, Zhao D, Ouyang P, Lima JA, Vaidya D, Ndumele CE, Bluemke DA, Shah SJ, Guallar E, Nwabuo CC, Allison MA, Heckbert SR, Post WS, Michos ED. Sex hormone levels and change in left ventricular structure among men and post-menopausal women: The Multi-Ethnic Study of Atherosclerosis (MESA). Maturitas. 2018 Feb;108:37-44. doi: 10.1016/j.maturitas.2017.11.006. Epub 2017

22.       Yared G , Moreira HT, Ambale-Venkatesh B, Vasconcellos, Nwabuo CC, Ostovaneh MR, Reis JP, Lloyd-Jones D, Schreiner PJ, Lewis CE, Sidney S, Carr JJ, Gidding SS, Lima JA. Coronary Artery Calcium from Early Adulthood to Middle Age and Left Ventricular Structure and Function doi: 10.1161/CIRCIMAGING. Accepted May 22

23.       Betoko A, Nwabuo C, Ambale Venkatesh B, Ricketts EP, Bae S, Wu C, Gidding SS, Liu K, Lima JAC and Cox C. Application of measurement error models to correct for systematic differences among readers and vendors in echocardiography measurements: the CARDIA study. Journal of Applied Statistics. 2019:1-10

24.       Aghaji QN and Nwabuo CC. Association Between Maternal Fluoride Exposure and Child IQ. JAMA Pediatr. 2019

25.       Appiah D, Nwabuo CC, Owoade DR, Samad J, Ebong I, Winters SJ. Family history of premature myocardial infarction modifies the associations between bilateral oophorectomy and cardiovascular disease mortality in a US national cohort of postmenopausal women. Menopause. 2020 Jun;27(6):658-667. doi: 10.1097/GME.0000000000001522. PMID: 32132444.

26.       Nwabuo CC, Appiah D, Moreira HT, Vasconcellos HD, Aghaji QN, Ambale-Venkatesh B, Rana JS, Allen NB, Lloyd-Jones DM, Schreiner PJ, Gidding SS, Lima JAC. Temporal Changes in Resting Heart Rate, Left Ventricular Dysfunction, Heart Failure and Cardiovascular Disease: CARDIA Study. Am J Med. 2020 Aug;133(8):946-953. doi: 10.1016/j.amjmed.2019.12.035. Epub 2020 Jan 27. PMID: 32001229; PMCID: PMC7477638.
27.       Lovelace J, Shabaneh O, De La Cruz N, Owoade DR, Nwabuo CC, Nair N, Appiah D. The Joint Association of Septicemia and Cerebrovascular Diseases with In-Hospital Mortality Among Patients with Left Ventricular Assist Device in the United States. J Stroke Cerebrovasc Dis. 2021 Jan 19;30(4):105610. doi: 10.1016/j.jstrokecerebrovasdis.2021.105610. Epub ahead of print. PMID: 33482570.

28.       Nwabuo CC, Appiah D, Vasconcellos HD, Aghaji QN, Rana JS, Lima JAC. The Reply. Am J Med. 2021 Jan;134(1):e69. doi: 10.1016/j.amjmed.2020.09.005. PMID: 33342473.

29.       Nwabuo CC, Appiah D, The Influence of Individual and Neighborhood-Level Characteristics on Rural-Urban Disparities in Cardiovascular Disease Mortality among U.S. Women Diagnosed with Breast and Gynecologic Cancers. Gynecologic Oncology 2021

30.       Nwabuo CC, Rana JS. Letter by Nwabuo and Rana Regarding Article, "Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy: The Hallmark of Stage-B Heart Failure With Preserved Ejection Fraction". Circulation. 2020 May 19;141(20):e817-e818. doi: 10.1161/CIRCULATIONAHA.120.045705. Epub 2020 May 18. PMID: 32421412.

31.       Appiah D, Nwabuo CC, Ebong IA, Wellons MF, Winters SJ. Trends in Age at Natural Menopause and Reproductive Life Span Among US Women, 1959-2018.                       JAMA. 2021 Apr 6;325(13):1328-1330. doi: 10.1001/jama.2021.0278.


32.       Nwabuo CC, Yano Y, Moreira HT, Appiah D, Vasconcellos HD, Aghaji QN, Viera AJ, Rana JS, Shah RV, Murthy VL, Allen NB, Schreiner PJ, Lloyd-Jones DM, Lima JAC. Long-Term Blood Pressure Variability in Young Adulthood and Coronary Artery Calcium and Carotid Intima-Media Thickness in Midlife: The CARDIA Study. Hypertension. 2020 Aug;76(2):404-409. doi: 10.1161/HYPERTENSIONAHA.120.15394. Epub 2020 Jun 29. PMID: 32594795;
33.       Ying W, Post WS, Michos ED, Subramanya V, Ndumele CE, Ouyang P, Ambale-Venkatesh B, Doria De Vasconcellos H, Schreiner PJ, Lewis CE, Reis J, Lloyd-Jones D, Sidney S, Lima JAC, Vaidya D. Associations between menopause, cardiac remodeling, and diastolic function: the CARDIA study. Menopause. 2021 Jun 14. doi: 10.1097/GME.0000000000001815. Epub ahead of print. PMID: 34127631.