Funded Research
| Airways | |
| BREATHE | Smaller vs larger endotracheal tube size for intubation of critically ill adults Funding Agency: Patient Centered Outcomes Research Institute (PCORI) |
| ANGLE | Hyperangulated vs standard geometry video laryngoscope for intubation of critically ill adults Funding Agency: Internal |
| Trauma | |
| EFFECT Trial | A multicenter, open-label, two-arm, parallel, phase IV, adaptive randomized clinical trial comparing fibrinogen concentrate with usual care resuscitation versus usual care resuscitation among adult trauma patients with major hemorrhage and acquired fibrinogen deficiency. Funding Agency: Octapharma |
| RESOLUTE | Research and Scalable Infrastructure to Improve Outcomes on the Front Lines of Ukraine by Advancing Treatment and Evaluation Funding Agency: Department of Defense (DoD) / Medical Technology Enterprise Consortium (MTEC) |
| Plasma-RESCUE | Plasma Resuscitation for Emergency Stabilization in Combat Ukraine Environment Funding Agency: Octapharma |
| CASCAID | Implementation and clinical effectiveness of an emergency department (ED)-based palliative care social work program Funding Agency: Laerdal Foundation |
| EFFECT Cohort | Evaluating endothelial dysfunction in trauma patients (how the coagulation system reacts internally to external trauma) |
| ACME | Assessing antibiotic levels in the blood over time (comparing controls vs. MTP patients) Funding Agency: Department of Defense (DoD) |
| Lung Injury | |
| AURORA | Evaluating proportion of time spent in normoxemia (SpO2 90-96%) between an autonomous oxygen titration system (O2Matic PRO100) and manual titration in the prehospital environment Funding Agency: Department of Defense (DoD) / Medical Technology Enterprise Consortium (MTEC) |
| ALCOVE | Autonomous Closed Loop-Controlled Ventilation for Combat Casualty and En Route Care using Hamilton T1 Military with the INTELLiVENT-ASV Funding Agency: Hamilton Medical |
| OBSERVE-ARDS | Observational, non-interventional biomarker and endotyping study to inform current and future ARDS therapeutic development Funding Agency: Prenosis |
| SEPSIS | |
| SPARES | Study of Protection And Repair of Endothelial-glycocalyx in Sepsis. A multicenter, blinded, placebo-controlled randomized clinical trial Funding Agency: Octapharma |
| IGNITE | |
| ECCO | Epoprostenol versus placebo in patients already receiving the standard of care for frostbite, including alteplase Funding Agency: Department of Defense (DoD) / Medical Technology Enterprise Consortium (MTEC) |
| Frostbite | Treatment of frostbite injuries by aloe vs silver dressings, use of the antibiotic Dalbavancin, and/or evaluation of augmented renal clearance Funding Agency: Department of Defense (DoD) / Congressionally Directed Medical Research Program (CDMRP) |
| FROST | Multicenter study (Hennepin) to harmonize data collection to enable evaluation of the impact of warm ischemia time, use of thrombolytics and adjuvant therapy, and evaluation techniques for assessment of frostbite severity Funding Agency: Department of Defense (DoD) / U.S. Army Medical Research Acquisition Activity (USAMRAA) |
| BURN-PATCH | Evaluation Of Stroke Volume Surrogates Using A Wearable Doppler Ultrasound Patch (Flopatch) To Monitor Fluid Responsiveness In Severe Burns: An Observational Study Funding Agency: Department of Defense (DoD) |
| Airways | |
| RSI | Randomized Trial of Sedative Choice for Intubation Funding Source: Department of Defense (DoD) PMID: 41369227 |
| DEVICE | Direct Versus Video Laryngoscope Trial Funding Source: Department of Defense (DoD) PMID: 37326325 |
| PREOXI | Pragmatic Trial Examining Oxygenation Prior to Intubation Funding Agency: Department of Defense (DoD) PMID: 38869091 |
| IVIEW | An end-user assessment of the novel iView video laryngoscope Funding Agency: USAF/AFMC PMID: 40548927 |
| BOUGIE | Bougie or Stylet in Patients Undergoing Intubation Emergently: A Randomized, Multicenter Trial Funding Agency: Unfunded PMID: 34879143 |
| Trauma | |
| SAVE-O2 Burn | Strategy to Avoid Excessive Oxygen in Major Burn Patients Funding Agency: Department of Defense (DoD) / Medical Technology Enterprise Consortium (MTEC) PMID: 40604863 |
| SAVE-O2 Trauma | Strategy to Avoid Excessive Oxygen in Critically Ill Trauma Patients Funding Agency: Department of Defense (DoD) / (Joint Warfighter Medical Research Program) PMID: 40163121 |
| SAVE-O2 Pilot Study | Targeted Normoxia to Conserve Oxygen and Improve Clinical Outcomes in Combat-Injured Special Operations Forces Funding Agency: Department of Defense (DoD) / U.S. Special Operations Command PMID: 33797494 |
| BOOST-3 | Brain Oxygen Optimization in Severe Traumatic Brain Injury – Phase 3 Funding Agency: National Institute of Neurological Diseases and Stroke (NINDS) PMID: Pending |
| Lung Injury | |
| SAVE-O2 AI | Strategy to Avoid Excessive Oxygen Using Autonomous Oxygen Titration Intervention Funding Agency: Department of Defense (DoD) / Medical Technology Enterprise Consortium (MTEC) PMID: 42546017 |
| mAb | Implementation and Effectiveness of Monoclonal Antibodies to Treat High-Risk Outpatients with COVID-19 Funding Agency: National Center for Advancing Translational Sciences (NCATS) PMID(s): 38516779, 38384380, 38500962, 37072054, 36780912, 36229005, 36344927, 35576581, 36441040 |
| OTAC | Outpatient Treatment with Anti-Coronavirus Immunoglobulin Hyperimmune Intravenous Immunoglobulin (hIVIG) vs placebo to prevent progression of COVID-19 among adult outpatients Funding Agency: National Institutes of Health (NIH) PMID: Pending |
| IVY | Investigating Respiratory Viruses in the Acutely Ill Funding Agency: Centers for Disease Control and Prevention (CDC) PMID(s): 42790883, 42089368, 39107255, 41632473, 41275655, 41570181, 40884491, 40950434, 39107255, 40950434, 40063039, 40014628, 39515195, 38883802, 38421945, 37796753, 37301704, 37104244, 36580424, 35818721, 36264830, 35675695, 34932114, 35324878, 35085218, 34555004, 34437524, 33956782, 33237893, 33151918, 32915165, 32881855, 32730238 |
| STRIVE | Strategies and Treatments for Respiratory Infections & Viral Emergencies Funding Agency: National Institutes of Health (NIH) Trial 1: Shionogi Protease Inhibitor S-217622 (Ensitrelvir) PMID: 42017206 Trial 2: Immune Modulation Strategy Trial PMID: Pending |
| EPOC | Evaluation of the Feasibility and Efficacy of Point-of-Care Antibody Tests for Biomarker-Guided Management of Coronavirus Disease 2019 Funding Agency: National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) PMID: 39269490 |
| Colorado PETAL | Prevention and Early Treatment of Acute Lung Injury Clinical Center Funding Agency: National Heart, Lung, and Blood Institute (NHLBI) ASTER: Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis PMID: 38762798 ROSE: Re-evaluation of Systemic Early neuromuscular blockade. Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome PMID: 31112383 VIOLET: Vitamin D to Improve Outcomes by Leveraging Early Treatment PMID: 31826336 |
| VIOLET BUD | Vitamin D to Improve Outcomes by Leveraging Early Treatment: Long-term Brain Outcomes in Vitamin D Deficient Patients Funding Agency: Vanderbilt - National Heart, Lung, and Blood Institute (NHLBI) PMID: 33819472 |
| TREAT-NOW | Trial of Early Antiviral Therapies during Non-hospitalized Outpatient Window for COVID-19 Funding Agency: Department of Defense (DoD) and Abbvie PMID: 36581186 |
| HIBISCUS | Human Interferon Beta-1a Safety and Preliminary Efficacy in Hospitalized Subjects with Coronavirus
|
| ORCHID | Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease Funding Agency: National Heart, Lung, and Blood Institute (NHLBI) |
| PassItOn | Passive Immunity Trial for Our Nation |
| C3PO | Clinical Trial of COVID-19 Convalescent Plasma in Outpatients Funding Agency: National Heart, Lung, and Blood Institute (NHLBI) PMID: 34407339 |
| ACTIV-3 | A Multicenter, Adaptive, Randomized, Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for Hospitalized Patients with COVID-19 Funding Agency: National Heart, Lung, and Blood Institute (NHLBI) |
| ACTIV-4 HT | Master Protocol for Clinical Trials targeting macro-, micro-immuno-thrombosis, vascular hyperinflammation, and hypercoagulability and renin-angiotensin-aldosterone system (RAAS) in hospitalized patients with COVID-19 Funding Agency: National Institutes of Health (NIH) PMID: 39625722 |
| SEPSIS | |
| SEPSIGN | Early Identification of Sepsis Signs in Emergency Department Funding Agency: BioMerieux PMID: 39477836 |
| CLOVERS | Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis Funding Agency: National Heart, Lung, and Blood Institute (NHLBI) PMID: 36688507 |
| VICTAS | Vitamin C, Thiamine, and Steroids in Sepsis Funding Agency: Johns Hopkins University -The Marcus Foundation PMID: 33620405 |
| IGNITE (Frostbite and Burn) | |
| FFP | A Randomized Trial of Fresh Frozen Plasma versus Albumin in Acute Burn Resuscitation Funding Agency: Department of Defense (DoD) U.S. Army Medical Research Acquisition Activity (USAMRAA) PMID: Pending |